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  • 1
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    Murine MHC polymorphism and T cell specificities (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-05-05
    Description: The major histocompatibility complex (MHC) genes are polymorphic in mouse and man. The products of these genes are receptors for peptides, which while bound, are displayed to T lymphocytes. When bound peptides from antigens are recognized by T lymphocytes, an immune response is initiated against the antigens. This study assessed the relation of the polymorphic MHC molecules to their peptide specificity. The results indicate that although an individual of the species has a limited ability to recognize antigens, the species as a whole has broad reactivity. This rationalizes the extreme polymorphism observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roy, S -- Scherer, M T -- Briner, T J -- Smith, J A -- Gefter, M L -- AI13357/AI/NIAID NIH HHS/ -- CA28900/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1989 May 5;244(4904):572-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2470147" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens/immunology ; Bacteriophage lambda ; Epitopes/immunology ; Histocompatibility Antigens Class II/immunology ; Hybridomas/immunology ; Immunization ; *Major Histocompatibility Complex ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Peptide Fragments/immunology ; *Polymorphism, Genetic ; Repressor Proteins/immunology ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Influence of clonal selection on the expression of immunoglobulin variable region genes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-14
    Description: The humoral immune response of the mouse to certain antigens is characterized by the dominant expression of a single or limited number of related, immunoglobulin variable region (V) structures by antibody-secreting lymphocytes. Such dominance could be due to preferred expression of these V regions in the B cell population prior to the immune response or could result from the action of selective or regulatory mechanisms during the immune response. Expression of a heavy chain variable region (VH) gene segment that partially encodes a V region structure that dominates the immune response to para-azophenylarsonate (Ars) in strain A mice was examined in the B cell population of Ars nonimmune mice. This VH gene segment participates in encoding several hundred thousand different V region structures expressed in this B cell population. The immune system is therefore capable of recurrently selecting a single V region structure from such a repertoire for dominant expression by antibody-secreting lymphocytes during an immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manser, T -- Huang, S Y -- Gefter, M L -- AI13357/AI/NIAID NIH HHS/ -- CA28900/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1283-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6334361" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Diversity ; *Antibody Formation ; Azo Compounds/immunology ; B-Lymphocytes/immunology ; Base Sequence ; *Genes ; Hybridomas ; Immunoglobulin Variable Region/*genetics ; Mice ; Radioimmunoassay
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Structure and in vitro transcription of human globin genes (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: The alpha-like and beta-like subunits of human hemoglobin are encoded by a small family of genes that are differentially expressed during development. Through the use of molecular cloning procedures, each member of this gene family has been isolated and extensively characterized. Although the alpha-like and beta-like globin genes are located on different chromosomes, both sets of genes are arranged in closely linked clusters. In both clusters, each of the genes is transcribed from the same DNA strand, and the genes are arranged in the order of their expressions during development. Structural comparisons of immediately adjacent genes within each cluster have provided evidence for the occurrence of gene duplication and correction during evolution and have led to the discovery of pseudogenes, genes that have acquired numerous mutations that prevent their normal expression. Recently, in vivo and in vitro systems for studying the expression of cloned eukaryotic genes have been developed as a means of identifying DNA sequences that are necessary for normal gene function. This article describes the application of an in vitro transcription procedure to the study of human globin gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Proudfoot, N J -- Shander, M H -- Manley, J L -- Gefter, M L -- Maniatis, T -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1329-36.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6158093" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Cell-Free System ; Fetal Hemoglobin/genetics ; *Genes ; Genes, Regulator ; Genetic Linkage ; Globins/*genetics ; Hemoglobins/*genetics ; Humans ; Operon ; RNA Caps ; RNA Polymerase II/metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Immunological self, nonself discrimination (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-02-20
