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  • Articles  (151)
  • Latest Papers from Table of Contents or Articles in Press  (151)
  • United States  (119)
  • Rats, Inbred Strains  (32)
  • American Association for the Advancement of Science (AAAS)  (151)
  • Annual Reviews
  • 1980-1984  (151)
  • 1965-1969
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  • 1984  (151)
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  • Articles  (151)
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  • Latest Papers from Table of Contents or Articles in Press  (151)
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  • American Association for the Advancement of Science (AAAS)  (151)
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  • 1980-1984  (151)
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-17
    Description: The Interdisciplinary Panel on Carcinogenicity reviewed and reevaluated criteria for assessing evidence of carcinogenicity of chemical substances. The panel reviewed criteria applicable to data derived from human epidemiological studies and from both in vivo and in vitro laboratory studies. A critical appraisal of all these sources of information led to the conclusion that the characterization of human risk always requires interdisciplinary evaluation of the entire array of data on a case-by-case basis. Animal studies, whenever possible, should be augmented by studies of mechanisms, metabolism, and pharmacodynamics. Such studies may assist in assessing risk to man. Recognizing the utility of such data should point the way for better assessment in the future.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1984 Aug 17;225(4663):682-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6463646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; *Carcinogens/metabolism/pharmacology ; Carcinogens, Environmental ; Cell Transformation, Neoplastic ; Dose-Response Relationship, Drug ; Environmental Exposure ; Epidemiologic Methods ; Humans ; In Vitro Techniques ; Mixed Function Oxygenases/metabolism ; Mutagenicity Tests ; Neoplasms/chemically induced ; Risk ; Time Factors ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abelson, P H -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1023.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494919" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Pollution ; *Government Agencies ; Humans ; Legislation as Topic ; Leukemia/chemically induced ; Risk ; United States ; *United States Environmental Protection Agency
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1984 Jan 13;223(4632):116-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691138" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Environmental Exposure ; Humans ; *Intelligence ; *Lead ; United States ; United States Environmental Protection Agency
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmed, A K -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):440.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691155" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *Containment of Biohazards ; *DNA, Recombinant ; *Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; United States
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-27
    Description: Recent advances in biotechnology have created many public policy and legal issues, one of the most significant of which is the treatment of biotechnological industrial products, particularly under the patent system. Patents represent one of several types of intellectual property; their ownership confers the right to exclude others from benefitting from the tangible products of a proprietary subject matter. Intellectual property law and its protections will play a major role in the rate at which biotechnology develops in the United States. In this article biotechnological intellectual property issues are reviewed in the context of their underlying legal requirements. The implications of other factors, such as international competition, research funding, and gene ownership, are also considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, R G -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):357-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6584975" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Cell Line ; Copyright ; DNA, Recombinant ; Economic Competition ; Federal Government ; *Genetic Engineering ; *Genetics, Microbial ; Government Regulation ; Legislation as Topic ; Ownership ; *Patents as Topic ; Research ; *Technology ; United States ; as a question of intellectual property rights. Attention is focused on the major ; role played by the U.S. patent system in establishing such rights, as illustrated ; by the case of products of recombinant DNA research. Trade secret, copyright, and ; trademark protections are also considered, as are policy issues such as ; international competition in the development of biomedical technologies and ; financing arrangements.
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  • 6
    Publication Date: 1984-03-23
    Description: Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. Examination of the mesenteric microcirculation in situ revealed that dietary magnesium deficiency resulted in reduced capillary, postcapillary, and venular blood flow concomitant with reduced terminal arteriolar, precapillary sphincter, and venular lumen sizes. The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altura, B M -- Altura, B T -- Gebrewold, A -- Ising, H -- Gunther, T -- HL18015/HL/NHLBI NIH HHS/ -- HL29600/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701524" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arterioles/pathology ; *Blood Pressure ; Capillaries/pathology ; Magnesium/blood ; Magnesium Deficiency/pathology/*physiopathology ; Male ; *Microcirculation ; Rats ; Rats, Inbred Strains ; *Vasoconstriction ; Venules/pathology
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  • 7
    Publication Date: 1984-06-01
    Description: Crude extracts of rat atria reduced the basal amount of aldosterone released from rat zona glomerulosa cells and partially inhibited aldosterone stimulation by adrenocorticotropic hormone and angiotensin II. The destruction of this activity by trypsin suggests that the active factor is a peptide, possibly atrial natriuretic factor. These data suggest that atrial natriuretic factor affects sodium excretion by the kidneys both directly and through the inhibition of aldosterone production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Atarashi, K -- Mulrow, P J -- Franco-Saenz, R -- Snajdar, R -- Rapp, J -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):992-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326267" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/pharmacology ; Aldosterone/*biosynthesis ; Angiotensin II/pharmacology ; Animals ; *Atrial Function ; Dogs ; Female ; Kidney/drug effects/metabolism ; Mineralocorticoid Receptor Antagonists/pharmacology ; Natriuresis/drug effects ; Rats ; Rats, Inbred Strains ; Trypsin/pharmacology
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-16
    Description: The magnetic fields associated with penicillin-induced focal epilepsy were measured in laboratory rats. Interictal magnetic spikes were similar to those previously observed in humans with focal seizure disorders. The magnetic fields of the seizure itself displayed both slow and fast phenomena, reversing in direction on opposite sides of the head.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barth, D S -- Sutherling, W -- Beatty, J -- 1-R01-NS20806-01/NS/NINDS NIH HHS/ -- 1K07NS00678-01A1/NS/NINDS NIH HHS/ -- 5-S07 RR07009/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):855-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436979" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electroencephalography ; *Electromagnetic Fields ; *Electromagnetic Phenomena ; Electrophysiology ; Epilepsies, Partial/*physiopathology ; Humans ; Penicillins/pharmacology ; Rats ; Rats, Inbred Strains ; Seizures/physiopathology
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  • 9
    Publication Date: 1984-06-22
    Description: Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baekkeskov, S -- Dyrberg, T -- Lernmark, A -- AM26190/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1348-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6374896" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantibodies/*immunology ; Diabetes Mellitus, Experimental/*immunology ; Diabetes Mellitus, Type 1/immunology ; Humans ; Islets of Langerhans/*immunology ; Rats ; Rats, Inbred Strains ; Rats, Mutant Strains
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailey, M R -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):716-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695180" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution ; *Fires ; Humans ; United States ; *Wood
