Publication Date:
1983-10-28
Description:
Burkitt lymphoma cells carrying either a rearranged or unrearranged c-myc oncogene were examined with the use of probes from the 5' exon and for the second and third exon of the oncogene. The results indicate that the normal c-myc gene on chromosome 8 and the 5' noncoding and 3' coding segments of the c-myc oncogene separated by the chromosomal translocation are under different transcriptional control in the lymphoma cells. Burkitt lymphoma cells carrying a translocated but unrearranged c-myc oncogene express normal c-myc transcripts. In contrast, lymphoma cells carrying a c-myc gene rearranged head to head with the immunoglobulin constant mu region gene express c-myc transcripts lacking the normal untranslated leader.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉ar-Rushdi, A -- Nishikura, K -- Erikson, J -- Watt, R -- Rovera, G -- Croce, C M -- CA09171/CA/NCI NIH HHS/ -- CA10815/CA/NCI NIH HHS/ -- CA16685/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):390-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6414084" target="_blank"〉PubMed〈/a〉
Keywords:
Burkitt Lymphoma/*genetics
;
Chromosomes, Human, 13-15
;
Chromosomes, Human, 19-20
;
Chromosomes, Human, 6-12 and X
;
Gene Expression Regulation
;
Genes
;
Humans
;
Immunoglobulin Heavy Chains/genetics
;
*Oncogenes
;
Operon
;
Transcription, Genetic
;
Translocation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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