ALBERT

Notizen: Abstract The Raman spectrum of a protein or nucleic acid consists of numerous discrete bands representing molecular normal modes of vibration and serves as a sensitive and selective fingerprint of three-dimensional structure, intermolecular interactions, and dynamics. Recent improvements in instrumentation, coupled with innovative approaches in experimental design, dramatically increase the power and scope of the method, particularly for investigations of large supramolecular assemblies. Applications are considered that involve the use of (a) time-resolved Raman spectroscopy to elucidate assembly pathways in icosahedral viruses, (b) polarized Raman microspectroscopy to determine detailed structural parameters in filamentous viruses, (c) ultraviolet-resonance Raman spectroscopy to probe selective DNA and protein residues in nucleoprotein complexes, and (d) difference Raman methods to understand mechanisms of protein/DNA recognition in gene regulatory and chromosomal complexes.

Notizen: Abstract Transcription in eukaryotes is frequently regulated by a mechanism termed combinatorial control, whereby several different proteins must bind DNA in concert to achieve appropriate regulation of the downstream gene. X-ray crystallographic studies of multiprotein complexes bound to DNA have been carried out to investigate the molecular determinants of complex assembly and DNA binding. This work has provided important insights into the specific protein-protein and protein-DNA interactions that govern the assembly of multiprotein regulatory complexes. The results of these studies are reviewed here, and the general insights into the mechanism of combinatorial gene regulation are discussed.

Notizen: Abstract Analytical ultracentrifugation is a classical method of biochemistry and molecular biology. Because it is a primary technique, sedimentation can provide first-principle hydrodynamic and first-principle thermodynamic information for nearly any molecule, in a wide range of solvents and over a wide range of solute concentrations. For many questions, it is the technique of choice. This review stresses what information is available from analytical ultracentrifugation and how that information is being extracted and used in contemporary applications.

Notizen: Abstract Measurement of the distance between two spin label probes in proteins permits the spatial orientation of elements of defined secondary structure. By using site-directed spin labeling, it is possible to determine multiple distance constraints and thereby build tertiary and quaternary structural models as well as measure the kinetics of structural changes. New analytical methods for determining interprobe distances and relative orientations for uniquely oriented spin labels have been developed using global analysis of multifrequency electron paramagnetic resonance data. New methods have also been developed for determining interprobe distances for randomly oriented spin labels. These methods are being applied to a wide range of structural problems, including peptides, soluble proteins, and membrane proteins, that are not readily characterized by other structural techniques.

Notizen: Abstract Current computer simulations of biomolecules typically make use of classical molecular dynamics methods, as a very large number (tens to hundreds of thousands) of atoms are involved over timescales of many nanoseconds. The methodology for treating short-range bonded and van der Waals interactions has matured. However, long-range electrostatic interactions still represent a bottleneck in simulations. In this article, we introduce the basic issues for an accurate representation of the relevant electrostatic interactions. In spite of the huge computational time demanded by most biomolecular systems, it is no longer necessary to resort to uncontrolled approximations such as the use of cutoffs. In particular, we discuss the Ewald summation methods, the fast particle mesh methods, and the fast multipole methods. We also review recent efforts to understand the role of boundary conditions in systems with long-range interactions, and conclude with a short perspective on future trends.

Notizen: Abstract Recent structural and biochemical studies have begun to illuminate how cells solve the problems of recognizing and removing damaged DNA bases. Bases damaged by environmental, chemical, or enzymatic mechanisms must be efficiently found within a large excess of undamaged DNA. Structural studies suggest that a rapid damage-scanning mechanism probes for both conformational deviations and local deformability of the DNA base stack. At susceptible lesions, enzyme-induced conformational changes lead to direct interactions with specific damaged bases. The diverse array of damaged DNA bases are processed through a two-stage pathway in which damage-specific enzymes recognize and remove the base lesion, creating a common abasic site intermediate that is processed by damage-general repair enzymes to restore the correct DNA sequence.

Notizen: Abstract A significant number of exciting papain-like cysteine protease structures have been determined by crystallographic methods over the last several years. This trove of data allows for an analysis of the structural features that empower these molecules as they efficiently carry out their specialized tasks. Although the structure of the paradigm for the family, papain, has been known for twenty years, recent efforts have reaped several structures of specialized mammalian enzymes. This review first covers the commonalities of architecture and purpose of the papain-like cysteine proteases. From that broad platform, each of the lysosomal enzymes for which there is an X-ray structure (or structures) is then examined to gain an understanding of what structural features are used to customize specificity and activity. Structure-based design of inhibitors to control pathological cysteine protease activity will also be addressed.

Notizen: Abstract For nuclear magnetic resonance determinations of the conformation of oligosaccharides in solution, simple molecular mechanics calculations and nuclear Overhauser enhancement measurements are adequate for small oligosaccharides that adopt single, relatively rigid conformations. Polysaccharides and larger or more flexible oligosaccharides generally require additional types of data, such as scalar and dipolar coupling constants, which are most conveniently measured in 13C-enriched samples. Nuclear magnetic resonance relaxation data provide information on the dynamics of oligosaccharides, which involves several different types of internal motion. Oligosaccharides complexed with lectins and antibodies have been successfully studied both by X-ray crystallography and by nuclear magnetic resonance spectroscopy. The complexes have been shown to be stabilized by a combination of polar hydrogen bonding interactions and van der Waals attractions. Although theoretical calculations of the conformation and stability of free oligosaccharides and of complexes with proteins can be carried out by molecular mechanics methods, the role of solvent water for these highly polar molecules continues to present computational problems.

Notizen: Abstract Proteasomes are large multisubunit proteases that are found in the cytosol, both free and attached to the endoplasmic reticulum, and in the nucleus of eukaryotic cells. Their ubiquitous presence and high abundance in these compartments reflects their central role in cellular protein turnover. Proteasomes recognize, unfold, and digest protein substrates that have been marked for degradation by the attachment of a ubiquitin moiety. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: The ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome. This core particle appears to be more ancient than the ubiquitin system. Both prokaryotic and archaebacterial ancestors have been identified. Crystal structures are now available for the E. coli proteasome homologue and the T. acidophilum and S. cerevisiae 20S proteasomes. All three enzymes are cylindrical particles that have their active sites on the inner walls of a large central cavity. They share the fold and a novel catalytic mechanism with an N-terminal nucleophilic threonine, which places them in the family of Ntn (N terminal nucleophile) hydrolases. Evolution has added complexity to the comparatively simple prokaryotic prototype. This minimal proteasome is a homododecamer made from two hexameric rings stacked head to head. Its heptameric version is the catalytic core of archaebacterial proteasomes, where it is sandwiched between two inactive antichambers that are made up from a different subunit. In eukaryotes, both subunits have diverged into seven different subunits each, which are present in the particle in unique locations such that a complex dimer is formed that has six active sites with three major specificities that can be attributed to individual subunits. Genetic, biochemical, and high-resolution electron microscopy data, but no crystal structures, are available for the 19S caps. A first step toward a mechanistic understanding of proteasome activation and regulation has been made with the elucidation of the X-ray structure of the alternative, mammalian proteasome activator PA28.

