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  • United States  (380)
  • Chemistry
  • Fisheries
  • Organic Chemistry
  • Physics
  • American Association for the Advancement of Science (AAAS)  (413)
  • 1980-1984  (413)
  • 1935-1939
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-17
    Description: The Interdisciplinary Panel on Carcinogenicity reviewed and reevaluated criteria for assessing evidence of carcinogenicity of chemical substances. The panel reviewed criteria applicable to data derived from human epidemiological studies and from both in vivo and in vitro laboratory studies. A critical appraisal of all these sources of information led to the conclusion that the characterization of human risk always requires interdisciplinary evaluation of the entire array of data on a case-by-case basis. Animal studies, whenever possible, should be augmented by studies of mechanisms, metabolism, and pharmacodynamics. Such studies may assist in assessing risk to man. Recognizing the utility of such data should point the way for better assessment in the future.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1984 Aug 17;225(4663):682-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6463646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; *Carcinogens/metabolism/pharmacology ; Carcinogens, Environmental ; Cell Transformation, Neoplastic ; Dose-Response Relationship, Drug ; Environmental Exposure ; Epidemiologic Methods ; Humans ; In Vitro Techniques ; Mixed Function Oxygenases/metabolism ; Mutagenicity Tests ; Neoplasms/chemically induced ; Risk ; Time Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abelson, P H -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1023.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494919" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Pollution ; *Government Agencies ; Humans ; Legislation as Topic ; Leukemia/chemically induced ; Risk ; United States ; *United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1984 Jan 13;223(4632):116-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691138" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Environmental Exposure ; Humans ; *Intelligence ; *Lead ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmed, A K -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):440.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691155" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *Containment of Biohazards ; *DNA, Recombinant ; *Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-27
    Description: Recent advances in biotechnology have created many public policy and legal issues, one of the most significant of which is the treatment of biotechnological industrial products, particularly under the patent system. Patents represent one of several types of intellectual property; their ownership confers the right to exclude others from benefitting from the tangible products of a proprietary subject matter. Intellectual property law and its protections will play a major role in the rate at which biotechnology develops in the United States. In this article biotechnological intellectual property issues are reviewed in the context of their underlying legal requirements. The implications of other factors, such as international competition, research funding, and gene ownership, are also considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, R G -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):357-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6584975" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Cell Line ; Copyright ; DNA, Recombinant ; Economic Competition ; Federal Government ; *Genetic Engineering ; *Genetics, Microbial ; Government Regulation ; Legislation as Topic ; Ownership ; *Patents as Topic ; Research ; *Technology ; United States ; as a question of intellectual property rights. Attention is focused on the major ; role played by the U.S. patent system in establishing such rights, as illustrated ; by the case of products of recombinant DNA research. Trade secret, copyright, and ; trademark protections are also considered, as are policy issues such as ; international competition in the development of biomedical technologies and ; financing arrangements.
