ISSN:
0025-116X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
4-(1,2,3,4-Tetrahydro-5-methyl-2,4-dioxo-1-pyrimidinyl)-3-hydroxybutyric acid (1a) and 4-(1,2,3,4-tetrahydro-2,4-dioxo-1-pyrimidinyl)-3-hydroxybutyric acid (1b) were synthesized via the addition reaction of thymine (3) and 4-ethoxy-1,2-dihydro-2-oxopyrimidine (7), respectively, to 1-chloro-2,3-epoxypropane and subsequent cyanization, followed by acid hydrolysis of the products. Condensation polymerizations of 1a and 1b were carried out using dicyclohexylcarbodiimide, 2,4,6-triisopropylbenzenesulfonyl chloride or p-toluenesulfonyl chloride as dehydrating agents. The resulting oligoesters 2a and 2b are light-yellow powders with molecular weights of about 700, according to gel filtration measurements. Their UV spectra show a hypochromicity of 3-4% when mixed with denatured yeast RNA in 0,1 M Na2HPO4 solution.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/macp.1978.021790405
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