Notizen: Abstract I present the general picture of how galactic magnetic fields grow in disks according to the alpha-Omega dynamo theory. Emphasis is placed on following the lines of force during the dynamo process. The dynamo equation is presented together with a simple growing solution for the galactic disk. Then I take up the various critical questions that have been raised concerning the galactic dynamo theory. These are (1) the importance of the escape of flux from the disk in order for the magnetic field to grow; (2) the physics of turbulent diffusion and its mixing of field lines together so that the rms field is possibly greater than the mean field; (3) whether magnetic reconnection plays a role in the galactic dynamo; (4) whether small-scale fields can grow large enough to swamp the dynamo. Then I discuss the possible seed fields from which the dynamo starts and their relation to the primordial hypothesis. Finally I take up the question of the final evolution of the galactic field after the alpha effect saturates. My conclusion is that all these problems warrant attention but none of them seem to be serious enough to cast any real doubt on the dynamo as the most likely generator of galactic fields.

Notizen: Abstract Advances in wide-angle astrometric measurements of three to four orders of magnitude in the last thirty years have resulted in a redefinition of the fundamental astronomical reference frame. This new frame, the International Celestial Reference Frame (ICRF), is based on the radio positions of 212 compact extragalactic radio sources. The ICRF defines the direction of the axes of the International Celestial Reference System (ICRS) with a precision of approximately 20 muas. At optical wavelengths, the Hipparcos catalog is the realization of this frame. The precision with which the ICRF is now determined requires that the ICRS models for precession, nutation, and others, be revised. Increases in the precision of measurements from astrometric space missions will further improve the celestial reference frame and may require its redefinition within the next ten years. These improvements will again challenge the models for the celestial reference system.

Notizen: Abstract Black holes of stellar mass and neutron stars in binary systems are first detected as hard X-ray sources using high-energy space telescopes. Relativistic jets in some of these compact sources are found by means of multiwavelength observations with ground-based telescopes. The X-ray emission probes the inner accretion disk and immediate surroundings of the compact object, whereas the synchrotron emission from the jets is observed in the radio and infrared bands, and in the future could be detected at even shorter wavelengths. Black-hole X-ray binaries with relativistic jets mimic, on a much smaller scale, many of the phenomena seen in quasars and are thus called microquasars. Because of their proximity, their study opens the way for a better understanding of the relativistic jets seen elsewhere in the Universe. From the observation of two-sided moving jets it is inferred that the ejecta in microquasars move with relativistic speeds similar to those believed to be present in quasars. The simultaneous multiwavelength approach to microquasars reveals in short timescales the close connection between instabilities in the accretion disk seen in the X-rays, and the ejection of relativistic clouds of plasma observed as synchrotron emission at longer wavelengths. Besides contributing to a deeper understanding of accretion disks and jets, microquasars may serve in the future to determine the distances of jet sources using constraints from special relativity, and the spin of black holes using general relativity.

Notizen: Abstract Far-ultraviolet radiation is a ubiquitous, if unanticipated, phenomenon in elliptical galaxies and early-type spiral bulges. It is the most variable photometric feature associated with old stellar populations. Recent observational and theoretical evidence shows that it is produced mainly by low-mass, small-envelope, helium-burning stars in extreme horizontal branch and subsequent phases of evolution. These are probably descendants of the dominant, metal rich population of the galaxies. Their lifetime UV outputs are remarkably sensitive to their physical properties and hence to the age and the helium and metal abundances of their parents. UV spectra are therefore exceptionally promising diagnostics of old stellar populations, although their calibration requires a much improved understanding of giant branch mass loss, helium enrichment, and atmospheric diffusion.

Notizen: Abstract Nuclear magnetic resonance (NMR) measurements of flowing materials are reviewed with emphasis on applications to multiphase flows. After a brief presentation of NMR physics, experimental considerations related to flow measurements are discussed. Both imaging and non-imaging NMR as well as topics such as Earth's field NMR and rapid imaging are covered. Specific topics that follow are tagging and time-of-flight, phase measurement of velocity, diffusion, turbulence, and calibration and validations. Finally, recent applications are reviewed in the areas of sedimentation, suspension flows in Couette and pipe geometries, rheometers and viscometers, liquid-liquid multiphase flows, porous media flow, granular flows, and turbulence.

Notizen: Abstract In this review, we describe the dynamics and thermodynamics of liquid and vapor flow through hot fractured rock. Such flows occur in geothermal reservoirs and have important implications for geothermal power generation; we describe both forced flows associated with liquid injection into such systems, and natural convective flows associated with the vertical heat transfer through such systems. First we focus on permeable media and describe the heat transfer of single-phase liquid or vapor flow through a medium of different temperature. Then we consider the dynamics and thermodynamics of a liquid front as it advances into a superheated region and boils. The morphological stability of such an interface is discussed, and we describe conditions under which the interface breaks down to form a two-phase zone between the liquid and vapor. We next examine the heat transfer and boiling in gravity-driven flows advancing through a superheated permeable rock, identifying that at large times such currents asymptote to a family of similarity solutions. In the second part of the review, we describe the analogous heat transfer and boiling processes associated with liquid flow along a fracture embedded in an impermeable rock. We describe some simple asymptotic solutions for the temperature distribution in the bounding rock, which reveal that in the fracture, a two-phase boiling region develops between the purely liquid and purely vapor zones. Model predictions are successfully tested with laboratory experiments. In the final section of the review, we briefly discuss natural convective flows, illustrating how single-phase and two-phase convective regions interact and in some cases produce instability.

Notizen: Abstract We discuss the thickness of the liquid layer entrained by a solid drawn out of a bath, focusing on the case where the solid is a fiber or a wire. Slow withdrawals out of a pure or a complex fluid are described as well as quick coatings. We specify the general laws of entrainment and stress the cases where the fiber curvature plays a role. We finally give an overview on the further evolution of the coated film.