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailey, M R -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):716-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695180" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution ; *Fires ; Humans ; United States ; *Wood
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, I S -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):243.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710142" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *DNA, Recombinant ; Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; *Professional Staff Committees ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):521.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494899" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Legislation, Medical ; National Institutes of Health (U.S.)/organization & administration ; New York ; *Primates ; United States
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    Electronic ISSN: 1095-9203
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):151.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484568" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Jurisprudence ; Malathion/adverse effects ; *National Institutes of Health (U.S.) ; Neoplasms/chemically induced ; United States
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):324.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484573" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Humans ; Male ; Mental Disorders/*epidemiology/therapy ; National Institute of Mental Health (U.S.) ; United States
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1376-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474183" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; *Government Agencies ; *Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Aug 24;225(4664):815, 818.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089330" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome ; *Budgets ; Centers for Disease Control and Prevention (U.S.) ; *Financial Management ; Humans ; *National Institutes of Health (U.S.) ; *Research ; United States ; United States Substance Abuse and Mental Health Services Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):488.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740322" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; National Institutes of Health (U.S.) ; New York ; *Primates ; *Research Support as Topic ; United States ; Universities/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):489.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740323" target="_blank"〉PubMed〈/a〉
    Keywords: Medical Laboratory Science/*standards ; Quality Assurance, Health Care ; *Societies, Scientific ; United States ; *United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; California ; Cats ; Dogs ; *Ethics, Medical ; Legislation, Medical ; Maryland ; National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):969.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6372094" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; *National Institutes of Health (U.S.) ; United States
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 May 25;224(4651):849-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719113" target="_blank"〉PubMed〈/a〉
    Keywords: Dioxins/*adverse effects ; Environmental Exposure ; *Jurisprudence ; United States ; Vietnam
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):483-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740321" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Information Services ; *Government Agencies ; United States ; *United States Environmental Protection Agency
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1319-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Craniocerebral Trauma ; Ethics, Medical ; Humans ; National Institutes of Health (U.S.) ; Papio ; Pennsylvania ; United States
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 May 11;224(4649):582.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6369539" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Toxins/*genetics ; *Cloning, Molecular ; Containment of Biohazards ; Escherichia coli/genetics ; *National Institutes of Health (U.S.) ; Shiga Toxins ; United States
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):966.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6372093" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; National Institutes of Health (U.S.) ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):267-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710143" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States ; *Universities
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):364-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710147" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Husbandry/standards ; Animals ; *Animals, Laboratory ; Ethics ; National Institutes of Health (U.S.) ; *Research ; United States ; Vivisection
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  • 26
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jul 13;225(4658):148-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328665" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institute of Mental Health (U.S.) ; Research Support as Topic ; United States ; *United States Substance Abuse and Mental Health Services Administration
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 May 11;224(4649):584-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200939" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; *DNA, Recombinant ; Factor VIII/genetics ; Humans ; Industry ; Interferons/genetics ; *Patents as Topic/legislation & jurisprudence ; United States ; current patent disputes within the biotechnology industry. Fox reports on the ; participants and products involved in six actions, some over substances that are ; still being tested. Companies often use these legal contests to gain an edge on ; the competition ; some firms without the resources to wage long court cases will ; go under or be bought out, while others will be forced to disclose research ; secrets to defend themselves against charges of patent infringement. Given the ; nature of the genetic engineering industry, patent battles are expected for years ; to come.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):36-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; *Legislation as Topic ; Research ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; *Legislation, Veterinary ; *Research ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):568-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695167" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Ethics ; Military Medicine ; United States ; *Wounds, Gunshot
