Publication Date:
1984-12-14
Description:
The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuo, T -- Heller, M -- Petti, L -- O'Shiro, E -- Kieff, E -- AI07099/AI/NIAID NIH HHS/ -- CA 17281/CA/NCI NIH HHS/ -- CA 19264/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1322-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6095452" target="_blank"〉PubMed〈/a〉
Keywords:
Base Sequence
;
Burkitt Lymphoma/*microbiology
;
DNA, Viral/*analysis
;
Herpesvirus 4, Human/*genetics
;
Humans
;
Lymphocytes/ultrastructure
;
Nucleic Acid Hybridization
;
Plasmids
;
Recombination, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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