Notizen: Abstract Noncircular jets have been the topic of extensive research in the last fifteen years. These jets were identified as an efficient technique of passive flow control that allows significant improvements of performance in various practical systems at a relatively low cost because noncircular jets rely solely on changes in the geometry of the nozzle. The applications of noncircular jets discussed in this review include improved large- and small-scale mixing in low- and high-speed flows, and enhanced combustor performance, by improving combustion efficiency, reducing combustion instabilities and undesired emissions. Additional applications include noise suppression, heat transfer, and thrust vector control (TVC). The flow patterns associated with noncircular jets involve mechanisms of vortex evolution and interaction, flow instabilities, and fine-scale turbulence augmentation. Stability theory identified the effects of initial momentum thickness distribution, aspect ratio, and radius of curvature on the initial flow evolution. Experiments revealed complex vortex evolution and interaction related to self-induction and interaction between azimuthal and axial vortices, which lead to axis switching in the mean flow field. Numerical simulations described the details and clarified mechanisms of vorticity dynamics and effects of heat release and reaction on noncircular jet behavior. The research on noncircular jets has also led to technology transfer. A topic that started as an academic curiosity-an interesting flow phenomenon-subsequently has had various industrial applications. The investigations reviewed include experimental, theoretical, numerical, and technological aspects of the subject.

Notizen: Abstract An overview of preconditioning for the steady-state compressible inviscid fluid dynamic equations is presented. Extensions to the Navier-Stokes equations are also considered. These preconditioners are necessary for many algorithms in order to have the correct behavior at low speeds and to converge to the solution of the incompressible equations as the Mach number goes to zero. In addition, the preconditioning accelerates the convergence to a steady state for problems in which a significant portion of the flow is low speed. This low speed preconditioner can be combined with Jacobi and line preconditioners to damp high frequencies at all speeds. This is necessary for use with multigrid methods. Such combined methods are also better at accelerating problems with high aspect ratios. Details of the implementation are presented including several different variants for the preconditioning matrix.

Notizen: Abstract The paper reviews striking features of swirling flows-collapse, swirl generation, vortex breakdown, hysteresis, and axisymmetry breaking-and the mechanisms involved with the help of conical similarity solutions of the Navier-Stokes equations. The strong accumulation of axial and angular momenta, observed in tornadoes and flows over delta wings, corresponds to collapse, i.e. the singularity development in these solutions. Bifurcation of swirl explains the threshold character of swirl development in capillary and electrovortex flows. Analytical solutions for fold catastrophes and hysteresis reveal why there are so few stable states and why the jump transitions between the states occur-features typical of tornadoes, of flows over delta wings, and in vortex devices. Finally, the divergent instability explains such effects as the splitting of a tornado and the development of spiral branches in tree and near-wall swirling flows.

Notizen: Abstract An RNA fold is the result of packing together two or more coaxial helical stacks. To date, four RNA folds have been determined at near-atomic resolution by X-ray crystallography: transfer RNA, the hammerhead ribozyme, the P4-P6 domain of the Tetrahymena group I intron, and the hepatitis delta virus ribozyme. All four folds result in RNAs that are considerably more compact than isolated A-form duplexes. These structures illustrate, to varying degrees, three modes of fold stabilization: association of complementary molecular surfaces, stabilization of close RNA packing by binding of cations, and stabilization through pseudoknotting.

Notizen: Abstract The F0F1 ATP synthase is a large multisubunit complex that couples translocation of protons down an electrochemical gradient to the synthesis of ATP. Recent advances in structural analyses have led to the demonstration that the enzyme utilizes a rotational catalytic mechanism. Kinetic and biochemical evidence is consistent with the expected equal participation of the three catalytic sites in the alpha3beta3 hexamer, which operate in sequential, cooperative reaction pathways. The rotation of the core gamma subunit plays critical roles in establishing the conformation of the sites and the cooperative interactions. Mutational analyses have shown that the rotor subunits are responsible for coupling and in doing so transmit specific conformational information between transport and catalysis.

Notizen: Abstract Solid-state nuclear magnetic resonance (NMR) is rapidly emerging as a successful and important technique for protein and peptide structural elucidation from samples in anisotropic environments. Because of the diversity of nuclei and nuclear spin interactions that can be observed, and because of the broad range of sample conditions that can be studied by solid-state NMR, the potential for gaining structural constraints is great. Structural constraints in the form of orientational, distance, and torsional constraints can be obtained on proteins in crystalline, liquid-crystalline, or amorphous preparations. Great progress in the past few years has been made in developing techniques for obtaining these constraints, and now it has also been clearly demonstrated that these constraints can be assembled into uniquely defined three-dimensional structures at high resolution. Although much progress toward the development of solid-state NMR as a routine structural tool has been documented, the future is even brighter with the continued development of the experiments, of NMR hardware, and of the molecular biological methods for the preparation of labeled samples.

Notizen: Abstract Stably folded membrane proteins reside in a free energy minimum determined by the interactions of the peptide chains with each other, the lipid bilayer hydrocarbon core, the bilayer interface, and with water. The prediction of three-dimensional structure from sequence requires a detailed understanding of these interactions. Progress toward this objective is summarized in this review by means of a thermodynamic framework for describing membrane protein folding and stability. The framework includes a coherent thermodynamic formalism for determining and describing the energetics of peptide-bilayer interactions and a review of the properties of the environment of membrane proteins-the bilayer milieu. Using a four-step thermodynamic cycle as a guide, advances in three main aspects of membrane protein folding energetics are discussed: protein binding and folding in bilayer interfaces, transmembrane helix insertion, and helix-helix interactions. The concepts of membrane protein stability that emerge provide insights to fundamental issues of protein folding.

Notizen: Abstract Bacteriorhodopsin is the best understood ion transport protein and has become a paradigm for membrane proteins in general and transporters in particular. Models up to 2.5 A resolution of bacteriorhodopsin's structure have been published during the last three years and are basic for understanding its function. Thus one focus of this review is to summarize and to compare these models in detail. Another focus is to follow the protein through its catalytic cycle in summarizing more recent developments. We focus on literature published since 1995; a comprehensive series of reviews was published in 1995 (112).

Notizen: Abstract Gravitational lenses can provide crucial information on the geometry of the Universe, on the cosmological scenario of formation of its structures as well as on the history of its components with look-back time. In this review, I focus on the most recent results obtained during the last five years from the analysis of the weak lensing regime. The potential of weak lensing as a probe of dark matter and the study of the coupling between light and mass on scales of clusters of galaxies, large-scale structures and galaxies is discussed first. Then I present the impact of weak lensing for the study of distant galaxies and of the population of lensed sources as a function of redshift. Finally, I discuss the potential of weak lensing to constrain the cosmological parameters, either from pure geometrical effects observed in peculiar lenses, or from the coupling of weak lensing with the CMB.

