ALBERT

Description: Due to the clime change scenario, severe hydro-meteorological phenomena are having a high impact on the ecosystems of the earth. Some strategies based on the use of natural communities associated with geomorphological changes that restore the natural landscape are gaining success due the resistance and resilience against damages. All of these strategies are known as nature-based solutions (NBS). Soil and water bioengineering techniques are one of the most appreciated tools to reach effectiveness for slope stabilization. They are based on the capacity of some plants to consolidate the soil with his rooting system in special conditions (high slope, flooding impact). Slope stabilization solutions with soil and water bioengineering techniques need to be adapted to this new scenario. Crib wall is one of the most complete soil and water bioengineering technique for structural slope stabilization. It is based on a wooden box full of live plants that in the future will grow and gain stability at the same time that wood decays. The crib wall box is full of soil, and the front area is traditionally stabilized with some branches of fascines to let plants grow, maintaining the structure. Fascines are made of branches of riparian species with the capacity for vegetative propagation. Their diameter can change due to the humidity variation, so the stiffness of the system is at risk against severe hydro-meteorological phenomena. This study aims to assess that the introduction of HDCL in crib walls improves planting success and makes them more resistant to adverse weather events in Mediterranean areas. Four experiments were performed in controlled and natural conditions with this proposal. The results show that the use of natural fibers instead of branch fascine helps to maintain the humidity conditions and increase the resistance capacity. High-density coir logs (HDCL) are not affected by volume changes for humidity conditions. HDCL maintains the plant’s humidity conditions longer and makes plants grow faster, bigger and increase their survival. This method of Crib wall construction increases the associated biodiversity. The most important results are that the use of HDCL in crib walls has an effect on the growth of planted shrub, the development of roots, the colonization of native vegetation and ultimately, the resistance of the structure to the floods. The results also show that crib walls are a good technique for the stabilization of slopes with considerable gradients and high hydraulic impacts. HDCL can reduce the water stress of plantations, and they can be a good system to retain runoff and provide it to the plants. Finally, the HDCL allows the revegetation of a crib wall 30% faster than with branch fascine.

Description: Business organizations all around the globe are looking to expand circular models into their supply chains to harness economic and environmental benefits. Moreover, the act of giving incentives to retailers by the manufacturer is also quite prevalent in the present business environment. These incentives are offered to promote the sales of products of a manufacturer. Therefore, this paper examines the optimal decisions for a dual-retailer closed-loop supply chain (CLSC) in which the manufacturer bestows the credit period to the one retailer (a firm that possesses shallow market penetration and has a higher insistence on the usage of the capital venture), and cash discount to the next retailer (a firm that occupies the market to a greater extent and receives lower thrust on the usage of invested capital) under a non-coordinated system and coordinated systems. This study proposes the mathematical model to determine the optimal decisions of the manufacturer in terms of credit period and cash discount and also compute the optimal decisions of the retailers for their retail prices and order quantities to maximize individual’s profit in the CLSC. Moreover, numerical analysis and sensitivity analysis is performed to get insights into the optimal decisions of the manufacturer and retailers. The results of sensitivity analysis show that credit period and cash discount increases with the rise in price elasticity, and decreases with an increase in cross-price elasticity. The findings also confirm that members of dual-retailer CLSC under coordination and manufacture’s incentive scenario generate higher environmental and economic benefits required to attain sustainability in production and consumption.

Description: Over the last decades, growing interest has been devoted to employees’ perceptions of Human Resource Management Practices because of their positive influence on individual attitudes and behaviors as well as on organizational performance. Furthermore, assuming the mutual benefits coming from a people-based management of the human capital in organizations, both in terms of employees’ increased motivation, engagement and commitment, and consequently enhanced performance and competitive advantage, recent research in the field concentrated on the impact of HRM practices perceptions on some distinctive individual attitudes and behaviors driving the success of organizations especially in times of radical change like the present ones. Moving from these assumptions, the aim of the present study was to examine the relationship between HRM practices perception and objective career success, considering the mediating role played by employability and extra-role behaviors. Participants were 960 Italian employees who filled an online self-report questionnaire available through the web platform Google Forms. The questionnaire encompassed socio-demographic information and self-report scales assessing the study variables. Results showed that HRM practices perception was positively related to employability, objective career success, and extra-role behaviors. Implications for theory and practice, limitations, and future research directions were also discussed.

Description: Lockdown policies applied worldwide to limit the spread of COVID-19, and mainly based on health considerations, have negatively impacted on public transport (PT) usage, suspected as a means for the virus spreading due to difficulties ensuring social distancing. This resulted not only in a setback to sustainable mobility, but also impacting on equity and social exclusion issues. The paper aimed to cover this topic, investigating the conjecture that the spread of the coronavirus is directly correlated to PT usage. A correlation analysis among the daily number of certified coronavirus cases and the PT trips measured in the day in which the contagions occurred was performed within the second wave in Italy. The appropriateness of the case study is twofold because Italy was one of the main European countries with a high mass contagion and because the vaccination campaign had not yet started in Italy. Estimation results show a high correlation (up to 0.87) between COVID-19 contagion and PT trips performed 22 days before. This threshold indicates that quarantine measures, commonly set at two weeks and based only on incubation considerations, were inadequate as a containment strategy, and may have produced a possible slowdown in identifying new cases and hence, in adopting mitigation policies. A cause–effect test was also implemented, concluding that there is a strong causal link between COVID-19 and PT trips. The main issues discussed in this research cover the transportation and the health filed but also laid the groundwork for ethical considerations concerning the right to mobility and social equity. Obtained results could yield significant insights into the context variables that influence the spread of the virus, also helping appropriate definition of restrictive policies, thereby ensuring a sustainable recovery and development of urban areas in the post-pandemic era.

Description: Non-motorized forms of transportation are increasingly perceived as an option that can contribute to reducing the ecological impact of the transportation of tourists while offering satisfactory opportunities to appreciate the urban environment. Walking, bicycles, and other forms of non-motorized transport are increasingly used in urban contexts, both by residents and tourists. By looking into the characteristics and trip motivations of international tourists visiting the city of Barcelona, our analysis identifies the groups of tourists more oriented to these soft forms of mobility and also takes into consideration how they obtained previous information about the destination. Based on an extensive survey conducted in the city, the results of our multinomial logistic regressions reveal a slight generational divide when looking at sources of information (with retired tourists less oriented to digital tools) and a strong generational divide when observing transport choices (younger tourists more oriented to both soft or collective forms of mobility). Our results also show that tourists traveling in groups and/or with trips organized by travel companies and other organizations tend to prefer the utilization of private cars. These results can be used to promote the non-motorized mobility of tourists in other urban destinations.

Description: China is world renowned for its significant achievements in several fields. China’s economic growth has been prominent, with the country’s GDP ranking second globally. China’s Foreign Direct Investment (FDI) inflows have been significant, with the country now known as the second largest economy in the world. FDI however does have some negative consequences on China’s environment. While attracting FDI promotes economic growth through industrial upgrading, the deleterious impacts of the latter on the environment cannot be ignored. The current study analyses the actual use of FDI and carbon emissions in China from 1997 to 2018. Quantitative analysis was employed to analyze the trends of FDI and carbon emissions in China as a whole and in the respective regions, namely the eastern, central and western regions. Regression analysis was then conducted to analyze the impact of FDI on carbon emissions in China on the national level and regional levels, i.e., in the eastern, central and western regions. The conclusion of this article is that FDI will play a positive role in China’s overall carbon emissions. The study has important implications for policy. We recommend that the corresponding investment policies need to be formulated according to the different levels of economic development among the regions.

Description: A number of studies have demonstrated that local government’s self-governing mechanisms can bring about positive collective outcomes for an entire region. However, less attention has been paid to different levels of collective outcomes (e.g., individual local governments vs. entire regions). Comparing such selective and collective outcomes in interlocal collaborations, this study attempts to explore which specific collaborative self-governing mechanisms can better work for which respective outcomes. Applying network approaches with time-series cross-sectional data, this study investigates how each local government’s network position and the network structure as a whole influence the impact of Energy Efficiency and Conservation Block Grants on job creation in terms of the regional green economy. Empirical results demonstrate the need for separating selective and collective outcomes in developing theories of regional governance. Additionally, the results provide practitioners with advice on how to manage interlocal relationships in order to maximize collective outcomes at different levels

Description: This work studied the efforts of the Technical Committee on Cultural Heritage in Cyprus to explore how effectively the TCCH applies diplomatic relation-building efforts towards cultural heritage management and how this can be used to construct a bridge to a process of sustainable development of social relations and heritage use in Cyprus. The Committee’s efforts demonstrate community heritage diplomacy and civil heritage diplomacy, employed by the two largest communities of the island as they attempt to build relations with each other and other minor communities across the border via various heritage practices, and public heritage diplomacy, which is employed by the authorities of each side via the Committee to influence the public of the other side. The Committee employs these forms of heritage diplomacy via a language of cooperation and by bridging gaps in and crossing borders for collaboration, so as to transfer knowledge, values, and experience, and to build trust with institutions and communities. The significance of the study lies in illustrating that the technical and collaborative successes of the Committee via application of the determined types of diplomacy may be successfully applied for a sustainable approach to build relations and confidence under ideologically and politically strained circumstances in Cyprus.

Description: An increase in energy consumption indicates increased economic activity; whether it leads to prosperity depends on the sustainability and stability of the energy source. This study has selected the top ten highly carbon emitting countries to assess renewable energy consumption dynamics for 1991 to 2018. The development of renewable energy ventures is not an overnight transformation. Further, it also entails an infrastructure development gestation which may increase CO2 emissions for the short term. To assess this non-linear pattern with CO2 and its heterogeneities, renewable energy consumption and its three types (Wind, Solar and Hydropower) are used. The empirical results estimated with a pooled mean group (PMG) method indicate that renewable energy consumption and hydropower follows inverted U-shaped behavior, with wind and solar energy consumption behavior also U-shaped. Forest area and patents are responsible for carbon remissions, while economic growth is responsible for increasing carbon emissions in sampled countries.

Description: Climate change is one of the major risks facing developing countries in Africa for which agriculture is a predominant part in the economy. Alterations in rainfall patterns and increasing temperatures projected by the Intergovernmental Panel on Climate Change (IPCC) could lead to a decline in agricultural production in many areas requiring significant changes in agricultural practices and land distribution. The study provided estimates of the economic impacts of climate change, compared these with historical impacts of drought spells, and estimated the extent to which the current Moroccan agricultural development and investment strategy, the Plan Maroc Vert, helps in agricultural adaptation to climate change and uncertainty. The aim of this study was to quantify the effects of climate change on the overall economy by using an integrated framework incorporating a computable general equilibrium model. A concomitant factor to climate change will be the increase in population and its distribution and level of consumption, which will also influence agricultural production strategies, the conversion of agricultural land, the type of irrigation, and technological development. We demonstrated how changes in cereal production and area, affluence, and climate (rainfall and temperature) can be acquired for 12 regions of Morocco and used to develop and validate an earth system model in relation to the environment and socio-economic level, which projects their impact on current and potential land use over the next 20 years. We used different mathematical equations based on cereal area and production, population, consumption (kg/person), and change in climate (temperature and rainfall) in bour and irrigated areas for the growing season of 2014 in 12 regions to project agricultural land use over the next 20 years. Therefore, several possible scenarios were investigated to explore how variations in climate change, socio-economic level, and technological development will affect the future of agricultural land use over the next 20 years, which in turn could have important implications for human well-being. Among the 12 Moroccan regions, only 4 had a surplus of cereal production compared to their local consumption. The increase in population will generate a cereal deficit in 2024 and 2034, thus lowering the average annual quantity available per capita of cereals from 204.75 to 160.61 kg/p in 2014 and 2034, respectively. Therefore, it is necessary to reduce the amount of cereals per person by 5 kg/p and 25 kg/p so that the 2014 production could satisfy the population projected in 2024 and 2034. We found that cereal production will decrease with increasing temperature and decreasing precipitation according to the simulated scenarios, which might not satisfy the growing population in 2024 and 2034. This study provides a practical tool that can be used to provide policy makers with advice on food security assurance policy based on our current knowledge of the impending onset of climate change, including socio-economic statistics and the agricultural constraints of cereals in the 12 regions of Morocco.