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-22
    Description: The pathophysiology of brain dysfunction was studied with an animal model of chronic alcoholism. Rats were fed a liquid diet with or without ethanol for 20 weeks and then the diet without ethanol for three more weeks. Hippocampal slices were prepared and intracellular recordings were obtained from dentate granule and CA1 cells. Significant depression of orthodromically elicited inhibitory postsynaptic potentials and postspike afterhyperpolarizations was observed in neurons from ethanol-exposed animals. No differences were observed in other active or passive membrane characteristics. These results suggest that a loss of neuronal inhibition could contribute to brain dysfunction in chronic alcoholism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Durand, D -- Carlen, P L -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1359-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328654" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Alcoholism/physiopathology ; Animals ; Calcium/physiology ; Ethanol/*pharmacology ; Humans ; Ion Channels/drug effects ; Male ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Rats ; Rats, Inbred Strains
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, I S -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):243.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710142" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *DNA, Recombinant ; Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; *Professional Staff Committees ; United States
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):521.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494899" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Legislation, Medical ; National Institutes of Health (U.S.)/organization & administration ; New York ; *Primates ; United States
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):151.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484568" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Jurisprudence ; Malathion/adverse effects ; *National Institutes of Health (U.S.) ; Neoplasms/chemically induced ; United States
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):324.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484573" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Humans ; Male ; Mental Disorders/*epidemiology/therapy ; National Institute of Mental Health (U.S.) ; United States
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1376-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474183" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; *Government Agencies ; *Research ; United States
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Aug 24;225(4664):815, 818.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089330" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome ; *Budgets ; Centers for Disease Control and Prevention (U.S.) ; *Financial Management ; Humans ; *National Institutes of Health (U.S.) ; *Research ; United States ; United States Substance Abuse and Mental Health Services Administration
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):488.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740322" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; National Institutes of Health (U.S.) ; New York ; *Primates ; *Research Support as Topic ; United States ; Universities/economics
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):489.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740323" target="_blank"〉PubMed〈/a〉
    Keywords: Medical Laboratory Science/*standards ; Quality Assurance, Health Care ; *Societies, Scientific ; United States ; *United States Dept. of Health and Human Services
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; California ; Cats ; Dogs ; *Ethics, Medical ; Legislation, Medical ; Maryland ; National Institutes of Health (U.S.) ; United States
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):969.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6372094" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; *National Institutes of Health (U.S.) ; United States
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 May 25;224(4651):849-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719113" target="_blank"〉PubMed〈/a〉
    Keywords: Dioxins/*adverse effects ; Environmental Exposure ; *Jurisprudence ; United States ; Vietnam
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):483-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740321" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Information Services ; *Government Agencies ; United States ; *United States Environmental Protection Agency
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1319-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Craniocerebral Trauma ; Ethics, Medical ; Humans ; National Institutes of Health (U.S.) ; Papio ; Pennsylvania ; United States
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 May 11;224(4649):582.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6369539" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Toxins/*genetics ; *Cloning, Molecular ; Containment of Biohazards ; Escherichia coli/genetics ; *National Institutes of Health (U.S.) ; Shiga Toxins ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):966.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6372093" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; National Institutes of Health (U.S.) ; United States
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):267-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710143" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States ; *Universities
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):364-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710147" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Husbandry/standards ; Animals ; *Animals, Laboratory ; Ethics ; National Institutes of Health (U.S.) ; *Research ; United States ; Vivisection
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Jul 13;225(4658):148-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328665" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institute of Mental Health (U.S.) ; Research Support as Topic ; United States ; *United States Substance Abuse and Mental Health Services Administration
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  • 30
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 May 11;224(4649):584-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200939" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; *DNA, Recombinant ; Factor VIII/genetics ; Humans ; Industry ; Interferons/genetics ; *Patents as Topic/legislation & jurisprudence ; United States ; current patent disputes within the biotechnology industry. Fox reports on the ; participants and products involved in six actions, some over substances that are ; still being tested. Companies often use these legal contests to gain an edge on ; the competition ; some firms without the resources to wage long court cases will ; go under or be bought out, while others will be forced to disclose research ; secrets to defend themselves against charges of patent infringement. Given the ; nature of the genetic engineering industry, patent battles are expected for years ; to come.
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):36-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; *Legislation as Topic ; Research ; United States
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; *Legislation, Veterinary ; *Research ; United States
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  • 33
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):568-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695167" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Ethics ; Military Medicine ; United States ; *Wounds, Gunshot
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  • 34
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Feb 24;223(4638):798-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695181" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Containment of Biohazards ; *DNA, Recombinant ; *Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; United States ; Health has encountered setbacks in its attempt to increase its regulatory ; authority over genetic engineering ventures. Competing claims by the ; Environmental Protection Agency have been supported in a congressional report ; authored by Rep. Albert Gore, Jr. (D-Tenn.) which is critical of RAC's actions in ; approving experimental release of genetically-modified organisms into the ; environment. During a 6 Feb 1984 public meeting, RAC faced a barrage of criticism ; led by activist Jeremy Rifkin, and learned of a U.S. Court of Appeals decision ; blocking its consideration of a proposed field test with engineered bacteria.
