Publication Date:
2017-09-06
Description:
Ratiometric Matryoshka biosensors from a nested cassette of green- and orange-emitting fluorescent proteins Nature Communications, Published online: 5 September 2017; doi:10.1038/s41467-017-00400-2 Single fluorescent protein biosensors are susceptible to expression and instrumental artifacts. Here Ast et al. describe a dual fluorescent protein design whereby a reference fluorescent protein is nested within a reporter fluorescent protein to control for such artifacts while preserving sensitivity and dynamic range.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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