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  • Articles  (29)
  • Cells, Cultured  (26)
  • Chemistry
  • General Chemistry
  • American Association for the Advancement of Science (AAAS)  (29)
  • 2005-2009
  • 1980-1984
  • 1975-1979  (29)
  • 1970-1974
  • 1950-1954
  • 1979  (29)
  • Computer Science  (29)
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  • Articles  (29)
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Keywords
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  • American Association for the Advancement of Science (AAAS)  (29)
Years
  • 2005-2009
  • 1980-1984
  • 1975-1979  (29)
  • 1970-1974
  • 1950-1954
Year
Journal
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  • 1
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    Metabolism of theophylline to caffeine in human fetal liver (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Caffeine (1,3,7-trimethylxanthine) is a biotransformation product of theophylline (1,3-dimethylxanthine) in the human fetus. Liver explants, obtained from human fetuses with gestational ages of 12 to 20 weeks, were incubated with theophylline and produced caffeine and, in lesser amounts, 1,3-dimethyluric acid and 3-methylxanthine. These findings suggest that the predominant pathway in theophylline metabolism in the fetus and newborn infant is the methylation reaction producing caffeine. This may contribute to the neonate's exceedingly slower elimination of caffeine relative to theophylline. Caffeine produced from theophylline may add to the pharmacologic effects of theophylline in newborn infants with apnea.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aranda, J V -- Louridas, A T -- Vitullo, B B -- Thom, P -- Aldridge, A -- Haber, R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1319-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515734" target="_blank"〉PubMed〈/a〉
    Keywords: Apnea/drug therapy ; Biotransformation ; Caffeine/*biosynthesis/metabolism/therapeutic use ; Cells, Cultured ; Gestational Age ; Humans ; Infant, Newborn ; Liver/*embryology/metabolism ; Methylation ; Theophylline/*metabolism/therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Exposure of L1210 leukemia cells first to 0.1 to 100 micromolar methotrexate and then to 10 micromolar 5-fluorouracil produces a synergistic effect on the number of cells killed in culture. Methotrexate dose-related increases occur in the concentrations of intracellular 5-fluorouracil ribonucleotides and 5-fluoro-2'-deoxyuridylate and in the incorporation of 5-fluorouracil into RNA. These increases are correlated with increased concentrations of intracellular phosphoribosylpyrophosphate. It is proposed that the enhanced formation of ribonucleotides of 5-fluorouracil and the subsequent incorporation of these compounds into RNA in methotrexate-treated cells may account for synergism between these agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cadman, E -- Heimer, R -- Davis, L -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Drug Administration Schedule ; Drug Synergism ; Fluorouracil/metabolism/*pharmacology ; Leukemia L1210 ; Methotrexate/*pharmacology ; Mice ; Phosphoribosyl Pyrophosphate/metabolism ; RNA, Neoplasm/metabolism ; Ribonucleotides/metabolism ; Thymidylate Synthase/metabolism
    Print ISSN: 0036-8075
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  • 3
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    Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Micropipettes containing 2 to 50 biological units of beta growth factor (NGF) were placed near growing axons of chick dorsal-root ganglion neurons in tissue culture. The axons turned and grew toward the NGF source within 21 minutes. This turning response to elevated concentrations of NGF appears to represent chemotactic guidance rather than a general enhancement of growth rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gundersen, R W -- Barrett, J N -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1079-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/growth & development/*physiology ; Cells, Cultured ; *Chemotaxis/drug effects ; Chick Embryo ; Dose-Response Relationship, Drug ; Ganglia, Spinal/physiology ; Nerve Growth Factors/*pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Specific nonopiate receptors for beta-endorphin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: Iodinated beta H-[2-D-alanine]endorphin exhibits specific binding to cultured human lymphocytes. The binding is inhibited by low concentrations of beta-endorphin and its D-alanine derivative, but is not affected by opiate agonists and antagonists, or by enkephalin analogs, beta-lipotropin, adrenocorticotrophic hormone, or alpha-melanocyte-stimulating hormone; this suggests the existence of a specific, non-opiate binding site (receptor) for beta-endorphin. The carboxy-terminal region of beta-endorphin is essential for this binding activity, since alpha-endorphin is not active. beta-Endorphin may be a circulating hormone with peripheral physiological effects that are not primarily mediated through interactions with opiate or enkephalin receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazum, E -- Chang, K J -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1033-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224457" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Cells, Cultured ; Endorphins/blood/*metabolism ; Humans ; Lymphocyte Activation ; Lymphocytes/*metabolism ; Receptors, Drug/*metabolism ; Receptors, Opioid/metabolism ; Stress, Physiological/metabolism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Benzo(a)pyrene-7,8-dihydrodiol 9,10-oxide adenosine and deoxyadenosine adducts: structure and stereochemistry (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, A M -- Grzeskowiak, K -- Weinstein, I B -- Nakanishi, K -- Roller, P -- Harvey, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316186" target="_blank"〉PubMed〈/a〉
