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  • Springer  (84,305)
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  • 1983  (49,382)
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  • 2010-2014
  • 2005-2009
  • 1980-1984  (49,382)
  • 1975-1979  (43,644)
  • 1925-1929
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  • 1
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    Bulletin of mathematical biology 37 (1975), S. 37-49 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The chromosomal theory of inbreeding based on a gametic interaction system lead us to define a depression coefficientD. Comparison of random, sib and half-sib matings (with inbreeding coefficientF=0, 1/4 and 1/8) shows thatD depends on the structure of the starting population and on values of the model parameters. This result accounts for responses of lines whose depression does not depend directly on the inbreeding coefficient and which theories of inbreeding based on increasing homozygosity fail to explain.
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    Bulletin of mathematical biology 37 (1975), S. 59-69 
    ISSN: 1522-9602
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    Notes: Abstract An idealization of chemical combination is formulated as a model of computability, and it is shown that this model has universal computational power just in case assembly has at least two-dimensional space in which to occur. It is also shown that this model, under reinterpretation, corresponds to a cellular automaton in which growth occurs by differentiation only (i.e., the state into which any cell is born is thereadfter fixed). Hence this latter model of growth is also computationally universal.
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  • 3
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    Notes: Abstract Kinetics of biological light emission processes do not mean what they seem to mean, because measured light intensity is not proportional to reactant concentration but to reaction rate. Therefore, the differential equation for light decay is usually different from that of concentration decay, so that mass action interpretations cannot be applied directly to light intensity decay. An observed second order light decay for Chlorella at 6.5°C, implies Elovich solid state reaction kinetics, which agrees with other evidence for solid state processes in photosynthesis. An observed 1.5 order light decay for Cholorella at 28°C implies second order liquid or solid state reaction kinetics. First ordere light decay implies first order reaction kinetics.
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    Bulletin of mathematical biology 37 (1975), S. 71-78 
    ISSN: 1522-9602
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    Notes: Abstract Analysis based on the integration of differential inequalities is employed to derive upper and lower bounds on the total populationN(t) = ∫ R θ(x 1,x 2,t) dx 1 dx 2 of a biological species with an area-density distribution function θ=θ(x 1,x 2,t) (≥0) governed by a reaction-diffusion equation of the form ∂θ/∂t =D∇2θ +fθ −gθ n+1 whereD (〉0),n (〉0),f andg are constant parameters, θ=0 at all points on the boundary ∂R of an (arbitrary) two-dimensional regionR, and the initial distribution (θ(x 1,x 2, 0) is such thatN(0) is finite. Forg≥0 withR the entire two-dimensional Euclidean space, a lower bound onN(t) is obtained, showing in particular thatN(∞) is bounded below by a finite positive quantity forf≥0 andn〉1. An upper bound onN(t) is obtained for arbitrary bounded or unbounded)R withn=1,f andg negative, and ∫ R θ(x 1,x 2, 0)2 dx 1 dx 2 sufficiently small in magnitude, implying that the population goes to extinction with increasing values of the time,N(∞)=0. Forg≥0 andR of finite area, the analysis yields upper bounds onN(t), predicting eventual extinction of the population if eitherf≤0 or if the area ofR is less than a certain grouping of the parameters in cases for whichf is positive. These results are directly applicable to biological species with distributions satisfying the Fisher equation in two spatial dimensions and to species governed by certain specialized population models.
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    Bulletin of mathematical biology 37 (1975), S. 127-138 
    ISSN: 1522-9602
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    Notes: Abstract The equilibrium probability distribution of the process level is studied for a general class of reversible stochastic reactions. A calculationally convenient approximation for equilibrium probabilities is derived and its accuracy is investigated over a range of values of the equilibrium constant. A method of approximating the equilibrium means and variance is developed and illustrated forQ th-order processes.
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    Bulletin of mathematical biology 37 (1975), S. 565-572 
    ISSN: 1522-9602
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    Notes: Abstract Beside the concept of material inputs and outputs of components of the representation of biological systems given to us by Rosen, the concept of energy is incorporated. The interaction of material and energy is represented by a cartesian product; and separate material and energetical mappings are considered as the new representation of components. These developments generate aMα category, and it is shown thatMα is isomorphic to theM category of previous developments.
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    Bulletin of mathematical biology 37 (1975), S. 555-564 
    ISSN: 1522-9602
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    Notes: Abstract This paper discusses the solution of a generaln-compartment system with time dependent transition probabilities utilizing the technique described by Cardenas and Matis (1975) (hereafter abbreviated (CM)). In addition, the cumulant generating function is derived for a special class of reversiblen-compartment systems where the time-dependent intensity coefficients corresponding to the migration and death rates are some multiple of each other. The immigration rates can be any integrable function of time. The moments are also obtained and the solution to the two-compartment system is presented explicitly. The solution is illustrated with a linear and a periodic function which forms have been widely reported in the literature.
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    Bulletin of mathematical biology 37 (1975), S. 573-588 
    ISSN: 1522-9602
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    Notes: Abstract The relations (inflow) = (dose)/(area under indicator curve), and (volume of distribution) = (throughflow) × (mean transit time) are derived by a matrix method for a system of interconnected subsystems, within which spatial indicator activity gradients may exist, and for compartments, within which the indicator activity is spatially uniform. The inflow theorem, is different from the outflow theorem. Equivalent labeling of multi-input systems reduces them formally to single input systems. Foreign indicator flow-volume kinetics are more general than, and include as a special case, tracer flux-mass (metabolic) kinetics. Volume of distribution in the indicator steady state may be different from the equilibrium volume of distribution.
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    Bulletin of mathematical biology 37 (1975), S. 219-219 
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    Bulletin of mathematical biology 37 (1975), S. 291-299 
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    Notes: Abstract Perturbation methods are applied to a differential equation predator-prey model to find the approximate amplitudes and period of limit cycle solutions. In the model the feeding rate per unit predator per unit prey decreases as the prey become scare. The rigorous applicability of the perturbation technique depends on the assumptions that the limit cycle amplitude is relatively small and that near the equilibrium point the growth rate of each species is most sensitive to changes in the density of the other species. The second assumption is usually roughly satisfied in practice and examples are considered which suggest that the first assumption can be greatly relaxed.
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    Bulletin of mathematical biology 37 (1975), S. 367-387 
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    Notes: Abstract Signal Detection Theory can be used to provide a mathematical model describing the choice of a predator trying to distinguish between a model and a Batesian mimic. The mathematical model yields a number of a deductions, in particular that it may or may not assist the mimic population if mimics more closely resemble their models. The assumptions underlying the analysis are discussed in some detail.
