Publication Date:
1981-10-09
Description:
Blockade of gamma-aminobutyric acid receptor function by direct microinjection of bicuculline into the nucleus ambiguous in cats produced a marked increase in gastric motility which was mediated by the vagus nerve. This effect was reversed by muscimol. These data indicate that the nucleus ambiguous may be an important brain site influencing gastric function and that the neurotransmitter controlling parasympathetic overflow from this nucleus to the stomach is gamma-aminobutyric acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williford, D J -- Ormsbee, H S 3rd -- Norman, W -- Harmon, J W -- Garvey, T Q 3rd -- DiMicco, J A -- Gillis, R A -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):193-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6269182" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bicuculline/pharmacology
;
Cats
;
Gastrointestinal Motility/drug effects
;
Medulla Oblongata/*physiology
;
Muscimol/pharmacology
;
Muscle Contraction/drug effects
;
Muscle, Smooth/physiology
;
Receptors, Cell Surface/*physiology
;
Receptors, GABA-A
;
Receptors, Neurotransmitter/*physiology
;
Stomach/*innervation/physiology
;
gamma-Aminobutyric Acid/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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