Notizen: Abstract Because of mean distortion, most turbulent flows are anisotropic. Two-point descriptions, forming the heart of this review of anisotropic models, capture the continuum of anisotropically structured turbulent scales and, moreover, allow exact treatment of the linear terms representing mean distortion, only needing closure assumptions for the nonlinear part of the model. The rapid-distortion limit, in which nonlinear terms are neglected, is the main subject of Section 2, while Section 3 introduces nonlinearity. It is shown that, even with significant nonlinearity, many features of turbulence can, at least qualitatively, be understood using linear theory alone, e.g. the directionality of velocity fluctuations and correlation lengths induced by strong mean shear near a wall or straining by duct flow, whereas some, e.g. wave resonances in rotating turbulence, involve a subtle combination of linear and nonlinear terms. The importance of linear effects is reflected in the triadic models of Section 3, which contain no approximations of the linear terms and whose anisotropic nonlinear closures are heavily dependent on linear theory. Despite being fundamentally less satisfactory (because they involve additional ad hoc hypotheses to compensate for the lack of two-point information), one-point models dominate industrial calculations because they are robust, well-established, and computationally relatively cheap. Although there are too many spectral degrees of freedom for a one-point model to reproduce two-point results in all circumstances, two-point theories-in particular RDT-have been exploited to develop new one-point models, as discussed in Section 4. Given the significant limitation of classical two-point models to homogeneous turbulence, some inhomogeneous extensions are described in Section 5.

Notizen: Abstract Natural ventilation of buildings is the flow generated by temperature differences and by the wind. The governing feature of this flow is the exchange between an interior space and the external ambient. Although the wind may often appear to be the dominant driving mechanism, in many circumstances temperature variations play a controlling feature on the ventilation since the directional buoyancy force has a large influence on the flow patterns within the space and on the nature of the exchange with the outside. Two forms of ventilation are discussed: mixing ventilation, in which the interior is at an approximately uniform temperature, and displacement ventilation, where there is strong internal stratification. The dynamics of these buoyancy-driven flows are considered, and the effects of wind on them are examined. The aim behind this work is to give designers rules and intuition on how air moves within a building; the research reveals a fascinating branch of fluid mechanics.

Notizen: Abstract This review deals primarily with the bifurcation, stability, and evolution of gravity and capillary-gravity waves. Recent results on the bifurcation of various types of capillary-gravity waves, including two-dimensional solitary waves at the minimum of the dispersion curve, are reviewed. A survey of various mechanisms (including the most recent ones) to explain the frequency downshift phenomenon is provided. Recent significant results are given on "horseshoe" patterns, which are three-dimensional structures observable on the sea surface under the action of wind or in wave tank experiments. The so-called short-crested waves are then discussed. Finally, the importance of surface tension effects on steep waves is studied.

Notizen: Abstract A review of planetary-entry gas dynamics is presented. Evolution of a blunt-body flowfield from a free molecular flow environment to a continuum environment is described. Simulations of near-wake flow phenomena, important for defining aerobrake payload environments, are also discussed. Some topics to be highlighted include aerodynamic coefficient predictions with emphasis on high-temperature gas effects; surface heating and temperature predictions for thermal protection system (TPS) design in a high-temperature, thermochemical nonequilibrium environment; and thermochemical models required for numerical flow simulation. Recent applications involving atmospheric entry into Jupiter (Galileo), Mars (Pathfinder and Global Surveyor), and a planned mission in which dust from the tail of a comet will be returned to Earth (Stardust) will provide context for this discussion.

Notizen: Abstract I was born and educated in Canada, obtaining my PhD in experimental nuclear physics. When I learned that technetium had been found in stellar spectra, I taught myself some astrophysics and began to study stellar nucleosynthesis. This is an account of those studies and of the pathway through much of theoretical astrophysics and planetary physics that was a natural outgrowth of the pursuit of nucleosynthesis problems. I also discuss my experiences in government service and in academia, in organization of conferences, in governmental advising, and in academic administration. In particular, I emphasize the logical connections among the various scientific themes that I have pursued.

Notizen: Abstract In 1960 ICSU set up an Inter-Union Commission (IUCAF) on the Allocation of Frequencies for Space Research and Radio Astronomy, to keep key parts of the radio spectrum clear for passive, scientific use. IUCAF represents URSI, IAU and COSPAR at World Radio Conferences (WRCs) convened by the International Telecommunications Union (ITU) in Geneva; the WRCs establish the international law which governs users of the radio spectrum. This review recounts many serious threats posed to passive scientific research by commercial and military operations, particularly those involving radio emissions from aircraft and spacecraft. The continual conflict between commercial greed and scientific curiosity has often put the future of radio astronomy, space research, and earth exploration in jeopardy. The conflict increases as we move into the Information Age.

Notizen: Abstract We present a review of nucleosynthesis in AGB stars outlining the development of theoretical models and their relationship to observations. We focus on the new high resolution codes with improved opacities, which recently succeeded in accounting for the third dredge-up. This opens the possibility of understanding low luminosity C stars (enriched in s-elements) as the normal outcome of AGB evolution, characterized by production of 12C and neutron-rich nuclei in the He intershell and by mass loss from strong stellar winds. Neutron captures in AGB stars are driven by two reactions: 13C(alpha,n)16O, which provides the bulk of the neutron flux at low neutron densities (Nn〈= 107 n/cm3), and 22Ne(alpha,n)25Mg, which is mildly activated at higher temperatures and mainly affects the production of s-nuclei depending on reaction branchings. The first reaction is now known to occur in the radiative interpulse phase, immediately below the region previously homogenized by third dredge-up. The second reaction occurs during the convective thermal pulses. The resulting nucleosynthesis phenomena are rather complex and rule out any analytical approximation (exponential distribution of neutron fluences). Nucleosynthesis in AGB stars, modeled at different metallicities, account for several observational constraints, coming from a wide spectrum of sources: evolved red giants rich in s-elements, unevolved stars at different metallicities, presolar grains recovered from meteorites, and the abundances of s-process isotopes in the solar system. In particular, a good reproduction of the solar system main component is obtained as a result of Galactic chemical evolution that mixes the outputs of AGB stars of different stellar generations, born with different metallicities and producing different patterns of s-process nuclei. The main solar s-process pattern is thus not considered to be the result of a standard archetypal s-process occurring in all stars. Concerning the 13C neutron source, its synthesis requires penetration of small amounts of protons below the convective envelope, where they are captured by the abundant 12C forming a 13C-rich pocket. This penetration cannot be modeled in current evolutionary codes, but is treated as a free parameter. Future hydrodynamical studies of time dependent mixing will be required to attack this problem. Evidence of other insufficiencies in the current mixing algorithms is common throughout the evolution of low and intermediate mass stars, as is shown by the inadequacy of stellar models in reproducing the observations of CNO isotopes in red giants and in circumstellar dust grains. These observations require some circulation of matter between the bottom of convective envelopes and regions close to the H-burning shell (cool bottom processing). AGB stars are also discussed in the light of their possible contribution to the inventory of short-lived radioactivities that were found to be alive in the early solar system. We show that the pollution of the protosolar nebula by a close-by AGB star may account for concordant abundances of 26Al, 41Ca, 60Fe, and 107Pd. The AGB star must have undergone a very small neutron exposure, and be of small initial mass ( ). There is a shortage of 26Al in such models, that however remains within the large uncertainties of crucial reaction rates. The net 26Al production problem requires further investigation.