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    Bulletin of mathematical biology 37 (1975), S. 419-425 
    ISSN: 1522-9602
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    Notes: Abstract A new type of physical transition, denotedS→S *, has been detected in irradiated organic molecules (λ=546 nm) through their interaction with specific biological macromolecules. In a specific enzyme-substrate interaction, a clear enhancement of the reaction rate is observed, when the substrate is irradiated with sharply well defined times. These “efficient irradiation times” are always of the 5k sec type (k=1, 2, 3, …). They have been consistently revealed in a great number of specific biological interactions. The present note demonstrates an important property, i.e. that forevery irradiation time aS→S * transition is induced in organic molecules. It is shown that for any irradiation times different from the 5k sec type (k=1, 2, 3, …) states of theS * type may occur, but the biological macromolecules may “detect” only theS * states induced by irradiations of the 5k sec type.
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    Bulletin of mathematical biology 37 (1975), S. 459-470 
    ISSN: 1522-9602
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    Notes: Abstract A semi-empirical model applicable to the flow of blood and other particulate suspensions through narrow tubes has been developed. It envisages a central core of blood surrounded by a wall layer of reduced hematocrit. With the help of this model the wall layer thickness and extent of plug flow may be calculated using pressure drop, flow rate and hematocrit reduction data. It has been found from the available data in the literature that for a given sample of blood the extent of plug flow increases with decreasing tube diameter. Also for a flow through a given tube it increases with hematocrit. The wall layer thickness is found to decrease with increase in blood hematocrit. A comparison between the results of rigid particulate suspensions and blood reveals that the thicker wall layer and smaller plug flow radius in the case of blood may be attributed to the deformability of the erythrocytes.
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    Bulletin of mathematical biology 37 (1975), S. 489-504 
    ISSN: 1522-9602
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    Notes: Abstract Three dimensional laminar, viscid flow is developed for Newtonian fluids which provides absolute values for axial, radial and tangential velocity fields everywhere if the dimensions of the vessel are known and two simultaneous axial velocities e.g. on and off the central axis in the same plane, and the central axis axial velocity gradient are measured. In addition, normal and shear stresses are determinable. The equation set satisfies geometric and other known flow limiting conditions such as no slip at surfaces etc. and are amenable for inclusion in general, dynamic flow expressions. Alternatively they may be used alone for certain problems involving gradients and secondary flows. A range of illustrations are shown for a distorting vessel with elliptic cross-section and small axial taper (analogous to the pulmonary trunk during ejection).
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    Bulletin of mathematical biology 37 (1975), S. 521-553 
    ISSN: 1522-9602
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    Notes: Abstract A regulated left ventricular dynamics model is presented which involves interaction of the dynamics of the left ventricular and circulatory systems and their regulation by the central nervous system. On-line human parametric simulation (parameter estimation) and consequential prognostic implications (based on parametric values) are demonstrated. Model responses to simulated physiologic stresses help delineate tolerances of subjects. In order to have an estimate of the reliability of the model, the sensitivity of the model's responses to changes in the values of its intrinsic parameters is assessed. Also determined is the extent to which errors in measuring the pressure affect the calculated values of the model's simulation parameters and subsequently influence the values of other diagnostically useful variables (such as contractility, oxygen consumption rate, heart rate), when the model is used to determine the limiting physiological stress sustainable by the subject. A comparison of the model's composition with those of other similar cardio-circulatory models is included.
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    Bulletin of mathematical biology 37 (1975), S. 659-673 
    ISSN: 1522-9602
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    Notes: Abstract Then-stage harvesting strategy of Elizarov and Svirezhev is examined. As a result, some important new features appear. A discussion is presented on whether or not one should harvest a species at one time stage or wait until a later time. The paper is concerned with contributions which are primarily mathematical formulations and results for continuous, as well as discrete time, logistic growth of a single species being harvested. Age class structure is ignored.
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    Bulletin of mathematical biology 45 (1983), S. 287-293 
    ISSN: 1522-9602
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    Notes: Abstract We postulate that the biomass distribution function for an ecological population may be derived from the condition that the biomas diversity functional is maximal subject to an energetic constraint on the total biomass. This leads to a biomass distribution of the form $$p(m) = \bar m^{ - 1} \exp ( - m/\bar m)$$ , where $$\bar m$$ is the mean biomass per individual. The same condition yields a unique value for the biomass diversity functional. These predictions are tested against fishery data and found to be in good agreement. It is argued that the existence of a unique value for biomass diversity may provide a preliminary theoretical foundation for the observed upper limit to species diversity.
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    Bulletin of mathematical biology 45 (1983), S. 311-321 
    ISSN: 1522-9602
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    Notes: Abstract Pigment distribution presages hydranth regeneration in the marine hydroidTubularia. We suggest that such a distribution could result from a reaction-diffusion system. A model system based on a practical reaction scheme is studied and spatial structures found which closely resemble this pigment distribution. Finite-amplitude spatial structures in reaction-diffusion systems are considered. Whereas in one spatial dimension the final structures are normally very similar to the transient patterns which emerge from a linear analysis, it is shown that in more than one dimension this is not necessarily the case. The reasons for this are discussed.
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    Bulletin of mathematical biology 45 (1983), S. 409-424 
    ISSN: 1522-9602
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    Notes: Abstract An analytical model is used to described the behavior of inhaled particulate matter in the human respiratory tract. Three different geometries, symmetric and asymmetric, are utilized to simultate the tracheobronchial (TB) tree. The suitability of each geometry for representing the human is evaluated by comparing calculated aerosol deposition probabilities with experimental data from inhalation exposure tests. A symmetric, dichotomously branching pattern is found to be a reliable description of the TB tree for studies of factors affecting aerosol deposition in the human lung. Calculations with the theoretical model are in excellent agreement with measured aerosol deposition efficiencies. Furthermore, the model accurately predicts experimentally observed features of inhalation exposure data, such as effects of inter-subject lung morphology differences and relative efficiencies of specific deposition mechanisms, on aerosol deposition patterns in the TB tree.
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    Bulletin of mathematical biology 45 (1983), S. 436-436 
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    Bulletin of mathematical biology 45 (1983), S. 437-437 
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    Bulletin of mathematical biology 45 (1983), S. 579-590 
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    Notes: Abstract In this paper we are concerned with problems of the long-term behavior for nonlinear systems in random environment. The general model is assumed to be given by an ordinary differential equation with random parameters or random input. The disturbance process can be taken from a fairly general class of Markov processes having a bounded state space. In terms of the system’s dynamics we give sufficient conditions for the existence and uniqueness of invariant probabilities. Finally, we apply these results to the two-dimensional biochemical model which is known as the Brusselator.
