Publication Date:
2017-08-22
Description:
A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate Nature Communications, Published online: 22 August 2017; doi:10.1038/s41467-017-00154-x The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent vinblastine, has remained largely unexplored. Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem, convert strictosidine to akuammicine, the stable shunt product of preakuammicine.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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