Description: An increasing number of people are interested in following a dietary pattern that is environmentally sustainable and water saving. However, consumers are mostly unable to recognize evidence-based information on food and nutrition and efficiently manage their diet. We conducted a narrative review aiming to support professionals to guide their assisted people that decide to follow a dietary pattern chosen for environmental or ethical reasons. We reviewed three scientific databases and Google Scholar, searching for papers that deal with the water consumption of widespread and well known dietary patterns (Healthy and Balanced Diet, Western Diet, and Vegan and Vegetarian diets). Our results suggest that moving toward a low-animal-based diet favors a reduction in water consumption, but current evidence is not sufficient to establish which is the winner in terms of water saving by comparing Vegetarian and Vegan diets.

Description: Managing a business-to-business (B2B) supply chain relationship is an endless challenge. Many recent systematic literature review studies have discussed supply chain relationships from various perspectives. However, a comprehensive analysis, summarising the existing research, explicitly identified the implemented B2B supply chain relationships and found the effects of these relationships on supply chain performance remain lacking. To address the gap, this article presents a systematic literature review based on the PRISMA approach regarding the nature of the supply chain relationships between B2B partners and their effect on supply chain performance. Web of Science and Scopus were used in the compilation of studies published between 2000 and 2020. Findings indicate that the majority of B2B partners use a collaborative relationship approach and that the impacts are marked on the operational, financial, innovation, environmental, social and economic performance of their supply chain. This study seeks to contribute to the existing literature on B2B supply chain relationships by conducting a thorough and unbiased review of previous studies, drawing more general conclusions about the adopted supply chain relationships between B2B partners and providing insights for future research.

Description: In real life situations, the material handling strategy of on-site storage systems is usually determined during the design of the storage system, which is no longer reviewed later. The strategy is typically determined by the person(s) designing the storage system, without the use of scientific methods, based on previous experience. Without a thorough periodic review of operational strategy, most companies’ warehousing systems have significant logistical losses (e.g., unnecessary material handling, waiting, operations), which also negatively affects the sustainability of the logistics operations. Therefore, eliminating these losses can increase both the competitiveness and the sustainability of companies. For this reason, the aim of this publication is to introduce a gap-filling test method that allows the selection of an optimal material handling strategy covering the total value stream in a demand-driven storage environment, using the opportunities offered by the Industry 4.0 concept, in particular in the field of big data analysis. This integrated approach has so far not emerged in the study of warehouse material handling strategies. Beyond the obvious economic benefits, the application of this method can clearly help companies to achieve a higher level of sustainability in their logistics operations, as it allows storage systems to operate more efficiently while minimizing material handling losses, ultimately resulting in a lesser demand for energy and raw materials. Moreover, this can also result in a reduction in the human and machine resources required to perform the tasks.

Description: Ports form a vital link in the global maritime supply chain, and adherence to the UN sustainable goals in each port development and operation is all-important. Improving the sustainability performance of port infrastructure requires identifying all relevant aspects of sustainability, defining suitable performance measures, applying tools for quantification, and proposing intervention measures if needed. We present a framework for assessing and managing the sustainability performance of port infrastructure incorporating these elements. We apply the framework to quay walls in the Port of Rotterdam (PoR); however, the information to assess only four out of fourteen sustainability themes was available. This fact underlines the need for sustainability monitoring and reporting. We also present a case study of a quay wall in PoR. Based on the vision of PoR and literature, the sustainability theme ‘air pollutants’ was given priority, the selected performance measure being the Greenhouse Gas (GHG) emissions. Dubocalc was chosen as a quantification tool and estimated a total emission of 1.9 kt of CO2eq for a 100-m length of quay wall over a 100-year lifecycle. The measures proposed to achieve climate neutrality in 2050 include using renewable energy for the Impressed Current Cathodic Protection and the temporary drainage systems, electrified transport and machinery, hydrogen as dredging fuel, and steel with hydrogen as a reduction-agent in the future. These could result in a total GHG reduction of 86% by the year 2050.

Description: Building energy management system involves the development of control strategies for the heating, ventilation, and air-conditioning (HVAC), as well as lighting, systems. Building energy modeling is a significant part of designing such strategies. In order to analyze the feasibility of a building energy system model for any desired control strategy, a mathematical assessment tool is developed in this paper. A multi-input multi-output (MIMO) building energy system model, consisting of an outdoor wall, an external wall, two partition walls, one roof, and a ceiling, has been considered as the virtual test setup. A methodology for conducting stability and controllability assessment tests on the building energy model is proposed using inverse dynamics input theory (IDIT). IDIT enables the decoupling of control variables so as to enable the conversion of an MIMO system to a number of independent single-input single-output systems. The controllability is assessed based on the design properties for continuous systems: asymptotes and transmission zeros. The results show that the relative humidity and air temperature of the building space were controllable for all operating points; however, in unconditioned situations, where the humidity levels of the building space were greater than that of the outdoor levels, the models were unstable.

Description: In this paper, a combined precipitation–flotation system is proposed for the removal of Fe(III), Zn(II), and Cd(II) as hydroxides. The efficiency of precipitation, as a function of pH, metal ion concentration, and dosage of the precipitating agent as the main variables, was evaluated. The results showed that 99% efficiency was attained from a mixture solution containing the three metal ions in sulfate media at pH 10.3 after 15 minutes of treatment. The sedimentation behavior showed that a larger precipitate facilitated solid/liquid separation at 30 minutes. The characterization of precipitates was performed by X-ray diffraction (XRD) identifying iron, zinc, and cadmium oxides; hydroxides; and sodium sulfate. For the flotation, a 20 mg/L solution of dodecylamine (DDA) was used as a collector. Such a solution allowed for the removal of 76% of precipitates in concentrate. An increase in the collector concentration diminished the float percentage due to the micelle formation and low adsorption of the collector on the surface of the precipitate. The results provide evidence of the effectivity of the removal of metal ions by the combined precipitation–flotation system as an alternative for the treatment of acid mine drainage (AMD) in less time in comparison with a sedimentation stage.

Description: Rural Romania faces many problems, the main one being depopulation. In general, young adults frequently choose to migrate to urban centers or leave the country entirely to satisfy economic and/or social aspirations. The aim of this study is to identify intractable issues that inhibit rural development and to identify actionable solutions. In this regard, a questionnaire was developed and administered at the local level. The results obtained were analyzed with the SPSS Statistical Program, with the Pearson Chi-square, and Cramer and Pearson coefficients were determined. The answers obtained from applying the questionnaire made it possible to identify the causes that inhibit the sustainable development of rural areas. It can be considered that a solution that could lead to the sustainable development of the rural areas from Romania would be represented by the development of a digital tool that would create a synergy between local authorities, researchers and the private sector. In order to be able to solve these problems, the Government of Romania should provide the necessary funds to local authorities, depending on the needs identified through the digital instrument, acting directly on the aspects that restrain the development of those areas.

Description: Throughout the 21st century, urban reports demand solutions to the obsolescence and aging process suffered by the existing buildings, due to the growth and expansion of cities that took place in the second half of the 20th century [...]

Description: Port resilience has become a crucial topic to achieve port sustainability. To assist ports to successfully develop policies to improve resilience, this study aims to develop a framework for measuring port resilience. This paper conceptualizes the framework to assess port resilience based on relevant literature by conducting exploratory and confirmatory factor analysis using 199 samples collected from port stakeholders in South Korea. As a result, it is validated that the framework is a multi-hierarchical structure based on nine factors, i.e., robustness, redundancy, visibility, flexibility, collaboration, agility, information sharing, response, and recovery. Our findings would serve as a theoretical footstep for further studies on the relations between port resilience and sustainability and also contribute to implement policies to strengthen port resilience.

Description: Low- and middle-income countries are implementing COVID-19 vaccination strategies in light of varying vaccine efficacies and costs, supply shortages, and resource constraints. Here, we use a microsimulation model to evaluate clinical outcomes and cost-effectiveness of a COVID-19 vaccination program in South Africa. We varied vaccination coverage, pace, acceptance, effectiveness, and cost as well as epidemic dynamics. Providing vaccines to at least 40% of the population and prioritizing vaccine rollout prevented 〉9 million infections and 〉73,000 deaths and reduced costs due to fewer hospitalizations. Model results were most sensitive to assumptions about epidemic growth and prevalence of prior immunity to SARS-CoV-2, though the vaccination program still provided high value and decreased both deaths and health care costs across a wide range of assumptions. Vaccination program implementation factors, including prompt procurement, distribution, and rollout, are likely more influential than characteristics of the vaccine itself in maximizing public health benefits and economic efficiency.

Description: Despite recent advances in understanding skin scarring, mechanisms triggering hypertrophic scar formation are still poorly understood. In the present study, we investigate mature human hypertrophic scars and developing scars in mice at single cell resolution. Compared to normal skin, we find significant differences in gene expression in most cell types present in scar tissue. Fibroblasts show the most prominent alterations in gene expression, displaying a distinct fibrotic signature. By comparing genes upregulated in murine fibroblasts during scar development with genes highly expressed in mature human hypertrophic scars, we identify a group of serine proteases, tentatively involved in scar formation. Two of them, dipeptidyl-peptidase 4 (DPP4) and urokinase (PLAU), are further analyzed in functional assays, revealing a role in TGFβ1-mediated myofibroblast differentiation and over-production of components of the extracellular matrix in vitro. Topical treatment with inhibitors of DPP4 and PLAU during scar formation in vivo shows anti-fibrotic activity and improvement of scar quality, most prominently after application of the PLAU inhibitor BC-11. In this study, we delineate the genetic landscape of hypertrophic scars and present insights into mechanisms involved in hypertrophic scar formation. Our data suggest the use of serine protease inhibitors for the treatment of skin fibrosis.

Description: Biological degradation of Polyethylene terephthalate (PET) plastic and assimilation of the corresponding monomers ethylene glycol and terephthalate (TPA) into central metabolism offers an attractive route for bio-based molecular recycling and bioremediation applications. A key step is the cellular uptake of the non-permeable TPA into bacterial cells which has been shown to be dependent upon the presence of the key tphC gene. However, little is known from a biochemical and structural perspective about the encoded solute binding protein, TphC. Here, we report the biochemical and structural characterisation of TphC in both open and TPA-bound closed conformations. This analysis demonstrates the narrow ligand specificity of TphC towards aromatic para-substituted dicarboxylates, such as TPA and closely related analogues. Further phylogenetic and genomic context analysis of the tph genes reveals homologous operons as a genetic resource for future biotechnological and metabolic engineering efforts towards circular plastic bio-economy solutions.

Description: The function and necessity of water resources make them an important factor affecting economic and social development. To explore various water security issues impacting water use, the pressure-state-response model was applied in this study to construct a water security evaluation indexing system for the Circum-Bohai Sea Region (CBSR) in China. In this study, the game method was used to balance the two weighting methods, and the water security grades were calculated by the forward cloud model. Compared with the previous work, this study tried to analyze the simulated scenarios using the ELECTRE III method, determined the optimal development scenario mode based on the water security grade, and put forward water security measures and suggestions based on the results. This study put forward three scenarios of development models. Under the scenario of “pressure reduction”, it can be proposed to build suburbs and transfer urban functional areas to relieve the pressure of urban population. Under the “ideal state” scenario, water diversion projects and water storage projects can be proposed to relieve the regional water shortage. Under the scenario of “efficient response”, strengthening ecological environment construction and improving sewage treatment capacity can be proposed.

Description: Education for Sustainable Development (ESD) and Entrepreneurial Education (EE) are quite abstract and demanding concepts for teacher students. Yet, Key Sustainability Competences and Entrepreneurial Competences entail important qualities of future citizens and workers, and teacher students should become prepared to accommodate education for these competencies in their teaching practice. This paper explores teacher students’ process of sense-making of sustainable development and how becoming a teacher who practices ESD connects with entrepreneurship. EE serves as a good mirroring surface to ESD as they both have their roots in Transformative Learning (TL) but pursue transformation towards different goals. The case study follows the vocational teacher education (VTE) students’ sensemaking of Sustainable Development as a part of teacher’s work during one semester which included integrated Thematic Studies of Sustainable Development. The qualitative content analysis of students’ texts focused on signs of transformative learning and was guided by the dimensions of sustainable development and learning goals set for teacher’s sustainability competences in the VTE curriculum. The results indicate that transformative learning is possible. Furthermore, they address the importance of certain entrepreneurial capabilities in the actualization of change agency.

