ISSN:
1522-9602
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Mathematics
Notes:
Abstract Two classes of dose-effect models for cell killing (additive damage and independent effects) are developed under alternative hypotheses about the damage that leads to cell death. Generalized models, along with specific models for cell killing after exposure to a specific cytotoxicant, are used to make predictions about the effects of sequential or simultaneous exposure to different cytotoxicants. It is demonstrated that with the additive damage models developed one can adequately account for the combined effects of the cytotoxicants considered. Theoretical results are presented which suggest that after simultaneous exposure of cells to low total doses (〈0.1 Gy) of different ionizing radiations, use of the conventional relative biological effectiveness approach to predict cell killing risks is unnecessary; cell killing risks can adequately be determined by assuming the effects of the different radiations to be independent. Also, for simultaneous exposure of cells to total doses of different radiations much larger than 0.1 Gy, use of the conventional RBE approach to arrive at cell killing risk could lead to overestimation of the risk.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02459396