    Keywords: *Benzopyrenes ; Chemical Phenomena ; Chemistry ; Circular Dichroism ; Dna ; *Deoxyadenosines/analogs & derivatives ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Mutation ; Stereoisomerism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacDonald, J F -- Barker, J L -- Paul, S M -- Marangos, P J -- Skolnick, P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):715-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/37602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Cells, Cultured ; Electric Conductivity ; Flurazepam/antagonists & inhibitors ; Inosine/*metabolism/pharmacology ; Ligands ; Mice ; Neurotransmitter Agents/metabolism ; Receptors, Drug/*metabolism ; Receptors, Neurotransmitter/metabolism ; Spinal Cord/*metabolism
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  • 7
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    New information about the development of the autonomic nervous system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):434-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/41320" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Adrenergic Fibers/growth & development ; Animals ; Autonomic Nervous System/*growth & development ; Cell Communication ; Cell Differentiation ; Cells, Cultured ; Cholinergic Fibers/growth & development ; Nerve Growth Factors/physiology ; Neural Crest/cytology ; Neural Pathways/growth & development ; Neurotransmitter Agents/*metabolism ; Synaptic Transmission
    Print ISSN: 0036-8075
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  • 8
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    DNA synthesis and mitosis in adult amphibian cardiac muscle cells in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: High-resolution autoradiography and fine structural analysis of adult newt heart tissue in long-term culture revealed that tritiated thymidine was concentrated in the nuclei of dedifferentiated myocardial cells. Mitotic chromosomes were observed in some of these cells. This demonstrates that adult amphibian myocardial cells in vitro are capable of DNA synthesis and mitosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nag, A C -- Healy, C J -- Cheng, M -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1281-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472744" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cells, Cultured ; DNA/*biosynthesis ; *Mitosis ; Muscle Proteins/metabolism ; Myocardial Contraction ; Myocardium/*metabolism ; Salamandridae ; Time Factors
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  • 9
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    Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, J D -- Barker, J L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1409-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cells, Cultured ; Electric Conductivity ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Membrane Potentials ; Mice ; Neural Inhibition ; Spinal Cord/cytology/*physiology ; Substance P/*physiology ; Synaptic Transmission
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  • 10
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    Molecular cloning of polyoma virus DNA in Escherichia coli: lambda phage vector system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: The biological activity of recombinant phage and recombinant phage DNA containing monomeric or dimeric polyoma DNA inserts was examined in mice and cultured mouse cells. Recombinant preparations containing a single copy of viral DNA were invariably noninfectious; molecules containing a dimeric polyoma DNA insert were at least seven orders of magnitude less infectious than polyoma virions after parenteral inoculation. No infection was detected with any recombinant preparation after oral administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, H W -- Israel, M A -- Garon, C F -- Rowe, W P -- Martin, M A -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):887-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/217088" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Coliphages/*genetics ; DNA Restriction Enzymes/metabolism ; *DNA, Recombinant ; DNA, Viral/genetics ; Escherichia coli/*genetics ; Mice ; Polyomavirus/*genetics ; Risk ; Tumor Virus Infections/*genetics ; Virus Replication
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Permeability of the cell-to-cell membrane channels in mammalian cell juncton (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. In respect to both factors, mammalian junctional channels are more restrictive than insect channels; hence the mammalian channels are narrower, more polar, or both. The channels of the various mammalian cell types differed slightly from each other; in some types the serum of the culture medium affected the channel permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J -- Simpson, I -- Loewenstein, W R -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):404-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377490" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/physiology ; *Cell Membrane Permeability ; Cells, Cultured ; Cricetinae ; Fluorescent Antibody Technique ; Kidney ; Mice ; Mice, Inbred BALB C ; Species Specificity
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  • 12
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    Galactosemia: alterations in sulfate metabolism secondary to galactose-1-phosphate uridyltransferase deficiency (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Cultures of nonmutant as well as galactokinase-deficient fibroblasts incorporate 20 percent more [35S]sulfate when galactose is substituted for glucose in the medium; galactose-1-phosphate uridyltransferase-deficient cells incorporate 65.5 percent less. In addition to incorporating less [35S]sulfate, the uridyltransferase-deficient cells showed significant accumulation of intracellular galactose-1-phosphate within 4 hours after galactose exposure. Under the same conditions, no difference in [3H]uridine incorporation was observed. This metabolic alteration, occurring in response to galactose exposure, may be related to the pathophysiology of classical galactosemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tedesco, T A -- Miller, K L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1395-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472754" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Galactose/metabolism ; Galactosemias/*metabolism ; Galactosephosphates/metabolism ; Glucose/metabolism ; Humans ; Nucleotidyltransferases/*deficiency ; Sulfates/*metabolism ; UTP-Hexose-1-Phosphate Uridylyltransferase/*deficiency
