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  • Springer  (90,881)
  • American Geophysical Union  (4,617)
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  • 1980-1984  (91,797)
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  • 1983  (47,493)
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  • 1925  (3,984)
  • 1
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    Bulletin of mathematical biology 42 (1980), S. 131-135 
    ISSN: 1522-9602
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    Notes: Abstract The theory of complementary variational principles is used to obtain maximum and minimum principles for diffusion problems with Michaelis-Menten kinetics. In an illustrative calculation we obtain an extremely accurate variational solution in good agreement with the numerical solution of McElwain (1978).
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    Bulletin of mathematical biology 42 (1980), S. 137-141 
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    Bulletin of mathematical biology 42 (1980), S. 181-189 
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    Notes: Abstract Necessary and sufficient conditions for primitivity of a product of two Leslie matrices are given. Such a product could be used in modeling the growth of a population governed alternately by two different sets of fertility and survival parameters.
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    Bulletin of mathematical biology 42 (1980), S. 173-180 
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    Notes: Abstract Zadeh's transfer function method for linear time-variable systems is used to apply frequency-domain analysis to a periodically time-varying elastance model of the left ventricle. Left ventricular pressure computed from the system function of the time-varying elastance and the phasors of aortic flow shows a typical waveform of the measured ventricular pressure.
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    Bulletin of mathematical biology 42 (1980), S. 901-901 
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    Bulletin of mathematical biology 45 (1983), S. 287-293 
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    Notes: Abstract We postulate that the biomass distribution function for an ecological population may be derived from the condition that the biomas diversity functional is maximal subject to an energetic constraint on the total biomass. This leads to a biomass distribution of the form $$p(m) = \bar m^{ - 1} \exp ( - m/\bar m)$$ , where $$\bar m$$ is the mean biomass per individual. The same condition yields a unique value for the biomass diversity functional. These predictions are tested against fishery data and found to be in good agreement. It is argued that the existence of a unique value for biomass diversity may provide a preliminary theoretical foundation for the observed upper limit to species diversity.
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    Bulletin of mathematical biology 45 (1983), S. 311-321 
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    Notes: Abstract Pigment distribution presages hydranth regeneration in the marine hydroidTubularia. We suggest that such a distribution could result from a reaction-diffusion system. A model system based on a practical reaction scheme is studied and spatial structures found which closely resemble this pigment distribution. Finite-amplitude spatial structures in reaction-diffusion systems are considered. Whereas in one spatial dimension the final structures are normally very similar to the transient patterns which emerge from a linear analysis, it is shown that in more than one dimension this is not necessarily the case. The reasons for this are discussed.
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    Bulletin of mathematical biology 45 (1983), S. 409-424 
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    Notes: Abstract An analytical model is used to described the behavior of inhaled particulate matter in the human respiratory tract. Three different geometries, symmetric and asymmetric, are utilized to simultate the tracheobronchial (TB) tree. The suitability of each geometry for representing the human is evaluated by comparing calculated aerosol deposition probabilities with experimental data from inhalation exposure tests. A symmetric, dichotomously branching pattern is found to be a reliable description of the TB tree for studies of factors affecting aerosol deposition in the human lung. Calculations with the theoretical model are in excellent agreement with measured aerosol deposition efficiencies. Furthermore, the model accurately predicts experimentally observed features of inhalation exposure data, such as effects of inter-subject lung morphology differences and relative efficiencies of specific deposition mechanisms, on aerosol deposition patterns in the TB tree.
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    Bulletin of mathematical biology 45 (1983), S. 436-436 
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    Bulletin of mathematical biology 45 (1983), S. 437-437 
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    Bulletin of mathematical biology 45 (1983), S. 579-590 
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    Notes: Abstract In this paper we are concerned with problems of the long-term behavior for nonlinear systems in random environment. The general model is assumed to be given by an ordinary differential equation with random parameters or random input. The disturbance process can be taken from a fairly general class of Markov processes having a bounded state space. In terms of the system’s dynamics we give sufficient conditions for the existence and uniqueness of invariant probabilities. Finally, we apply these results to the two-dimensional biochemical model which is known as the Brusselator.
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    Bulletin of mathematical biology 45 (1983), S. 571-577 
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    Notes: Abstract In various applications one faces the problem of estimating a signal from discontinuous observations. For example, in biomedical applications the signal may be the ‘state’ of a given organ and one observes through an external counter the amount of radioactivity sequestered by the organ after injection of a radioactive tracer. Here the problem is studied in the context of nonlinear filtering when the signal can be modelled as either a random variable or a diffusion process, and the observations have a continuous and a purely discontinuous component; both components may be affected by the signal. When the signal is a random variable an explicitly computable solution is obtained; for the diffusion case the solution is given as a sequence of approximating filters that can be computed recursively.
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    Bulletin of mathematical biology 45 (1983), S. 627-634 
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    Notes: Abstract Eigenvalue problems arise in various biological models. We outline a useful comparison method and a technique using Lyapunov functions that can be applied in many cases. An application to lateral diffusion is discussed.
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    Bulletin of mathematical biology 45 (1983), S. 605-616 
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    Notes: Abstract This paper reviews, up to their recent developments, two types of models of the cell cycle: those considering the size controls over the cycle events and the transition probability models. The distribution of inter-mitotic time and the sister-sister and motherdaughter correlations implied by the two approaches are discussed in view of some relevant experimental data.
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    Bulletin of mathematical biology 45 (1983), S. 617-626 
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    Notes: Abstract The development of a blood cell line originating from a pluripotent stem cell pool is modelled by a chain of multidimensional branching processes in which the sojourn times of the cells in certain resting states depend on the size of the following subpopulation. The stability of such a model is discussed qualitatively and some considerations concerning a possible malignant degeneration are presented. The behaviour of models for normal and malignant cell production are illustrated by stochastic stimulations. The model presented here describes the development of a certain line of blood cells (e.g. erythrocytes, monocytes or granulocytes) originating from the pluripotent stem cell up to the functional cell in the blood (for related models see, e.g., Rubinow and Lebowitz,J. math. Biol. 1, 87–225;Biophys. J. 16, 897–910).
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    Bulletin of mathematical biology 45 (1983), S. 635-641 
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    Notes: Abstract This paper reviews some recent advances in single population stochastic differential equation growth models. They are a natural way to model population growth in a randomly varying environment. The question of which calculus, Itô or Stratonovich, is preferable is addressed. The two calculi coincide when the noise term is linear, if we take into account the differences in the interpretation of the parameters. This clarifies, among other things, the controversy on the theory of niche limiting similarity proposed by May and MacArthur. The effects of correlations in the environmental fluctuations and statistical methods for estimating parameters and for prediction based on a single population trajectory are mentioned. Applications to fisheries, wildlife management and particularly to environmental impact assessment are now becoming possible and are proposed in this paper.