Description: Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradictory results. Here, we examine potential confounders in COVID-19 respiratory microbiome studies by analyzing the upper (n = 58) and lower (n = 35) respiratory tract microbiome in well-phenotyped COVID-19 patients and controls combining microbiome sequencing, viral load determination, and immunoprofiling. We find that time in the intensive care unit and type of oxygen support, as well as associated treatments such as antibiotic usage, explain the most variation within the upper respiratory tract microbiome, while SARS-CoV-2 viral load has a reduced impact. Specifically, mechanical ventilation is linked to altered community structure and significant shifts in oral taxa previously associated with COVID-19. Single-cell transcriptomics of the lower respiratory tract of COVID-19 patients identifies specific oral bacteria in physical association with proinflammatory immune cells, which show higher levels of inflammatory markers. Overall, our findings suggest confounders are driving contradictory results in current COVID-19 microbiome studies and careful attention needs to be paid to ICU stay and type of oxygen support, as bacteria favored in these conditions may contribute to the inflammatory phenotypes observed in severe COVID-19 patients.

Description: π−conjugated radicals have great promise for use in organic spintronics, however, the mechanisms of spin relaxation and mobility related to radical structural flexibility remain unexplored. Here, we describe a dumbbell shape azobenzene diradical and correlate its solid-state flexibility with spin relaxation and mobility. We employ a combination of X-ray diffraction and Raman spectroscopy to determine the molecular changes with temperature. Heating leads to: i) a modulation of the spin distribution; and ii) a “normal” quinoidal → aromatic transformation at low temperatures driven by the intramolecular rotational vibrations of the azobenzene core and a “reversed” aromatic → quinoidal change at high temperatures activated by an azobenzene bicycle pedal motion amplified by anisotropic intermolecular interactions. Thermal excitation of these vibrational states modulates the diradical electronic and spin structures featuring vibronic coupling mechanisms that might be relevant for future design of high spin organic molecules with tunable magnetic properties for solid state spintronics.

Description: Giant spin-orbit torque (SOT) from topological insulators (TIs) provides an energy efficient writing method for magnetic memory, which, however, is still premature for practical applications due to the challenge of the integration with magnetic tunnel junctions (MTJs). Here, we demonstrate a functional TI-MTJ device that could become the core element of the future energy-efficient spintronic devices, such as SOT-based magnetic random-access memory (SOT-MRAM). The state-of-the-art tunneling magnetoresistance (TMR) ratio of 102% and the ultralow switching current density of 1.2 × 105 A cm−2 have been simultaneously achieved in the TI-MTJ device at room temperature, laying down the foundation for TI-driven SOT-MRAM. The charge-spin conversion efficiency θSH in TIs is quantified by both the SOT-induced shift of the magnetic switching field (θSH = 1.59) and the SOT-induced ferromagnetic resonance (ST-FMR) (θSH = 1.02), which is one order of magnitude larger than that in conventional heavy metals. These results inspire a revolution of SOT-MRAM from classical to quantum materials, with great potential to further reduce the energy consumption.

Description: Converting charge current into spin current via the spin Hall effect enables efficient manipulation of magnetization by electrical current. However, its geometrical restriction is a serious obstacle to device applications because it prevents switching of perpendicular magnetization in the absence of an external field. To resolve this issue, ferromagnetic materials have attracted attentions because their time reversal asymmetry induces magnetic-dependent charge-to-spin conversion that removes this restriction. Here, we achieved a large enhancement of magnetic-dependent charge-to-spin conversion by clarifying its mechanism. Through layer thickness dependence of the conversion efficiency, we revealed a coexistence of interfacial and bulk contributions to the magnetic-dependent charge-to-spin conversion. Moreover, the interfacial contribution to charge-to-spin conversion is found to be dominant and can be controlled via interfacial band engineering. The efficiency of charge-to-spin conversion in ferromagnet was found to be an order larger than that of other materials with reduced symmetry.

Description: The efficient separation of metals from ores and secondary sources such as electronic waste is necessary to realising circularity in metal supply. Precipitation processes are increasingly popular and are reliant on designing and understanding chemical recognition to achieve selectivity. Here we show that a simple tertiary diamide precipitates gold selectively from aqueous acidic solutions, including from aqua regia solutions of electronic waste. The X-ray crystal structure of the precipitate displays an infinite chain of diamide cations interleaved with tetrachloridoaurate. Gold is released from the precipitate on contact with water, enabling ligand recycling. The diamide is highly selective, with its addition to 29 metals in 2 M HCl resulting in 70% gold uptake and minimal removal of other metals. At 6 M HCl, complete collection of gold, iron, tin, and platinum occurs, demonstrating that adaptable selective metal precipitation is controlled by just one variable. This discovery could be exploited in metal refining and recycling processes due to its tuneable selectivity under different leaching conditions, the avoidance of organic solvents inherent to biphasic extraction, and the straightforward recycling of the precipitant.

Description: Copper (Cu) has a narrow range between optimal concentrations as a micronutrient critical for phytoplankton growth and concentrations potentially toxic to living organisms. This sensitivity indicates an ecosystem vulnerability that threatens not only nature but also human health due to bioaccumulation. An important source of elevated Cu concentrations in coastal environments are biocides used as antifouling protection on ships. A pilot study conducted in the Marine Protected Area (MPA) of the Krka Estuary (Croatia) over a period of 16 months investigated the relationship between ship traffic and Cu concentrations. The aim was to contribute to more informed environmental management by assessing the associated risks. In the study presented here, Cu concentrations were monitored, analyzed, and correlated with vessel traffic. Observations revealed that the seasonal increase in maritime traffic caused by nautical tourism was associated with an increase in Cu concentrations of more than five times, posing a toxicity risk to the environment. In order to understand the distribution of copper emissions, a mapping of maritime traffic was carried out by counting transits, radar imagery, and drone photography. This approach has proven sufficient to identify the potential risks to the marine environment and human health, thus providing an effective assessment tool for marine stakeholders.

Description: Driver gene mutations that are more prevalent in metastatic, castration-resistant prostate cancer (mCRPC) than localized disease represent candidate prognostic biomarkers. We analyze 1,844 localized (1,289) or mCRPC (555) tumors and quantify the prevalence of 113 somatic driver single nucleotide variants (SNVs), copy number aberrations (CNAs), and structural variants (SVs) in each state. One-third are significantly more prevalent in mCRPC than expected while a quarter are less prevalent. Mutations in AR and its enhancer are more prevalent in mCRPC, as are those in TP53, MYC, ZNRF3 and PRKDC. ZNRF3 loss is associated with decreased ZNRF3 mRNA abundance, WNT, cell cycle & PRC1/2 activity, and genomic instability. ZNRF3 loss, RNA downregulation and hypermethylation are prognostic of metastasis and overall survival, independent of clinical and pathologic indices. These data demonstrate a strategy for identifying biomarkers of localized cancer aggression, with ZNRF3 loss as a predictor of metastasis in prostate cancer.

Description: Photocatalytic air purification is widely regarded as a promising technology, but it calls for more efficient photocatalytic materials and systems. Here we report a strategy to introduce an in-situ water (self-wetting) layer on WO3 by coating hygroscopic periodic acid (PA) to dramatically enhance the photocatalytic removal of hydrophilic volatile organic compounds (VOCs) in air. In ambient air, water vapor is condensed on WO3 to make a unique tri-phasic (air/water/WO3) system. The in-situ formed water layer selectively concentrates hydrophilic VOCs. PA plays the multiple roles as a water-layer inducer, a surface-complexing ligand enhancing visible light absorption, and a strong electron acceptor. Under visible light, the photogenerated electrons are rapidly scavenged by periodate to produce more •OH. PA/WO3 exhibits excellent photocatalytic activity for acetaldehyde degradation with an apparent quantum efficiency of 64.3% at 460 nm, which is the highest value ever reported. Other hydrophilic VOCs like formaldehyde that are readily dissolved into the in-situ water layer on WO3 are also rapidly degraded, whereas hydrophobic VOCs remain intact during photocatalysis due to the “water barrier effect”. PA/WO3 successfully demonstrated an excellent capacity for degrading hydrophilic VOCs selectively in wide-range concentrations (0.5−700 ppmv).

Description: Although researchers expect the valuation of ecosystems and their services to be used in various decision-making processes, some studies have insisted that the valuation results cannot be fully used in the real world. The so-called “information gap” was highlighted, and some reasons for the gap were raised by researchers. One of them is the lack of local-specific and demand-side information, such as who receives the benefits and to what extent. This study proposes a valuation that includes demand-side information for it to be practically useful for policy decision making, especially for local policymakers. We focus on the headwater conservation service of the forest ecosystem by referring to the case of constructing solar power plants in the Satetsu-gawa river basin in Ichinoseki, Japan. We estimate the size of the area and the number of households affected by deforestation caused by the construction of the plants. Furthermore, the lost value of ecosystem services is assessed in monetary terms to reflect information on the demand side. Based on the results, we present multiple indicators for assessing the impact of constructing the plants and discuss how the valuation can be used by local policymakers as well as how it can close the information gap.

Description: Governments formulate different subsidy policies to incentivize manufacturers to produce green products, and these policies may have different subsidy effects. The purpose of this study is to compare and analyze the dynamic effects of different subsidy policies to the manufacturer in a green supply chain composed of a manufacturer and a retailer. Three differential game models, considering the consumers preference, are established under three subsidy policies, and the corresponding optimal equilibrium strategies of the supply chain members are analyzed. An example is used to compare the effects of the three policies under the equal government subsidy expenditure. The study finds that the rankings of indexes to evaluate steady-state subsidy effects under the different subsidy policies are time invariant, and the government can preliminarily evaluate these policies according to different subsidy goals. The rankings of indexes to evaluate phased subsidy effects under these policies are time varying. If both subsidy effects and subsidy efficiencies in steady state are taken into account, the optimal selection paths of subsidy policies in the whole period can be obtained. The subsidy effects of the same policy are amplified under the condition of equal steady-state subsidy expenditure, but the rankings of effect indexes under the different subsidy policies are not affected.

Description: Numerous studies have shown that ERP systems can improve organizational performance and efficiency. Thus, the main concepts addressed in the paper are ERP systems, their performance and the manner in which they improve financial and non-financial reporting. The purpose of this paper is to observe the relationship between ERP systems and financial reporting. The role of these systems is to ensure transparency over the financial and non-financial reporting process of an organization. The research method is represented by an archival analysis (organization’s annual reports) to highlight the relationship between ERP systems and financial and non-financial reporting, given the impact of ERP systems on the information used to prepare financial and non-financial reports and how the organization changes after implementing these systems. The results highlight the significant role of ERP systems within an organization, in terms of performance and improvements in financial and non-financial reporting.

Description: For an industry to succeed in a competitive market, it should continuously take care of not only its stakeholders but also its technical efficiency and productivity. In this paper, data envelopment analysis was combined with Malmquist productivity analysis to investigate the pattern of multifactor productivity changes in the European energy industry over the period from 2005–2016. The results showed that the whole industry was technically inefficient and had large potential for improvement. A slight average increase in productivity that was observed over the studied period proved to be sensitive to the financial and economic situation and equally sensitive to technological and efficiency advances. As for efficiency gains, they reflected the nature of the energy industry, implying that they were due to scale efficiencies rather than human resource improvements. Although technological innovation and the optimal scale of production increased productivity, the slow pace at which this occurred and the negative outlook highlighted by the observed trends call for more serious consideration of the future productivity deployment of the European energy industry, particularly in the context of its decarbonisation, diversification, and modernisation.