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    Bulletin of mathematical biology 45 (1983), S. 571-577 
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    Notes: Abstract In various applications one faces the problem of estimating a signal from discontinuous observations. For example, in biomedical applications the signal may be the ‘state’ of a given organ and one observes through an external counter the amount of radioactivity sequestered by the organ after injection of a radioactive tracer. Here the problem is studied in the context of nonlinear filtering when the signal can be modelled as either a random variable or a diffusion process, and the observations have a continuous and a purely discontinuous component; both components may be affected by the signal. When the signal is a random variable an explicitly computable solution is obtained; for the diffusion case the solution is given as a sequence of approximating filters that can be computed recursively.
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    Bulletin of mathematical biology 45 (1983), S. 627-634 
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    Notes: Abstract Eigenvalue problems arise in various biological models. We outline a useful comparison method and a technique using Lyapunov functions that can be applied in many cases. An application to lateral diffusion is discussed.
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    Bulletin of mathematical biology 45 (1983), S. 605-616 
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    Notes: Abstract This paper reviews, up to their recent developments, two types of models of the cell cycle: those considering the size controls over the cycle events and the transition probability models. The distribution of inter-mitotic time and the sister-sister and motherdaughter correlations implied by the two approaches are discussed in view of some relevant experimental data.
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    Bulletin of mathematical biology 45 (1983), S. 617-626 
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    Notes: Abstract The development of a blood cell line originating from a pluripotent stem cell pool is modelled by a chain of multidimensional branching processes in which the sojourn times of the cells in certain resting states depend on the size of the following subpopulation. The stability of such a model is discussed qualitatively and some considerations concerning a possible malignant degeneration are presented. The behaviour of models for normal and malignant cell production are illustrated by stochastic stimulations. The model presented here describes the development of a certain line of blood cells (e.g. erythrocytes, monocytes or granulocytes) originating from the pluripotent stem cell up to the functional cell in the blood (for related models see, e.g., Rubinow and Lebowitz,J. math. Biol. 1, 87–225;Biophys. J. 16, 897–910).
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    Bulletin of mathematical biology 45 (1983), S. 635-641 
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    Notes: Abstract This paper reviews some recent advances in single population stochastic differential equation growth models. They are a natural way to model population growth in a randomly varying environment. The question of which calculus, Itô or Stratonovich, is preferable is addressed. The two calculi coincide when the noise term is linear, if we take into account the differences in the interpretation of the parameters. This clarifies, among other things, the controversy on the theory of niche limiting similarity proposed by May and MacArthur. The effects of correlations in the environmental fluctuations and statistical methods for estimating parameters and for prediction based on a single population trajectory are mentioned. Applications to fisheries, wildlife management and particularly to environmental impact assessment are now becoming possible and are proposed in this paper.
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    Bulletin of mathematical biology 45 (1983), S. 643-658 
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    Notes: Abstract A survey is given of the application of (functions of) continuous-time Markov chains in the statistical analysis of behavioural time series.
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    Bulletin of mathematical biology 45 (1983), S. 659-659 
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    Bulletin of mathematical biology 45 (1983), S. 661-664 
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    Notes: Abstract This paper demonstrates that there is one and only one solution to a non-linear singular two-point boundary-value problem which describes oxygen diffusion in a spherical cell. Previous authors have calculated numerical results that differ substantially. Numerical computations using the multiple shooting method support the results of McElwain.
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    Bulletin of mathematical biology 45 (1983), S. 665-720 
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    Notes: Abstract The mathematics of distance geometry constitutes the basis of a group of algorithms for revealing the structural consequences of diverse forms of information about a macromolecule's conformation. These algorithms are of proven utility in the analysis of experimental conformational data. This paper presents the basic theorems of distance geometry in Euclidean space and gives formal proofs of the correctness and, where possible, of the complexity of these algorithms. The implications of distance geometry for the energy minimization of macromolecules are also discussed.
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    Bulletin of mathematical biology 45 (1983), S. 721-737 
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    Notes: Abstract A fully developed pulsatile flow in a circular rigid tube is analysed by a microcontinuum approach. Solutions for radial variation of axial velocity and cell rotational velocity across the tube are obtained using the momentum integral method. Simplified forms of the solutions are presented for the relevant physiological data. Marked deviations in the results are observed when compared to a Newtonian fluid model. It is interesting to see that there is sufficient reduction in the mass flow rate, phase lag and friction due to the micropolar character of the fluid.
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    Bulletin of mathematical biology 45 (1983), S. 749-758 
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    Notes: Abstract A mathematical model of the transport of fluorescein across the blood-retina barrier in the transient state and the subsequent diffusion of fluorescein in the vitreous body is presented. The function of the barrier is lumped in a single parameter—the permeability. The sensitivity of this parameter due to changes in the other parameters of the model is given. This establishes the foundation for the quantitative assessment of the barrier function through vitreous fluorophotometry.
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    Bulletin of mathematical biology 45 (1983), S. 739-748 
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    Notes: Abstract The objective of this preliminary study was to develop a new quantitative method of setting the initial insulin infusion patterns in treatment of diabetic patients. The method is based upon the mathematical estimation of the insulin profile required to maintain the glucose level within the normal range after glucose loading in diabetic patients. Using our previously developed equivalent circuit model of glucose kinetics and the reported data of an intravenous glucose tolerance test (IVGTT) in two groups of normal and diabetic patients, two important physiological parameters of the model (the peripheral tissue's insulin resistivity and the hepatic sensitivity to glucose level) were computed for two clinical groups. Then the insulin profile was obtained by computing the plasma insulin concentrations required to keep the total glucose utilization rate of the tissue and the liver in the diabetic group equal to that of the normal group. The simulation result indicated that the computed insulin profile produced a plasma glucose profile which was more closely matched to the normal group's glucose profile than with the case of emulating the normal group's insulin profile in the diabetic group.
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    Bulletin of mathematical biology 45 (1983), S. 759-780 
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    Notes: Abstract This paper shows that the Na conductance changes can be explained quantitatively, based on the following assumptions: (1) there exist in nerve membranes the electron transfer (ET) complexes and traps, (2) there is energy migration among them. The gating mechanism is explained in physical terms. Its mathematical expression differs from the Hodgkin-Huxley equations, but resembles the Hoyt formulation. In the present model, the physical parameters for the squid axon can be estimated from currently available experimental data. The density of the ET complexes is on the order of 105/μm2, and the density of the traps is 103/μm2. The magnitude of the energy transfer rate between ET complexes is about 106/sec at large depolarization and decreases with decreasing depolarizations, as does the Na inactivation rate. The energy gap between the two stable states of the transfer electron in the ET complex is estimated to be around 0.1 eV, which is approximately the same as that for the photosynthetic systems.