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    Bulletin of mathematical biology 45 (1983), S. 643-658 
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    Notes: Abstract A survey is given of the application of (functions of) continuous-time Markov chains in the statistical analysis of behavioural time series.
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    Bulletin of mathematical biology 45 (1983), S. 659-659 
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    Bulletin of mathematical biology 45 (1983), S. 661-664 
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    Notes: Abstract This paper demonstrates that there is one and only one solution to a non-linear singular two-point boundary-value problem which describes oxygen diffusion in a spherical cell. Previous authors have calculated numerical results that differ substantially. Numerical computations using the multiple shooting method support the results of McElwain.
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    Bulletin of mathematical biology 45 (1983), S. 665-720 
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    Notes: Abstract The mathematics of distance geometry constitutes the basis of a group of algorithms for revealing the structural consequences of diverse forms of information about a macromolecule's conformation. These algorithms are of proven utility in the analysis of experimental conformational data. This paper presents the basic theorems of distance geometry in Euclidean space and gives formal proofs of the correctness and, where possible, of the complexity of these algorithms. The implications of distance geometry for the energy minimization of macromolecules are also discussed.
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    Bulletin of mathematical biology 45 (1983), S. 721-737 
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    Notes: Abstract A fully developed pulsatile flow in a circular rigid tube is analysed by a microcontinuum approach. Solutions for radial variation of axial velocity and cell rotational velocity across the tube are obtained using the momentum integral method. Simplified forms of the solutions are presented for the relevant physiological data. Marked deviations in the results are observed when compared to a Newtonian fluid model. It is interesting to see that there is sufficient reduction in the mass flow rate, phase lag and friction due to the micropolar character of the fluid.
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    Bulletin of mathematical biology 45 (1983), S. 749-758 
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    Notes: Abstract A mathematical model of the transport of fluorescein across the blood-retina barrier in the transient state and the subsequent diffusion of fluorescein in the vitreous body is presented. The function of the barrier is lumped in a single parameter—the permeability. The sensitivity of this parameter due to changes in the other parameters of the model is given. This establishes the foundation for the quantitative assessment of the barrier function through vitreous fluorophotometry.
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    Bulletin of mathematical biology 45 (1983), S. 739-748 
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    Notes: Abstract The objective of this preliminary study was to develop a new quantitative method of setting the initial insulin infusion patterns in treatment of diabetic patients. The method is based upon the mathematical estimation of the insulin profile required to maintain the glucose level within the normal range after glucose loading in diabetic patients. Using our previously developed equivalent circuit model of glucose kinetics and the reported data of an intravenous glucose tolerance test (IVGTT) in two groups of normal and diabetic patients, two important physiological parameters of the model (the peripheral tissue's insulin resistivity and the hepatic sensitivity to glucose level) were computed for two clinical groups. Then the insulin profile was obtained by computing the plasma insulin concentrations required to keep the total glucose utilization rate of the tissue and the liver in the diabetic group equal to that of the normal group. The simulation result indicated that the computed insulin profile produced a plasma glucose profile which was more closely matched to the normal group's glucose profile than with the case of emulating the normal group's insulin profile in the diabetic group.
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    Bulletin of mathematical biology 45 (1983), S. 759-780 
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    Notes: Abstract This paper shows that the Na conductance changes can be explained quantitatively, based on the following assumptions: (1) there exist in nerve membranes the electron transfer (ET) complexes and traps, (2) there is energy migration among them. The gating mechanism is explained in physical terms. Its mathematical expression differs from the Hodgkin-Huxley equations, but resembles the Hoyt formulation. In the present model, the physical parameters for the squid axon can be estimated from currently available experimental data. The density of the ET complexes is on the order of 105/μm2, and the density of the traps is 103/μm2. The magnitude of the energy transfer rate between ET complexes is about 106/sec at large depolarization and decreases with decreasing depolarizations, as does the Na inactivation rate. The energy gap between the two stable states of the transfer electron in the ET complex is estimated to be around 0.1 eV, which is approximately the same as that for the photosynthetic systems.
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    Bulletin of mathematical biology 45 (1983), S. 781-792 
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    Notes: Abstract The role of symmetry in simplifying the theory of complex neural systems is argued. When the structural symmetries of a network are expressed as an ismorphism group, implications emerge for the dynamics. Various qualitative possibilities concerning stability of uniform motion in homogeneous nets are discussed and an approach to neural hierarchies is outlined.
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    Bulletin of mathematical biology 45 (1983), S. 793-805 
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    Notes: Abstract By constructing appropriate Liapunov functionals, asymptotic behaviour of the solutions of various delay differential systems describing prey-predator, competition and symbiosis models has been studied. It has been shown that equilibrium states of these models are globally stable, provided certain conditions in terms of instantaneous and delay interaction coefficients are satisfied.
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    Bulletin of mathematical biology 45 (1983), S. 807-826 
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    Notes: Abstract Sensitivity analyses have been used to examine the flow structure of two hypothetical ecosystem models. These analyses have results which relate to important aspects of ecosystem theory. Cycles are shown to increase the sensitivity of the network, while increased throughflow is shown to decrease the sensitivity. Such results indicate that several factors can be modified to decrease the sensitivity of ecosystems to environmental stress.
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    Bulletin of mathematical biology 45 (1983), S. 827-836 
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    Notes: Abstract A continous, deterministic mathematical model is used to predict population distributions by age at any time, given the initial distribution and the variation of birth and death rates with age and time. Solutions are obtained on a computer using a semi-discretization algorithm in which time derivatives in the partial differential equations are replaced by finite-difference expressions. The resulting sets of ordinary differential equations are solved by a predictor-corrector method. Graphical results are shown for some examples.
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    Bulletin of mathematical biology 45 (1983), S. 849-855 
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    Notes: Abstract A new formula for the complexity of graphs is proposed and applied to the points lines and ‘connections’ of some chemically relevant graphs.
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    Bulletin of mathematical biology 45 (1983), S. 837-847 
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    Notes: Abstract This paper reports general and specialized results on analytical solutions to the governing phenomenological equations for chemotactic redistribution and population growth of motile bacteria. It is shown that the number of bacteria cells per unit volume,b, is proportional to a certain prescribed function ofs, the concentration of the critical substrate chemotactic agent, for steady-state solutions through an arbitrary spatial region with a boundary that is impermeable to bacteria cell transport. Moreover, it is demonstrated that the steady-state solution forb ands is unique for a prescribed total number of bacteria cells in the spatial region and a generic Robin boundary condition ons. The latter solution can be approximated to desired accuracy in terms of the Poisson-Green's function associated with the spatial region. Also, as shown by example, closed-form exact steady-state solutions are obtainable for certain consumption rate functions and geometrically symmetric spatial regions. A solutional procedure is formulated for the initialvalue problem in cases for which significant population growth is present and bacteria cell redistribution due to motility and chemotactic flow proceeds slowly relative to the diffusion of the chemoattractant substrate. Finally, a remarkably simple exact analytical solution is reported for a stradily propagating plane-wave which features motility, chemotactic motion and bacteria population growth regulated by substrate diffusion.
