Publication Date:
1978-07-07
Description:
Endogenous opiate-like peptides (endorphins) are putative neuroregulators located throughout the mammalian brainstem. There is some evidence for their role in pain, stress, and affect. We report that the opiate antagonist, naloxone, alters some schizophrenic symptoms. In a double-blind, cross-over study, naloxone produced decreases in auditory hallucinations in some schizophrenic patients. This finding supports the hypothesis that the endorphins may play a roll in modulating hallucinations in a highly selected subgroup of chronically hallucinating schizophrenic patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watson, S J -- Berger, P A -- Akil, H -- Mills, M J -- Barchas, J D -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):73-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351804" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Chronic Disease
;
Clinical Trials as Topic
;
Dose-Response Relationship, Drug
;
Double-Blind Method
;
Endorphins/physiology
;
Hallucinations/*drug therapy
;
Humans
;
Male
;
Naloxone/administration & dosage/*therapeutic use
;
Schizophrenia/*drug therapy/physiopathology
;
Schizophrenia, Paranoid/drug therapy
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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