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    Bulletin of mathematical biology 45 (1983), S. 781-792 
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    Notes: Abstract The role of symmetry in simplifying the theory of complex neural systems is argued. When the structural symmetries of a network are expressed as an ismorphism group, implications emerge for the dynamics. Various qualitative possibilities concerning stability of uniform motion in homogeneous nets are discussed and an approach to neural hierarchies is outlined.
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    Bulletin of mathematical biology 45 (1983), S. 793-805 
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    Notes: Abstract By constructing appropriate Liapunov functionals, asymptotic behaviour of the solutions of various delay differential systems describing prey-predator, competition and symbiosis models has been studied. It has been shown that equilibrium states of these models are globally stable, provided certain conditions in terms of instantaneous and delay interaction coefficients are satisfied.
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    Bulletin of mathematical biology 45 (1983), S. 807-826 
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    Notes: Abstract Sensitivity analyses have been used to examine the flow structure of two hypothetical ecosystem models. These analyses have results which relate to important aspects of ecosystem theory. Cycles are shown to increase the sensitivity of the network, while increased throughflow is shown to decrease the sensitivity. Such results indicate that several factors can be modified to decrease the sensitivity of ecosystems to environmental stress.
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    Bulletin of mathematical biology 45 (1983), S. 827-836 
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    Notes: Abstract A continous, deterministic mathematical model is used to predict population distributions by age at any time, given the initial distribution and the variation of birth and death rates with age and time. Solutions are obtained on a computer using a semi-discretization algorithm in which time derivatives in the partial differential equations are replaced by finite-difference expressions. The resulting sets of ordinary differential equations are solved by a predictor-corrector method. Graphical results are shown for some examples.
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    Bulletin of mathematical biology 45 (1983), S. 849-855 
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    Notes: Abstract A new formula for the complexity of graphs is proposed and applied to the points lines and ‘connections’ of some chemically relevant graphs.
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    Bulletin of mathematical biology 45 (1983), S. 837-847 
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    Notes: Abstract This paper reports general and specialized results on analytical solutions to the governing phenomenological equations for chemotactic redistribution and population growth of motile bacteria. It is shown that the number of bacteria cells per unit volume,b, is proportional to a certain prescribed function ofs, the concentration of the critical substrate chemotactic agent, for steady-state solutions through an arbitrary spatial region with a boundary that is impermeable to bacteria cell transport. Moreover, it is demonstrated that the steady-state solution forb ands is unique for a prescribed total number of bacteria cells in the spatial region and a generic Robin boundary condition ons. The latter solution can be approximated to desired accuracy in terms of the Poisson-Green's function associated with the spatial region. Also, as shown by example, closed-form exact steady-state solutions are obtainable for certain consumption rate functions and geometrically symmetric spatial regions. A solutional procedure is formulated for the initialvalue problem in cases for which significant population growth is present and bacteria cell redistribution due to motility and chemotactic flow proceeds slowly relative to the diffusion of the chemoattractant substrate. Finally, a remarkably simple exact analytical solution is reported for a stradily propagating plane-wave which features motility, chemotactic motion and bacteria population growth regulated by substrate diffusion.
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    Bulletin of mathematical biology 45 (1983), S. 857-867 
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    Notes: Abstract This paper discusses the flow of blood in large artries under the influence of linear periodic acceleration. The governing equations and boundary conditions are established and analytical solutions for the velocity, fluid acceleration, bulk flow and shear stress are obtained. The results for these physical quantitites are computed for the case of an artery the size of a normal human aorta. It is found that the flow field variables are directly proportional to the external accelerating force. The behaviour of the velocity profile along the radial distance at different stages of times at fixed applied acceleration is also shown.
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    Bulletin of mathematical biology 45 (1983), S. 931-968 
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    Notes: Abstract The evolutionary selection circuits model of learning has been specified algorithmically. The basic structural components of the selection circuits model are enzymatic neurons, that is, neurons whose firing behavior is controlled by membrane-bound macromolecules called excitases. Learning involves changes in the excitase contents of neurons through a process of variation and selection. In this paper we report on the behavior of a basic version of the learning algorithm which has been developed through extensive interactive experiments with the model. This algorithm is effective in that it enables single neurons or networks of neurons to learn simple pattern classification tasks in a number of time steps which appears experimentally to be a linear function of problem size, as measured by the number of patterns of presynaptic input. The experimental behavior of the algorithm establishes that evolutionary mechanisms of learning are competent to serve as major mechanisms of neuronal adaptation. As an example, we show how the evolutionary learning algorithm can contribute to adaptive motor control processes in which the learning system develops the ability to reach a target in the presence of randomly imposed disturbances.
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    Bulletin of mathematical biology 45 (1983), S. 981-990 
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    Notes: Abstract In the present paper we discuss the behaviour of solutions of a dynamical system describing the growth of cells in a well-mixed continuous culture where the supply of the growth-limiting nutrient depends on the activity of an enzyme outside the cell membrane. It turns out that for positive dilution rates there exists an exponentially attractive two-dimensional simplex. Furthermore, the reversed system restricted to this simplex is quasimonotone. In every case all trajectories tend to an equilibrium state.
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    Bulletin of mathematical biology 45 (1983), S. 991-1004 
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    Notes: Abstract We present a Gause predator-prey model incorporating mutual interference among predators, a density-dependent predator death rate and a time lag due to gestation. It is well known that mutual interference is stabilizing, whereas time delays are destabilizing. We show that in combining the two, a long time-lag usually, but not always, destabilizes the system. We also show that increasing delays can cause a bifurcation into periodic solutions.
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    Bulletin of mathematical biology 45 (1983), S. 969-980 
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    Notes: Abstract The cycle structure of enzymatic neural networks may be characterized in terms of number of cycles exhibited, size of cycle state sets and cycle lengths. Simulation experiments show that the stability properties of these networks have some unusual features which are not exhibited by networks of two-state switching elements or by randomly constructed ecosystem models. The behavioral and structural stability of these systems decreases with their structural complexity, as measured by the number of components. The behavioral and structural stability of enzymatic neural networks also decreases with structural complexity, as measured by the number of excitase types, but only up to the middle level of excitases per neuron. This is the point of highest potential responsiveness of the system to environmental stimuli. Beyond this point the behavioral and structural stability increase. This is due to the fact that the number of possible states increases up to this point and decreases beyond it. The number of possible states, not the number of components, serves as the useful measure of complexity in these types of systems. The selection circuits learning algorithm has been used to evolve networks whose cycle structures have desired features.