Description: Physical activity is associated with enhanced sleep quality and optimal body composition, as well as a reduction in cardiovascular risk factors in the general population. Although earlier research has established a link between physical exercise and excellent sleep quality as well as an optimum BMI in adults, little is known about the relationship in the young adult populations. The purpose of this study is to discover if there is a relationship between sleep quality, blood pressure, waist circumference, socio-demographic variables with physical activity among young adult in Kuala Lumpur. A cross-sectional sample of 120 university students was recruited for this study. Physical activity and sleep quality were assessed using the International Physical Activity Questionnaire and the Pittsburgh Sleep Quality Index, respectively. Blood pressure, Body mass index, and waist circumference were also measured. Approximately 36% of university students engage in moderate to vigorous physical exercise. The average physical activity was 2430.37 ± 2509.16 MET-minutes each week, which meets the minimal need. The median difference in MET-minutes per week between gender was not significant, with males having greater MET than females (p 〉 0.05). However, there was no statistically significant variation in MET-minutes each week between study year and mode of transportation. (p 〉 0.05). Approximately 40.3% of university students were classified as having good sleep quality. The average sleep quality is 5.37 ± 2.38, indicating that the students have slightly a poor sleep quality. There was no statistically significant variation in sleep score between gender, year of study, and mode of transportation (p 〉 0.05). The waist circumference (WC) has a significant relationship with body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP). According to multinomial logistic regression, there was a significant association between level of physical activity (PA) and BMI and year of study when comparing moderate and low PA. Physical activity is essential because it may alter a young adult’s lifestyle, encouraging active commuting to work or other short-distance destinations. Attention must be given to this particular population to encourage regular and sustainable participation in physical activity to achieve lifelong health benefits. Other variables, such as body fat, energy intake, stress level and muscle mass, can also be examined for future research.

Description: A basic assumption of many scientific theories on the topic of decision making is rational behaviour. However, previous authors assume the existence of behavioural biases in freight transport which impede rational decision making. Hardly any research exists on behavioural biases in freight transport. To address this gap, we carry out a systematic literature review on the influencing factors of freight mode choice and provide empirical evidence for the occurrence of behavioural biases in the logistics sector. Fifteen logistics service providers and six shippers are involved in interviews and a focus group to understand their mode choice process and derive information on the existence of behavioural biases. Several biases showed to exist in the practical decision-making process. For example, decision makers tend to avoid complex options (principle of least effort), they stick to already tried and tested options (status quo bias, zero-risk bias) and they tend to make decisions based on immediate and easily accessible information (availability bias). These biases distort the demand for sustainable freight transport. We therefore conclude with several motivational, cognitive and technological debiasing strategies to reduce the negative impact of behavioural biases in freight transport.

Description: The main objective of this study was to explore the perceptions of LGBTQIA+ students regarding sexual and gender diversity in the university context by (1) identifying conceptions about a being LGBTQIA+ student in the higher education context, (2) researching perceptions of the stigma and discrimination against, and inclusion of LGBTQIA+ students and (3) to recognize discourses and scenarios identified by students in the university context regarding sexual diversity and gender diversity, distinguishing their experiences in the classroom as well as in the university, with their peers and with their professors. This research was based on a quantitative method, the sample consisted of 171 students from the School of Medicine of a public university in the United States in the state of Texas. The results showed that there is currently a greater knowledge of the subject of sexual and gender diversity and of the spaces and resources offered by the university on the subject compared to previous years, however, it is found that knowledge is still limited and that this knowledge may possibly be due to the faculty in which they study.

Description: This paper analyzes the impact of the managerial ability and level of compensation on firm value in small and medium enterprises. The ability of managers is important for the sustainability and growth of small and medium enterprises because they lack awareness of resources, technology, and reputation compared to large enterprises. The managerial ability is the ability to efficiently utilize resources and choose the investment plan with the highest future net cash flows. Managerial ability is also an indicator of the level of compensation for executives. Therefore, the level of executive compensation can help a firm value or growth if it is based on managerial abilities. In addition, high executive compensation standards can be an opportunity or motivation to work hard for the wealth of companies and shareholders. We analyzed 1872 small and medium-sized companies listed on the Korean stock market to achieve the purpose of the research. We analyzed the accounting period of 6 years from 2012 to 2017. Our results have had a positive impact on firm value with executive compensation. In groups with excellent managerial skills, executive compensation has had a positive (+) impact on firm value. However, executive compensation did not have a significant impact on firm value in groups with poor managerial skills. These results validate that the CEO’s role in small and medium enterprise is important and that the level of compensation for executives is important to motivate. It also suggests that executive compensation cannot affect the firm value in groups with low managerial abilities.

Description: During the last few years, attention has overwhelmingly focused on the integrated management of urban services and the demand of customers for locally-based supply. The rapid growth in developing smart measuring devices has made the underlying systems more observable and controllable. This exclusive feature has led the system designers to pursue the implementation of complex protocols to provide faster services based on data exchanges. On the other hand, the demands of consumers for locally-based supply could cause a disjunction and islanding behavior that demands to be dealt with by precise action. At first, keeping a centralization scheme was the main priority. However, the advent of distributed systems opened up new solutions. The operation of distributed systems requires the implementation of strong communication links to boost the existing infrastructure via smart control and supervision, which requires a foundation and effective investigations. Hence, necessary actions need to be taken to frustrate any disruptive penetrations into the system while simultaneously benefiting from the advantages of the proposed smart platform. This research addresses the detection of false data injection attacks (FDIA) in energy hub systems. Initially, a multi-hub system both in the presence of a microgrid (the interconnected smart energy hub-based microgrid system) and without it has been modeled for energy management in a way that allows them to cooperate toward providing energy with each other. Afterward, an FDIA is separately exerted to all three parts of the energy carrier including the thermal, water, and electric systems. In the absence of FDIA detection, the impact of FDIA is thoroughly illustrated on energy management, which considerably contributes to non-optimal operation. In the same vein, the intelligent priority selection based reinforcement learning (IPS-RL) method is proposed for FDIA detection. In order to model the uncertainty effects, the unscented transformation (UT) is applied in a stochastic framework. The results on the IEEE standard test system validate the system’s performance.

Description: With a growing global population and energy demand, there is increasing concern about the world’s reliance on fossil fuels, which have a negative impact on the climate, necessitating the immediate transition to a cleaner energy resource. This effort can be initiated in the rural areas of developing countries for a sustainable, efficient and affordable energy source. This study evaluated four types of renewable energy (solar, wind, biomass, and mini-hydro energy) using the integrated Life Cycle Assessment (LCA) and Analytical Hierarchy Process (AHP) approaches to select the best renewable energy source in Tatau, Sarawak. The criteria under consideration in this study included the environment, engineering and economics. The LCA was used to assess the environmental impact of renewable energies from gate-to-grave boundaries based on 50 MJ/day of electricity generation. The AHP results showed that solar energy received the highest score of 0.299 in terms of the evaluated criteria, followed by mini-hydro, biomass and wind energy, which received scores of 0.271, 0.230 and 0.200, respectively. These findings can be used to develop a systematic procedure for determining the best form of renewable energy for rural areas. This approach could be vital for the authorities that are responsible for breaking down multi-perspective criteria for future decision making in the transition into renewable energy.

Description: Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson’s disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by lentiviral-mediated selective α-synuclein (αSYN) accumulation in microglial cells. Surprisingly, these mice developed progressive degeneration of dopaminergic (DA) neurons without endogenous αSYN aggregation. Transcriptomics and functional assessment revealed that αSYN-accumulating microglial cells developed a strong reactive state with phagocytic exhaustion and excessive production of oxidative and proinflammatory molecules. This inflammatory state created a molecular feed-forward vicious cycle between microglia and IFNγ-secreting immune cells infiltrating the brain parenchyma. Pharmacological inhibition of oxidative and nitrosative molecule production was sufficient to attenuate neurodegeneration. These results suggest that αSYN accumulation in microglia induces selective DA neuronal degeneration by promoting phagocytic exhaustion, an excessively toxic environment and the selective recruitment of peripheral immune cells.

Description: The construction sector is one of the main contributors to greenhouse gas emissions and consumers of energy, making it one of the most relevant sectors when planning reduction strategies and policies. The use of timber in the built environment has been identified as a key strategy to reduce the carbon footprint of the construction sector. In this paper, we use the concept of policy gap analysis to identified underlying challenges in the implementation of timber construction on three Nordic countries, Finland, Norway, and Sweden. We carried out a series of semi-structured interviews with experts from the countries of study. The interviews came from industry, government, and construction companies. The use of the gap analysis approach was useful not only to identify areas that are being targeted but also those areas that were not covered by any programme at the time of study. The results showed that the studied programmes have a large level of coverage and congruence with the identified challenges. Moreover, they also showed that challenges related to fire safety regulations and insurance policies for timber buildings still need to be addressed, whereas the challenges of high price variability and lack of promotion are being addressed by multiple programmes. With this work, we have seen how timber construction is gaining momentum and how the challenges have been addressed systematically.

Description: Silicon (Si), the most abundant mineral element in the earth’s crust, is taken up by plant roots in the form of silicic acid through Low silicon rice 1 (Lsi1). Lsi1 belongs to the Nodulin 26-like intrinsic protein subfamily in aquaporin and shows high selectivity for silicic acid. To uncover the structural basis for this high selectivity, here we show the crystal structure of the rice Lsi1 at a resolution of 1.8 Å. The structure reveals transmembrane helical orientations different from other aquaporins, characterized by a unique, widely opened, and hydrophilic selectivity filter (SF) composed of five residues. Our structural, functional, and theoretical investigations provide a solid structural basis for the Si uptake mechanism in plants, which will contribute to secure and sustainable rice production by manipulating Lsi1 selectivity for different metalloids.

Description: The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the immune system. The biofilm cells release extracellular vesicles (EVs) that promote extracellular matrix formation and resistance to antifungal drugs. Here, we define functions for numerous EV cargo proteins in biofilm matrix assembly and drug resistance, as well as in fungal cell adhesion and dissemination. We use a machine-learning analysis of cargo proteomic data from mutants with EV production defects to identify 63 candidate gene products for which we construct mutant and complemented strains for study. Among these, 17 mutants display reduced biofilm matrix accumulation and antifungal drug resistance. An additional subset of 8 cargo mutants exhibit defects in adhesion and/or dispersion. Representative cargo proteins are shown to function as EV cargo through the ability of exogenous wild-type EVs to complement mutant phenotypic defects. Most functionally assigned cargo proteins have roles in two or more of the biofilm phases. Our results support that EVs provide community coordination throughout biofilm development in C. albicans.

Description: The United Nations 2030 Agenda has emphasized the potential of digital technology to enhance sustainability performance, assuming that digital transformation can enable firms’ convergence toward the Sustainable Development Goals. Despite this, the literature is unclear regarding whether there is a positive relationship between digitalization and sustainability, as the effects of digital transformation are controversial. The main goal of this study was to assess the hypothesis that digital technology contributes to the achievement of Sustainable Development Goals within the UN 2030 Agenda. To test this hypothesis, a textual analysis was performed to assess Italian firms’ digitalization efforts; the obtained results were then related to the selected firms’ ESG scores using a regression analysis. The analysis focused on Italian FTSE MIB listed firms for the period 2016–2019. The findings show a positive relation between digitalization and Sustainable Development Goals, highlighting the relevance of digital technology in implementing the sustainability agenda.

Description: Recent advances in wavefront shaping have enabled complex classes of Structured Light which carry spin and orbital angular momentum, offering new tools for light-matter interaction, communications, and imaging. Controlling both components of angular momentum along the propagation direction can potentially extend such applications to 3D. However, beams of this kind have previously been realized using bench-top setups, requiring multiple interaction with light of a fixed input polarization, thus impeding their widespread applications. Here, we introduce two classes of metasurfaces that lift these constraints, namely: i) polarization-switchable plates that couple any pair of orthogonal polarizations to two vortices in which the magnitude and/or sense of vorticity vary locally with propagation, and ii) versatile plates that can structure both components of angular momentum, spin and orbital, independently, along the optical path while operating on incident light of any polarization. Compact and integrated devices of this type can advance light-matter interaction and imaging and may enable applications that are not accessible via other wavefront shaping tools.

Description: Optical interferometry plays an essential role in precision metrology such as in gravitational wave detection, gyroscopes, and environmental sensing. Weak value amplification enables reaching the shot-noise-limit of sensitivity, which is difficult for most optical sensors, by amplifying the interferometric signal without amplifying certain technical noises. We implement a generalized form of weak value amplification on an integrated photonic platform with a multi-mode interferometer. Our results pave the way for a more sensitive, robust, and compact platform for measuring phase, which can be adapted to fields such as coherent communications and the quantum domain. In this work, we show a 7 dB signal enhancement in our weak value device over a standard Mach-Zehnder interferometer with equal detected optical power, as well as frequency measurements with 2 kHz sensitivity by adding a ring resonator.