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Feb 24;223(4638):798-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695181" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Containment of Biohazards ; *DNA, Recombinant ; *Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; United States ; Health has encountered setbacks in its attempt to increase its regulatory ; authority over genetic engineering ventures. Competing claims by the ; Environmental Protection Agency have been supported in a congressional report ; authored by Rep. Albert Gore, Jr. (D-Tenn.) which is critical of RAC's actions in ; approving experimental release of genetically-modified organisms into the ; environment. During a 6 Feb 1984 public meeting, RAC faced a barrage of criticism ; led by activist Jeremy Rifkin, and learned of a U.S. Court of Appeals decision ; blocking its consideration of a proposed field test with engineered bacteria.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Mar 2;223(4639):914.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6607532" target="_blank"〉PubMed〈/a〉
    Keywords: *Genetic Engineering ; Humans ; *Legislation, Drug ; United States ; United States Food and Drug Administration ; alpha 1-Antitrypsin/*genetics/therapeutic use
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gore, A Jr -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):6,8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587567" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; DNA, Recombinant ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Humans ; Legislation as Topic ; National Institutes of Health (U.S.) ; United States ; United States Environmental Protection Agency
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1379-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701527" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Computers ; DNA/genetics ; *Molecular Biology ; National Institutes of Health (U.S.) ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1078.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719131" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Humans ; Risk ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):672.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320366" target="_blank"〉PubMed〈/a〉
    Keywords: *Centers for Disease Control and Prevention (U.S.) ; Child ; Humans ; *Jurisprudence ; Lead Poisoning/*prevention & control ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Jan 27;223(4634):379-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691150" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine/analogs & derivatives/toxicity ; Carcinogens ; Fungicides, Industrial/toxicity ; *Government Agencies ; Herbicides/toxicity ; Pesticide Residues/toxicity ; Pesticides/*toxicity ; United States ; *United States Environmental Protection Agency
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
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  • 41
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, Colin -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):265.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644124" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Federal Government ; Financial Support ; *Fraud ; Government ; *Government Regulation ; Humans ; International Cooperation ; Internationality ; National Institutes of Health (U.S.) ; Public Policy ; Punishment ; *Research ; Research Personnel ; *Scientific Misconduct ; *Social Control, Formal ; Switzerland ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):35-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701531" target="_blank"〉PubMed〈/a〉
    Keywords: Books/*legislation & jurisprudence ; *Crime ; *Fraud ; Publishing/*legislation & jurisprudence ; Textbooks as Topic/*legislation & jurisprudence ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):463.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691156" target="_blank"〉PubMed〈/a〉
    Keywords: Research ; Research Support as Topic ; *Technology Assessment, Biomedical/economics ; United States
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  • 45
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-05
    Description: Although most medical educators believe that education, research, and patient care are inseparable and essential to their academic mission, the educational component of this triad has never been given adequate, earmarked support. To fund educational programs, medical centers first relied on research grants and later on third-party payments intended for patient care. However, research money has long since ceased to be available for other purposes and recent federal cost containment measures have started to reduce payments for patient care. Teaching hospitals are threatened with loss of support not only for education, but for their capital improvements and care of the poor. Many institutions are now hoping to generate new income through business deals with for-profit health care corporations, but this effort probably will also fail and may compromise professional traditions. Teaching hospitals serve the public interest and will have to depend, at least in part, on public subsidy of their unavoidable extra costs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Relman, A S -- New York, N.Y. -- Science. 1984 Oct 5;226(4670):20-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382612" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Education, Medical/*economics ; Education, Medical, Graduate/*economics ; Health Facilities, Proprietary ; Hospitals, Teaching/*economics ; Humans ; Insurance, Health ; Medicare ; National Institutes of Health (U.S.) ; Research Support as Topic ; Training Support ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1400-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505696" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1056.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494923" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*economics ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms/*economics ; Politics ; *Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):419-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494893" target="_blank"〉PubMed〈/a〉