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  • 35
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1984 Mar 2;223(4639):914.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6607532" target="_blank"〉PubMed〈/a〉
    Keywords: *Genetic Engineering ; Humans ; *Legislation, Drug ; United States ; United States Food and Drug Administration ; alpha 1-Antitrypsin/*genetics/therapeutic use
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  • 36
    Publication Date: 1984-08-03
    Description: Grafts of fetal septal tissue rich in cholinergic neurons were implanted as a dissociated cell suspension into the depth of the hippocampal formation in aged rats with severe impairments in spatial learning abilities. After 2 1/2 to 3 months, the rats with grafts, but not the controls, had improved their performance in a spatial learning test. Their improvement was due, at least in part, to an increased ability to use spatial cues in the task. In all animals the grafts had produced an extensive acetylcholinesterase-positive terminal network in the surrounding host hippocampal formation. Thus, the action of cholinergic neurons in the graft onto elements in the host hippocampal circuitry may be a necessary, but perhaps not sufficient, prerequisite for the observed functional recovery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gage, F H -- Bjorklund, A -- Stenevi, U -- Dunnett, S B -- Kelly, P A -- AG 03766/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):533-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6539949" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Disease Models, Animal ; Female ; Fetus ; Hippocampus/embryology/growth & development/*transplantation ; Humans ; *Learning ; Memory Disorders/*physiopathology ; Rats ; Rats, Inbred Strains
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  • 37
    Publication Date: 1984-11-02
    Description: Smooth muscle cells with 4C (double diploid) DNA content have been found in major arteries. The proportion of 4C cells increases with normal aging and with hypertension. These cells may represent a state of arrest at the G2 phase of the cell cycle or may be examples of true tetraploidy. Flow cytometric cell sorting was used to isolate 4C smooth muscle cells from the rat aorta, and the cells were cultured. Flow cytometry, Feulgen microdensitometry, and karyotyping of the progeny of the 4C cells established the presence of true tetraploid cells. These findings demonstrate the presence of reproductively viable tetraploid cells in a normal mammalian tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, I D -- Rosen, E M -- Shapiro, H M -- Zoller, L C -- Myrick, K -- Levenson, S E -- Christenson, L -- 5-P01-CA-12662/CA/NCI NIH HHS/ -- AG00599/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):559-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494901" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta, Thoracic/analysis/*cytology ; Cells, Cultured ; DNA/analysis ; Flow Cytometry ; Humans ; Karyotyping ; Muscle, Smooth, Vascular/analysis/*cytology ; *Polyploidy ; Rats ; Rats, Inbred Strains
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gore, A Jr -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):6,8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587567" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; DNA, Recombinant ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Humans ; Legislation as Topic ; National Institutes of Health (U.S.) ; United States ; United States Environmental Protection Agency
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  • 39
    Publication Date: 1984-08-17
    Description: Leukotriene B4, at the same intracutaneous doses as bradykinin, reduced the nociceptive threshold in the rat paw. The mechanism of leukotriene B4-induced hyperalgesia was distinguished from that of the hyperalgesia elicited by prostaglandin E2 and bradykinin by its dependence on polymorphonuclear leukocytes and independence of the cyclooxygenation of arachidonic acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, J D -- Lau, W -- Kwiat, G -- Goetzl, E J -- AM 32634/AM/NIADDK NIH HHS/ -- DE 05369/DE/NIDCR NIH HHS/ -- HL 31809/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):743-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6087456" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics/*pharmacology ; Animals ; Bradykinin/pharmacology ; Dinoprostone ; Indomethacin/pharmacology ; Leukotriene B4/analogs & derivatives/*pharmacology ; Male ; Neutrophils/*drug effects/physiology ; Prostaglandin-Endoperoxide Synthases/metabolism ; Prostaglandins E/pharmacology ; Rats ; Rats, Inbred Strains ; SRS-A/pharmacology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1379-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701527" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Computers ; DNA/genetics ; *Molecular Biology ; National Institutes of Health (U.S.) ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1078.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719131" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Humans ; Risk ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):672.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320366" target="_blank"〉PubMed〈/a〉
    Keywords: *Centers for Disease Control and Prevention (U.S.) ; Child ; Humans ; *Jurisprudence ; Lead Poisoning/*prevention & control ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Jan 27;223(4634):379-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691150" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine/analogs & derivatives/toxicity ; Carcinogens ; Fungicides, Industrial/toxicity ; *Government Agencies ; Herbicides/toxicity ; Pesticide Residues/toxicity ; Pesticides/*toxicity ; United States ; *United States Environmental Protection Agency
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  • 44
    Publication Date: 1984-03-09
    Description: Soil environmentally contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was given by gavage to guinea pigs and rats. The development of a characteristic clinicopathologic syndrome in guinea pigs, the induction of aryl hydrocarbon hydroxylase in rats, and the presence of TCDD in the livers of both species show that TCDD in soil exhibits high biological availability after ingestion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McConnell, E E -- Lucier, G W -- Rumbaugh, R C -- Albro, P W -- Harvan, D J -- Hass, J R -- Harris, M W -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695194" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/biosynthesis ; Biological Availability ; Body Weight/drug effects ; Cytochrome P-450 Enzyme System/metabolism ; Dioxins/*metabolism ; Eating ; Enzyme Induction ; Female ; Guinea Pigs ; Intestinal Absorption ; Liver/drug effects ; Male ; Microsomes, Liver/enzymology ; Organ Size/drug effects ; Rats ; Rats, Inbred Strains ; *Soil Pollutants/toxicity ; Tetrachlorodibenzodioxin/*metabolism/toxicity ; Thymus Gland/drug effects
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, Colin -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):265.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644124" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Federal Government ; Financial Support ; *Fraud ; Government ; *Government Regulation ; Humans ; International Cooperation ; Internationality ; National Institutes of Health (U.S.) ; Public Policy ; Punishment ; *Research ; Research Personnel ; *Scientific Misconduct ; *Social Control, Formal ; Switzerland ; United States