Description: Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develop a strategy to compare the epigenetic and transcriptional make-up of primary GBM cells (GIC) with patient-matched expanded potential stem cell (EPSC)-derived NSC (iNSC). Using a comparative analysis of the transcriptome of syngeneic GIC/iNSC pairs, we identify a glycosaminoglycan (GAG)-mediated mechanism of recruitment of regulatory T cells (Tregs) in GBM. Integrated analysis of the transcriptome and DNA methylome of GBM cells identifies druggable target genes and patient-specific prediction of drug response in primary GIC cultures, which is validated in 3D and in vivo models. Taken together, we provide a proof of principle that this experimental pipeline has the potential to identify patient-specific disease mechanisms and druggable targets in GBM.

Description: We developed a method, ArchaicSeeker 2.0, to identify introgressed hominin sequences and model multiple-wave admixture. The new method enabled us to discern two waves of introgression from both Denisovan-like and Neanderthal-like hominins in present-day Eurasian populations and an ancient Siberian individual. We estimated that an early Denisovan-like introgression occurred in Eurasia around 118.8–94.0 thousand years ago (kya). In contrast, we detected only one single episode of Denisovan-like admixture in indigenous peoples eastern to the Wallace-Line. Modeling ancient admixtures suggested an early dispersal of modern humans throughout Asia before the Toba volcanic super-eruption 74 kya, predating the initial peopling of Asia as proposed by the traditional Out-of-Africa model. Survived archaic sequences are involved in various phenotypes including immune and body mass (e.g., ZNF169), cardiovascular and lung function (e.g., HHAT), UV response and carbohydrate metabolism (e.g., HYAL1/HYAL2/HYAL3), while “archaic deserts” are enriched with genes associated with skin development and keratinization.

Description: This article aims to assess how fiscal and financial incentives and government support conditioned the profitability of Portuguese SMEs between 2010 and 2019. The high tax and financial burdens on SMEs have consequences for sustainability and business development. Thus, the study analyzes different incentives provided by the Portuguese government to ease this burden and improve business profitability. The study uses panel data with fixed effects using five different sources of information from five internal tax grant types, three different European Union program financial subventions, and three national budget-specific expenses. The results obtained suggest that tax incentives influence the profitability of SMEs; however, government incentives do not have any impact. The QREN (financial) incentives positively decide the ROA and negatively impact the ROE, contributing to sustainable performance. Portugal 2020 incentives have a weak effect on the first years, improving in the following years. However, the incentive related to R&D is not relevant. This work aims to contribute to decision making for managers, shareholders, and government entities, allowing them to choose those measures that could increase the company’s added value, and for governments, as a tool to select incentives that will most benefit SMEs’’ profitability. This work identifies the key incentives that impact companies’ profitability.

Description: Climate change-related natural disasters, including wildfires and extreme weather events, such as intense storms, floods, and heatwaves, are increasing in frequency and intensity. These events are already profoundly affecting human health in the United States and globally, challenging the ability of communities to prepare, respond, and recover. The purpose of this research was to examine the peer-reviewed literature on community resilience initiatives in one of the most densely populated and economically important regions, the Northeastern United States, and to identify evidence-based interventions and metrics that had been field-tested and evaluated. This paper addresses two critical gaps in the literature: (1) what strategies or interventions have been implemented to build or enhance community resilience against climate change-related natural disasters; and (2) what metrics were used to measure community resilience as an outcome of those strategies or interventions? This review provides a succinct list of effective interventions with specific health outcomes. Community or state-level health officials can use the results to prioritize public health interventions. This review used existing database search tools to discover 205 studies related to community resilience and health outcomes. Methods set criteria to assess if interventions were able to measure and change levels of community resilience to the health impacts associated with a changing climate. Criteria included: (a) alignment with the United States’ National Preparedness Goal for reducing risks to human health and for recovering quickly from disasters; (b) derived from publicly available data sources; (c) developed for use by communities at a local scale; and (d) accessible to modestly resourced municipalities and county health agencies. Five (5) peer-reviewed, evidence-based studies met all of the selection criteria. Three of these articles described intervention frameworks and two reported on the use of standardized tools. Health-related outcomes included mental health impacts (PTSD/depression), mental stress, emergency preparedness knowledge, social capital skills, and emergency planning skills. The paper recommends the COAST project, COPEWELL Rubric for self-assessment, and Ready CDC intervention as examples of strategies that could be adapted by any community engaged in building community resilience.

Description: Adeno-associated viruses (AAV) rely on helper viruses to transition from latency to lytic infection. Some AAV serotypes are secreted in a pre-lytic manner as free or extracellular vesicle (EV)-associated particles, although mechanisms underlying such are unknown. Here, we discover that the membrane-associated accessory protein (MAAP), expressed from a frameshifted open reading frame in the AAV cap gene, is a novel viral egress factor. MAAP contains a highly conserved, cationic amphipathic domain critical for AAV secretion. Wild type or recombinant AAV with a mutated MAAP start site (MAAPΔ) show markedly attenuated secretion and correspondingly, increased intracellular retention. Trans-complementation with MAAP restored secretion of multiple AAV/MAAPΔ serotypes. Further, multiple processing and analytical methods corroborate that one plausible mechanism by which MAAP promotes viral egress is through AAV/EV association. In addition to characterizing a novel viral egress factor, we highlight a prospective engineering platform to modulate secretion of AAV vectors or other EV-associated cargo.

Description: Understanding the trajectory, duration, and determinants of antibody responses after SARS-CoV-2 infection can inform subsequent protection and risk of reinfection, however large-scale representative studies are limited. Here we estimated antibody response after SARS-CoV-2 infection in the general population using representative data from 7,256 United Kingdom COVID-19 infection survey participants who had positive swab SARS-CoV-2 PCR tests from 26-April-2020 to 14-June-2021. A latent class model classified 24% of participants as ‘non-responders’ not developing anti-spike antibodies, who were older, had higher SARS-CoV-2 cycle threshold values during infection (i.e. lower viral burden), and less frequently reported any symptoms. Among those who seroconverted, using Bayesian linear mixed models, the estimated anti-spike IgG peak level was 7.3-fold higher than the level previously associated with 50% protection against reinfection, with higher peak levels in older participants and those of non-white ethnicity. The estimated anti-spike IgG half-life was 184 days, being longer in females and those of white ethnicity. We estimated antibody levels associated with protection against reinfection likely last 1.5-2 years on average, with levels associated with protection from severe infection present for several years. These estimates could inform planning for vaccination booster strategies.

Description: Deviations from Brownian motion leading to anomalous diffusion are found in transport dynamics from quantum physics to life sciences. The characterization of anomalous diffusion from the measurement of an individual trajectory is a challenging task, which traditionally relies on calculating the trajectory mean squared displacement. However, this approach breaks down for cases of practical interest, e.g., short or noisy trajectories, heterogeneous behaviour, or non-ergodic processes. Recently, several new approaches have been proposed, mostly building on the ongoing machine-learning revolution. To perform an objective comparison of methods, we gathered the community and organized an open competition, the Anomalous Diffusion challenge (AnDi). Participating teams applied their algorithms to a commonly-defined dataset including diverse conditions. Although no single method performed best across all scenarios, machine-learning-based approaches achieved superior performance for all tasks. The discussion of the challenge results provides practical advice for users and a benchmark for developers.

Description: This article analyses the role of intermediaries’ engagements to bridge the gaps between research, education and practice in the processes of knowledge production needed for the shift to sustainable agri-food systems. It is based on an immersive study of an intermediary organization in the USA, including comprehensive interviews with the staff of the organization about their professional activities, their career paths, their close and longstanding professional relationships, and their values. Three characteristics of engaged intermediaries are identified, which can be positive add-ons for bridging activities: they consider farmers and scientists as equal contributors to the production of knowledge; they are involved in multiple life-worlds: for instance, being both a farmer and an outreach specialist or scientist; and they are closely associated with movements furthering the development of local and sustainable agri-food systems and an equitable sharing of knowledge. The article addresses topics often neglected in the innovation systems literature: the experience, social relations and political engagement of intermediary actors.

Description: In the last two decades, school coexistence in Spain has suffered an important deterioration with consequences in the quality of working life and the health of teachers, as well as in the academic performance of students. Educational administrations have promoted actions to improve it; however, the results have not been positive. To give a more adequate answer we must know in depth the scope of the problem. The objective of this study was to analyze the most common types of conflicts, the degree of incidence of each one and how they are distributed among students, as well as to determine the most important underlying cause according to the teachers. The field work was carried out during the 2018/2019 academic year, in a Secondary School located in the south of the Valencian Community (Spain). The student population was 1040, 532 women and 508 men. The research followed a mixed, qualitative, and quantitative methodology, making use of in-depth interviews with the teaching staff, participant observation and a quantitative analysis of 1501 incidents that were reported throughout the academic year. The results show us differences by sex: 84% of the incidents are produced by male students and 16% by female students. Incident distribution is very uneven among the different courses. Of the center’s problems, 88.14% are concentrated in the first two years of Compulsory Secondary Education. It is remarkable that 51% of the problems are generated by only 3% of the students, mostly men and with a significant academic disinterest; therefore, it is a very small number of students, but with a great impact on coexistence.

Description: COVID-19 has brought serious challenges to education and many other sectors. Within the educational context, the main difficulties experienced have been reported as challenges related to not only mechanical impediments—such as technology or infrastructure—but also to methodological and personal features, such as lack of motivation or online learning/teaching experiences. The abrupt transition from face-to-face to online education has created the need for some specific abilities, such as digital literacy on the side of the learners at all educational levels. In this context, this mixed-method study aims to determine the digital literacy levels of learners belonging to different school levels and whether age, gender and school degree were significant variables. This study also investigates the technology-related challenges students experienced during COVID-19 pandemic. The sample consisted of 510 participants representing different school levels, age groups, and genders; in addition, a smaller representative group (n = 30) revealed their own evaluations related to their levels of digital literacy and the technology-related challenges they had about online learning. The findings suggest that there is a statistically significant relationship between students’ digital literacy and their gender and school degree, while age was not found to be a statistically significant variable. The qualitative self-reported data suggested that learners have sufficient levels of digital literacy, and that the major technology-related challenges were reported to be lack of the necessary technologies and difficulties in adapting to a new approach to learning.

Description: “Clean water and sanitation” is listed as one of the 17 United Nations’ Sustainable Development Goals and implementing circular economy principles in the water sector has been widely regarded as an important approach in achieving this goal. In the era of Industry 4.0, research and practice in the digitalisation of the water sector to create a smart water system have attracted increasing attention. Despite the growing interest, limited research has been devoted to how digital technologies might enhance circularity. In practice, smart water systems often fail to promote circularity in such aspects as water reuse and resources recovery. This paper aims to identify the main barriers to implementing circularity in the smart water management system in Zhejiang, China. The research adopts a mixed research method that includes a literature review to identify the potential barriers from the existing studies, a case study to determine the most critical barriers in practice, and a fuzzy Delphi method to reach a consensus on the crucial barriers. The research identified 22 main barriers to implementing circular economy in smart water management. The barriers are divided into three categories: infrastructure and economic, technology, and institution and governance. The results show that the barriers related to recycling technologies, digital technology know-how, and the lack of CE awareness raise the most concern. Our findings also indicate that experts are interested in the decentralized wastewater treatment system. This research provides significant insights that practitioners, researchers, and policymakers can use in developing and implementing digital-based CE strategies to reduce water scarcity and pollution.