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Lens epithelial cell elongation in the absence of microtubules: evidence for a new effect of colchicine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Embryonic chick lens epithelial cells cultured in serum-supplemented medium elongated in the absence of microtubules after treatment with the antimicrotubule drug nocodazole. Colchicine, at concentrations lower than those that dissociate microtubules, blocks cell elongation and the associated increase in cell volume. These results indicate that an increase in cell volume, not microtubules, is responsible for lens cell elongation and suggest a previously undescribed effect of colchicine on cell volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beebe, D C -- Feagans, D E -- Blanchette-Mackie, E J -- Nau, M E -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):836-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493982" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzimidazoles/pharmacology ; Carbamates/pharmacology ; Cells, Cultured ; Chick Embryo ; Colchicine/*pharmacology ; Epithelium/ultrastructure ; Lens, Crystalline/*cytology ; Microtubules/*drug effects
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  • 14
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    "Sontaneous" neoplastic transformation in vitro: a form of foreign body (smooth surface) tumorigenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Explants of subcutaneous connective tissue from adult BALB/c mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate (2.4 x 10(4) to 3.4 x 10(5) cells per plate) formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did not form tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1 1/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smooth-surfaced foreign bodies, regardless of their chemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogen first in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boone, C W -- Takeichi, N -- Eaton, S D -- Paranjpe, M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Connective Tissue/pathology ; Female ; Foreign-Body Reaction/*complications ; Mice ; Neoplasms, Experimental/*etiology ; *Plastics ; Sarcoma, Experimental/etiology ; Time Factors
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  • 15
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    Noncycling tumor cells are sensitive targets for the antiproliferative activity of human interferon (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Resting Burkitt's lymphoma cells (Daudi) in culture are more sensitive targets for the antiproliferative activity of purified human fibroblast interferon than cells that are rapidly multiplying. Thus, interferon may be of significant clinical value in neoplasms involving stem cells and, after chemotherapy, in suppressing the reemergence of tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horoszewicz, J S -- Leong, S S -- Carter, W A -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1091-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493995" target="_blank"〉PubMed〈/a〉
    Keywords: Burkitt Lymphoma/drug therapy/pathology ; Cell Cycle/drug effects ; Cell Division/*drug effects ; Cell Line ; Cells, Cultured ; Humans ; Interferons/*pharmacology/therapeutic use ; Lymphocytes/drug effects
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  • 16
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    Developmental fate of skeletal muscle satellite cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: Radioisotopically labeled satellite cells from clonal cultures were implanted into normal muscle of the original donor. Implanted cells invariably retained their myogenic potential by participating in the regeneration of damaged myofibers or in the development of existing fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lipton, B H -- Schultz, E -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1292-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472747" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cells, Cultured ; Coturnix ; Muscles/cytology/*physiology/transplantation ; Rats ; *Regeneration ; Transplantation, Homologous
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  • 17
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    Sister chromatid exchanges in human lymphocytes after exposure to diagnostic ultrasound (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The frequency of sister chromatid exchanges increased in freshly isolated human lymphocytes as well as in a continuously growing lymphoblast line by exposure to diagnostic levels of ultrasound for 30 minutes. The results confirm previous findings indicating that ultrasound of diagnostic intensities can affect the DNA of animal cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liebeskind, D -- Bases, R -- Mendez, F -- Elequin, F -- Koenigsberg, M -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1273-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472742" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; *Chromatids ; *Crossing Over, Genetic ; Humans ; Lymphocytes ; *Ultrasonics/adverse effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Simultaneous production of Q and R bands after staining with chromomycin A3 or olivomycin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Human and mouse chromosomes, stained with either chromomycin A3 or olivomycin, which bind preferentially to G - C-rich DNA (where G is guanosine and C is cytosine), exhibit a Q or a reverse banding pattern, depending on the wavelength used for excitation. The two complementary banding patterns can be observed in the same metaphase simply by changing the combination of excitation filters. These data suggest, therefore, that in addition to base composition, other factors are involved in the production of chromosome banding by chromomycin A3 and olivomycin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prantera, G -- Bonaccorsi, S -- Pimpinelli, S -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):79-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cells, Cultured ; Centromere/ultrastructure ; *Chromomycins ; Chromosomes/*ultrastructure ; *Dna ; Fluorescent Dyes ; Humans ; Mice ; *Olivomycins ; Staining and Labeling