Notizen: Abstract Quasar (QSO) elemental abundances provide unique probes of high-redshift star formation and galaxy evolution. There is growing evidence from both the emission and intrinsic absorption lines that QSO environments have roughly solar or higher metallicities out to redshifts 〉4. The range is not well known, but solar to a few times solar metallicity appears to be typical. There is also evidence for higher metallicities in more luminous objects and for generally enhanced N/C and Fe/alpha abundances compared with solar ratios. These results identify QSOs with vigorous, high-redshift star formation-consistent with the early evolution of massive galactic nuclei or dense protogalactic clumps. However, the QSOs offer new constraints. For example, (a) most of the enrichment and star formation must occur before the QSOs "turn on" or become observable, on time scales of 1 Gyr at least at the highest redshifts. (b) The tentative result for enhanced Fe/alpha suggests that the first local star formation began at least ~1 Gyr before the QSO epoch. (c) The star formation must ultimately be extensive to reach high metallicities; that is, a substantial fraction of the local gas must be converted into stars and stellar remnants. The exact fraction depends on the shape of the initial mass function (IMF). (d) The highest derived metallicities require IMFs that are weighted slightly more toward massive stars than in the solar neighborhood. (e) High metallicities also require deep gravitational potentials. By analogy with the well-known mass-metallicity relation among low-redshift galaxies, metal-rich QSOs should reside in galaxies (or protogalaxies) that are minimally as massive (or as tightly bound) as our own Milky Way.

Notizen: Abstract We illustrate how cogent visiometrics can provide peak insights that lead to pathways for discovery through computer simulation. This process includes visualizing, quantifying, and tracking evolving coherent structure morphologies. We use the vortex paradigm (Hawley & Zabusky 1989) to guide, interpret, and model phenomena arising in numerical simulations of accelerated inhomogeneous flows, e.g. Richtmyer-Meshkov shock-interface and shock-bubble environments and Rayleigh-Taylor environments. Much of this work is available on the Internet at the sites of my collaborators, A Kotelnikov, J Ray, and R Samtaney, at our Vizlab URL, http://vizlab.rutgers.edu/vizlab.html.

Notizen: Abstract The physical conditions in molecular clouds control the nature and rate of star formation, with consequences for planet formation and galaxy evolution. The focus of this review is on the conditions that characterize regions of star formation in our Galaxy. A review of the tools and tracers for probing physical conditions includes summaries of generally applicable results. Further discussion distinguishes between the formation of low-mass stars in relative isolation and formation in a clustered environment. Evolutionary scenarios and theoretical predictions are more developed for isolated star formation, and observational tests are beginning to interact strongly with the theory. Observers have identified dense cores collapsing to form individual stars or binaries, and analysis of some of these cores support theoretical models of collapse. Stars of both low and high mass form in clustered environments, but massive stars form almost exclusively in clusters. The theoretical understanding of such regions is considerably less developed, but observations are providing the ground rules within which theory must operate. The richest and most massive star clusters form in massive, dense, turbulent cores, which provide models for star formation in other galaxies.

Notizen: Abstract The completion and publication of the Hipparcos astrometric catalogue has revitalized studies in many fundamental areas of Galactic structure and stellar evolution. This article reviews the impact of the new parallax results on our understanding of the location of the main-sequence as a function of abundance, of the luminosity calibration of primary distance indicators and of the Galactic distance scale. Many of these issues remain to be resolved.

Notizen: Abstract Observational studies of low-mass stars during their early stages of evolution, from protostars through the zero-age main sequence, show highly elevated levels of magnetic activity. This activity includes strong fields covering much of the stellar surface and powerful magnetic reconnection flares seen in the X-ray and radio bands. The flaring may occur in the stellar magnetosphere, at the star-disk interface, or above the circumstellar disk. Ionization from the resulting high-energy radiation may have important effects on the astrophysics of the disk, such as promotion of accretion and coupling to outflows, and on the surrounding interstellar medium. The bombardment of solids in the solar nebula by flare shocks and energetic particles may account for various properties of meteorites, such as chondrule melting and spallogenic isotopes. X-ray surveys also improve our samples of young stars, particularly in the weak-lined T Tauri phase after disks have dissipated, with implications for our understanding of star formation in the solar neighborhood.

Notizen: PROLOGUE In 1999 we celebrate the 50th anniversary of the initial bringing into operation of the Palomar 200-inch Hale telescope. When this telescope was dedicated, it opened up a much larger and clearer window on the universe than any telescope that had gone before. Because the Hale telescope has played such an important role in twentieth century astrophysics, we decided to invite one or two of the astronomers most familiar with what has been achieved at Palomar to give a scientific commentary on the work that has been done there in the first fifty years. The first article of this kind which follows is by Allan Sandage, who has been an active member of the staff of what was originally the Mount Wilson and Palomar Observatories, and later the Carnegie Observatories for the whole of these fifty years. The article is devoted to the topics which covered the original goals for the Palomar telescope, namely observational cosmology and the study of galaxies, together with discoveries that were not anticipated, but were first made at Palomar and which played a leading role in the development of high energy astrophysics. The Palomar work first showed how optical astronomy would be the key to our understanding of observations made in other parts of the electromagnetic spectrum, particularly at radio wavelengths and at X-ray energies. -Geoffrey Burbidge, Editor An account is given of the history of two observational programs set for the Palomar 200-inch telescope, one by Walter Baade and the other by Edwin Hubble near the start of the scheduled operation of the telescope 50 years ago. The review is partly an assessment of whether, and how well, these programs have been carried to completion, and partly an account of the response of Palomar to new discoveries and developments not foreseen in 1950. Stellar evolution, the discovery of variations in the metallicity of stars of different populations, the chemical evolution of the Galaxy, the Cepheid P-L relation, the redshift-distance relation of the expanding universe, and the extragalactic distance scale are discussed as they relate to the predictions for progress on the programs set out by Baade and Hubble. Not foreseen was the invention and development of radio astronomy and high energy astrophysics, leading to the discovery of radio galaxies, quasars, and the gradual realization of violent events, both in stars and in galaxies. The review is highly restricted to these subjects, covering only three areas among the totality of the work in observational astrophysics studied during the first 50 years at Palomar.

Notizen: Abstract This article reviews the transport properties of coherent vortices in rotating barotropic flows. It is shown that vortices induce regular Lagrangian motion inside their cores and are highly impermeable to inward and outward particle fluxes. Passive tracers can be trapped inside vortex cores for long times and are transported by the vortex motion over large distances. Absolute dispersion in vortex-dominated flows is discussed by studying particle dynamics in 2D turbulence, point-vortex systems, and subsurface float trajectories in the ocean. Finally, it is shown that anticyclonic coherent vortices in cyclonically rotating reference frames can concentrate heavy impurities (e.g. dust grains) in their cores. This process may play an important role in the formation of planetesimals in the early solar nebula.