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    Bulletin of mathematical biology 45 (1983), S. 857-867 
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    Notes: Abstract This paper discusses the flow of blood in large artries under the influence of linear periodic acceleration. The governing equations and boundary conditions are established and analytical solutions for the velocity, fluid acceleration, bulk flow and shear stress are obtained. The results for these physical quantitites are computed for the case of an artery the size of a normal human aorta. It is found that the flow field variables are directly proportional to the external accelerating force. The behaviour of the velocity profile along the radial distance at different stages of times at fixed applied acceleration is also shown.
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    Bulletin of mathematical biology 45 (1983), S. 931-968 
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    Notes: Abstract The evolutionary selection circuits model of learning has been specified algorithmically. The basic structural components of the selection circuits model are enzymatic neurons, that is, neurons whose firing behavior is controlled by membrane-bound macromolecules called excitases. Learning involves changes in the excitase contents of neurons through a process of variation and selection. In this paper we report on the behavior of a basic version of the learning algorithm which has been developed through extensive interactive experiments with the model. This algorithm is effective in that it enables single neurons or networks of neurons to learn simple pattern classification tasks in a number of time steps which appears experimentally to be a linear function of problem size, as measured by the number of patterns of presynaptic input. The experimental behavior of the algorithm establishes that evolutionary mechanisms of learning are competent to serve as major mechanisms of neuronal adaptation. As an example, we show how the evolutionary learning algorithm can contribute to adaptive motor control processes in which the learning system develops the ability to reach a target in the presence of randomly imposed disturbances.
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    Bulletin of mathematical biology 45 (1983), S. 981-990 
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    Notes: Abstract In the present paper we discuss the behaviour of solutions of a dynamical system describing the growth of cells in a well-mixed continuous culture where the supply of the growth-limiting nutrient depends on the activity of an enzyme outside the cell membrane. It turns out that for positive dilution rates there exists an exponentially attractive two-dimensional simplex. Furthermore, the reversed system restricted to this simplex is quasimonotone. In every case all trajectories tend to an equilibrium state.
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    Bulletin of mathematical biology 45 (1983), S. 991-1004 
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    Notes: Abstract We present a Gause predator-prey model incorporating mutual interference among predators, a density-dependent predator death rate and a time lag due to gestation. It is well known that mutual interference is stabilizing, whereas time delays are destabilizing. We show that in combining the two, a long time-lag usually, but not always, destabilizes the system. We also show that increasing delays can cause a bifurcation into periodic solutions.
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    Bulletin of mathematical biology 45 (1983), S. 969-980 
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    Notes: Abstract The cycle structure of enzymatic neural networks may be characterized in terms of number of cycles exhibited, size of cycle state sets and cycle lengths. Simulation experiments show that the stability properties of these networks have some unusual features which are not exhibited by networks of two-state switching elements or by randomly constructed ecosystem models. The behavioral and structural stability of these systems decreases with their structural complexity, as measured by the number of components. The behavioral and structural stability of enzymatic neural networks also decreases with structural complexity, as measured by the number of excitase types, but only up to the middle level of excitases per neuron. This is the point of highest potential responsiveness of the system to environmental stimuli. Beyond this point the behavioral and structural stability increase. This is due to the fact that the number of possible states increases up to this point and decreases beyond it. The number of possible states, not the number of components, serves as the useful measure of complexity in these types of systems. The selection circuits learning algorithm has been used to evolve networks whose cycle structures have desired features.
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    Bulletin of mathematical biology 45 (1983), S. 1005-1011 
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    Notes: Abstract Similarity criteria of the functional design of the mammalian cardiovascular system are scant. For the analysis of mammalian cardiac energetics physiological parameters such as mean arterial blood pressure, stroke volume, heart rate, metabolic rate and heart and body weights are considered pertinent. Based on these parameters, a new similarity principle is established via allometric equations, dimensional analysis and Buckingham's pi-theorem. The principle states that the ratio of left ventricular external work to metabolic rate is inversely proportional to resting heart rates of mammals. The proportionality constant is dimensionless and is invariant of mammalian body weights.
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    Bulletin of mathematical biology 45 (1983), S. 1029-1045 
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    Notes: Abstract The mathematical theory of categories is used as a tool in the description of the structure and function of natural systems. The connections between the category of natural systems, with observables and dynamics, and the phenomenological calculus of response tensors, duality- and adjoint-invariance diagrams are established. The unified theory is applied to the analysis of hierarchies, pattern generation and the structure and dynamics of proteins.
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    Bulletin of mathematical biology 45 (1983), S. 1047-1072 
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    Notes: Abstract This is an investigation of natural systems from the standpoint of the mathematical theory of categories. It examines the relationships which exist between different descriptions through measurement of observables and dynamical interactions. We begin with a category theory of formal systems with observables, and then proceed to a category theory of dynamical systems. The two categories are then combined to represent natural systems. Topological considerations enter in the study of stability and bifurcation phenomena. Special emphasis is placed on natural systems which model biological processes. The categorical system theory developed is applied to the analysis of several biological problems and biological system theories.
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    Notes: Abstract Tetanic hyperpolarization for theXenopus node is simulated by means of iterative solutions of the Frankenhaeuser-Huxley excitation equations together with an active transport current density term which is dependent on sodium and potassium levels as well as the ADP/ATP ratio. All time-dependent variables at the end of one interspike interval are introduced as initial conditions for the next response, whereupon all time-dependent changes in voltage and permeability factors appear identical for the third and fourth responses of a sequence. Net change in internal sodium concentration is zero throughout the third and fourth intervals if sodium loading of the system is initially adjusted to a critical level. Extent of tetanic hyperpolarization is a function of the pump conductance.
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    Bulletin of mathematical biology 45 (1983), S. 1097-1097 
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    Bulletin of mathematical biology 45 (1983), S. 1073-1096 
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    Notes: Abstract The properties of nonlinear equations describing the solute and solvent transport across a simplified Patlak-Goldstein-Hoffman model (two membranes in series without unstirred layers) are investigated both analytically and numerically. The analysis shows that the principal coefficients measured in transport experiments in the presence of active transport are dependent on the experimental conditions. These ‘apparent’ system parameters are extensions of the corresponding parameters determined both in passive systems and in the linear Kedem-Katchalsky theory. Moreover, they are related to the local phenomenological coefficients of the single membranes of the array. Several relationships between measurable quantities and the local system parameters are indicated, allowing the planning of experiments aimed at the measurement of the latter. Data in the literature have been used to check the proposed volume flow equation.