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    Bulletin of mathematical biology 45 (1983), S. 1005-1011 
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    Notes: Abstract Similarity criteria of the functional design of the mammalian cardiovascular system are scant. For the analysis of mammalian cardiac energetics physiological parameters such as mean arterial blood pressure, stroke volume, heart rate, metabolic rate and heart and body weights are considered pertinent. Based on these parameters, a new similarity principle is established via allometric equations, dimensional analysis and Buckingham's pi-theorem. The principle states that the ratio of left ventricular external work to metabolic rate is inversely proportional to resting heart rates of mammals. The proportionality constant is dimensionless and is invariant of mammalian body weights.
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    Bulletin of mathematical biology 45 (1983), S. 1029-1045 
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    Notes: Abstract The mathematical theory of categories is used as a tool in the description of the structure and function of natural systems. The connections between the category of natural systems, with observables and dynamics, and the phenomenological calculus of response tensors, duality- and adjoint-invariance diagrams are established. The unified theory is applied to the analysis of hierarchies, pattern generation and the structure and dynamics of proteins.
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    Bulletin of mathematical biology 45 (1983), S. 1047-1072 
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    Notes: Abstract This is an investigation of natural systems from the standpoint of the mathematical theory of categories. It examines the relationships which exist between different descriptions through measurement of observables and dynamical interactions. We begin with a category theory of formal systems with observables, and then proceed to a category theory of dynamical systems. The two categories are then combined to represent natural systems. Topological considerations enter in the study of stability and bifurcation phenomena. Special emphasis is placed on natural systems which model biological processes. The categorical system theory developed is applied to the analysis of several biological problems and biological system theories.
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    Notes: Abstract Tetanic hyperpolarization for theXenopus node is simulated by means of iterative solutions of the Frankenhaeuser-Huxley excitation equations together with an active transport current density term which is dependent on sodium and potassium levels as well as the ADP/ATP ratio. All time-dependent variables at the end of one interspike interval are introduced as initial conditions for the next response, whereupon all time-dependent changes in voltage and permeability factors appear identical for the third and fourth responses of a sequence. Net change in internal sodium concentration is zero throughout the third and fourth intervals if sodium loading of the system is initially adjusted to a critical level. Extent of tetanic hyperpolarization is a function of the pump conductance.
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    Bulletin of mathematical biology 45 (1983), S. 1097-1097 
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    Bulletin of mathematical biology 45 (1983), S. 1073-1096 
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    Notes: Abstract The properties of nonlinear equations describing the solute and solvent transport across a simplified Patlak-Goldstein-Hoffman model (two membranes in series without unstirred layers) are investigated both analytically and numerically. The analysis shows that the principal coefficients measured in transport experiments in the presence of active transport are dependent on the experimental conditions. These ‘apparent’ system parameters are extensions of the corresponding parameters determined both in passive systems and in the linear Kedem-Katchalsky theory. Moreover, they are related to the local phenomenological coefficients of the single membranes of the array. Several relationships between measurable quantities and the local system parameters are indicated, allowing the planning of experiments aimed at the measurement of the latter. Data in the literature have been used to check the proposed volume flow equation.
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    Bulletin of mathematical biology 37 (1975), S. 97-100 
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    Bulletin of mathematical biology 37 (1975), S. 1-9 
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    Notes: Abstract The study of systems exhibiting a band-pass function is completed for systems whose parameters are time-dependent. In the case of periodic parametric excitations, it is demonstrated that some systems can get into “resonance” for a particular frequency. By studying this problem, a new and probably fruitful approach of some rhythmic behaviours can be made.
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    Bulletin of mathematical biology 37 (1975), S. 19-35 
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    Notes: Abstract Analytical techniques are developed which permit objective control of asiist device driving systems. In addition to being objective, the techniques described in this paper are optimal in the sense of minimizing a performance index which consists of a term involving left ventricular power and a term involving deviations of aorta hemodynamic parameters from normal values. Comparisons are included of off-line computations and measurements on dogs with experimentally induced myocardial infarctions undergoing intraaortic balloon pumping.
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    Bulletin of mathematical biology 37 (1975), S. 427-458 
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    Notes: Abstract A mathematical model simulating a cell growing in a culture medium is obtained. Using this model, various behavioral patterns of the cell are obtained under different types of disturbances, in particular when (i) a Mg2+ deficiency experiment and, (ii) a split-dose ionizing radiation experiment are carried out, (iii) when disturbances on the rate constants of the biochemical reactions taking place in the nucleus of the cell are applied, and (iv) when the cell's interior components are perturbed. The cell model results obtained agree well with experimental results for the Mg2+ and split dose experiments, and explain the mechanism of the split dose radiation experiment without the need to introduce additional axioms (e.g. healing processes) into the dynamics of the cell. Conditions are obtained which cause the cell to behave in a rapidly growing ‘tumor-like’ mode; it is shown that once the cell moves into this ‘tumor-like’ mode, its behavior is irreversible, i.e. if a disturbance of opposite type is then applied to the ‘tumor’ cell, the cell will not revert back to its original normal behavior.
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    Bulletin of mathematical biology 37 (1975), S. 85-90 
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    Notes: Abstract Solution of the equation that describes simulatenous liquid flow and diffusion in a spherical model of the vitreous body of the eye shows that a small dissolved specie can move both anteriorly and posteriorly from a source behind the lens even though there is a slow liquid movement almost entirely in the posterior direction. This results explains why tracer studies using large particles (dyes or colloids) show only a posterior flow, whereas studies using sodium ion show anterior movement as well.
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    Bulletin of mathematical biology 37 (1975), S. 101-107 
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    Bulletin of mathematical biology 37 (1975), S. 111-111 
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    Bulletin of mathematical biology 37 (1975), S. 221-221 
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    Bulletin of mathematical biology 37 (1975), S. 255-268 
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    Notes: Abstract The equations relating hybridized RNA to free RNA, in the case of simple hybridization, or to ratio of labelled and unlabelled RNA in competitive hybridization, are derived. Analysis of the equations shows how hybridization data may be used to infer properties of the distribution of components in an RNA mixture, or the relation between two distributions in competitive hybridization. A critical examination of the assumptions underlying the equations indicates that some of then may be violated in certain cases, or have no current support, evidential or theoretical. The consequences of such qualifications for the interpretation of hybridization data are indicated.