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):35-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701531" target="_blank"〉PubMed〈/a〉
    Keywords: Books/*legislation & jurisprudence ; *Crime ; *Fraud ; Publishing/*legislation & jurisprudence ; Textbooks as Topic/*legislation & jurisprudence ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):463.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691156" target="_blank"〉PubMed〈/a〉
    Keywords: Research ; Research Support as Topic ; *Technology Assessment, Biomedical/economics ; United States
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-05
    Description: Although most medical educators believe that education, research, and patient care are inseparable and essential to their academic mission, the educational component of this triad has never been given adequate, earmarked support. To fund educational programs, medical centers first relied on research grants and later on third-party payments intended for patient care. However, research money has long since ceased to be available for other purposes and recent federal cost containment measures have started to reduce payments for patient care. Teaching hospitals are threatened with loss of support not only for education, but for their capital improvements and care of the poor. Many institutions are now hoping to generate new income through business deals with for-profit health care corporations, but this effort probably will also fail and may compromise professional traditions. Teaching hospitals serve the public interest and will have to depend, at least in part, on public subsidy of their unavoidable extra costs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Relman, A S -- New York, N.Y. -- Science. 1984 Oct 5;226(4670):20-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382612" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Education, Medical/*economics ; Education, Medical, Graduate/*economics ; Health Facilities, Proprietary ; Hospitals, Teaching/*economics ; Humans ; Insurance, Health ; Medicare ; National Institutes of Health (U.S.) ; Research Support as Topic ; Training Support ; United States
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1400-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505696" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1056.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494923" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*economics ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms/*economics ; Politics ; *Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):419-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494893" target="_blank"〉PubMed〈/a〉
    Keywords: American Medical Association ; Curriculum ; *Education, Medical ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):151.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385249" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms ; Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Sep 14;225(4667):1128, 1130-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089342" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*blood ; Antibodies, Viral/*analysis ; Blood Donors ; Blood Transfusion/adverse effects ; Deltaretrovirus/*immunology ; Federal Government ; Humans ; United States ; United States Dept. of Health and Human Services ; epidemiological study by the National Heart, Lung and Blood Institute. Blood ; samples from 200,000 presumably healthy donors will soon be drawn and stored, to ; be screened when the test becomes available. Donors and recipients of blood which ; tests AIDS-positive will then be followed to see if AIDS develops. The study ; raises ethical issues in the areas of obtaining informed consent from donors and ; notifying donors and recipients of test results. The plan now is to obtain ; consent from donors and notify them of positive test results, and to decide later ; about notifying recipients.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691133" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *DNA, Recombinant ; *Federal Government ; *Government Regulation ; *National Institutes of Health (U.S.) ; United States ; Recombinant DNA Advisory Committee (RAC) are seen as potentially detrimental to ; RAC's credibility. Each session was closed on grounds that proprietary data were ; being reviewed. NIH Director James B. Wyngaarden has implemented a formal review ; of the extent of the authority of RAC, which currently reviews not only research ; projects funded by its parent agency but also voluntarily-submitted industrial ; proposals and proposals of other federal government agencies.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cummings, M M -- Johnson, F B -- Fox, C H -- New York, N.Y. -- Science. 1984 Nov 23;226(4677):912.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6390678" target="_blank"〉PubMed〈/a〉
    Keywords: History, 19th Century ; History, 20th Century ; Microscopy/*history ; Military Medicine/history ; National Library of Medicine (U.S.)/*history ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1984 Jan 13;223(4632):149-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691140" target="_blank"〉PubMed〈/a〉
    Keywords: *Education, Medical, Continuing ; *National Institutes of Health (U.S.) ; *Research ; *Training Support ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):521.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387909" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/adverse effects ; 2,4-Dichlorophenoxyacetic Acid/adverse effects ; Combat Disorders/psychology ; Female ; Humans ; Pregnancy ; Tetrachlorodibenzodioxin/adverse effects ; *Twins/psychology ; United States ; *United States Department of Veterans Affairs ; *Veterans ; Vietnam
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1155.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701518" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; *Neoplasms ; *Professional Staff Committees ; United States
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  • 59
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Apr 13;224(4645):139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322308" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; Humans ; Substance-Related Disorders/prevention & control ; United States ; *United States Substance Abuse and Mental Health Services Administration
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  • 60
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):670.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695175" target="_blank"〉PubMed〈/a〉
    Keywords: *Empathy ; *Humanism ; Humans ; *Internal Medicine ; Internship and Residency ; *Societies, Medical ; United States ; technological advances has begun to manifest itself in actions by professional ; societies and medical schools. The American Board of Internal Medicine now ; requires proof of a physician's "integrity, respect, and compassion" for ; certification. More humanities majors are being encouraged to enter medicine, and ; many residency programs are exploring ways of helping residents develop a more ; humanistic approach to patient care.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-02-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):569.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6229877" target="_blank"〉PubMed〈/a〉