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    Bulletin of mathematical biology 42 (1980), S. 147-160 
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    Notes: Abstract A theory of noise fluctuations is developed which is applicable to systems of any size in which unimolecular or bimolecular reactions are occurring. The main difference between small and large reacting systems is that in the former the probability of finding a particle in a particular state does not obey a Gaussian distribution, but satisfies a distribution which reflects the mechanism of the chemical reaction. This difference is reflected in the main result of the theory: an autocorrelation function that is expressible as a sum of exponentials, the amplitudes of which are explicit functions of the moments of the distribution. Thus, by using small systems, the autocorrelation function,in principle, allows the elucidation of reaction mechanisms. Numerical simulations indicate that for reacting systems having ten or fewer particles, the deviation of the autocorrelation function from a single exponential should be easily detectable, and that estimates of the first four moments of the distribution should be possible. Accurate inference of the distribution, however, will require further mathematical and experimental advances.
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    Bulletin of mathematical biology 42 (1980), S. 161-172 
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    Notes: Abstract The recent mathematical formalization of the concepts of matter and extrinsical energy, which are used for the relational representation of biological systems, is employed in the analysis of the important experimental discoveries of Comorosanet al. related to low energy electromagnetic irradiations on enzyme substrates. By means of the present analysis one of the properties inherent to the experimental phenomena is more precisely exposed, and theoretical developments corresponding to “energetical evolutions” in a biological system (Leguizamón, 1976) may now have an experimental basis. Important limitations are introduced for the validity of the commutativity and associativity of cartesian product of sets, when they represent matter and its linked extrinsical energy. In connection with this last aspect, new important knowledge is obtained for the relational mathematical representation of biological systems.
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    Bulletin of mathematical biology 42 (1980), S. 397-429 
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    Notes: Abstract The structure of solutions to a simple spatially dependent population model involving growth and death is investigated. Two forms of motility of the population are considered: (1) random motion only modeled by a Fickian law, and (2) a directed component of motion (chemotaxis), included in addition to the random motion. Under certain growth conditions a traveling wave of constant speed is approached. This speed can be increased by the addition of the chemotaxis with a corresponding increase in the asymptotic population. Development of initial conditions into a wave is illustrated numerically.
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    Bulletin of mathematical biology 42 (1980), S. 365-396 
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    Notes: Abstract This paper describes mechanisms of intracellular and intercellular adaptation that are due to spatial or temporal factors. The spatial mechanisms support self-regulating pattern formation that is capable of directing self-organization in a large class of systems, including examples of directed intercellular growth, transmitter production, and intracellular conductance changes. A balance between intracellular flows and counterflows causes adaptation. This balance can be shifted by environmental inputs. The decrease in Ca2+-modulated outward K+ conductance in certain molluscan nerve cells is a likely example. Examples wherein Ca2+ acts as a second messenger that shunts receptor sensitivity can also be discussed from this perspective. The systems differ in basic ways from recent diffusion models. Chemical transducers driven by membrane-bound intracellular signals can establish long-range intercellular interactions that compensate for variable intercellular distances and are invariant under developmental size changes; diffusional signals do not. The intracellular adaptational mechanisms are formally analogous to intercellular mechanisms that include cellular properties which are omitted in recent reaction-diffusion models of pattern formation. The cellular models use these properties to compute size-invariant properties despite wide variations in their intercellular signals. Mechanisms of temporal adaptation can be derived from the simplest laws of chemical transduction by using a correspondence principle. These mechanisms lead to such properties of intercellular signals as transient overshoot, antagonistic rebound, and an inverted U in sensitivity as intracellular signals or adaptation levels shift. Such effects are implicated in studies of behavioral, reinforcement, motor control, and cognitive coding.
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    Bulletin of mathematical biology 42 (1980), S. 447-459 
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    Notes: Abstract Large radiation doses to the lung can cause early death from cardiopulmonary insufficiency resulting from radiation pneumonitis and pulmonary fibrosis. A model for early death following inhalation of insoluble radioactive particles is propose. The model is based on three assumptions: (1) early death results from damage to a cluster of cells from a large number of cell clusters at risk, (2) the dose that causes early death depends on how the radiation is delivered in time and (3) the cell clusters at risk to damage are equally sensitive ro radiation. Results from asymptotic theory of extreme values, along with biophysical considerations, suggest that the cumultive distribution function for the absorbed radiation dose to the production of pulmonary injury sufficient to cause early death is best estimated by the third asymptotic distribution without a threshold. This distribution function is identical to the Weibull cumulative distribution function. Data for Beagle dogs after inhaling relatively insoluble forms of alpha- or beta-gamma-emitting particles are shown to support the Weibull model.
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    Bulletin of mathematical biology 42 (1980), S. 461-480 
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    Notes: Abstract Models of the human respiratory tract were developed based on detailed morphometric measurements of a silicone rubber cast of the human tracheobronchial airways. Emphasis was placed on the “Typical Path Lung Model” which used one typical pathway to represent a portion of the lung, such as a lobe, or to represent the whole lung. The models contain geometrical parameters, including airway segment diameters, lengths, branching angles and angles of inclination to gravity, which are needed for estimating inhaled particle deposition. Aerosol depositions for various breathing patterns and particle sizes were calculated using these lung models and the modified Findeisen-Landahl computational scheme. The results agree reasonably well with recent experimental data. Regional deposition, including lobar deposition fractions, are also calculated and compared with results based on the ICRP lung deposition model.
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    Bulletin of mathematical biology 42 (1980), S. 481-488 
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    Notes: Abstract The completely symmetrical system is defined as having identical transfer coefficients between pairs of compartments and the same loss coefficient for each compartment. The eigenvalues and eigenvector are explicitly found along with the inverses of the system matrix and the matrix of eigenvectors. Many properties, special instances of more general theorems, can be seen at once from the explicit analytic solution of the initial value, washout and washin problems. The system serves as a known case for testing estimation procedures, algorithms for solutions of linear systems, eigenvalue-eigenvector and inversion routines and is of considerable tutorial value.
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    Bulletin of mathematical biology 42 (1980), S. 431-446 
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    Notes: Abstract The mathematical structures underlying the theories of organismic sets, (M, R)-systems and molecular sets are shown to be transformed naturally within the theory of categories and functors. Their natural transformations allow the comparison of distinct entities, as well as the modelling of dynamics in “organismic” structures.
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    Bulletin of mathematical biology 42 (1980), S. 489-505 
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    Notes: Abstract To explain the sodium conductance change using Wei's dipole model (Wei, 1969), we may expect that during depolarization the dipole's population difference, ΔN, is first reduced and then returns more slowly to its resting value. This paper shows that the experimental results of gating currents support this idea. Such time course of ΔN, however, is not a usual relaxation process. To account for the unusual behavior of ΔN, we propose two additional assumptions: (1) there exists a special coupling system (probably the intramolecular vibrations) whose coupling strength with the dipoles is much stronger than with the thermal bath (intermolecular vibrations), and (2) there also exist “traps” for the dipole's excitation energy so that this energy is transformed into other energy forms at a rate increasing with the increase of depolarization. Experiments suggest that the traps are proteins located at the inner membrane surface.