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    Bulletin of mathematical biology 37 (1975), S. 589-636 
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    Notes: Abstract The steady state spatial patterns arising in nonlinear reaction-diffusion systems beyond an instability point of the thermodynamic branch are studied on a simple model network. A detailed comparison between the analytical solutions of the kinetic equations, obtained by bifurcation theory, and the results of computer simulations is presented for different boundary conditions. The characteristics of the dissipative structures are discussed and it is shown that the observed behavior depends strongly on both the boundary and initial conditions. The theoretical expressions are limited to the neighborhood of the marginal stability point. Computer simulations allow not only the verification of their predictions but also the investigation of the behavior of the system for larger deviations from the instability point. It is shown that new features such as multiplicity of solutions and secondary bifurcations can appear in this region.
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    Bulletin of mathematical biology 45 (1983), S. 139-142 
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    Notes: Abstract As an alternative to optimum-processor models in which sensors attempt to circumvent internal and external noise, a mechanism-independent argument is presented for Weber's law in vision and hearing. In vision, the argument is that categories of objects should be independent of the light intensity on these objects. In hearing, sound categorization should be independent of the distance from the sound source. An analogous desideratum for computer-based image segmentation is also presented.
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    Bulletin of mathematical biology 45 (1983), S. 193-207 
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    Notes: Abstract Rashevsky's treatment of general binary relations between sets of biological elements is extended using the novel mathematical concept of lattice-valued relation (l.v.r.). This yields a quantitative measure of the strength of the relations between components of a biological organism, and some illustrative examples are given. Specific l.v.r.'s are used to define (more precisely than in Rashevsky's preliminary theory of binary relations) the biologically important relationships amongst hormones, metabolism and energy exchange involved in metabolic reactions. The ‘strongest link’ between the set of hormones and the set of metabolic reactions is quantified using a special l.v.r., and other specific biological realisations of lattice-valued relations in abstract-relational biology are presented. L.v.r.'s may also be regarded as a form ofG-relation in relational biology, or as a particular case of generating diagrams. Further possible developments of this approach, using more complex tools of the newly developed mathematical theory of lattice-valued relations, such as function space l.v.r., group l.v.r., l.v.r. morphisms, l.v.r. homology andn-ary l.v.r.'s are suggested.
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    Bulletin of mathematical biology 45 (1983), S. 259-267 
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    Notes: Abstract The effects of the viscosity-concentration dependence and of the concentration profile on blood flow through a vessel with stenosis have been studied. The flow resistance and the wall shear stress have been found to be smaller than in the two-fluid model with constant viscosities.
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    Bulletin of mathematical biology 45 (1983), S. 507-519 
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    Notes: Abstract A survey is given of branching process type methods in cell kinetics. Some results are given that allow circadian rhythm and do not require complete independence between cells. Some more classical results on balanced exponential growth are given and some comments are made on flow microfluorometry.
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    Bulletin of mathematical biology 45 (1983), S. 439-442 
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    Bulletin of mathematical biology 45 (1983), S. 443-465 
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    Notes: Abstract The spike train activity of neurones is considered as a point process, and methods of analysing and interpreting recorded spike trains are considered. The generation of a continuous process (membrane noise) from interacting point processes is described.
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    Bulletin of mathematical biology 45 (1983), S. 521-554 
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    Notes: Abstract Stochastic models of population genetics are studied with special reference to the biological interest. Mathematical methods are described for treating some simple models and their modifications aimed at the problems of the molecular evolution. Unified theory for treating different quantities is extensively developed and applied to some typical problems of current interest in genetics. Mathematical methods for treating geographically structured populations are given. Approximation formulae and their accuracy are discussed. Some criteria are given for a structured population to behave almost like a panmictic population of the same total size. Some quantities are shown to be independent of the geographical structure and their dynamics are described.
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    Circuits, systems and signal processing 2 (1983), S. 35-44 
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    Notes: Abstract Via fractional representation methods, this paper tries to clarify the role of various conditions used in the feedback system design and stability with respect to the well-posedness of the system, the existence of a solution for stability and design, and the parameterization of the set of complete solutions. The design criterion for stable feedback system design can be used for filters design, as shown in Section 5. Systems to be considered in this paper include the linear time-varying case and results can easily be extended to the case where systems do not have the same number of inputs and outputs.
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    Circuits, systems and signal processing 2 (1983), S. 57-76 
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    Notes: Abstract Conditions are established which ensure the existence (or non-existence) of limit cycles in feedback systems containing discontinuous elements or elements with hysteresis. The results are applied to a specific example.
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    Circuits, systems and signal processing 2 (1983), S. 45-55 
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    Notes: Conclusion A necessary condition for consistent initial conditions for singular nonlinear systems has been discussed. It is shown that for linear systems or systems of index less than three these conditions are equivlaent to previously reported results. However, for nonlinear systems of index greater than two these new conditions correct those previously reported. One consequence is that Euler's method may fail to estimate solutions for some semi-state equations. R. W. Newcomb's provision of an earlier version of [14] and subsequent correspondence is gratefully acknowledged.
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    Circuits, systems and signal processing 2 (1983), S. 161-177 
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    Notes: Abstract Thep-plane scattering and admittance matrices of SAW transducers consisting ofn equal sections modeled through the hybrid equivalent circuit are explicitly calculated. The results are specialized to the in-line and crossed-field models, and the technique is developed for unequal section transducers.
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    Circuits, systems and signal processing 2 (1983), S. 203-211 
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    Notes: Abstract A set of eight linear spectral transformations which can be used in the design of two-dimensional digital filters is studied from a group-theoretic point of view. Several properties of the transformations, some of them known and some of them new, are deduced and are then applied in the implementation of 2-D digital filters. It is shown that trade-offs exist which can be used to reduce either the amount of memory required for the programming or the amount of data manipulation.
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    Circuits, systems and signal processing 2 (1983), S. 213-238 
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    Notes: Abstract A physically justifiable mathematical model is proposed for a class of current-controlled, negative resistance oscillators having terminal characteristics which are poorly represented by the van der Pol, Scott, and Ceschia-Zecchin equations. Such resonators are typified by the monolithic emitter-coupled astable multivibrator (ECAM). A unique, three-parameter equation, based on the inverse hyperbolic tangent, is matched to the ECAM voltage-current curve. Using the method of Kryloff and Bogoliuboff, the transient and steady-state behavior of the ECAM is derived for oscillation with single-mode and double-mode LCR networks under quasi-linear conditions. An expression for the time of amplitude build-up and decay is derived. A phase plane is constructed for the double-mode case, yielding a system apparently free of simultaneous modes. The validity of the model is experimentally verified for quartz-controlled ECAM devices. The analysis results are extendable ton resonant modes and may be generalized to voltage-controlled devices.