Description: Stabilizing climate change well below 2 °C and towards 1.5 °C requires comprehensive mitigation of all greenhouse gases (GHG), including both CO2 and non-CO2 GHG emissions. Here we incorporate the latest global non-CO2 emissions and mitigation data into a state-of-the-art integrated assessment model GCAM and examine 90 mitigation scenarios pairing different levels of CO2 and non-CO2 GHG abatement pathways. We estimate that when non-CO2 mitigation contributions are not fully implemented, the timing of net-zero CO2 must occur about two decades earlier. Conversely, comprehensive GHG abatement that fully integrates non-CO2 mitigation measures in addition to a net-zero CO2 commitment can help achieve 1.5 °C stabilization. While decarbonization-driven fuel switching mainly reduces non-CO2 emissions from fuel extraction and end use, targeted non-CO2 mitigation measures can significantly reduce fluorinated gas emissions from industrial processes and cooling sectors. Our integrated modeling provides direct insights in how system-wide all GHG mitigation can affect the timing of net-zero CO2 for 1.5 °C and 2 °C climate change scenarios.

Description: This paper investigates information leakage and financing simultaneously in a supply chain (SC) consisting of one capital-constrained supplier and two retailers with private demand-forecast signals. The supplier invests in corporate social responsibility (CSR) events and displays supply uncertainty. The supplier decides whether to leak information (L) or not (N). Additionally, the supplier has two financing strategies: bank credit financing (B) and trade credit financing (T). Thus, by combining the supplier’s information leakage and financing decisions, we formulated four possible strategies (i.e., NB, NT, LB, LT) and built a game analysis model to address the interaction of information leakage and financing decisions. We first provide the SC members’ optimal operational decisions (including the order quantity, the wholesale price and CSR effort level) under four strategies. Subsequently, we compare the profits of the suppliers and retailers under four strategies by combining analytical and numerical analysis. Several interesting results were found: (1) the supplier’s optimal wholesale price, CSR effort level, and profit under information leakage were higher than those under no information leakage; (2) the supplier’s financing decisions are dependent on the loan interest rate as low supply uncertainty and low supply correlation motivate the supplier to prefer choosing trade credit financing; and (3) finally, several interesting insights in managing SCs are provided.

Description: Based on the panel data of 41 cities in the Yangtze River Delta region from 2006–2018, this paper constructed an index system of measuring green urban land use efficiency (green land use efficiency), including input-expected output-unexpected output (input-expected output-unexpected output) and used the unexpected output-SBM model to calculate the green land use efficiency of the region. The spatial and temporal evolution characteristics of urban land green use efficiency in this area were studied by the Dagum Gini coefficient, decomposition, and exploratory spatial data analysis. The results show that (1) the temporal evolution characteristics of green land use efficiency in the whole region of the Yangtze River Delta, provinces (municipalities directly under the central government), and cities all show an upward trend of fluctuation. Among them, the green land use efficiency of the whole region is between 0.258 and 0.377, the gap in the green land use efficiency of the provinces (municipalities directly under the central government) is accelerating, and the green land use efficiency of the cities is gradually advancing to the middle and high efficiency areas. (2) Spatial evolution: On the one hand, the spatial difference in the green use efficiency of urban land in this region is gradually expanding. On the other hand, the green use efficiency of urban land in this region has a significant positive spatial correlation, the agglomeration pattern is dominated by high agglomeration and low agglomeration, and the low high agglomeration is supplemented.

Description: The trend towards personalized healthcare has led to an increase in applying deep learning techniques to improve healthcare service quality and sustainability. With the increasing number of patients with multiple comorbidities, they need comprehensive care services, where comprehensive care is a synonym for complete patient care to respond to a patient’s physical, emotional, social, economic, and spiritual needs, and, as such, an efficient prediction system for comprehensive care suggestions could help physicians and healthcare providers in making clinical judgement. The experiment dataset contained a total of 2.9 million electrical medical records (EMRs) from 250 thousand hospitalized patients collected retrospectively from a first-tier medical center in Taiwan, where the EMRs were de-identified and anonymized and where 949 cases had received comprehensive care. Recurrent neural networks (RNNs) are designed for analyzing time-series data but are still lacking in studying predicting personalized healthcare. Furthermore, in most cases, the collected evaluation data are imbalanced with a small portion of positive cases. This study examined the impact of imbalanced data in model training and suggested an effective approach to handle such a situation. To address the above-mentioned research issue, this study analyzed the care need in the different patient groupings, proposed a personalized care suggestion system by applying RNN models, and developed an efficient model training scheme for building AI-assisted prediction models. This study observed several findings: (1) the data resampling schemes could mitigate the impact of imbalanced data on model training, and the under-sampling scheme achieved the best performance with an ACC of 99.80%, a PPV of 70.18%, an NPV of 99.87%, a recall of 82.91%, and an F1 score of 0.7602, while the model trained with the original data had a very low PPV of 6.42% and a low F1 score of 0.1116; (2) patient clustering with multi-classier could predict comprehensive care needs efficiently with an ACC of 99.87%, a PPV of 77.90%, an NPV of 99.90%, a recall of 92.19%, and an F1 score of 0.8404; (3) the proposed long short-term memory (LSTM) prediction model achieved the best overall performance with an ACC of 99.80%, a PPV of 70.18%, an NPV of 99.87%, a recall of 82.91%, and an F1 score of 0.7602.

Description: With over 1.1 billion trips made daily for work, education, or leisure, transportation systems are vital to the functioning of cities in the United States. However, these systems are highly vulnerable to the impacts of climate change. The current study investigated perception differences about climate change between transportation professionals (N = 22) and the general public (N = 2034). The study revealed that (i) transportation professionals find climate change important, worrisome and harmful to themselves and future generations; (ii) knowledge of climate change and its consequences on transportation systems is limited on average among the general public; (iii) the public holds higher levels of misperceptions about climate change; (iv) the general public is more willing to embrace the suggestions of family and friends than climate scientists regarding the issue; (v) the general public holds a higher perception of behavioral control and confidence in their ability to carry out mitigative actions; and (vi) the public has lower information-seeking intentions about climate change. Based on the study findings, areas where perceptions differ may be considered during policy formulation and implementation processes to encourage pro-environmental behavioral changes that will reduce anthropogenic carbon emissions and enhance the functionality of transportation infrastructure.

Description: Buildings of the future are called to meet increasingly high-performance requirements and to ensure adequate environmental sustainability of the production and construction chain. This issue has stimulated a keen interest in the use of natural materials in construction. Among these, raw earth has proved to be particularly interesting for its intrinsic availability, sustainability, and recyclability. In Europe, the spread of raw earth building technologies has often been hindered by the lack of specific legislation regulating its use for load-bearing structures, even if in many countries, it can be noticed a widespread and well-established constructive tradition. Some transoceanic research experiences attest that unfired earth can be used, together with different types of reinforcements, to create seismic-resistant buildings. After presenting a review of the main raw earth reinforced technologies, the present study focuses on a novel reinforced and modular rammed earth construction made with natural or recycled materials, developing a technology with low energy consumption and low environmental impact, specifically designed for areas with high seismic risk. In particular, the work presents the results of a prototyping procedure aiming at developing a new seismic-resistant construction system that combines rammed earth with timber reinforcement elements and nylon/polyester ropes. These elements have a dual function: (1) they are fundamental components of the construction process (as they integrate the formwork system), and (2) they act as seismic-resistant devices once the structure is completed. In line with the performance-based approach required by the construction sector, the study aims at defining a controlled and standardised supply chain for rammed earth construction.

Description: In recent years, green finance has emerged as a commonly used strategy for dealing with environmental problems. However, it still remains to be seen whether green finance deals effectively with current global environmental problems. More recently, proposals regarding greening monetary policy have emerged. The goal of this paper is to provide a conceptual framework that helps to distinguish between different forms of green finance and monetary policy. We systematically analyse forms, tools and measures of green finance and monetary policy against different theoretical backgrounds. In so doing, we fill a research gap by providing an appropriate classification that is intended to facilitate future academic research. We provide different categories and distinguish, on an abstract level, between neoliberal, reformist and progressive forms of green finance. Furthermore, we provide sub-categories on a more concrete level of abstraction. With this, we focus on both financial market regulation and monetary policy strategies. Against the background of our categorisation, the different focuses on green finance and green monetary policy and the (often implicitly) underlying theoretical assumptions become transparent. The classification has significant implications for the evaluation of different perspectives and is, therefore, important for academic debate. The classification also potentially represents a basis for policy related discussions. We conclude that neoliberal forms of green finance and monetary policy that rely on the assumption of the effectiveness of markets for contributing to sustainability tend to neglect or abstract from potentially adverse distributional effects. Reformist forms of green finance and monetary policy are more skeptical of the effectiveness of market processes and, therefore, consider a greater role for government policies. In addition, reformist approaches are more concerned about the potentially adverse distributional effects of environmental policies. Finally, progressive green finance and monetary policy adopts a more global perspective on environmental issues and links the discussion intrinsically with questions of global inequality and socio-ecological transformation. Moreover, progressive approaches are skeptical of global capitalism at a systemic level and therefore demand global rules and financial and monetary regimes that allow for solutions of environmental problems based on global solidarity and a democratic economic governance.

Description: Typically, the main control on alternating current (AC) power systems is performed by the scheduling of rotary machines of synchronous generators and static machines of on-load tap changer (OLTC) transformers and volt-ampere reactive (VAR) sources. Large machines of synchronous generators can be managed by utilizing terminal voltage control when synchronized in parallel to the power system. These machines are typically terminal voltage regulated. In addition, substation on-load tap changer (OLTC) transformers improve system voltage management by controlling variable turn ratios that are adjusted in different levels known as taps along either the primary or secondary winding. Moreover, volt-ampere reactive (VAR) sources of static VAR compensators (SVCs), which are automated impedance devices connected to the AC power network, are designed for voltage regulation and system stabilization. In this paper, scheduling of these machines is coordinated for optimal power system operation (OPSO) using a recent algorithm of social network search optimizer (SNSO). The OPSO is performed by achieving many optimization targets of cost of fuel, power losses, and polluting emissions. The SNS is a recent optimizer that is inspired from users in social networks throughout the different moods of users such as imitation, conversation, disputation, and innovation mood. The SNSO is developed for handling the OPSO problem and applied on an IEEE standardized 57-bus power system and real Egyptian power system of the West Delta area. The developed SNSO is used in various assessments and quantitative analyses with various contemporary techniques. The simulated findings prove the developed SNSO’s solution accuracy and resilience when compared to other relevant techniques in the literature.

Description: The COVID-19 pandemic has hit organizations and employees in every sector worldwide in unprecedented ways. It became extremely difficult for organizations and employees across sectors to operate under increased mobility restrictions. The pandemic effectively disrupted previous operational models and imbued changes such as telework and digital adoption that are pervasive and may potentially last beyond the pandemic. Amid these circumstances, it was essential to ask how organizations and employees will sustain themselves in the post-COVID-19 ”new normal”. Although so much research is conducted about COVID-19, there is no comprehensive view of the changes at the meso (organizational) and micro (individual) levels. This article aims to explain this using the emergency-learning-institutionalization-new normal (ELIN) framework, which is based on the timeline of the pandemic. The article aims to bring forth the overall trends in how organizations and employees are adapting to the pandemic, the lessons they have learned, and how they will change and adapt in a post-COVID-19 “new normal”. We have analyzed existing policy papers, articles published in business, public administration, nonprofit journals, and other studies to achieve this. We find an increasing trend towards the adoption of telework and digital tools at both meso- and micro-levels. The effective implementation of telework policies and digital transformation plans at the meso-level will ensure the sustainability of organizations and jobs in the new normal. Although these trends vary across sectors and within and across countries, there is an overall increase in the flexibility of organizations and employees in adopting new solutions, making them more open to innovation. The article makes important recommendations for organizations to make these transitions more sustainable in the medium and long term.

Description: The COVID-19 pandemic has disrupted supply chain operations globally. Nevertheless, resilient firms have the capacity to combat an unprecedented situation with the right strategic approach. The current research has developed an integrated research model that combines factors such as supply chain intelligence, supply chain communication, leadership commitment, risk management orientation, supply chain capability and network complexity to investigate supply chain resilience. The research model of this study was empirically tested with 309 responses collected from supply chain managers. Results revealed that supply chain resilience is measured with supply chain intelligence, supply chain communication, leadership commitment, risk management orientation, supply chain capability and network complexity and demonstrated a substantial variance of 0.548% towards supply chain resilience. Practically, this study suggests that supply chain managers should focus on factors such as big data analytics, risk management orientation,1 supply chain communication and leadership commitment to enhance supply chain resilience and sustainable supply chain performance.