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    Bulletin of mathematical biology 42 (1980), S. 507-528 
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    Notes: Abstract Current research into the dynamics of iterative ecological and biological models has lead to a number of theorems concerning the existence of various types of iterative dynamical behavior. In particular, much study has been done on the dynamical behavior of the “simplest dynamical system”f b(x)=bx(1−x), which is just the canonical discrete form of logistic growth equations found in ecology, sociobiology, and population biology. In this paper, we make use of some of the techniques and concepts of topological dynamics to construct a number of generalized conjugacy theorems. These theorems are then used to demonstrate that the mappingf b has a number of conjugacy classes in which the dynamics of the iterates is equivalent to within a change of variables. The concepts of fitness and survival in logistic equations are then shown to be independent, if we follow certain intuitive definitions for these concepts. This conclusion follows from a comparison of the conjugacy classes of the functionf b and the extinction sets off b.
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    Notes: Abstract For chemical reactions not at equilibrium but proceeding in the forward direction in the steady state, a result found by a method first introduced by H. G. Britton (1963, 1965) is generalized to prove that if $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ is the unidirectional flux ratio, $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ exp (−ΔG/RT). The conditions under which the equality or inequality applies are discussed. If the unidirectional fluxes are not in the steady state, the unidirectional flux ratio is time invariant in certain specific situations. One such important case is for chemical reaction systems with an ordered sequence of reactions. For systems with more than one pathway, $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ is not constant except for special cases. These results also apply to diffusional and active transport systems.
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    Bulletin of mathematical biology 42 (1980), S. 599-600 
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    Bulletin of mathematical biology 42 (1980), S. 539-549 
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    Bulletin of mathematical biology 42 (1980), S. 551-597 
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    Notes: Abstract The nonlinear second-order difference equationx n+1=axn(1-xn−1), where 0≦x nX≦1 anda ≧1, is examined from varying points of view, analytical, numerical and geometrical. An analytic expression is obtained for an invariant attracting curveC ∞ (a) in phase space, which becomes the central object of study. This basic curve, which replaces the simple parabolic shape typical of many analogous first-order models, may have a complicated geometrical structure. As the parametera increases,C ∞(a) undergoes transformations characterized by the dynamical descriptions: stable node→stable focus→stable limit cycle →chaotic attractor. Although the limited characterization ofchaos by the appearance of nonperiodic solutions and solutions of arbitrarily large period is relied upon, this appears to be only a simplified approximation of the real behavior of solutions. Trajectories (x n, xn+1),n=0,1,…, are calculated using the related nonlinear planar mapT a(x,y)=(y,ay(1−x)), and regions of persistence and escape are described for characteristic values ofa. The study of persistence, of even more fundamental interest than the associated problems of periodicity and stability, receives special attention. We introduce a geometrical model, similar in many respects to that for the well-known analoguex n+1=axn(1−x n), but having several new and important features. It appears that as the parametera increases in the chaotic regime there are infinitely many intermittent bursts of increase in the probability that any initial point (x 0, x1) will persist in the unit square under successive iterations of the mappingT a, an unexpected property that should be of interest for applications. A discussion of the applicability of these results to population dynamics theory is given, and it is suggested that such equations might find useful application to problems in developmental biology as well.
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    Bulletin of mathematical biology 42 (1980), S. 627-645 
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    Notes: Abstract Based on the principle of minimum power, a mathematical model of the functional state of the oxygen transport system is presented. The optimization model minimizes the power expenditure of the heart, bone marrow, lung and other tissues. The model is used to determine the functional parameters of the oxygen transport system in man under both normal and varying barometric pressures. Theoretical results are compared with experimental data.
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    Bulletin of mathematical biology 42 (1980), S. 601-625 
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    Notes: Abstract A quantitative model of ion binding and molecular interactions in the lipid bilayer membrane is proposed and found to be useful in examining the factors underlying such membrane characteristics as shape, sidedness, stability and vesicle size at various cation concentrations. The lipid membrane behaves as a bilayer couple whose preferential radius of curvature depends on the expansion or contraction of one monolayer relative to the other. It is proposed that molecular packing may be altered by electrostatic repulsion of adjacent like-charged phospholipid headgroups, or by bringing two headgroups closer together by divalent cation crossbridging. The surface concentrations of each type of cation-phospholipid complex can be described by simple binding equilibria and the Gouy-Chapman-Stern formulation for the surface potential in a diffuse double layer. The asymmetric distribution of acidic phospholipids in most biological membranes can account for the differential effects of identical ionic environments on either side of the bilayer. The fraction of vesicle material which tends to have a right-side-out orientation may be approximated by a normal distribution about the mean curvature. The theory generates vesicle sidedness distributions that, when fitted to experimental results from human erythrocyte membranes, provide an alternative method of estimating intrinsic cationphospholipid dissociation constants and other molecular parameters of the bilayer. The results also corroborate earlier suggestions that the Gouy-Chapman theory tends to overestimate free counter-ion concentrations at the surface under large surface potentials.
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    Bulletin of mathematical biology 42 (1980), S. 681-689 
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    Notes: Abstract The “yellow strips” on the cuticle of the Oriental Hornet (Vespa orientalis, Hymenoptera, Vespinae), present photoelectric properties. A mathematical model for the relative changes in resistance as a photoconductive process conforms to the general model for a semiconductor with traps.
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    Bulletin of mathematical biology 42 (1980), S. 701-718 
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    Notes: Abstract Damped nonlinear oscillations in biological and biochemical systems are investigated by the extended Krylov-Bogoliubov-Mitropolskii (KBM) method. A review on the extension made by Popov to the KBM method is given and also further improvements are presented. Applications are made to models of oscillating chemical reactions (Lefever and Nicolis, 1971), FitzHugh (1961) equations, and population dynamics (Gatto and Rinaldi, 1977). Comparison to damped oscillating physical and engineering systems is made.
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    Bulletin of mathematical biology 42 (1980), S. 719-728 
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    Notes: Abstract The conditions that will allow the lumping together of several age classes in the Leslie model are investigated. We show that if the lumping is to be valid for all population distributions, then the parameters of the model must be periodic. Lumping is valid when the population is in equilibrium, but equilibrium should be tested before the model is lumped.
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    Bulletin of mathematical biology 42 (1980), S. 647-679 
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    Notes: Abstract Catastrophe theory is a mathematical theory which, allied with a new and controversial methodology, has claimed wide application, particularly in the biological and the social sciences. These claims have recently been heatedly opposed. This article describes the debate and assesses the merits of the different arguments advanced.