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    Circuits, systems and signal processing 2 (1983), S. 421-443 
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    Notes: Abstract The problem of adaptively detecting two sinusoids corrupted by noise is considered, with emphasis on resolution properties. The approach is to form a spectral estimate from the coefficients of a Δ-step-ahead adaptive predictor. A theoretical analysis reveals that attention to the choice of the prediction horizon Δ gives a distinct improvement in the spectral estimate and in the resolution of the signals. The theoretical results are illustrated with numerical examples. Comparisons with previously suggested techniques are also made.
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    Bulletin of mathematical biology 37 (1975), S. 109-109 
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    Bulletin of mathematical biology 37 (1975), S. i 
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    Bulletin of mathematical biology 37 (1975), S. 139-146 
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    Notes: Abstract Krylov-Bogoliubov-Mitropolsky perturbation method was used to study the effect of nonlinearity in the Volterra-gause-Witt (VGW) model for a two species prey-predator system. The first order corrections to both the frequency of oscillation and the amplitude of the linearized system were computed. It was found that the basic qualitative features of the nonlinearity are exhibited by the first order result. We have also discussed the Lotka-Volterra problem which is a special case of VGW model.
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    Bulletin of mathematical biology 37 (1975), S. 147-160 
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    Notes: Abstract This paper presents a mathematical analysis of a tumor model first proposed by Skipper and Zubrod. The tumor model is comprised of three compartments, a proliferative compartment, a nonproliferative but viable compartment, and a dead compartment. By the suitable selection of functions describing loss of cells from the proliferative and nonproliferative compartments, the model is capable of describing tumor behavior during periods of growth and drug treatment. The loss functions during treatment are related to pharmacokinetic functions and may be chosen according to known drug properties. Tumor properties may be simulated by the appropriate choice of cell cycle parameters. It therefore seems feasible to simulate tumor behavior for scheduled treatment with chemotherapeutic agents. Another important result of this analysis is the derivation of a fraction labelled mitosis function which incorporates the nonproliferative compartments.
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    Bulletin of mathematical biology 37 (1975), S. 161-180 
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    Notes: Abstract Techniques of modelling and simulation are discussed as they relate to bioengineering systems. The advantages and disadvantages of different analytical engineering methods utilized to gather information concerning the behavior of complex physiological and neuromuscular control mechanisms are explained. An Inners Criterion is developed to determine if the roots of a model lie within a certain “biologically realistic region” ΓB, in the complex plane which contains the roots of linearized models for a large variety of neuromuscular systems. Several algorithmic methods based on the Jury Inners Test are described which specify whether the model roots lie within the desired region, thereby providing an indication as to the validity of the proposed model. This technique can help to eliminate tedious simulation on an unrealistic model with roots lying far outside this region. An exemplary model for control of vergence eye movements is presented and shown to satisfy the ΓB criterion; several counter-examples are also discussed. The Inners approach can be adapted to other classes of bioengineering systems by specifying the region based on models that are contained in the class of interest.
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    Bulletin of mathematical biology 37 (1975), S. 215-218 
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    Bulletin of mathematical biology 37 (1975), S. 220-220 
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    Bulletin of mathematical biology 37 (1975), S. 223-254 
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    Notes: Abstract In this paper I consider how information is required to specify various systems. It is shown that the transitive information of any physical system, is distributed among three distinct components. One of these, the selective component, is required to specify the elemental parts of the system. Another, the connective component, is required to specify the macrostructure of the system; that is the way the parts are put together. And a third, the conformative component, is required to specify the intrinsic complexion or microstructure of the system. An interesting method for analyzing branched systems which takes account of connective ambiguity is described in some detail. The relationship between information and entropy, known as the Clausius-Shannon Identity, is then discussed with reference to selected thermodynamic models: and that aspect of information which is often overlooked, namely the distinction, between transitive and intransitive information is highlighted. The applications (or perhaps more correctly, the limitations of applying this treatment) to problems of biological interest are also indicated.
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    Bulletin of mathematical biology 37 (1975), S. 269-275 
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    Notes: Abstract This paper discusses two compartment models with interaction allowed between the compartments. The total number of particles in the system at any time is discussed along with the number to the found in each separate compartment. An interesting result is that the number of particles in each of the two compartments areindependent random variables. Some asymptotic results are also given. The paper is a continuation of some earlier work by the author.
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    Bulletin of mathematical biology 37 (1975), S. 277-289 
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    Notes: Abstract General criteria which either preclude time-periodic dissipative structure solutions or imply asymptotically steady solutions are derived for generic systems of reaction-diffusion equations ∂c i /∂t =D i ∇2 c i +Q i (c) subject to boundary conditions of practical interest, where the enumerator indexi runsl ton, c i =c i (x,t) denotes the concentration or density of theith participating molecular or biological species,D i is the diffusivity constant for theith species, andQ i (c), an algebraic function of then-tuplec=(c 1,...,c n ), expresses the local rate of production of theith species due to chemical reactions or biological interactions. It is demonstrated that certain functionals ofc which decrease monotonically with time can often be found, as exemplified here for Volterra and Verhulst-Volterran-species model systems, and thus time-periodic dissipative structure solutions are precluded for such systems of reaction-diffusion equations. It is shown that all solutions to a generic system of reaction-diffusion equations evolve dynamically to a unique steady state, $$\mathop {\lim }\limits_{t \to \infty } c_i (x, t) = \hat c_i (x)$$ , if the diffusivity constants are all sufficiently large in magnitude. A necessary condition for the existence of a periodic solution (either spatially uniform or non-uniform) is formulated in terms of the curl ofQ(c) inc-space. Finally, necessary and sufficient conditions are derived for the existence of time-periodic dissipative structure solutions in cases of “weak diffusion” with the reaction rate terms dominant in the governing equations.
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    Bulletin of mathematical biology 37 (1975), S. 323-365 
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    Notes: Abstract A model nonlinear network involving chemical reactions and diffusion is studied. The time evolution and bounds on the steady state solutions are analyzed. Spatially ordered solutions of the equations of the dissipative structure type are found by bifurcation theory. These solutions are calculated analytically and their qualitative properties are discussed.