    Keywords: *Disabled Persons ; *Ethics, Medical ; Humans ; *Infant, Newborn ; Patient Advocacy/*legislation & jurisprudence ; *Societies, Medical ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enstrom, J E -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):878.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474159" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Humans ; *Longevity ; Male ; *Smoking ; United States
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  • 63
    Publication Date: 1984-09-07
    Description: Two micrograms of prostaglandin E2 injected into the lateral ventricle of the brain in rats had the same anorectic and gastrointestinal motor effect as central administration of 0.02 unit of calcitonin. The effects of calcitonin were blocked by a previous intracerebroventricular administration of 0.25 milligram of indomethacin. These results suggest that both anorectic and gastrointestinal motor effects of calcitonin are centrally mediated by the release of prostaglandins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fargeas, M J -- Fioramonti, J -- Bueno, L -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1050-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6591429" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects/*physiology ; Calcitonin/administration & dosage/*pharmacology ; Dinoprostone ; Feeding Behavior/*drug effects ; Gastrointestinal Motility/*drug effects ; Indomethacin/administration & dosage/pharmacology ; Injections, Intraventricular ; Male ; Prostaglandins E/administration & dosage/*pharmacology ; Rats ; Rats, Inbred Strains
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  • 64
    Publication Date: 1984-12-07
    Description: Administration of cholecystokinin was recently found to attenuate opiate analgesia. In the present study, the role of endogenous cholecystokinin in opiate analgesia was examined. Endogenously released cholecystokinin was sequestered by antibodies to cholecystokinin developed in response to an active immunization procedure. Morphine analgesia was potentiated and prolonged in rats immunized against cholecystokinin. The rate of development of morphine tolerance, however, was not affected by the antibodies. Endogenous cholecystokinin appears to function as a short-term modulator of opiate action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faris, P L -- McLaughlin, C L -- Baile, C A -- Olney, J W -- Komisaruk, B R -- ES-07066/ES/NIEHS NIH HHS/ -- MH-38894/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505689" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Cholecystokinin/immunology/*physiology ; *Drug Tolerance ; Immunization ; Male ; Morphine/*pharmacology ; Pain/*physiology ; Rats ; Rats, Inbred Strains ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feulner, R L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):266.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740309" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens ; *Government Agencies ; Humans ; Male ; Rats ; Triazines/*adverse effects ; United States ; *United States Environmental Protection Agency
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):705-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6463647" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects ; Calcium/*deficiency ; Calcium, Dietary/metabolism/pharmacology ; Diet ; Humans ; Hypertension/*etiology ; Rats ; Sodium/metabolism ; United States
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  • 67
    Publication Date: 1984-01-27
    Description: An important early event in mammalian gustatory transduction with respect to sodium chloride has been found to be the passage of sodium ions through specific transport pathways in the apical region of the taste bud. The inward current caused by sodium chloride placed on the mucosal surface of an in vitro preparation of rat dorsal lingual epithelium can be substantially reduced by the blocker of sodium ion transport, amiloride. The data show (i) that amiloride is a specific blocker of the chorda tympani response to sodium chloride, but not to potassium chloride, (ii) that the sodium and potassium gustatory systems are largely independent at the peripheral level, and (iii) that the classical ion taste "receptor" is actually a specific transport pathway permitting the cation to enter the taste-bud cell and thereby to spread depolarizing current.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heck, G L -- Mierson, S -- DeSimone, J A -- NS 13767/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 27;223(4634):403-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691151" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/*pharmacology ; Animals ; Biological Transport/drug effects ; Epithelium/metabolism ; Potassium Chloride/pharmacology ; Pyrazines/*pharmacology ; Rats ; Rats, Inbred Strains ; Sodium/*metabolism ; Sodium Chloride/pharmacology ; Taste/*physiology ; Taste Buds/innervation/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-09
    Description: Since the discovery in 1969 of a man-made surface-active material that would bond to bone, a range of materials with the same ability has been developed. These include glass, glass-ceramic, and ceramic materials which have a range of reaction rates and from which it should be possible to select a surface-active material for a specific application. The available materials and their similarities, differences, and current clinical applications are reviewed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hench, L L -- Wilson, J -- New York, N.Y. -- Science. 1984 Nov 9;226(4675):630-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6093253" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biocompatible Materials/metabolism/therapeutic use ; Bone Cements/therapeutic use ; Bone and Bones/metabolism ; Ceramics ; Dogs ; Durapatite ; Glass ; Humans ; Hydroxyapatites/therapeutic use ; Male ; Orthodontics ; Rabbits ; Rats ; Rats, Inbred Strains ; Surface Properties ; Tissue Adhesives/therapeutic use
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1052-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494921" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; National Institutes of Health (U.S.) ; Politics ; Research Support as Topic/*legislation & jurisprudence ; *Social Sciences ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 1984 Jul 27;225(4660):396.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644144" target="_blank"〉PubMed〈/a〉
    Keywords: *Abortion, Induced ; China ; Coercion ; Developing Countries ; Economics ; *Family Planning Services ; *Financing, Government ; Humans ; *International Cooperation ; *Internationality ; Mandatory Programs ; *Population Control ; Prevalence ; *Public Policy ; Social Change ; United Nations ; United States ; conference concerning U.S. plans to halt foreign aid to nongovernmental ; organizations that "perform or actively promote" abortions, several reports ; appeared about problems which developing nations face in contending with rapid ; population growth. The World Bank's World Development Report 1984 analyzes ; population and development trends, argues for providing more aid for population ; programs, and recounts what has happened in countries where abortion has been ; outlawed. A National Research Council report documents China's rapid fertility ; drop since its 1969 antinatalist campaign began. A Population Reports ; International report advocates housing, education, and incentive-based family ; planning programs in developing countries.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729465" target="_blank"〉PubMed〈/a〉