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    Bulletin of mathematical biology 42 (1980), S. 765-795 
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    Notes: Abstract Estimates of capillary tracer permeability calculated using multiple indicator data depend upon the particular model adopted to describe blood tissue exchange. The model proposed by Crone (1963) is appropriate when some of the injected tracer diffuses into the tissue but does not return appreciably to the bloodstream before data collection is terminated. Under these conditions extraction of tracer by the tissue depends on a single dimensionless parameter, αcap, defined as the ratio of capillary permeability surface area to water flow. The effects of finite red cell tracer permeability on the Crone model estimate of capillary permeability are examined in the present study. The results indicate that even when back diffusion from the extravascular space is negligible, significant errors in the Crone model estimate can be expected when capillary permeability is relatively high and the ratio of red cell to capillary permeability is less than unity. However, when an aliquot of blood is equilibrated with tracer prior to injection and the dimensionless capillary permeability is relatively low (i.e. αcap ≦ 0.25 for a haematocrit≦50%), the whole blood Crone model estimate of αcap will be within 10% of the actual value, irrespective of red cell permeability. Red cell-plasma exchange for commonly used tracer-organ combinations should not significantly affect Crone estimates of capillary permeability under normal physiological conditions, but may be important in low flow situations.
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    Bulletin of mathematical biology 42 (1980), S. 807-828 
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    Notes: Abstract Assuming truncated ellipsoidal geometry for the right and left ventricles, a model is developed for the myocardium enabling biventricular mechanical behavior to be studied. Employing pressure-volume data taken from normal dog hearts and from hearts in which the pulmonary artery has been banded over periods of 2–40 weeks, it is shown that: (a) right ventricular wall stresses are higher than left ventricular stresses; (b) right ventricular wall stress increases initially to a maximum after 3–4 weeks followed by a decline to normal and even subnormal levels, attaining a minimum value at 32–33 weeks; (c) left ventricular stresses behave in a similar manner, attaining their maximum and minimum levels after 7–8 weeks and 32–33 weeks respectively. These results suggest that surgical or medical therapy in patients with hypertrophied ventricles might be more appropriate during the period of wall stress reduction.
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    Bulletin of mathematical biology 42 (1980), S. 837-845 
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    Notes: Abstract In this paper we describe a mathematical model of the oscillations of the diaphragm which limits the vitreous body from the anterior segment of the human eye after the lens has been removed in a cataract operation. We study the motion of this diaphragm driven by movements of the eye. Firstly, a mathematical statement of the problem is given and then we solve the problem exactly for a given class of eye movements. From the analysis we deduce that significant oscillations of the membrane are driven by saccades and that it is the angular acceleration of the eye which causes these types of oscillations. A numerical example is given.
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    Bulletin of mathematical biology 42 (1980), S. 871-887 
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    Notes: Abstract The Lotka-Volterra system of prey-predator equations is considered with a special type of continuous time delay. In the case of equal diffusion coefficients Hopf’s bifurcation technique is used to show the existence of travelling wave train solutions for the prey-predator system.
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    Bulletin of mathematical biology 42 (1980), S. 861-870 
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    Notes: Abstract A mathematical model of prothrombin activation is being proposed which includes the feedback mechanism of thrombin and the alteration of factor V by thrombin. This model is in good agreement with experimental data for the dependence of the rate of thrombin formation on the concentrations of factors V and X a . In particular, it correctly predicts the existence and location of a maximum in both of these cases.
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    Bulletin of mathematical biology 42 (1980), S. 847-859 
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    Notes: Abstract A new model of the upper tracheobronchial tree is proposed to account for the three-dimensional nature of the airway system. In addition to the tube length, the tube diameter, and the branching angle, the model includes information on the orientation angle of each tube relative to its parent tube. The orientation angle, defined as the angle between two successive bifurcations, is useful for calculating the gravitational inclination of each tube. The information on orientation angle is further used to construct a binary coding system for identifying individual tubes in the airway tree. The proposed model is asymmetrical, but the same principles can be readily used to construct a symmetrical one.
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    Bulletin of mathematical biology 42 (1980), S. 889-897 
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    Notes: Abstract In any control system for which the number of independent controls is smaller than the number of degrees of freedom to be controlled, our choice of control in any state is restricted to a submanifold of smaller dimension than the tangent space. This simple fact has a number of important consequences for questions of biological import; we consider its implications for adaptation, for senescent phenomena and for the determination of tertiary structures of polypeptides through control of certain average properties. We also formulate the Pontryagin Maximum Principle of Optimal control theory in such a way as to inquire whether specific biodynamic systems can be regarded as optimal with respect to rate of accumulation of particular quantities of the system. We find that if this is possible, the quantity in question must play the role of a clock.
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    Bulletin of mathematical biology 42 (1980), S. 899-900 
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    Bulletin of mathematical biology 45 (1983), S. 139-142 
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    Notes: Abstract As an alternative to optimum-processor models in which sensors attempt to circumvent internal and external noise, a mechanism-independent argument is presented for Weber's law in vision and hearing. In vision, the argument is that categories of objects should be independent of the light intensity on these objects. In hearing, sound categorization should be independent of the distance from the sound source. An analogous desideratum for computer-based image segmentation is also presented.
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    Bulletin of mathematical biology 45 (1983), S. 193-207 
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    Notes: Abstract Rashevsky's treatment of general binary relations between sets of biological elements is extended using the novel mathematical concept of lattice-valued relation (l.v.r.). This yields a quantitative measure of the strength of the relations between components of a biological organism, and some illustrative examples are given. Specific l.v.r.'s are used to define (more precisely than in Rashevsky's preliminary theory of binary relations) the biologically important relationships amongst hormones, metabolism and energy exchange involved in metabolic reactions. The ‘strongest link’ between the set of hormones and the set of metabolic reactions is quantified using a special l.v.r., and other specific biological realisations of lattice-valued relations in abstract-relational biology are presented. L.v.r.'s may also be regarded as a form ofG-relation in relational biology, or as a particular case of generating diagrams. Further possible developments of this approach, using more complex tools of the newly developed mathematical theory of lattice-valued relations, such as function space l.v.r., group l.v.r., l.v.r. morphisms, l.v.r. homology andn-ary l.v.r.'s are suggested.
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    Bulletin of mathematical biology 45 (1983), S. 259-267 
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    Notes: Abstract The effects of the viscosity-concentration dependence and of the concentration profile on blood flow through a vessel with stenosis have been studied. The flow resistance and the wall shear stress have been found to be smaller than in the two-fluid model with constant viscosities.
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    Bulletin of mathematical biology 45 (1983), S. 507-519 
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    Notes: Abstract A survey is given of branching process type methods in cell kinetics. Some results are given that allow circadian rhythm and do not require complete independence between cells. Some more classical results on balanced exponential growth are given and some comments are made on flow microfluorometry.
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    Bulletin of mathematical biology 45 (1983), S. 439-442 
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    Bulletin of mathematical biology 45 (1983), S. 443-465 
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    Notes: Abstract The spike train activity of neurones is considered as a point process, and methods of analysing and interpreting recorded spike trains are considered. The generation of a continuous process (membrane noise) from interacting point processes is described.