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    Bulletin of mathematical biology 37 (1975), S. 637-657 
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    Notes: Abstract Models based on molecular mechanisms are presented for pattern formation in developing organisms. It is assumed that there exists a diffusion governed gradient in the morphogenetic field. It is shown that cellular differentiation and the subsequent pattern formation result from the interaction of the diffusing morphogen with the genetic regulatory mechanism of cells. In a second stage it is shown that starting from a homogeneous distribution of morphogen, polarity can be generated spontaneously in the morphogenetic field giving rise to the establishment of a gradient. The stability of these gradients is demonstrated. The onset of a morphogenetic gradient and pattern formation are combined in a single coherent model. Size invariance and its biological implications are discussed.
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    Bulletin of mathematical biology 45 (1983), S. 11-20 
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    Notes: Abstract This paper is concerned with a generalization of the simple epidemic model in which the infective population is partitioned intom classes, each of specific infectiousness. Attention is restricted, however, to the case where all the meeting rates between two individuals are equal to each other. Both deterministic and stochastic versions are examined. In either case the development in time of the epidemic process is investigated by exploiting a connection with the standard simple epidemic model. Finally, it is shown that the technique used also applies to a similar model for the spread of information.
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    Bulletin of mathematical biology 45 (1983), S. 33-40 
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    Notes: Abstract For each rooted binary tree witht labeled terminal vertices (leaves) a natural number can be assigned uniquely. Unrooted trees witht labeled terminal vertices andt-2 unlabeled internal vertices of degree 3 can also be numbered uniquely using the same convention. Rooted trees in which the hights of the internal vertices are rank ordered are also considered. Applications to problems in taxonomy are discussed.
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    Bulletin of mathematical biology 45 (1983), S. 41-50 
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    Notes: Abstract Expressions and numerical values for hematocrit reduction are calculated as blood flows from a cylindrical feeding tube into a cylindrical capillary at a right-angle branch. Blood is considered to consist of two Newtonian fluids, plasma and red cell suspension, which have equal densities but different viscosities. The concentration profile of the red cells is concluded to depend on the size of the feeding tube. An estimate for the thickness of the plasma layer adjacent to the wall is obtained.
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    Bulletin of mathematical biology 45 (1983), S. 51-67 
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    Notes: Abstract Asimple model system of two self-reproducing objects is considered. A set of equations, similar to Eigen's equation, describing competition of these objects is derived and analyzed under the effect of an ‘ecological constraint’. The relation with other constraints used in the literature is discussed.
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    Bulletin of mathematical biology 45 (1983), S. 69-90 
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    Notes: Abstract A membrane with an arbitrary distribution of fixed charges inside and on its surfaces is considered. A procedure for calculating the local electrostatic potential at an arbitrary point of the system is described and its validity discussed. This procedure is based on the linearization of the 3-dimensional Poisson-Boltzmann equation around an exact 1-dimensional solution.
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    Bulletin of mathematical biology 45 (1983), S. 103-116 
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    Notes: Abstract In this, the first of a series of papers on stochastic and deterministic non-linear allometric growth models, a deterministic model is proposed which generalizes the widely applicable classical linear model of Huxley and Needham. There aren types of producers, each type depositing a product which accumulates monotonically in the environment. Producers interact via a mass action law satisfying an optimality condition. Coefficients may be interpreted as competition between the various producer types in the usual Volterra sense. An ideal coral reef is studied in which then species of coral polyps lay down aragonite calcium carbonate in building the reef framework. This deterministic model predicts that younger reefs are strongly unstable relative to initial species abundance, while older reefs grow in the classical sense of Huxley and Needham, asymptotically, as time goes to infinity.
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    Bulletin of mathematical biology 45 (1983), S. 151-153 
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    Notes: Abstract First-order spatial gradients are reliquished in the Schrödinger-Bloch equation for bacterial chemotaxis if and only if the flux coefficient-motility ratio equals 2, the precise value measured in recent experiments onEscherichia coli attracted by oxygen. Moreover, for δ/μ=2 the Schrödinger-Bloch function Ψ is simply equal to the number of bacteria cells per unit volume divided by the chemoattractant concentration.
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    Bulletin of mathematical biology 45 (1983), S. 169-192 
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    Notes: Abstract A mathematical formulation useful in characterizing the effects of light on the pupal eclosion rhythm of the fruit flyDrosophila pseudoobscura is presented. It is based upon the premise that the underlying pacemaker oscillator behaves in a manner analogous to a customized version of a phase-locked loop circuit. Theoretical analyses supplemented with numerical simulations reveal that this phase-locked loop approach yields a concise mathematical characterization which is quite comprehensive in its scope, yet surprisingly accurate in the detail with which it can be used to successfully predict observed experimental results.
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    Bulletin of mathematical biology 45 (1983), S. 155-168 
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    Notes: Abstract Pointwise upper and lower bounds for the solution of a class of nonlinear problems arising in the steady-state finite cable model of cell membranes are presented. Simple analytical bounding curves are obtained for an illustrative example in the theory of nerve membranes.
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    Bulletin of mathematical biology 45 (1983), S. 209-227 
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    Notes: Abstract Single-species reaction-diffusion models are analyzed to determine the effect of various diffusion mechanisms on species persistence or extinction.
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    Bulletin of mathematical biology 45 (1983), S. 401-408 
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    Notes: Abstract A restriction is imposed on the number of particles that can possibly move at any time from a compartment, so that any other particles present in the compartment must wait until such particles have moved out. The equations for such a system are formulated and the solution is given for a single compartment system; increased variability of the compartmental particle count is one effect of this restriction.
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    Bulletin of mathematical biology 45 (1983), S. 323-345 
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    Notes: Abstract Two classes of dose-effect models for cell killing (additive damage and independent effects) are developed under alternative hypotheses about the damage that leads to cell death. Generalized models, along with specific models for cell killing after exposure to a specific cytotoxicant, are used to make predictions about the effects of sequential or simultaneous exposure to different cytotoxicants. It is demonstrated that with the additive damage models developed one can adequately account for the combined effects of the cytotoxicants considered. Theoretical results are presented which suggest that after simultaneous exposure of cells to low total doses (〈0.1 Gy) of different ionizing radiations, use of the conventional relative biological effectiveness approach to predict cell killing risks is unnecessary; cell killing risks can adequately be determined by assuming the effects of the different radiations to be independent. Also, for simultaneous exposure of cells to total doses of different radiations much larger than 0.1 Gy, use of the conventional RBE approach to arrive at cell killing risk could lead to overestimation of the risk.
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