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    N-formyliminodiacetic acid, a new compound from the reaction of nitrilotriacetic acid and chlorine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: It has been proposed that nitrilotriacetic acid be substituted for trisodium polyphosphates in detergents as a way to reduce the rate of eutrophication in the Great Lake Basin. The reaction of nitrilotriacetic acid with chlorine-containing solutions produces a hitherto unknown degradation production, N-formyliminodiacetic acid, in high yield. The toxicological and environmental implications of this reaction are unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spanggord, R J -- Tyson, C A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1081-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36659" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetates ; Chemical Phenomena ; Chemistry ; *Chlorine ; Dicarboxylic Acids ; Environmental Pollutants ; Hydrogen-Ion Concentration ; *Imino Acids ; Mutagens ; *Nitrilotriacetic Acid
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Calcification of differentiating skeletal mesenchyme in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Embryonic limb-bud mesenchyme was induced to calcify in culture by the addition of 3 mM inorganic phosphate to the medium. Phosphate enhanced calcification of the matrix produced by mesenchymal or fibroblast-like cells, whereas no calcification was evident in areas where cartilage had developed. However, calcification was induced throughout the cell layer by altering the cartilage matrix properties with certain enzymes or by changing the phenotypic expression of the cells with vitamin A.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Binderman, I -- Greene, R M -- Pennypacker, J P -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):222-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482937" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Development/drug effects ; Bromodeoxyuridine/pharmacology ; *Calcification, Physiologic/drug effects ; Cell Differentiation ; Cells, Cultured ; Chick Embryo ; Collagen/physiology ; Fibroblasts/cytology ; Hyaluronoglucosaminidase/metabolism ; Mesoderm/cytology ; Phosphates/metabolism ; Proteoglycans/physiology ; Vitamin A/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Dendritic growth in the aged human brain and failure of growth in senile dementia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Golgi-stained dendrites of single randomly chosen layer-II pyramidal neurons in the human parahippocampal gyrus were quantified with a computer-microscope system. In nondemented aged cases (average age, 79.6 years), dendritic trees were more extensive than in adult cases (average age, 51.2), with most of the difference resulting from increases in the number and average length of terminal segments of the dendritic tree. These results provide morphological evidence for plasticity in the mature and aged human brain. In senile dementia (average age, 76.0), dendritic trees were less extensive than in adult brains, largely because their terminal segments were fewer and shorter. Cells with shrunken dendritic trees were found in all brains. These data suggest a model of aging in the central nervous system in which one population of neurons dies and regresses and the other survives and grows. The latter appears to be the dominant population in aging without dementia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buell, S J -- Coleman, P D -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):854-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493989" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; *Aging ; Cells, Cultured ; Dementia/pathology/*physiopathology ; Dendrites/pathology/physiology/ultrastructure ; Hippocampus/pathology ; Humans ; Middle Aged
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    Cycloheximide-dependent reversion of human cells transformed by MSV and chemical carcinogen (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: The protein synthesis inhibitor cycloheximide, at a concentration of 0.08 microgram per milliliter, induced flat morphology within 24 to 48 hours and low saturation density in human osteosarcoma cells transformed by Kirsten murine sarcoma virus (Ki-MSV) or N-methyl-N' nitro-N-nitrosoguanidine. Removal of the protein synthesis inhibitor caused both transformed cells to revert to the transformed phenotype. The demonstration of cell-surface antigens, cross-reacted with antiserums induced by extracts of both types of transformed human cells, was dependent on the presence or absence of cycloheximide in the culture medium. The results show that protein synthesis is required to maintain the transformed state in virally or chemically transformed human cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho, H Y -- Rhim, J S -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):691-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/223242" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/analysis ; Cell Division/drug effects ; Cell Survival/drug effects ; Cell Transformation, Neoplastic/*drug effects/pathology ; Cell Transformation, Viral/*drug effects ; Cells, Cultured ; Cycloheximide/*pharmacology ; *Gammaretrovirus ; Humans ; Methylnitronitrosoguanidine ; Neoplasm Proteins/biosynthesis ; *Sarcoma Viruses, Murine
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    HCN did not condense to give heteropolypeptides on the primitive earth (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, J P -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218287" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen Cyanide ; *Peptides