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    Bulletin of mathematical biology 45 (1983), S. 521-554 
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    Notes: Abstract Stochastic models of population genetics are studied with special reference to the biological interest. Mathematical methods are described for treating some simple models and their modifications aimed at the problems of the molecular evolution. Unified theory for treating different quantities is extensively developed and applied to some typical problems of current interest in genetics. Mathematical methods for treating geographically structured populations are given. Approximation formulae and their accuracy are discussed. Some criteria are given for a structured population to behave almost like a panmictic population of the same total size. Some quantities are shown to be independent of the geographical structure and their dynamics are described.
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    Circuits, systems and signal processing 2 (1983), S. 35-44 
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    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Via fractional representation methods, this paper tries to clarify the role of various conditions used in the feedback system design and stability with respect to the well-posedness of the system, the existence of a solution for stability and design, and the parameterization of the set of complete solutions. The design criterion for stable feedback system design can be used for filters design, as shown in Section 5. Systems to be considered in this paper include the linear time-varying case and results can easily be extended to the case where systems do not have the same number of inputs and outputs.
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    Circuits, systems and signal processing 2 (1983), S. 57-76 
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    Notes: Abstract Conditions are established which ensure the existence (or non-existence) of limit cycles in feedback systems containing discontinuous elements or elements with hysteresis. The results are applied to a specific example.
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    Circuits, systems and signal processing 2 (1983), S. 45-55 
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    Notes: Conclusion A necessary condition for consistent initial conditions for singular nonlinear systems has been discussed. It is shown that for linear systems or systems of index less than three these conditions are equivlaent to previously reported results. However, for nonlinear systems of index greater than two these new conditions correct those previously reported. One consequence is that Euler's method may fail to estimate solutions for some semi-state equations. R. W. Newcomb's provision of an earlier version of [14] and subsequent correspondence is gratefully acknowledged.
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    Circuits, systems and signal processing 2 (1983), S. 161-177 
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    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Thep-plane scattering and admittance matrices of SAW transducers consisting ofn equal sections modeled through the hybrid equivalent circuit are explicitly calculated. The results are specialized to the in-line and crossed-field models, and the technique is developed for unequal section transducers.
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    Circuits, systems and signal processing 2 (1983), S. 203-211 
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    Notes: Abstract A set of eight linear spectral transformations which can be used in the design of two-dimensional digital filters is studied from a group-theoretic point of view. Several properties of the transformations, some of them known and some of them new, are deduced and are then applied in the implementation of 2-D digital filters. It is shown that trade-offs exist which can be used to reduce either the amount of memory required for the programming or the amount of data manipulation.
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    Circuits, systems and signal processing 2 (1983), S. 213-238 
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    Notes: Abstract A physically justifiable mathematical model is proposed for a class of current-controlled, negative resistance oscillators having terminal characteristics which are poorly represented by the van der Pol, Scott, and Ceschia-Zecchin equations. Such resonators are typified by the monolithic emitter-coupled astable multivibrator (ECAM). A unique, three-parameter equation, based on the inverse hyperbolic tangent, is matched to the ECAM voltage-current curve. Using the method of Kryloff and Bogoliuboff, the transient and steady-state behavior of the ECAM is derived for oscillation with single-mode and double-mode LCR networks under quasi-linear conditions. An expression for the time of amplitude build-up and decay is derived. A phase plane is constructed for the double-mode case, yielding a system apparently free of simultaneous modes. The validity of the model is experimentally verified for quartz-controlled ECAM devices. The analysis results are extendable ton resonant modes and may be generalized to voltage-controlled devices.
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    Circuits, systems and signal processing 2 (1983), S. 421-443 
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    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The problem of adaptively detecting two sinusoids corrupted by noise is considered, with emphasis on resolution properties. The approach is to form a spectral estimate from the coefficients of a Δ-step-ahead adaptive predictor. A theoretical analysis reveals that attention to the choice of the prediction horizon Δ gives a distinct improvement in the spectral estimate and in the resolution of the signals. The theoretical results are illustrated with numerical examples. Comparisons with previously suggested techniques are also made.
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    Bulletin of mathematical biology 42 (1980), S. 1-15 
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    Notes: Abstract A computational model to predict deposition of a wide variety of particulate pollutants in several species of mammals is presented. The model incorporates breathing pattern and detailed anatomical models of the respiratory tract based on extensive morphometric measurements of individual airways. The predicted deposition from this general model is in close agreement with observed deposition of monodisperse aerosols in rats. Particle size and density and respiratory breathing patterns are the critical parameters affecting regional deposition.
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    Bulletin of mathematical biology 42 (1980), S. 17-36 
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    Notes: Abstract A theory of antigen-antibody induced particulate aggregation is developed by investigating the stability of model systems of particles. Conditions for the formation of large aggregates are derived by imposing the requirement that at equilibrium a statistically significant number of redundant bonds would occur in a reduced monomer-dimer model system. A relationship is obtained which predicts the fractional agglutination in the reduced dimer system as a function of the antigen, antibody and particulate concentrations: $$\frac{g}{{2f c_0 (1 - g)^{2^ - } }} = \frac{{s_1 }}{r} + \frac{{s_1 s_2 }}{{2!r^2 }} + ... + \frac{{s_1 s_2 ...s_j }}{{j!r^j }},$$ wherec 0 is the initial concentration of monomer,f is a proximity factor,g is the fractional agglutination,s i is the average rate of formation of theith bond from an (i−1)th bound dimer, andr is the average rate of dissociation of a single antibody-antigen bond.
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    Bulletin of mathematical biology 42 (1980), S. 37-56 
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    Notes: Abstract The roles of the concentrations of the three interacting constituents in the aggregation process (antibodies, antigens and particulates) are analyzed in detail. It is shown that the basic equation derived in Part I is consistent over a broad range of conditions with experimental findings previously reported.
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    Bulletin of mathematical biology 42 (1980), S. 57-78 
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    Notes: Abstract A general mathematical model describing the biochemical interactions of the hormones luteinizing hormone releasing hormone (LHRH), luteinizing hormone (LH) and testosterone (T) in the male is presented. The model structure consists of a negative feedback system of three ordinary differential equations, in which the qualitative behavior is either a stable constant equilibrium solution or oscillatory solutions. A specific realization of the model is used to describe the experimental observations of pulsatile hormone release, its experimental suppression, the onset of puberty, the effects of castration, and several other qualitative and quantitative results. This model is presented as a first step in understanding the physicochemical interactions of the hypothalamic-pituitary-gonadal axis.