    Keywords: American Medical Association ; Curriculum ; *Education, Medical ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):151.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385249" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Sep 14;225(4667):1128, 1130-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089342" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*blood ; Antibodies, Viral/*analysis ; Blood Donors ; Blood Transfusion/adverse effects ; Deltaretrovirus/*immunology ; Federal Government ; Humans ; United States ; United States Dept. of Health and Human Services ; epidemiological study by the National Heart, Lung and Blood Institute. Blood ; samples from 200,000 presumably healthy donors will soon be drawn and stored, to ; be screened when the test becomes available. Donors and recipients of blood which ; tests AIDS-positive will then be followed to see if AIDS develops. The study ; raises ethical issues in the areas of obtaining informed consent from donors and ; notifying donors and recipients of test results. The plan now is to obtain ; consent from donors and notify them of positive test results, and to decide later ; about notifying recipients.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691133" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *DNA, Recombinant ; *Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; United States ; Recombinant DNA Advisory Committee (RAC) are seen as potentially detrimental to ; RAC's credibility. Each session was closed on grounds that proprietary data were ; being reviewed. NIH Director James B. Wyngaarden has implemented a formal review ; of the extent of the authority of RAC, which currently reviews not only research ; projects funded by its parent agency but also voluntarily-submitted industrial ; proposals and proposals of other federal government agencies.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cummings, M M -- Johnson, F B -- Fox, C H -- New York, N.Y. -- Science. 1984 Nov 23;226(4677):912.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6390678" target="_blank"〉PubMed〈/a〉
    Keywords: History, 19th Century ; History, 20th Century ; Microscopy/*history ; Military Medicine/history ; National Library of Medicine (U.S.)/*history ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Jan 13;223(4632):149-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691140" target="_blank"〉PubMed〈/a〉
    Keywords: *Education, Medical, Continuing ; *National Institutes of Health (U.S.) ; *Research ; *Training Support ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):521.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387909" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/adverse effects ; 2,4-Dichlorophenoxyacetic Acid/adverse effects ; Combat Disorders/psychology ; Female ; Humans ; Pregnancy ; Tetrachlorodibenzodioxin/adverse effects ; *Twins/psychology ; United States ; *United States Department of Veterans Affairs ; *Veterans ; Vietnam
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1155.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701518" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; *Neoplasms ; *Professional Staff Committees ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Apr 13;224(4645):139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322308" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; Humans ; Substance-Related Disorders/prevention & control ; United States ; *United States Substance Abuse and Mental Health Services Administration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):670.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695175" target="_blank"〉PubMed〈/a〉
    Keywords: *Empathy ; *Humanism ; Humans ; *Internal Medicine ; Internship and Residency ; *Societies, Medical ; United States ; technological advances has begun to manifest itself in actions by professional ; societies and medical schools. The American Board of Internal Medicine now ; requires proof of a physician's "integrity, respect, and compassion" for ; certification. More humanities majors are being encouraged to enter medicine, and ; many residency programs are exploring ways of helping residents develop a more ; humanistic approach to patient care.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):569.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6229877" target="_blank"〉PubMed〈/a〉
    Keywords: *Disabled Persons ; *Ethics, Medical ; Humans ; *Infant, Newborn ; Patient Advocacy/*legislation & jurisprudence ; *Societies, Medical ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enstrom, J E -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):878.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474159" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Humans ; *Longevity ; Male ; *Smoking ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feulner, R L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):266.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740309" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens ; *Government Agencies ; Humans ; Male ; Rats ; Triazines/*adverse effects ; United States ; *United States Environmental Protection Agency
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):705-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6463647" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects ; Calcium/*deficiency ; Calcium, Dietary/metabolism/pharmacology ; Diet ; Humans ; Hypertension/*etiology ; Rats ; Sodium/metabolism ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1052-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494921" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; National Institutes of Health (U.S.) ; Politics ; Research Support as Topic/*legislation & jurisprudence ; *Social Sciences ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 1984 Jul 27;225(4660):396.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644144" target="_blank"〉PubMed〈/a〉
    Keywords: *Abortion, Induced ; China ; Coercion ; Developing Countries ; Economics ; *Family Planning Services ; *Financing, Government ; Humans ; *International Cooperation ; *Internationality ; Mandatory Programs ; *Population Control ; Prevalence ; *Public Policy ; Social Change ; United Nations ; United States ; conference concerning U.S. plans to halt foreign aid to nongovernmental ; organizations that "perform or actively promote" abortions, several reports ; appeared about problems which developing nations face in contending with rapid ; population growth. The World Bank's World Development Report 1984 analyzes ; population and development trends, argues for providing more aid for population ; programs, and recounts what has happened in countries where abortion has been ; outlawed. A National Research Council report documents China's rapid fertility ; drop since its 1969 antinatalist campaign began. A Population Reports ; International report advocates housing, education, and incentive-based family ; planning programs in developing countries.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729465" target="_blank"〉PubMed〈/a〉
