Publication Date:
1984-12-21
Description:
Cyclosporin A blocked production of the lymphokine interleukin 2 by activated T lymphocytes. In a human and a murine cell line this inhibition reflected an absence of interleukin 2 messenger RNA. Under conditions in which these cells are normally stimulated to secrete high levels of interleukin 2, they failed to do so in the presence of cyclosporin A. In both cell lines this failure was accompanied by an absence of interleukin 2 messenger accumulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elliott, J F -- Lin, Y -- Mizel, S B -- Bleackley, R C -- Harnish, D G -- Paetkau, V -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1439-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6334364" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Line
;
Cyclosporins/*pharmacology
;
Humans
;
Interleukin-2/biosynthesis/*genetics
;
Mice
;
Protein Biosynthesis/drug effects
;
RNA, Messenger/*metabolism
;
T-Lymphocytes/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