Notizen: Abstract The current state of the art in computational aerodynamics for whole-body aircraft flowfield simulations is described. Recent advances in geometry modeling, surface and volume grid generation, and flow simulation algorithms have led to accurate flowfield predictions for increasingly complex and realistic configurations. As a result, computational aerodynamics has emerged as a crucial enabling technology for the design and development of flight vehicles. Examples illustrating the current capability for the prediction of transport and fighter aircraft flowfields are presented. Unfortunately, accurate modeling of turbulence remains a major difficulty in the analysis of viscosity-dominated flows. In the future, inverse design methods, multidisciplinary design optimization methods, artificial intelligence technology, and massively parallel computer technology will be incorporated into computational aerodynamics, opening up greater opportunities for improved product design at substantially reduced costs.

Notizen: Abstract Magnetic fields can be used to melt, pump, stir, and stabilize liquid metals. This provides a nonintrusive means of controlling the flow of metal in commercial casting and refining operations. The quest for greater efficiency and more control in the production of steel, aluminum, and high-performance superalloys has led to a revolution in the application of magnetohydrodynamics (MHD) to process metallurgy. Three typical applications are described here, chosen partially on the basis of their general interest to fluid dynamicists, and partially because of their considerable industrial importance. We look first at magnetic stirring, where a rotating magnetic field is used to agitate and homogenize the liquid zone of a partially-solidified ingot. This is a study in Ekman pumping. Next, we consider magnetic damping, where an intense, static magnetic field is used to suppress fluid motion. In particular, we look at the damping of jets, vortices, and turbulence. We conclude with a discussion of the magnetic destabilization of liquid-liquid interfaces. This is of particular importance in aluminum production.

Notizen: Abstract We survey the newly developed Hilbert spectral analysis method and its applications to Stokes waves, nonlinear wave evolution processes, the spectral form of the random wave field, and turbulence. Our emphasis is on the inadequacy of presently available methods in nonlinear and nonstationary data analysis. Hilbert spectral analysis is here proposed as an alternative. This new method provides not only a more precise definition of particular events in time-frequency space than wavelet analysis, but also more physically meaningful interpretations of the underlying dynamic processes.

Notizen: Abstract In forthcoming years, connections between cosmology and particle physics will become increasingly important with the advent of a new generation of cosmic microwave background (CMB) experiments. Here, we review a number of these links. Our primary focus is on new CMB tests of inflation. We explain how the inflationary predictions for the geometry of the Universe and primordial density perturbations will be tested by CMB temperature fluctuations, and how the gravitational waves predicted by inflation can be pursued with the CMB polarization. The CMB signatures of topological defects and primordial magnetic fields from cosmological phase transitions are also discussed. Furthermore, we review current and future CMB constraints on various types of dark matter (e.g. massive neutrinos, weakly interacting massive particles, axions, vacuum energy), decaying particles, the baryon asymmetry of the Universe, ultra-high-energy cosmic rays, exotic cosmological topologies, and other new physics.

Notizen: Abstract Data and their interpretations are reviewed for J/psi and psi' production in heavy-ion collisions with particular emphasis on the recently reported anomaly in Pb-Pb reactions. The observed suppressions in pA collisions are discussed in terms of final-state absorption of a pre-meson and the pT distributions due to parton scattering in the initial state. The experimental setup is described and the various results for J/psi and psi' suppressions, including their pT-dependence, are presented. The data, in particular the observed anomalous suppression in Pb-Pb collisions, are discussed in the light of the proposed ideas, among them quark-gluon plasma formation and suppression via co-movers.

Notizen: Abstract We review the direct measurements of the top quark mass Mt using the sample of events collected by the DO and CDF experiments at Fermilab. Measurements using events in the lepton plus jets, dilepton, and all-hadronic decay modes are reviewed, as is the combination of the results to yield the current world average Mt = 174.3 +- 3.2 (stat.) +- 4.0 (syst.) GeV/c2. We close by estimating the precision attainable with future data sets at Fermilab and the Large Hadron Collider.

Notizen: Abstract High-energy jet distributions measured since 1992 at the Fermilab Tevatron proton-antiproton collider are presented and compared with theoretical predictions. The statistical uncertainties on these measurements are significantly reduced relative to previous results. The systematic uncertainties are comparable in size to the uncertainty in the theoretical predictions. Although some discrepancies between theory and measurements are noted, the inclusive jet and dijet cross sections can be described by quantum chromodynamics. Prospects for reducing the uncertainty in the theoretical predictions by incorporating Tevatron measurements into the proton parton distributions are discussed. Dijet distributions, in excellent agreement with quantum chromodynamics, set a 2.5-TeV limit on the mass scale of quark constituents.

Notizen: Abstract Mixed-layer clay minerals are intermediate products of reactions involving pure end-member clays. They come from natural environments ranging from surface to low-grade metamorphic and hydrothermal conditions. Most often mixed layering is essentially two component, but more complicated interstratifications have also been documented. Variable tendency to form regular 1:1 interstratifications has been observed and explanations of this phenomenon have been proposed. Mixed-layer clays are either di- or trioctahedral; di/trioctahedral interstratifications are rare. Most mixed-layer clays contain smectite or vermiculte as a swelling component. Exceptions are all trioctahedral: serpentine/chlorite in low-temperature environments, and mica/chlorite and talc/chlorite at high temperatures. Solid state transformation and dissolution/crystallization are the two mechanisms responsible for the formation of different mixed-layer clays. In general, the weathering reactions that produce mixed layering are reversals of the corresponding high-temperature reactions, but the reaction paths are quite different. Weathering reactions alter smectite into kaolinite via mixed-layer kaolinite/smectite. Illite, chlorite, and micas react into mixed-layer clays involving vermiculite layer, then into vermiculite, and finally smectite. Interstratifications of smectite and glauconite, serpentine and chlorite, and smectite and talc are characteristic of early diagenesis and indicative of sedimentary environments. Three reactions involving mixed-layer clays-smectite to illite, smectite to chlorite, and serpentine/chlorite to chlorite-proceed gradually during burial diagenesis and are used for reconstructing maximum burial conditions, illite/smectite being the most useful tool. Rectorite, tosudite, talc/chlorite, and mica/chlorite are mixed-layer minerals indicative of temperatures higher than diagenetic, characteristic of low-temperature metamorphism or hydrothermal alteration.

Notizen: Abstract In this paper, an overview is presented of coupled processes linking thermo-hydro-mechanical (THM) effects in fractured rocks. A formulation is first presented to show the linkage mathematically, which can be used as a basis for numerical solutions and for further developments. Two simple examples of hydromechanical (HM) and thermo-hydro-mechanical (THM) coupled processes are discussed to convey physical insight into such couplings. Finally, three large-scale, long-term experiments currently under way are described. These are being conducted specifically to study coupled processes in situ.