    Keywords: Australia ; *Fertilization in Vitro ; Humans ; Internationality ; Jurisprudence ; United States ; without arranging for the disposition of two of the woman's fertilized ova in ; frozen storage has renewed debate over the legal and moral aspects of in vitro ; fertilization. Experts doubt that the zygotes are still viable, but questions ; have been raised about their legal status, their inheritance rights, and the ; possibility of implanting them in the womb of a surrogate mother. Disposition of ; unused fertilized eggs in the United States is currently governed by informal ; guidelines, although a public consensus on the issues raised by new and future ; reproductive technologies has not been attained.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):36.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729467" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Mice ; *National Institutes of Health (U.S.) ; Nuclear Transfer Techniques ; *Research Support as Topic ; Switzerland ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644140" target="_blank"〉PubMed〈/a〉
    Keywords: *Abortion, Induced ; Capitalism ; Coercion ; Developing Countries ; Economics ; *Family Planning Services ; Federal Government ; *Financing, Government ; Government ; Government Agencies ; Humans ; *International Cooperation ; *Internationality ; Political Systems ; *Population Control ; *Public Policy ; United Nations ; United States ; paper to be presented at the August 1984 United Nations world population ; conference in Mexico City. The paper dismisses population growth in developing ; countries as a cause of unemployment, illegal migration, or famine, and asserts ; that population programs are no substitute for ending government controls that ; stifle economic growth. It also contains a strong statement against abortion, ; states the U.S. position against coercion in family planning, and declares the ; Reagan administration's resolve not to fund programs advocating abortion. The ; U.S. stance is expected to antagonize developing countries and isolate the United ; States at the U.N. conference.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1078-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719132" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Multiple ; Federal Government ; *Government Regulation ; Humans ; Infant, Newborn ; *Jurisprudence ; Legislation, Medical ; United States ; other medical organizations, a federal district court judge has struck down the ; February 1984 version of the Department of Health and Human Services' "Baby Doe" ; regulations. It was the second time a court had denied the government's claim ; that federal statutes forbidding discrimination against the handicapped give it ; the authority to intervene in treatment decisions concerning handicapped ; newborns. At the time of the ruling, no complaints about the care of any infant ; had been handled by DHHS under the provisions of this latest set of regulations.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1157.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6367037" target="_blank"〉PubMed〈/a〉
    Keywords: Combat Disorders/epidemiology ; Female ; Humans ; Male ; *Military Medicine ; Pregnancy ; *Twins ; United States ; United States Department of Veterans Affairs ; *Veterans ; Vietnam ; *Warfare
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):264.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701511" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Infant, Newborn ; Patient Advocacy/*legislation & jurisprudence ; United States ; United States Dept. of Health and Human Services
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    Publication Date: 1984-08-24
    Description: The importance and origin of antimicrobial-resistant Salmonella infections were examined in 52 outbreaks investigated by the Centers for Disease Control between 1971 and 1983. The case fatality rate was higher for patients infected with antimicrobial-resistant Salmonella (4.2 percent) than for those with antimicrobial-sensitive infections (0.2 percent). In the 38 outbreaks with identified sources, food animals were the source of 11 (69 percent) of 16 resistant and 6 (46 percent) of 13 sensitive outbreak strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holmberg, S D -- Wells, J G -- Cohen, M L -- New York, N.Y. -- Science. 1984 Aug 24;225(4664):833-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/*pharmacology ; Cattle/microbiology ; *Disease Outbreaks ; Drug Resistance, Microbial ; *Food Microbiology ; Humans ; Meat ; Milk/microbiology ; Poultry/microbiology ; Salmonella/*drug effects ; Salmonella Infections/microbiology/*transmission ; Salmonella typhimurium/drug effects ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):34-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691132" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Japan ; *Military Medicine ; Multiple Myeloma/*epidemiology ; *National Academy of Sciences (U.S.) ; *Organizations ; *Radioactive Fallout ; United States ; *Veterans
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    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-03
    Description: The article "Reagan seeks expansion of Soviet ties" by R. Jeffrey Smith (News and Comment, 13 July, p. 145) erroneously stated that the U.S. Senate had passed a resolution calling for a U.S.-Soviet summit "without preconditions or assurances of success." Shortly before midnight on 19 June, the resolution was amended to call for a summit at "the earliest practical time following thorough preparation." It was approved in this form.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jako, G J -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):462.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740318" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Legislation, Medical ; *National Institutes of Health (U.S.) ; Neoplasms/mortality/*prevention & control ; *Research ; United States
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-09