Description: In this paper, we use an evolutionary swarm intelligence approach to build an automatic electric dispatch controller for an offshore wind power plant (WPP). The optimal power flow (OPF) problem for this WPP is solved by the Canonical Differential Evolutionary Particle Swarm Optimization algorithm (C-DEEPSO). In this paper, C-DEEPSO works as a control system for reactive sources in energy production. The control operation takes place in a daily energy dispatch, scheduled into 15 min intervals and resulting in 96 operating test scenarios. As the nature of the optimization problem is dynamic, a fine-tuning of the initialization parameters of the optimization algorithm is performed at each dispatch interval. Therefore, a version of the C-DEEPSO algorithm has been built to automatically learn the best set of initialization parameters for each scenario. For this, we have coupled C-DEEPSO with the irace tool (an extension of the iterated F-race (I/F-Race)) by using inferential statistic techniques. The experiments carried out showed that the methodology employed here is robust and able to tackle this OPF-like modeling. Moreover, the methodology works as an automatic control system for a dynamic schedule operation.

Description: Buildings are accountable for waste generation, utilization of natural resources, and ecological contamination. The construction sector is one of the biggest consumers of resources available naturally and is responsible for significant CO2 emissions on the planet. The effects of the buildings on the environment are commonly determined using Life Cycle Assessments (LCA). The investigation and comparison of the Life Cycle Ecological Footprint (LCEF) and Life Cycle Energy (LCE) of five residential buildings situated in the composite climatic zone of India is presented in this study. The utilization of resources (building materials) along with developing a mobile application and a generic model to choose low emission material is the uniqueness of this study. The utilization of eco-friendly building materials and how these are more efficient than conventional building materials are also discussed. In this investigation, the two approaches, (a) Life Cycle Energy Assessment (LCEA) and (b) Life Cycle Ecological Footprint (LCEF), are discussed to evaluate the impacts of building materials on the environment. The energy embedded due to the materials used in a building is calculated to demonstrate the prevalence of innovative construction techniques over traditional materials. The generic model developed to assess the LCEA of residential buildings in the composite climate of India and the other results show that the utilization of low-energy building materials brings about a significant decrease in the LCEF and the LCE of the buildings. The results are suitable for a similar typology of buildings elsewhere in different climatic zone as well. The MATLAB model presented will help researchers globally to follow-up or replicate the study in their country. The developed user-friendly mobile application will enhance the awareness related to energy, environment, ecology, and sustainable development in the general public. This study can help in understanding and thus reducing the ecological burden of building materials, eventually leading towards sustainable development.

Description: This paper proposes an integrated approach towards rapid decision-making in the agricultural sector aimed at improvement of its resilience. Methodologically, we seek to devise a framework that is able to take the uncertainty regarding policy preferences into account. Empirically, we focus on the effects of COVID-19 on agriculture. First, we propose a multi-criteria decision-making framework following the Pugh matrix approach for group decision-making. The Monte Carlo simulation is used to check the effects of the perturbations in the criteria weights. Then, we identify the factors behind agricultural resilience and organize them into the three groups (food security, agricultural viability, decent jobs). The expert survey is carried out to elicit the ratings in regard to the expected effects of the policy measures with respect to dimensions of agricultural resilience. The case of Lithuania is considered in the empirical analysis. The existing and newly proposed agricultural policy measures are taken into account. The measures related to alleviation of the financial burden (e.g., credit payment deferral) appear to be the most effective in accordance with the expert ratings.

Description: The correlations between investments in transport infrastructure and territorial development continue to concern public authorities. They are responsible for optimising the allocation of financial resources, and they are interested in the correct short- and long-term estimations of investments in transport infrastructure’s consequences for development. The direct and indirect effects of transport infrastructure are present in the socio-economic assessment methodologies of projects. Despite the recorded progress, uncertainties remain in technical assessments, especially socio-economic ones, and they do not remove decision-makers’ concerns regarding the necessity and appropriateness of investments. Based on these aspects, this paper aimed to clarify the effects of new infrastructure on socio-economic development.

Description: In this article, we problematize conventional views regarding culture presented in the assessment report entitled Climate Change 2014: Impacts, Adaptation, and Vulnerability. This report is a contribution to the Fifth Assessment Report produced by the Intergovernmental Panel on Climate Change (IPCC). We posit that when culture is seen as a stable category and imagined as a space composed of humans—and, more precisely, only certain humans—an epistemological, ontological, and ethical order is reproduced in which (a) nature is framed as a passive and apolitical “out there”, (b) knowledge based on this division is misleading and partial (e.g., social scientists study culture and natural scientists study nature), and (c) dominant humanist assumptions become common-sense explanations for inequalities. We conduct a critical discourse analysis of the IPCC report to better understand which assumptions produce the conceptualization of culture as a stable category. In our conclusion, we offer an example of a semiotic-meaning intervention of a section of the report to demonstrate the vitality of the concepts presented in this document. Subsequently, we discuss the consequences of omitting the vital traffic between the biological, social, and cultural realms from discussions on climate change to reexamine the production and reproduction of inequalities.

Description: Agenda 2030 is a universal call to action which emphasises that all sectors of society should mobilise to create an inclusive and equal society and improve the lives of people world-wide. Education, physical activity and sport are recognised as critical means to achieve the Sustainable Development Goals (SDGs); therefore, it makes sense that school physical education (PE) also has the potential to contribute to the visions set out by Agenda 2030. A critical question is how sustainability can be understood, framed and integrated in PE. In this explorative paper, we, therefore, performed a review regarding the distinct role of PE in the context of Agenda 2030 and its SDGs. The overall research question that guided this paper is as follows: what perspectives related to PE in the context of Agenda 2030 and its SDGs have been discussed in the research literature? To identify relevant papers, five electronic databases (Education Research Complete, ERIC, Education database, SportDiscus, and Scopus) were systematically searched with search strings developed in an effort to identify research that supports the SDGs. The search resulted in about 4300 papers published between 2015 and 2021. Three unique papers met the inclusion criteria. We conclude that, so far, Agenda 2030 is a largely unexplored area of research in the field of PE, and that more research is needed to understand how sustainability can be understood, framed and integrated in PE. Based on the findings, we conclude the paper by providing suggestions for future work.

Description: Although there has been considerable research on consumers’ opinions about sustainable foods and purchasing behaviors, the experience of university students remains unclear. This study aims to characterize university students’ perceptions of the importance of sustainable foods and determine the relationship between perceptions and the frequency of purchasing sustainable foods. In a non-random sample of university students, a cross-sectional, online survey determined students’ perceptions of the importance of locally grown food and sustainable foods, and the self-reported frequency of purchasing sustainable foods. Multivariate binary logistic regression was conducted. Survey respondents (n = 1858; 71% female; 80% domestic enrolled; 43% aged 18–24 years; 38% food insecure) perceived locally grown food (77%) and sustainable food (84%) as important, and 68% reported buying sustainable foods frequently. Students who purchased sustainable foods frequently were more likely to be female, older and food insecure, and also were significantly more likely to perceive sustainable foods as important (OR: 7.317; 95% CI: 5.538–9.667; SE: 0.142; p 〈 0.001). Our results demonstrate that university students perceive sustainable foods as important and a relationship between perceptions and actions for purchasing sustainable foods is evident. Our results should inform the development of strategies within universities aligned with the United Nations Sustainable Development Goals, including improving access to locally grown and sustainable foods on campus to reflect student preferences, particularly for food insecure students.

Description: Level 4 autonomous vehicles (AVs) are smart vehicles that can move between two different points without any human interference. In 2018, the Saudi Arabian ban on female drivers was finally lifted, resulting in a large number of novice women drivers of different ages. The Kingdom might therefore be considered a risky place to drive, but AVs would help novices to reduce their fear of driving and reduce accidents. Previous studies focused narrowly on those who already had sufficient driving experience and held a valid driving license, but there were no studies on the adoption of smart cars by novice drivers. Based on a literature search, no studies had used a net valence model (NVM) for the adoption of AVs to understand their benefits/risks. Therefore, this study proposed an adoption model for AVs using an NVM to identify the benefit and risk factors that have an impact on beginner drivers’ adoption of autonomous vehicles. A survey method was applied using the purposive sampling technique. Data were collected from 1400 female Saudi novice drivers who had experience with driving AVs. Data analysis was performed using Smart PLS Version 3. The results showed that individuals tended to ignore potential risks and focus instead on the potential benefits of using AVs. Performance expectancy, enjoyment, and effort expectancy were found to be positively related to the perceived advantages. On the other hand, the perceived risk as a construct did not have an impact on beginner drivers’ adoption of autonomous vehicles. Therefore, the major theoretical contribution of this study was the formation of a new NVM model by incorporating three more constructs, which were social influence, personal innovativeness, and alternatives. Finally, the enhanced NVM model could assist AV developers in identifying the expected benefits and drawbacks of AV adoption.

Description: In algal pond used for treating wastewater, a part of the solar radiation (PAR) is used by algae for photosynthesis, and rest of the solar energy is wasted. To date, no studies have been conducted that optimize these aspects (wasted solar radiation for heat production) from an operational cost perspective. Therefore, a model is developed for the estimation of photosynthetically active radiation (PAR) from solar radiation. Subsequently, derived PAR was utilized in the optimization algorithm. Experimental data on PAR and solar radiation were used to obtain empirical parameters of the developed model. Using empirical parameters, diurnal PAR was estimated for other locations for which the diurnal variation of solar radiation was not available. Afterwards, the estimated solar radiation was used to obtain the cost of algal biomass production using wastewater. For this purpose, a cost function was minimized. The cost function contains various cost components of algae-based wastewater treatment. The major costs of the treatment were incurred by the sunlight harvesting, and distribution equipment, whereas the major income was registered through the conversion of sunlight to heat and biomass production. The yearly cost of treating 1m3 wastewater in the proposed wastewater treatment plant could be varied from 186 to −44 (Rs, INR). The capital cost of constructing a proposed treatment plant having a capacity of 1000 m3/day varied from 11–45 crores INR.

Description: α-Synuclein (α-Syn) can form different fibril strains with distinct polymorphs and neuropathologies, which is associated with the clinicopathological variability in synucleinopathies. How different α-syn fibril strains are produced and selected under disease conditions remains poorly understood. In this study, we show that the hereditary mutation G51D induces α-syn to form a distinct fibril strain in vitro. The cryogenic electron microscopy (cryo-EM) structure of the G51D fibril strain was determined at 2.96 Å resolution. The G51D fibril displays a relatively small and extended serpentine fold distinct from other α-syn fibril structures. Moreover, we show by cryo-EM that wild-type (WT) α-syn can assembly into the G51D fibril strain via cross-seeding with G51D fibrils. Our study reveals a distinct structure of G51D fibril strain triggered by G51D mutation but feasibly adopted by both WT and G51D α-syn, which suggests the cross-seeding and strain selection of WT and mutant α-syn in familial Parkinson’s disease (fPD).

Description: Due to their ability to recognize complex patterns, neural networks can drive a paradigm shift in the analysis of materials science data. Here, we introduce ARISE, a crystal-structure identification method based on Bayesian deep learning. As a major step forward, ARISE is robust to structural noise and can treat more than 100 crystal structures, a number that can be extended on demand. While being trained on ideal structures only, ARISE correctly characterizes strongly perturbed single- and polycrystalline systems, from both synthetic and experimental resources. The probabilistic nature of the Bayesian-deep-learning model allows to obtain principled uncertainty estimates, which are found to be correlated with crystalline order of metallic nanoparticles in electron tomography experiments. Applying unsupervised learning to the internal neural-network representations reveals grain boundaries and (unapparent) structural regions sharing easily interpretable geometrical properties. This work enables the hitherto hindered analysis of noisy atomic structural data from computations or experiments.