Notizen: Abstract The Chicxulub crater ejecta stratigraphy is reviewed, in the context of the stratigraphy of underlying and overlying rock sequences. The ejecta sequence is regionally grouped in (a) thick polymict and monomict breccia sequences inside the crater and within 300 km from the rim of the crater known from drill holes in and close to the breater, and exposures near the border of Yucatan and Belize; (b) Gulf of Mexico region, 〈2500 m from the crater, with up to 9 m thick, complex, tsunami-wave influenced, tektite-bearing sequences in shallow marine (〈500 m deep) environments and tektite bearing, decimeter thick gravity-flow deposits in deep water sites; (c) an intermediate region between 2500 and 4000 km from the crater where centimeter thick, tektite-bearing layers occur, and (d) a global distal region with a millimeter thin ejecta layer. The distal ejecta layer is characterized by sub-millimeter sized microkrystites, often rich in Ni-rich spinels and (altered) clinopyroxene. Wherever present, the ejecta layers mark exactly the sudden mass-mortality horizon of the K/T boundary. What exactly caused the mass mortality is still uncertain, but it appears the main event leading to the K/T mass extinctions.

Notizen: Abstract Once disregarded as noise, scattered seismic waves are finding increasing application in subsurface imaging. This sea change is driven by the increasing density and quality of seismic recordings and advances in waveform modeling which, together, are allowing seismologists to exploit their unique properties. In addition to extensive application in the energy exploration industry, seismic scattering is now used to characterize heterogeneity in the lower continental crust and subcrustal lithosphere, to examine the relationship between crustal structure and seismogenesis, and to probe the plumbing of active volcanoes. In each application, the study of seismic scattering brings wavelength-scale structure into sharper focus and characterizes the short scale-length fabric of geology.

Notizen: Abstract The region of the solar system immediately beyond Neptune's orbit is densely populated with small bodies. This region, known as the Kuiper Belt, consists of objects that may predate Neptune, the orbits of which provide a fossil record of processes operative in the young solar system. The Kuiper Belt contains some of the Solar System's most primitive, least thermally processed matter. It is probably the source of the short-period comets and Centaurs, and may also supply collisionally generated interplanetary dust. I discuss the properties of the Kuiper Belt and provide an overview of the outstanding scientific issues.

Notizen: Abstract Orbitally induced increase in northern summer insolation after growth of a large ice sheet triggered deglaciation and associated global warming. Ice-albedo, sea-level, and greenhouse-gas feedbacks, together with tropical warming from weakening winds in response to polar amplification of warming, caused regional-to-global (near-) synchronization of deglaciation. Effects were larger at orbital rather than millennial frequencies because ice sheets and carbon dioxide vary slowly. Ice-sheet-linked changes in freshwater delivery to the North Atlantic, and possibly free oscillations in the climate system, forced millennial climate oscillations associated with changes in North Atlantic deep water (NADW) flow. The North Atlantic typically operates in one of three modes: modern, glacial, and Heinrich. Deglaciation occurred from a glacial-mode ocean that, in comparison to modern, had shallower depth of penetration of NADW formed further south, causing strong northern cooling and the widespread cold, dry, and windy conditions associated with the glacial maximum and the cold phases of the millennial Dansgaard-Oeschger oscillations. The glacial mode was punctuated by meltwater-forced Heinrich conditions that caused only small additional cooling at high northern latitudes, but greatly reduced the formation of NADW and triggered an oceanic "seesaw" that warmed some high-latitude southern regions centered in the South Atlantic.

Notizen: Abstract Cenozoic extension in the western United States presents a complex interrelation of extension, volcanism, and plate boundary tectonics that defeats simple notions of "active" or "passive" rifting. Forces driving extension can originate at plate boundaries, through basal traction, basal normal forces, or from buoyancy forces internal to the crust and lithospheric mantle. The latter two are most responsible for driving extension where it is observed in the Basin and Range. The complex evolution of the northern Basin and Range probably represents removal or alteration of mantle lithosphere interacting with buoyancy stored in the crust. In contrast, crustal buoyancy forces combined with a divergent plate boundary between about 28 and 16 Ma to drive extension in the southern Basin and Range. The central Basin and Range most likely extended as a result of boundary forces external to itself but arising from buoyancy forces elsewhere in the western United States.

Notizen: Abstract The history of carnivorous mammals is characterized by a series of rise-and-fall patterns of diversification in which declining clades are replaced by phylogenetically distinct but functionally similar clades. Seven such examples from the last 46 million years are described for North America and Eurasia. In three of the seven turnover events, competition with replacement taxa may have driven the decline of formerly dominant taxa. In the remaining four this is less likely because inferred functional similarity was minimal during the interval of temporal overlap between clades. However, competition still may have been important in producing the rise-and-fall pattern through suppression of evolution within replacement taxa; as long as the large carnivore ecospace was filled, the radiation of new taxa into that ecospace was limited, only occurring after the extinction of the incumbents. The apparently inevitable decline of incumbent taxa may reflect the tendency for clades of large carnivorous mammals to produce more specialized species as they mature, leading to increased vulnerability to extinction when environments change.

Notizen: Abstract Low-mass particles, such as neutrinos, axions, other Nambu-Goldstone bosons, and gravitons, are produced in the hot and dense interior of stars. Therefore, astrophysical arguments constrain the properties of these particles in ways that are often complementary to cosmological arguments and to laboratory experiments. This review provides an update on the most important stellar-evolution limits and discusses them in the context of other information from cosmology and laboratory experiments.

Notizen: Abstract Introduced in 1988, microstrip gas chambers perform considerably better than classic multiwire detectors. Excellent localization, high rate capability, and good granularity make them attractive for charged-particle tracking at high-luminosity colliders, among other applications. The technology continues to improve; for example, substrates have been developed that prevent charge accumulations. Some problems persist, namely the slow degradation under sustained irradiation (aging) and the serious damage that can result from accidental discharges. New types of detectors aim at improving on these points; the microdot, micromegas, and gas electron multiplier detectors are promising examples. They are generally more reliable and cheaper.

Notizen: Abstract This paper reviews recent developments in the field of nonlinear chemical kinetics. Five topics are dealt with: (a) new approaches to complex reaction mechanisms, stoichiometric network analysis, classification of chemical oscillators and formulation of their mechanisms by deduction from experiments, and correlation metric construction of reaction pathways from measurements; (b) thermodynamic and stochastic theory of nonequilibrium processes, the eikonal approximation, the evaluation of stochastic potentials, experimental tests of the thermodynamic and stochastic theory of relative stability, and fluctuation-dissipation relations in nonequilibrium chemical systems; (c) chemical kinetics and cellular automata and lattice gas automata; (d) theoretical approaches and experimental studies of stochastic resonance in chemical kinetics; and (e) rate processes in disordered systems, stochastic Liouville equations, stretched exponential relaxation in disordered systems, and universality classes for rate processes in systems with static or dynamic disorder.