    Description: There is increasing recognition that federal food safety laws and policies need to be revised. Congressional debate on proposed amendments to the Food, Drug, and Cosmetic Act has generated several different perspectives on how the food safety laws should be changed. Before a consensus can be reached, scientists, regulators, the food industry, and consumers will have to review such complex and controversial issues as the level of acceptable risk, the value of risk-benefit analysis, the proper role of independent scientific review, and the reliability of quantitative risk assessment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kessler, D A -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1034-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695192" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; Food Additives ; Food Analysis ; Food Coloring Agents ; Food Contamination ; Legislation, Drug ; *Legislation, Food/trends ; Pesticide Residues ; Risk ; Safety ; United States ; *United States Food and Drug Administration
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1083-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6426059" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Disease Models, Animal ; Haplorhini ; Humans ; Parkinson Disease/*etiology ; Parkinson Disease, Secondary/etiology ; Pyridines/*adverse effects ; Rats ; Substance-Related Disorders ; Substantia Nigra/drug effects ; United States
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):34-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729464" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/prevention & control ; Child ; Gasoline/*adverse effects ; Humans ; Lead/adverse effects ; *Lead Poisoning/etiology/prevention & control ; *Legislation as Topic ; Petroleum/*adverse effects ; United States
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):367-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710148" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; Chemical Industry ; Civil Rights/*legislation & jurisprudence ; *Employee Discipline ; National Institutes of Health (U.S.) ; *Personnel Management ; Pesticides/toxicity ; United States
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  • 81
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 May 25;224(4651):851-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547002" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; *Food Contamination ; Insecticides/*adverse effects ; *Legislation as Topic ; Triazines/*adverse effects ; United States ; United States Environmental Protection Agency
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-29
    Description: A data base of the National Center for Health Statistics, Health and Nutrition Examination Survey I (HANES I), was used to perform a computer-assisted, comprehensive analysis of the relation of 17 nutrients to the blood pressure profile of adult Americans. Subjects were 10,372 individuals, 18 to 74 years of age, who denied a history of hypertension and intentional modification of their diet. Significant decreases in the consumption of calcium, potassium, vitamin A, and vitamin C were identified as the nutritional factors that distinguished hypertensive from normotensive subjects. Lower calcium intake was the most consistent factor in hypertensive individuals. Across the population, higher intakes of calcium, potassium, and sodium were associated with lower mean systolic blood pressure and lower absolute risk of hypertension. Increments of dietary calcium were also negatively correlated with body mass. Even though these correlations cannot be accepted as proof of causation, they have implications for future studies of the association of nutritional factors and dietary patterns with hypertension in America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCarron, D A -- Morris, C D -- Henry, H J -- Stanton, J L -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1392-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729459" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Ascorbic Acid/metabolism ; *Blood Pressure/drug effects ; Calcium/metabolism ; Continental Population Groups ; Energy Intake ; Female ; Humans ; Hypertension/metabolism ; Male ; Middle Aged ; National Center for Health Statistics (U.S.) ; Nutrition Surveys ; *Nutritional Physiological Phenomena ; Obesity/metabolism ; Potassium/metabolism ; Sex Factors ; Sodium/metabolism ; United States ; Vitamin A/metabolism
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):811-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494908" target="_blank"〉PubMed〈/a〉
    Keywords: Legislation, Medical ; *National Institutes of Health (U.S.)/organization & administration ; United States
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1055.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494922" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.)/*organization & administration ; Research Support as Topic ; United States
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):517.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494897" target="_blank"〉PubMed〈/a〉
    Keywords: Legislation, Medical ; *National Institutes of Health (U.S.)/organization & administration ; United States
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):417-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494892" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; *Financial Management ; *National Institutes of Health (U.S.)/organization & administration ; United States
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  • 87
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1371-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474181" target="_blank"〉PubMed〈/a〉
    Keywords: *Politics ; *Research Support as Topic ; United States
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 May 11;224(4649):581.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710157" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; Federal Government ; *Fraud ; *Government Regulation ; *National Institutes of Health (U.S.) ; Research/*standards ; United States ; look into institutional procedures at Emory University, where an internal ; investigation had revealed extensive data fabrication by John Darsee, found a ; pattern of lax supervision of Darsee's research. Rather than prescribe action for ; Emory alone, the panel recommended seven procedural steps that should be taken by ; all NIH-supported research centers to guard against similar occurrences. These ; recommendations are being reviewed by NIH.