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsueh, A J -- Erickson, G F -- New York, N.Y. -- Science. 1979 May 25;204(4395):854-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/375393" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Estrogens/*biosynthesis ; Female ; Follicle Stimulating Hormone/*antagonists & inhibitors ; Gonadotropin-Releasing Hormone/*pharmacology ; Granulosa Cells/drug effects ; Hypophysectomy ; Ovary/*drug effects/metabolism ; Progestins/*biosynthesis ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: A series of recombinant plasmids containing polyoma virus (PY) DNA were constructed, and their biological activity was evaluated in mice and in cultured mouse cells. While all of the recombinants studied contain the complete, potentially infectious viral DNA, in no case was the intact recombinant PY-plasmid DNA, or live Escherichia coli containing the recombinant plasmids, capable of inducing PY infection of mice, either by feeding or by parenteral injection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Israel, M A -- Chan, H W -- Rowe, W P -- Martin, M A -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):883-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/217087" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Chromosome Mapping ; *DNA, Recombinant ; DNA, Viral/genetics ; Escherichia coli/*genetics ; Mice ; *Plasmids ; Polyomavirus/*genetics ; Transcription, Genetic ; Tumor Virus Infections/*genetics ; Virus Replication
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  • 26
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    Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm of enzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kasal, C A -- Menaker, M -- Perez-Polo, J R -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):656-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569904" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/*metabolism ; Animals ; Cells, Cultured ; Chick Embryo ; Chickens ; *Circadian Rhythm ; Darkness ; Pineal Gland/enzymology/*physiology
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  • 27
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    Killing of fibroblasts by dexamethasone or dibutyryl adenosine 3',5'-monophosphate is not a valid test for cystic fibrosis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Assays based on the counting of total cells and of colony-forming cells were used to demonstrate that neither dexamethasone nor dibutyryl adenosine 3',5'-monophosphate (cyclic AMP) kills human fibroblasts under a variety of conditions. These results contradict those of previous studies showing that dexamethasone and dibutyryl cyclic AMP kill a higher percentage of fibroblasts from normal humans than from individuals with cystic fibrosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurz, J B -- Perkins, J P -- Buchwald, M -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1317-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/229552" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Bucladesine/*pharmacology ; Cell Division/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Child ; Child, Preschool ; Cystic Fibrosis/*diagnosis ; Dexamethasone/*pharmacology ; Dose-Response Relationship, Drug ; Female ; Fibroblasts/*drug effects ; Humans ; Ouabain/pharmacology ; Skin/cytology
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  • 28
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    Premature senescence in cultured skin fibroblasts from subjects with cystic fibrosis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: Cultured skin fibroblasts from subjects with cystic fibrosis exhibited normal population doubling times in early passages. After about 13 cumulative population doublings, cystic fibrosis lines doubled more slowly than controls and ceased doubling after about 19 weekly passages. Control lines continued doubling for 27 passages. The premature senescence noted in cells from subjects with cystic fibrosis reconciles controversial observations of cell doubling reported in the literature. Data presented here demonstrate that experiments with cystic fibrosis cells in late passage may generate misleading results since differences from control lines may be ascribed to generalized senile changes rather than to specific results of the cystic fibrosis genotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, B L -- Lam, L F -- Fast, L H -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1251-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424752" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aging ; Cell Division ; *Cell Survival ; Cells, Cultured ; Child ; Cystic Fibrosis/*pathology ; DNA/biosynthesis ; Female ; Humans ; Male ; Skin/pathology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 29
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    In vitro model for stretch-induced hypertrophy of skeletal muscle (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-19
    Description: Mechanical stretch of embryonic chicken skeletal myotubes developed in vitro leads to many of the biochemical changes seen in skeletal muscle hypertrophy. These include increased amino acid accumulation, increased incorporation of amino acids into general cellular proteins and myosin heavy chains, and increased accumulation of total protein and myosin heavy chains. This model system should aid in understanding how the growth rate of skeletal muscle is regulated by its activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vandenburgh, H -- Kaufman, S -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):265-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569901" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Aminoisobutyric Acids/metabolism ; Animals ; Cell Division ; Cells, Cultured ; Chick Embryo ; Fibroblasts/cytology ; Hypertrophy ; Muscle Proteins/biosynthesis ; Muscles/metabolism/*physiology ; Myosins/biosynthesis
    Print ISSN: 0036-8075
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