    Keywords: Australia ; *Fertilization in Vitro ; Humans ; Internationality ; Jurisprudence ; United States ; without arranging for the disposition of two of the woman's fertilized ova in ; frozen storage has renewed debate over the legal and moral aspects of in vitro ; fertilization. Experts doubt that the zygotes are still viable, but questions ; have been raised about their legal status, their inheritance rights, and the ; possibility of implanting them in the womb of a surrogate mother. Disposition of ; unused fertilized eggs in the United States is currently governed by informal ; guidelines, although a public consensus on the issues raised by new and future ; reproductive technologies has not been attained.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):36.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729467" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Mice ; *National Institutes of Health (U.S.) ; Nuclear Transfer Techniques ; *Research Support as Topic ; Switzerland ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644140" target="_blank"〉PubMed〈/a〉
    Keywords: *Abortion, Induced ; Capitalism ; Coercion ; Developing Countries ; Economics ; *Family Planning Services ; Federal Government ; *Financing, Government ; Government ; Government Agencies ; Humans ; *International Cooperation ; *Internationality ; Political Systems ; *Population Control ; *Public Policy ; United Nations ; United States ; paper to be presented at the August 1984 United Nations world population ; conference in Mexico City. The paper dismisses population growth in developing ; countries as a cause of unemployment, illegal migration, or famine, and asserts ; that population programs are no substitute for ending government controls that ; stifle economic growth. It also contains a strong statement against abortion, ; states the U.S. position against coercion in family planning, and declares the ; Reagan administration's resolve not to fund programs advocating abortion. The ; U.S. stance is expected to antagonize developing countries and isolate the United ; States at the U.N. conference.
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1078-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719132" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Multiple ; Federal Government ; *Government Regulation ; Humans ; Infant, Newborn ; *Jurisprudence ; Legislation, Medical ; United States ; other medical organizations, a federal district court judge has struck down the ; February 1984 version of the Department of Health and Human Services' "Baby Doe" ; regulations. It was the second time a court had denied the government's claim ; that federal statutes forbidding discrimination against the handicapped give it ; the authority to intervene in treatment decisions concerning handicapped ; newborns. At the time of the ruling, no complaints about the care of any infant ; had been handled by DHHS under the provisions of this latest set of regulations.
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1157.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6367037" target="_blank"〉PubMed〈/a〉
    Keywords: Combat Disorders/epidemiology ; Female ; Humans ; Male ; *Military Medicine ; Pregnancy ; *Twins ; United States ; United States Department of Veterans Affairs ; *Veterans ; Vietnam ; *Warfare
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):264.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701511" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Infant, Newborn ; Patient Advocacy/*legislation & jurisprudence ; United States ; United States Dept. of Health and Human Services
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  • 77
    Publication Date: 1984-08-24
    Description: The importance and origin of antimicrobial-resistant Salmonella infections were examined in 52 outbreaks investigated by the Centers for Disease Control between 1971 and 1983. The case fatality rate was higher for patients infected with antimicrobial-resistant Salmonella (4.2 percent) than for those with antimicrobial-sensitive infections (0.2 percent). In the 38 outbreaks with identified sources, food animals were the source of 11 (69 percent) of 16 resistant and 6 (46 percent) of 13 sensitive outbreak strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holmberg, S D -- Wells, J G -- Cohen, M L -- New York, N.Y. -- Science. 1984 Aug 24;225(4664):833-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/*pharmacology ; Cattle/microbiology ; *Disease Outbreaks ; Drug Resistance, Microbial ; *Food Microbiology ; Humans ; Meat ; Milk/microbiology ; Poultry/microbiology ; Salmonella/*drug effects ; Salmonella Infections/microbiology/*transmission ; Salmonella typhimurium/drug effects ; United States
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):34-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691132" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Japan ; *Military Medicine ; Multiple Myeloma/*epidemiology ; *National Academy of Sciences (U.S.) ; *Organizations ; *Radioactive Fallout ; United States ; *Veterans
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-19
    Description: Norepinephrine, briefly superfused during high-frequency stimulation of the mossy fibers in the rat hippocampal slice in vitro, produced a reversible increase in the magnitude, duration, and probability of induction of long-term synaptic potentiation in the CA3 subfield. Similar results were obtained with isoproterenol, whereas propranolol or timolol reversibly blocked long-term potentiation. Norepinephrine had little apparent effect on responses obtained during low-frequency stimulation of the mossy fibers. These data suggest that norepinephrine can mediate long-lasting, frequency-dependent modulation of synaptic transmission in the mammalian brain. Furthermore, the results suggest a plausible mechanism for some of the known associative interactions between synaptic inputs to hippocampal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hopkins, W F -- Johnston, D -- NS11535/NS/NINDS NIH HHS/ -- NS15772/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):350-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6091272" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*physiology ; Animals ; Electric Stimulation ; Evoked Potentials ; Hippocampus/drug effects/*physiology ; In Vitro Techniques ; Isoproterenol/pharmacology ; Male ; Norepinephrine/pharmacology/*physiology ; Propranolol/pharmacology ; Rats ; Rats, Inbred Strains ; Synapses/physiology ; Synaptic Transmission/drug effects ; Timolol/pharmacology
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  • 80
    Publication Date: 1984-08-03
    Description: Sensory axons were counted in untreated 1-month-old rats and in littermates that were injected with antibodies to nerve growth factor. There were 45 percent more unmyelinated and 17 percent more myelinated axons in dorsal roots of the fifth thoracic spinal segment in treated rats. This suggests that the number of sensory axons can be changed by postnatal inactivation of nerve growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hulsebosch, C E -- Coggeshall, R E -- Perez-Polo, J R -- NS 18707/NS/NINDS NIH HHS/ -- S07-RR05427/RR/NCRR NIH HHS/ -- S07-RR07205/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):525-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740324" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; *Antibodies ; Antigen-Antibody Complex ; Axons/*physiology/ultrastructure ; Microscopy, Electron ; Myelin Sheath/physiology/ultrastructure ; Nerve Growth Factors/immunology/*physiology ; Rats ; Rats, Inbred Strains ; Spinal Cord/*growth & development/ultrastructure