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1218.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587565" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; DNA, Recombinant ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Jurisprudence ; *National Institutes of Health (U.S.) ; United States ; recommended to NIH director James B. Wyngaarden on 1 June 1984 that two ; companies, Cetus Corporation and Advanced Genetic Sciences, Inc., be allowed to ; proceed with experiments involving release into the environment of organisms ; altered by gene splicing. The recommendation followed by two weeks a ruling by ; federal judge John J. Sirica which halted a very similar experiment by ; federally-funded University of California researcher Steven Lindow. The ruling ; did not apply to experiments conducted by private companies. Wyngaarden thus ; faces the political dilemma that, if he accepts the advisory committee's ; recommendation, a dual standard will be established allowing industry to conduct ; experiments that university scientists are currently barred from doing.
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):962-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719128" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *DNA, Recombinant ; Federal Government ; *Government Regulation ; Jurisprudence ; National Institutes of Health (U.S.) ; United States ; University of California experiment, already approved by the National Institutes ; of Health's Recombinant DNA Advisory Committee, which would have involved the ; first deliberate release into the environment of genetically modified bacteria. ; Agreeing with social activist Jeremy Rifkin's charge that NIH had failed to ; comply with the National Environmental Policy Act when it approved the ; experiment, Sirica strongly suggested that he would also rule in Rifkin's favor ; on a suit to block all similar federally funded experiments until NIH has ; conducted an exhaustive evaluation of their potential environmental impact. ; Sirica's decision, however, left the NIH Recombinant Advisory Committee free to ; approve privately-funded experiments, which are not covered by the same ; environmental laws.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1370-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6142529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cuba ; Culicidae/parasitology ; History, 19th Century ; History, 20th Century ; Humans ; Insect Vectors/parasitology ; United States ; Yellow Fever/*history/transmission
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):564-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695166" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; *Financial Management ; Government Agencies ; Politics ; *Research Support as Topic ; United States
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  • 93
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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  • 94
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1215-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587564" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Warfare ; Biomedical Research ; Federal Government ; Genetic Engineering ; Humans ; Internationality ; Ussr ; United States ; Advancement of Science addressed concerns that recent developments in molecular ; biology have undermined the 1972 Biological and Toxin Weapons Convention, ; necessitating compliance verification changes in this international treaty ; banning the development and use of biological weapons. A group of scientists, ; military analysts, and arms control experts discussed types of biological ; research projects funded by the Department of Defense which could be diverted to ; the production of relatively efficient, inexpensive new weapons. Most of the ; panelists challenged the Pentagon's claim that biological weapons are currently ; being developed by the Soviet Union.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1984 May 25;224(4651):853, 856.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719114" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Jurisprudence ; Neoplasms, Radiation-Induced/*etiology ; *Radioactive Fallout ; United States
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):671.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6364350" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ethylene Dibromide/*toxicity ; *Government Agencies ; Humans ; Hydrocarbons, Brominated/*toxicity ; United States ; *United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):37.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701533" target="_blank"〉PubMed〈/a〉
    Keywords: United States ; United States Food and Drug Administration/*organization & administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1984 Apr 13;224(4645):132-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701536" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Humans ; *Jurisprudence ; *Shock, Septic ; Staphylococcus aureus/metabolism ; Swine ; Tampons, Surgical/adverse effects ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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