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    Bulletin of mathematical biology 42 (1980), S. 79-94 
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    Notes: Abstract Based upon the transition rate equation of dipoles in the membrane, we deal with two important aspects of interaction of nerve signals: (1) conditions for nerve excitation and (2) frequency spectrum analysis of nerve impulse. Interrelations between signal amplitudes and frequencies are formulated in detail. There are several important conclusions which can be drawn from our calculations. First, toexcite the nerve, low frequencies are generally more effective than high frequencies. Second, tosedate the nerve (i.e. to suppress undesired activities), high frequencies would suit better. Third, harmonics produced through interactions of nerve signals are not necessarily weaker than the fundamental frequencies. The great significance of our theory is that it indicates in principle the feasibility to alter or rewrite the information contents of a nerve message in our body by applying stimulations of appropriate strengths and frequencies. Thus, the theory provides a physical basis and hence some understanding for a new branch of medicine—neuro therapy such as Nogier's auriculotherapy, Lamy's phonophoresis, Voll's electroacupuncture and the fast rising TENS (transcutaneous electro-neuro stimulation).
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    Bulletin of mathematical biology 42 (1980), S. 107-117 
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    Notes: Abstract A new physical property, called resonance of the B-type is hypothetically attached to the λ =546 nm irradiated crystalline (small) molecules. In this respect an up or down configuration is assumed for those states obtained through irradiation times that are multiples of 5 sec. With these assumptions, the cellular receptors that may detect these states appear to belong to three classes: the up, down and alternatively mixed up-down. Using the classic formalism of eigenvectors and eigenvalues, a simple spectroscopic type of formula is derived, through which all the possible states of the above characteristic may be obtained.
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    Bulletin of mathematical biology 42 (1980), S. 119-130 
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    Notes: Abstract A model of ecosystems with migration is proposed from the viewpoint of flow. This model explains the following two points: (1) How the density-dependent terms in population dynamics arise as a consequence of migration. (2) How the ecosystem exhibits a hierarchy in energy per unit biomass.
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    Bulletin of mathematical biology 42 (1980), S. 143-145 
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    Bulletin of mathematical biology 42 (1980), S. 95-106 
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    Notes: Abstract For precise boundary conditions of biological relevance, it is proved that the steadily propagating plane-wave solution to the Fisher equation requires the unique (eigenvalue) velocity of advance 2(Df)1/2, whereD is the diffusivity of the mutant species andf is the frequency of selection in favor of the mutant. This rigorous result shows that a so-called “wrong equation”, i.e. one which differs from Fisher's by a term that is seemingly inconsequential for certain initial conditions, cannot be employed readily to obtain approximate solutions to Fisher's, for the two equations will often have qualitatively different manifolds of exact solutions. It is noted that the Fisher equation itself may be inappropriate in certain biological contexts owing to the manifest instability of the lowerconcentration uniform equilibrium state (UES). Depicting the persistence of a mutantdeficient spatial pocket, an exact steady-state solution to the Fisher equation is presented. As an alternative and perhaps more faithful model equation for the propagation of certain species properties through a homogeneous population, we consider a reaction-diffusion equation that features a cubic-polynomial rate expression in the species concentration, with two stable UES and one intermediate unstable UES. This equation admits a remarkably simple exact analytical solution to the steadily propagating plane-wave eigenvalue problem. In the latter solution, the sign of the eigenvelocity is such that the wave propagates to yield the “preferred” stable UES (namely, the one further removed from the unstable intermediate UES) at all spatial points ast→∞. The cubic-polynomial equation also admits an exact steady-state solution for a mutant-deficient or mutant-isolated spatial pocket. Finally, the perpetuating growth of a mutant population from an arbitrary localized initial distribution, a mathematical problem analogous to that for ignition in laminar flame theory, is studied by applying differential inequality analysis, and rigorous sufficient conditions for extinction are derived here.
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    Bulletin of mathematical biology 42 (1980), S. 191-220 
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    Notes: Abstract The binding of mono-, di- and trivalent cations to negatively charged surfaces is studied within the framework of a modified Gouy-Chapman equation. For any given combination of ions of the above valences, the existence and uniqueness of the solution for the surface potential is shown. The treatment provides the surface potential and charge density. For a system containing only monovalent and divalent ions, analytical solutions are given. When trivalent ions are also present, a procedure based on numerical integration is described. The distance dependence of the electrostatic potential for planar surfaces is given. The calculations provide the amount of cations tightly bound and the amount trapped in the double layer region. The competition between cations for binding to surfaces is elucidated.
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    Bulletin of mathematical biology 42 (1980), S. 221-238 
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    Notes: Abstract This paper deals with a model describing the behavior of barium-treatedApalysia neurons. The model is represented by a dynamical system, so-called “complete system”, defined in R4 and depending on a small parameter. The study of this system under zero membrane current conditions was performed with the use of the qualitative theory of singular perturbations. We show that this system has a stable periodic solution of the discontinuous type when the small parameter tends to 0+. A reduced system defined in R3, associated to the complete system was also studied: it corresponds to a constant activation of the inward current. We demonstrate that the corresponding hypothetical cell remains silent under zero current conditions.
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    Notes: Abstract In the study of chemical modification of enzymes and other biologically active proteins, plots of fractional residual activity as a function of number of groups modified per enzyme molecule are often used to establish a correlation between the chemical modification and enzyme inactivation reactions and to determine the stoichiometry of the modification reaction. This paper presents a critical examination of the underlying theoretical framework of such graphs. Whereas these plots are usually presented as linear functions, it is shown here that the general equation describing the relationship between inactivation and modification contains an exponential term; therefore, in the general case, the plot is actually a curve. It is suggested that caution be exercised in the interpretation of such plots and that equations such as those derived in the text be used to fit theoretical curves to the data, in order to maximize the information gained from chemical modification experiments.
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    Bulletin of mathematical biology 42 (1980), S. 257-265 
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    Notes: Abstract This communiction argues that so-called “hermaphroditic” tracer systems, which are neither open nor closed, do not exist physically. The argument is based on the assumption that any observable (possibly nonhomogeneous) macroscopic compartment can be approximated by a compartmentC with a finite number of entry points for the tracer, each associated with an abstract subcompartment ofC. It is shown that the “hermaphroditic” property requires that the mean waiting time be infinite in at least one of the subcompartments, or in a subcompartment elsewhere in the system. A subcompartment with infinite mean waiting time must have some sort of memory, of infinite duration, which knows how long a given particle has been retained, however long that is, and thereby determines its probability of departure. Assuming, as seems likely, that no physical basis exists for such an infinite memory, it follows that “hermaphroditic” systems do not exist.
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    Bulletin of mathematical biology 42 (1980), S. 273-274 
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    Bulletin of mathematical biology 42 (1980), S. 275-275 
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    Bulletin of mathematical biology 42 (1980), S. 277-281 
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    Bulletin of mathematical biology 42 (1980), S. 267-272 
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    Notes: Abstract The implication of state space structure on the existence of a repeatable experimentE designed to determine if a states∈L has propertyP or notP is investigated. It is shown that if a state spaceL is connected, then no experimentE is repeatable. This formalism is used to demonstrate that if a propertyP has an associated set of points inL which is dense with dense complement inL, then there exists no repeatable experimentE which can be used to test whethers has propertyP or notP. Other consequences of this formalization are discussed.
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