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  • 81
    Publication Date: 1984-11-23
    Description: Injections of leupeptin (a thiol proteinase inhibitor) or chloroquine (a general lysosomal enzyme inhibitor) into the brains of young rats induced the formation of lysosome-associated granular aggregates (dense bodies) which closely resembled the ceroid-lipofuscin that accumulates in certain disease states and during aging. The dense material increased in a dose- and time-dependent fashion and was differentially distributed across brain regions and cell types. These observations provide clues to the origins of ceroid-lipofuscin and suggest means for studying the consequences of its accumulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ivy, G O -- Schottler, F -- Wenzel, J -- Baudry, M -- Lynch, G -- AG 00538/AG/NIA NIH HHS/ -- NS 18950/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 23;226(4677):985-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects/*ultrastructure ; Chloroquine/*pharmacology ; Leupeptins/*pharmacology ; Lysosomes/drug effects/enzymology/*ultrastructure ; Microscopy, Electron ; Oligopeptides/*pharmacology ; Rats ; Rats, Inbred Strains
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-03
    Description: The article "Reagan seeks expansion of Soviet ties" by R. Jeffrey Smith (News and Comment, 13 July, p. 145) erroneously stated that the U.S. Senate had passed a resolution calling for a U.S.-Soviet summit "without preconditions or assurances of success." Shortly before midnight on 19 June, the resolution was amended to call for a summit at "the earliest practical time following thorough preparation." It was approved in this form.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jako, G J -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):462.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740318" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Legislation, Medical ; *National Institutes of Health (U.S.) ; Neoplasms/mortality/*prevention & control ; *Research ; United States
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-09
    Description: There is increasing recognition that federal food safety laws and policies need to be revised. Congressional debate on proposed amendments to the Food, Drug, and Cosmetic Act has generated several different perspectives on how the food safety laws should be changed. Before a consensus can be reached, scientists, regulators, the food industry, and consumers will have to review such complex and controversial issues as the level of acceptable risk, the value of risk-benefit analysis, the proper role of independent scientific review, and the reliability of quantitative risk assessment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kessler, D A -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1034-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695192" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; Food Additives ; Food Analysis ; Food Coloring Agents ; Food Contamination ; Legislation, Drug ; *Legislation, Food/trends ; Pesticide Residues ; Risk ; Safety ; United States ; *United States Food and Drug Administration
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-20
    Description: A monoclonal antibody produced against hippocampal cell membranes labeled the surface of neurons in the rat limbic system. With a few exceptions, all nonlimbic components were unstained. This specific distribution of immunopositive neurons provides strong evidence of molecular specificity among functionally related neurons in the mammalian brain and supports the concept of a limbic system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levitt, P -- NS 19606/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6199842" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal ; Axons/immunology ; Brain Stem/immunology ; Cell Membrane/immunology ; Cerebellum/immunology ; Cerebral Cortex/immunology ; Diencephalon/immunology ; Epitopes/*analysis ; Female ; Hippocampus/*immunology ; Hypothalamus/immunology ; Immunoenzyme Techniques ; Limbic System/cytology/*immunology ; Neurons/*immunology ; Rats ; Rats, Inbred Strains ; Spinal Cord/immunology ; Telencephalon/immunology
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1083-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6426059" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Disease Models, Animal ; Haplorhini ; Humans ; Parkinson Disease/*etiology ; Parkinson Disease, Secondary/etiology ; Pyridines/*adverse effects ; Rats ; Substance-Related Disorders ; Substantia Nigra/drug effects ; United States
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  • 86
    Publication Date: 1984-10-26
    Description: Intravenous infusion of morphine sulfate in rats for 24 hours produced marked opioid dependence, manifested by a series of well-documented signs appearing after injection of the opiate antagonist naloxone. Treatment of rats with naloxonazine significantly reduced the analgesia associated with the morphine infusions for more than 24 hours. Furthermore, 14 of 16 withdrawal signs observed in naloxonazine-treated rats were virtually identical to those in rats that received morphine alone. These results raise the possibility that different receptor mechanisms mediate morphine analgesia and many of the withdrawal signs associated with morphine dependence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ling, G S -- MacLeod, J M -- Lee, S -- Lockhart, S H -- Pasternak, G W -- DA 002615/DA/NIDA NIH HHS/ -- NS 00415/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):462-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6541807" target="_blank"〉PubMed〈/a〉
    Keywords: *Analgesia ; Animals ; Humans ; Male ; Morphine/*pharmacology ; Naloxone/*analogs & derivatives/pharmacology ; Rats ; Rats, Inbred Strains ; Substance Withdrawal Syndrome ; *Substance-Related Disorders
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  • 87
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):34-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729464" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/prevention & control ; Child ; Gasoline/*adverse effects ; Humans ; Lead/adverse effects ; *Lead Poisoning/etiology/prevention & control ; *Legislation as Topic ; Petroleum/*adverse effects ; United States
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):367-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710148" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; Chemical Industry ; Civil Rights/*legislation & jurisprudence ; *Employee Discipline ; National Institutes of Health (U.S.) ; *Personnel Management ; Pesticides/toxicity ; United States
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1984 May 25;224(4651):851-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547002" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; *Food Contamination ; Insecticides/*adverse effects ; *Legislation as Topic ; Triazines/*adverse effects ; United States ; United States Environmental Protection Agency
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-29