Description: Lack of dystrophin causes muscle degeneration, which is exacerbated by chronic inflammation and reduced regenerative capacity of muscle stem cells in Duchenne Muscular Dystrophy (DMD). To date, glucocorticoids remain the gold standard for the treatment of DMD. These drugs are able to slow down the progression of the disease and increase lifespan by dampening the chronic and excessive inflammatory process; however, they also have numerous harmful side effects that hamper their therapeutic potential. Here, we investigated Resolvin-D2 as a new therapeutic alternative having the potential to target multiple key features contributing to the disease progression. Our in vitro findings showed that Resolvin-D2 promotes the switch of macrophages toward their anti-inflammatory phenotype and increases their secretion of pro-myogenic factors. Moreover, Resolvin-D2 directly targets myogenic cells and promotes their differentiation and the expansion of the pool of myogenic progenitor cells leading to increased myogenesis. These effects are ablated when the receptor Gpr18 is knocked-out, knocked-down, or blocked by the pharmacological antagonist O-1918. Using different mouse models of DMD, we showed that Resolvin-D2 targets both inflammation and myogenesis leading to enhanced muscle function compared to glucocorticoids. Overall, this preclinical study has identified a new therapeutic approach that is more potent than the gold-standard treatment for DMD.

Description: The research presented in this paper examines the experiences of Poles traveling for leisure purposes in the summer season of 2020, taking into account the context of the COVID-19 pandemic. The study involved the analysis of source data, including statistical data, and a survey administered via the computer-assisted web interviewing (CAWI) method. The survey questionnaire was created on the Google platform. The link to the questionnaire was provided via social media to participants of travel groups in the period from 30 November 2020 to 15 February 2021. The sampling was purposive (included only travelers) despite efforts to maintain the gender balance; the proportion of women was higher. Therefore, caution must be applied when interpreting the results which may not be transferable. The survey included questions regarding the respondents’ travel behavior and risk perceptions. 433 correctly completed questionnaires were collected. The dataset was analyzed quantitatively and qualitatively. Descriptive statistics measures and correlation coefficients were used in the analysis of the results. The study shows that some respondents decided against traveling because of the pandemic situation, while those who decided to travel adjusted their behavior by avoiding crowded places and resigning from traveling abroad. Compliance with hygiene standards in the area of tourism services varied, and was the highest in the case of accommodation services. Women rated hygiene standards in chain cafes statistically higher than men and younger people rated hygiene on public transport, trains, air transport and in fast food services higher than older people. The higher the tourism expenditure, the lower the assessment of sanitary standards in tour guide services, air transport and chain cafes decreased.

Description: The use of intelligent compaction (IC) in asphalt overlay includes the use of double-drum IC rollers, a roller measurement system, global position system (GPS) radio/receiver/base station, infrared temperature sensors, and an onboard computer reporting system. GPS based mapping and optional feedback control help to overcome the drawbacks associated with conventional compaction such as identifying soft spots, achieving consistent roller patterns, and monitoring asphalt surface temperature and levels of compaction with adequate quality control or quality assurance (QC/QA). Cost-effectiveness of both compaction types was measured in terms of initial and roadway lifecycle cost based on the cost inputs received from South Korea and other published literatures. Roadway lifecycle cost was reported based on the improvement in in-place density, smoothness, and fatigue life. The results of this study showed that: (1) with IC an approximate 4.1% initial cost reduction can be achieved compared to conventional compaction; (2) QC/QA cost is found to have the most significant effect on the higher initial cost of conventional compaction compared to other associated costs whereas intelligent roller cost is the vital cost category for IC; (3) improvement of in-place air voids and density due to the IC has shown that at 97% field density (or at 3% air void content) the State Highway Agency can save approximately 44% over a 20-year service period; and (4) agency cost is observed to be reduced by approximately 62% with the IC method based on the 25-year analysis period due to the increase in fatigue life.

Description: According to the current European scenario, cultural, creative, and community-led policies play an increasingly important role in influencing local resources, systems, and infrastructures management and demand a novel approach in governing, financing, and monitoring urban regeneration processes. Therefore, cities become contexts where cultural and creative practices can be implemented, integrating social cohesion principles based on communities, shared values, and collaborative decision-making approaches, with particular attention to enhancing cultural heritage, mainly unused or underutilised. The purpose of this research is to explore how the Cultural and Creative Cities Monitor (CCCM) methodological framework, developed by the Joint Research Centre of the European Commission, can be integrated at the local scale to assess the impacts of urban regeneration processes in an interactive and dynamic way, through the data emerging from the monitoring of urban regeneration experiences activated with the communities. The paper describes the “Play ReCH (Re-use Cultural Heritage)” approach, that promotes a process of collaboration, gamification, and innovation in cultural heritage reuse, as an opportunity to test how cultural, creative, and community-led urban strategies can support the enhancement of heritage generating enabling environments and culturally vibrant contexts. The Play ReCH approach and the “Hack the City Salerno” mission, activated in the Salerno historic centre (Italy), open the reflection on some relevant issues related to how citizens become makers of cultural and creative cities’ policies, and contribute to evaluating and monitoring their implementation at diverse urban scales. The Play ReCH mission underlines how new evidence suggests declining the CCCM conceptual framework and related urban policies assessment, co-defining suitable community-based indicators.

Description: Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).

Description: In this paper, a new methodology for the assessment of the so-called “acoustic capacity” of a road infrastructure is proposed. This aspect is very important in the field of transportation planning as, currently, road infrastructures are verified only in terms of physical capacity; at most, the environmental capacity due to atmospheric pollutants is taken into account, while the acoustic capacity is completely neglected. The acoustic capacity is assessed based on the Harmonoise model, which is widely recognized at the European level. The Harmonoise model, starting from traffic data, such as traffic flows, average speed, and typologies of vehicles, provides the levels of noise emissions and immissions, which can be compared to the noise limit levels established by law. The validity of the proposed methodology was assessed on a test network. The results of this analysis show that, generally, the acoustic capacity is actually a capacity constraint, which involves several traffic flows: this occurs in particular in the case of an intersection, but also in the case of a bi-directional road. Furthermore, the acoustic capacity of a road infrastructure is generally lower than its physical capacity.

Description: Cochlear implants restore hearing in patients with severe to profound deafness by delivering electrical stimuli inside the cochlea. Understanding stimulus current spread, and how it correlates to patient-dependent factors, is hampered by the poor accessibility of the inner ear and by the lack of clinically-relevant in vitro, in vivo or in silico models. Here, we present 3D printing-neural network co-modelling for interpreting electric field imaging profiles of cochlear implant patients. With tuneable electro-anatomy, the 3D printed cochleae can replicate clinical scenarios of electric field imaging profiles at the off-stimuli positions. The co-modelling framework demonstrated autonomous and robust predictions of patient profiles or cochlear geometry, unfolded the electro-anatomical factors causing current spread, assisted on-demand printing for implant testing, and inferred patients’ in vivo cochlear tissue resistivity (estimated mean = 6.6 kΩcm). We anticipate our framework will facilitate physical modelling and digital twin innovations for neuromodulation implants.

Description: To respond to global climate change and achieve a “carbon peak” and “carbon neutrality” as soon as possible has become a common goal around the world. Economic growth relies heavily on financial development; indeed, low-carbon economic development is inseparable from financial support. This paper studies the impact of financial development on carbon emission intensity and its mechanism from both theoretical and empirical aspects. Based on the 2005–2018 data on Chinese cities and the Spatial Durbin Model (SDM) research results, this paper finds that: (1) Financial development has significantly reduced China’s carbon emission intensity overall. After considering spatial effects, financial development increases local carbon emission intensity, although it may lead to a more significant decrease in the surrounding area. (2) The analysis of heterogeneity shows that only the financial development in the eastern region has a substantial detrimental impact on total carbon emission intensity and the carbon emission intensity of neighboring cities. The financial development in the central and western regions has no significant effect on carbon emission intensity. (3) The mechanism test shows that financial development mainly reduces carbon emission intensity through technological innovation and structural optimization, with the effect of technological innovation being 9.5%, and the effect of structural optimization being 12.15%. The expansion of the consumption effects of financial development has no significant impact on carbon emission intensity. Accordingly, this article believes that it is necessary to further support financial development, build large-scale financial centers, continue to optimize the structure of financial products, and encourage the development of green finance.

Description: Global quantification of protein abundances in single cells could provide direct information on cellular phenotypes and complement transcriptomics measurements. However, single-cell proteomics is still immature and confronts many technical challenges. Herein we describe a nested nanoPOTS (N2) chip to improve protein recovery, operation robustness, and processing throughput for isobaric-labeling-based scProteomics workflow. The N2 chip reduces reaction volume to 240 single cells on a single microchip. The tandem mass tag (TMT) pooling step is simplified by adding a microliter droplet on the nested nanowells to combine labeled single-cell samples. In the analysis of ~100 individual cells from three different cell lines, we demonstrate that the N2 chip-based scProteomics platform can robustly quantify ~1500 proteins and reveal membrane protein markers. Our analyses also reveal low protein abundance variations, suggesting the single-cell proteome profiles are highly stable for the cells cultured under identical conditions.

Description: Precise control of gene expression during differentiation relies on the interplay of chromatin and nuclear structure. Despite an established contribution of nuclear membrane proteins to developmental gene regulation, little is known regarding the role of inner nuclear proteins. Here we demonstrate that loss of the nuclear scaffolding protein Matrin-3 (Matr3) in erythroid cells leads to morphological and gene expression changes characteristic of accelerated maturation, as well as broad alterations in chromatin organization similar to those accompanying differentiation. Matr3 protein interacts with CTCF and the cohesin complex, and its loss perturbs their occupancy at a subset of sites. Destabilization of CTCF and cohesin binding correlates with altered transcription and accelerated differentiation. This association is conserved in embryonic stem cells. Our findings indicate Matr3 negatively affects cell fate transitions and demonstrate that a critical inner nuclear protein impacts occupancy of architectural factors, culminating in broad effects on chromatin organization and cell differentiation.

Description: High-entropy alloys (HEAs) with unique physicochemical properties have attracted tremendous attention in many fields, yet the precise control on dimension and morphology at atomic level remains formidable challenges. Herein, we synthesize unique PtRuNiCoFeMo HEA subnanometer nanowires (SNWs) for alkaline hydrogen oxidation reaction (HOR). The mass and specific activities of HEA SNWs/C reach 6.75 A mgPt+Ru−1 and 8.96 mA cm−2, respectively, which are 2.8/2.6, 4.1/2.4, and 19.8/18.7 times higher than those of HEA NPs/C, commercial PtRu/C and Pt/C, respectively. It can even display enhanced resistance to CO poisoning during HOR in the presence of 1000 ppm CO. Density functional theory calculations reveal that the strong interactions between different metal sites in HEA SNWs can greatly regulate the binding strength of proton and hydroxyl, and therefore enhances the HOR activity. This work not only provides a viable synthetic route for the fabrication of Pt-based HEA subnano/nano materials, but also promotes the fundamental researches on catalysis and beyond.

Description: Wood has been gaining popularity as a building material over the last few decades. There has been significant progress in technology during this period to push the limits of wood construction. At the same time, it has become more economically competitive to build with wood beyond low-rises. As a result, there has been a noteworthy shift in public perception in terms of acceptance of wood as a material for high-rise buildings. There is a growing list of tall wood buildings that have been constructed in different continents over the last decade. With worldwide population growth and increased urbanization, the trend is expected to continue. Considerable urgency for using sustainable resources to tackle the threat of climate change has resulted in a surge in demand as well as applications in recent decades. This paper reviews the significant technical advances that have contributed to those achievements and are expected to facilitate further developments.

Description: This study investigated seasonal variation, spatial distribution, sources, composition and potential ecological risks of 16 polycyclic aromatic hydrocarbons (PAHs) in Red Sea coastal water. Surface seawater samples were collected at fourteen different locations. The sum of 16 PAHs concentrations in Red Sea showed clear variation between seasons, ranged from 1.08–6.10, 0.79–50.86, 1.37–54.47 and 0.21–7.18 μg/L in summer, autumn, winter, and spring respectively. PAHs levels in Red Sea coastal waters were relatively high at certain sites during autumn and winter seasons. They could be classified as highly polluted by PAHs contaminants (〉10 μg/L). According to the diagnostic ratios measured, the majority of PAHs in this study originated from pyrogenic sources, while minor amounts originated from petrogenic sources. Four rings PAHs accounted for more than 64% of the total PAHs studied. PAHs pose a high ecological risk along the period of study, according to the ecological risk assessment by Risk quotients (RQNCs and RQMPCs).