Publication Date:
1983-10-28
Description:
Antiserum to a synthetic peptide corresponding to the carboxyl-terminus of the human c-myc protein immunoprecipitated a 48,000-dalton protein from a number of normal and malignant human and mouse cells. The size of the protein is consistent with the potential coding region predicted from the c-myc nucleotide sequence, and is the same for malignant cells carrying either a rearranged or an unrearranged c-myc oncogene. Because c-myc transcripts are expressed at higher levels in malignant than in normal B cells, it appears that an increased level of the c-myc protein rather than a change in the gene product is the relevant factor in determining transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giallongo, A -- Appella, E -- Ricciardi, R -- Rovera, G -- Croce, C M -- CA10815/CA/NCI NIH HHS/ -- CA16685/CA/NCI NIH HHS/ -- CA25685/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):430-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6604943" target="_blank"〉PubMed〈/a〉
Keywords:
B-Lymphocytes/*physiology
;
Burkitt Lymphoma/*genetics
;
Gene Expression Regulation
;
Humans
;
*Oncogenes
;
Peptide Fragments/immunology
;
Proteins/immunology/*isolation & purification
;
Transformation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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