    Description: A data base of the National Center for Health Statistics, Health and Nutrition Examination Survey I (HANES I), was used to perform a computer-assisted, comprehensive analysis of the relation of 17 nutrients to the blood pressure profile of adult Americans. Subjects were 10,372 individuals, 18 to 74 years of age, who denied a history of hypertension and intentional modification of their diet. Significant decreases in the consumption of calcium, potassium, vitamin A, and vitamin C were identified as the nutritional factors that distinguished hypertensive from normotensive subjects. Lower calcium intake was the most consistent factor in hypertensive individuals. Across the population, higher intakes of calcium, potassium, and sodium were associated with lower mean systolic blood pressure and lower absolute risk of hypertension. Increments of dietary calcium were also negatively correlated with body mass. Even though these correlations cannot be accepted as proof of causation, they have implications for future studies of the association of nutritional factors and dietary patterns with hypertension in America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCarron, D A -- Morris, C D -- Henry, H J -- Stanton, J L -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1392-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729459" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Ascorbic Acid/metabolism ; *Blood Pressure/drug effects ; Calcium/metabolism ; Continental Population Groups ; Energy Intake ; Female ; Humans ; Hypertension/metabolism ; Male ; Middle Aged ; National Center for Health Statistics (U.S.) ; Nutrition Surveys ; *Nutritional Physiological Phenomena ; Obesity/metabolism ; Potassium/metabolism ; Sex Factors ; Sodium/metabolism ; United States ; Vitamin A/metabolism
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  • 91
    Publication Date: 1984-12-21
    Description: High-resolution proton nuclear magnetic resonance (NMR) studies of intact cancer cells revealed differences between cells with the capacity to metastasize and those that produce locally invasive tumors. The NMR resonances that characterize the metastatic cells were associated with an increased ratio of cholesterol to phospholipid and an increased amount of plasma membrane-bound cholesterol ester. High-resolution NMR spectroscopy could therefore be used to assess the metastatic potential of primary tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mountford, C E -- Wright, L C -- Holmes, K T -- Mackinnon, W B -- Gregory, P -- Fox, R M -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1415-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505699" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/analysis ; Cholesterol Esters/analysis ; *Magnetic Resonance Spectroscopy ; Membrane Lipids/analysis ; Neoplasm Metastasis/*etiology ; Neoplasms, Experimental/*analysis/pathology ; Rats ; Rats, Inbred Strains ; Triglycerides/analysis
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):811-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494908" target="_blank"〉PubMed〈/a〉
    Keywords: Legislation, Medical ; *National Institutes of Health (U.S.)/organization & administration ; United States
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1055.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494922" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.)/*organization & administration ; Research Support as Topic ; United States
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  • 94
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):517.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494897" target="_blank"〉PubMed〈/a〉
    Keywords: Legislation, Medical ; *National Institutes of Health (U.S.)/organization & administration ; United States
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):417-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494892" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; *Financial Management ; *National Institutes of Health (U.S.)/organization & administration ; United States
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1371-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474181" target="_blank"〉PubMed〈/a〉
    Keywords: *Politics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 May 11;224(4649):581.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710157" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; Federal Government ; *Fraud ; *Government Regulation ; *National Institutes of Health (U.S.) ; Research/*standards ; United States ; look into institutional procedures at Emory University, where an internal ; investigation had revealed extensive data fabrication by John Darsee, found a ; pattern of lax supervision of Darsee's research. Rather than prescribe action for ; Emory alone, the panel recommended seven procedural steps that should be taken by ; all NIH-supported research centers to guard against similar occurrences. These ; recommendations are being reviewed by NIH.
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1218.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587565" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; DNA, Recombinant ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Jurisprudence ; *National Institutes of Health (U.S.) ; United States ; recommended to NIH director James B. Wyngaarden on 1 June 1984 that two ; companies, Cetus Corporation and Advanced Genetic Sciences, Inc., be allowed to ; proceed with experiments involving release into the environment of organisms ; altered by gene splicing. The recommendation followed by two weeks a ruling by ; federal judge John J. Sirica which halted a very similar experiment by ; federally-funded University of California researcher Steven Lindow. The ruling ; did not apply to experiments conducted by private companies. Wyngaarden thus ; faces the political dilemma that, if he accepts the advisory committee's ; recommendation, a dual standard will be established allowing industry to conduct ; experiments that university scientists are currently barred from doing.
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):962-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719128" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *DNA, Recombinant ; Federal Government ; *Government Regulation ; Jurisprudence ; National Institutes of Health (U.S.) ; United States ; University of California experiment, already approved by the National Institutes ; of Health's Recombinant DNA Advisory Committee, which would have involved the ; first deliberate release into the environment of genetically modified bacteria. ; Agreeing with social activist Jeremy Rifkin's charge that NIH had failed to ; comply with the National Environmental Policy Act when it approved the ; experiment, Sirica strongly suggested that he would also rule in Rifkin's favor ; on a suit to block all similar federally funded experiments until NIH has ; conducted an exhaustive evaluation of their potential environmental impact. ; Sirica's decision, however, left the NIH Recombinant Advisory Committee free to ; approve privately-funded experiments, which are not covered by the same ; environmental laws.
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1370-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6142529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cuba ; Culicidae/parasitology ; History, 19th Century ; History, 20th Century ; Humans ; Insect Vectors/parasitology ; United States ; Yellow Fever/*history/transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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