    Description: The ability of immunodominant peptides derived from several antigen systems to compete with each other for T cell activation was studied. Only peptides restricted by a given transplantation antigen are mutually competitive. There is a correlation between haplotype restriction, ability to bind to the appropriate transplantation antigen, and ability to inhibit activation of other T cells restricted by the same transplantation antigen. An exception was noted in that a peptide derived from an antigen, bacteriophage lambda cI repressor, binds to the I-Ed molecule in a specific way, yet is not I-Ed-restricted. Comparison of the sequence of the repressor peptide with that of other peptides able to bind to (and be restricted by) I-Ed and a polymorphic region of the I-Ed molecule itself revealed a significant degree of homology. Thus, peptides restricted by a given class II molecule appear to be homologous to a portion of the class II molecule itself. The repressor-derived peptide is identical at several polymorphic residues at this site, and this may account for the failure of I-Ed to act as a restriction element. Comparison of antigenic peptide sequences with transplantation antigen sequences suggests a model that provides a basis for explaining self, nonself discrimination as well as alloreactivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guillet, J G -- Lai, M Z -- Briner, T J -- Buus, S -- Sette, A -- Grey, H M -- Smith, J A -- Gefter, M L -- AI13357/AI/NIAID NIH HHS/ -- AI18634/AI/NIAID NIH HHS/ -- CA28900/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1987 Feb 20;235(4791):865-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2433769" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens/*immunology ; Autoantigens/immunology ; *DNA-Binding Proteins ; Epitopes ; Histocompatibility Antigens Class II/*immunology ; Hybridomas ; Isoantigens/immunology ; Lymphocyte Activation ; Mice ; Micrococcal Nuclease/immunology ; Ovalbumin/immunology ; Protein Binding ; Receptors, Immunologic/*immunology ; Repressor Proteins/immunology ; T-Lymphocytes/*immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Viral Proteins ; Viral Regulatory and Accessory Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Interactions between Immunogenic Peptides and MHC Proteins (1991)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 9 (1991), S. 527-565 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.iy.09.040191.002523
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    DNA Replication (1975)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 44 (1975), S. 45-78 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bi.44.070175.000401
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  • 7
    Electronic Resource
    Electronic Resource
    Gene Conversion and the Generation of Antibody Diversity (1989)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 58 (1989), S. 509-527 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bi.58.070189.002453
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  • 8
    Electronic Resource
    Electronic Resource
    Expression of a V H C κ chimaeric protein in mouse myeloma cells (1984)
    [s.l.] : Nature Publishing Group
    Nature 309 (1984), S. 364-367 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Figure 1 shows the scheme used to construct two plasmids, AHpV and AHpVE, bearing the VHCK chimaeric gene and the selectable marker Ecogpt6' . Both AHpV and AHpVE contain the rearranged 36-65 VH gene with its 5' flanking sequence8, and DNA encoding the C region of the light chain of the SI07 BALB/c ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/309364a0
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  • 9
    Electronic Resource
    Electronic Resource
    Enzymatic reactions at termini of DNAThis work was supported by grants from the National Institutes of Health, the National Science Foundation, the New York City Research Council, and the American Cancer Society. (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 70 (1967), S. 181-199 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A number of reactions which lead to the removal of 3′-phosphate and 5′-phosphate ends of DNA have been detected in extracts of E. coli. Two new enzymes which attack the ends of DNA chains have been purified from phage-infected cells. One enzyme removes only 3′-phosphate termini specifically from DNA, whereas the other removes only 5′-phosphate ends from both DNA and RNA. Synthetic reactions occurring at ends of DNA have also been detected. In phage-infected extracts, 5′-hydroxyl polynucleotide kinase catalyzes the phosphorylation of 5′-hydroxyl-terminated polynucleotides. Another phage-induced enzyme, in the presence of ATP and deoxynucleoside triphosphates, leads to the conversion of 5′-32P-labeled DNA to a form resistant to alkaline phosphatase. This enzyme preparation also catalyzes the conversion of the Hershey circle form of lambda DNA to a covalent form. Enzyme fractions purified from E. coli K12 also catalyze the latter reaction.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040700413
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  • 10
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    The enzymatic repair of DNA. I. Formation of circular lambda-DNA. (1967)
    National Academy of Sciences
    Details
    Publication Date: 1967-07-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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