Notizen: Abstract Experimental and computational studies of photophysical processes in silver halide imaging materials are presented. Recent investigations that have refined our understanding of carrier recombination paths, exciton behavior, quantum confinement effects, and the structure and function of small surface silver clusters are detailed. The theory and mechanism of electron and hole injection from photoexcited surface-adsorbed dye molecules are outlined. The carrier trapping properties and subsequent photophysics of transition-metal dopant complexes are presented. Particular emphasis is given to the role of relaxation processes in electron and hole trapping events.

Notizen: Abstract The elastic, thermodynamic, and transport properties of crystals and fluids at high temperature and pressure play a central role in the earth and planetary sciences as well as in a variety of technologies. These properties also constitute a principal experimental constraint on the description of intermolecular interactions at short distances. Aspects of "impulsive stimulated scattering," when adapted to measurements in the diamond-anvil high-pressure cell, provide an approach to the determination of a subset of equilibrium and dynamic properties at high density.

Notizen: Abstract This review is about understanding and controlling organic molecular adsorption on silicon. The goal is to provide a microscopic picture of structure and bonding in covalently attached molecule-silicon surface systems. The bias here is that an unprecedented, detailed understanding of adsorbate-surface structures is required in order to gain the control necessary to incorporate organic function into existing technologies or, eventually, to make new molecule-scale devices. A discussion of recent studies of adsorbate structure is presented. This includes simple alkenes, polyenes, benzene, and carene adsorbed on Si(100). Also included is a discussion of wet chemical procedures for forming alkyl and alkoxy covalently functionalized silicon. These discussions are presented together with comments on the related issues of adsorption dynamics and nano-scale manipulation in an effort to point the way toward principles and procedures that will allow the hybrid properties of organic molecules and surfaces to be harnessed.

Notizen: Abstract This paper describes the reproducing kernel Hilbert space (RKHS) method for constructing accurate, smooth, and efficient global potential energy surface (PES) representations for polyatomic systems using high-level ab initio data. The RKHS method provides a rigorous and effective framework for smooth multivariate interpolation of arbitrarily scattered data points and also for incorporating various physical requirements onto the PESs. Smoothness, permutation symmetry, and the asymptotic properties of polyatomic systems can be incorporated into the construction of reproducing kernels to render globally accurate PESs. Tensor products of one-dimensional generalized-spline-reproducing kernels are amenable to a fast algorithm, which makes a single evaluation of RKHS PESs essentially independent of the number of interpolated ab initio data points. This efficient implementation enables the study of the detailed dynamics of polyatomic systems based on high-quality RKHS PESs.

Notizen: Abstract Although exploration by remote, in situ spacecraft has been the primary tool used in scientific exploration of the planets and other solar system objects for the last three decades, the unique capabilities of the Hubble Space Telescope (HST) have made it an invaluable tool for solar system research and have led to many important discoveries. HST's extended lifetime has made it possible to continue observations of planets and satellites that were started by earlier space missions and has thereby provided new insight into dynamic surface and atmospheric phenomena on these bodies. The ultraviolet capability of HST has made it possible to study important time-variable phenomena such as the auroras on Jupiter and Saturn and the circulation of planetary atmospheres. This review provides an overview of HST observations of and discoveries relating to planets and satellites in the solar system.

Notizen: Abstract Deepwater formation, the process whereby surface water is actively converted into deep water through heat and freshwater exchange at the air-sea interface, is known to occur in the North Atlantic but not in the North Pacific. As such, the thermohaline circulation is fundamentally different in these two regions. In this review we provide a description of this circulation and outline a number of reasons as to why deep water is formed in the North Atlantic but not in the North Pacific. Special emphasis is given to the role of interactions with the Arctic Ocean. We extend our analysis to discuss the observational evidence and current theories for decadal-interdecadal climate variability in each region, with particular focus on the role of the ocean. Differences between the North Atlantic and North Pacific are highlighted.

Notizen: Abstract Stromatolites are attached, lithified sedimentary growth structures, accretionary away from a point or limited surface of initiation. Though the accretion process is commonly regarded to result from the sediment trapping or precipitation-inducing activities of microbial mats, little evidence of this process is preserved in most Precambrian stromatolites. The successful study and interpretation of stromatolites requires a process-based approach, oriented toward deconvolving the replacement textures of ancient stromatolites. The effects of diagenetic recrystallization first must be accounted for, followed by analysis of lamination textures and deduction of possible accretion mechanisms. Accretion hypotheses can be tested using numerical simulations based on modern stromatolite growth processes. Application of this approach has shown that stromatolites were originally formed largely through in situ precipitation of laminae during Archean and older Proterozoic times, but that younger Proterozoic stromatolites grew largely through the accretion of carbonate sediments, most likely through the physical process of microbial trapping and binding. This trend most likely reflects long-term evolution of the earth's environment rather than microbial communities.

Notizen: Abstract Measurements of transverse beam size are tremendously important to the performance of e+e- linear colliders. In this paper we review the traditional technologies used to make such measurements, such as profile monitors and wire scanners, and their limitations. We introduce a new technique for electron beam-size measurement: Compton-scattered laser light, which may be used as an unbreakable "wire" or in the form of an interferometer beam-size monitor (BSM). We describe the use of such an interferometer BSM, noting both the general issues related to its design and operation and the specific experiences with such an interferometer at the Final Focus Test Beam at SLAC. We conclude by considering the ultimate limitations of the laser-interferometer BSM.

Notizen: Abstract We review the study of the internal spin structure of the proton and neutron. High-energy scattering of polarized leptons by polarized protons, neutrons, and deuterons provides a measurement of the nucleon spin structure functions. These structure functions give information on the polarized quark contributions to the spin of the proton and the neutron and allow tests of the quark-parton model and quantum chromodynamics. We discuss the formalism of deep inelastic scattering of polarized leptons on polarized nucleons, the past decade of experimental progress, and future programs to measure the polarized gluon contribution to the proton spin.

Notizen: Abstract The question of neutrino mass is one of the major riddles in particle physics. Recently, strong evidence that neutrinos have nonzero masses has been found. Though tiny, these masses could be large enough to contribute significantly to the mass density of the universe. The evidence for nonvanishing neutrino masses is based on the apparent observation of neutrino oscillation-the transformation of a neutrino from one type or "flavor" to another. We explain the physics of neutrino oscillation and review and weigh the evidence that it actually occurs in nature. We discuss the constraints on neutrino mass from cosmology and from experiments with negative results. After presenting illustrative neutrino mass spectra suggested by the present data, we consider how experiments in the near and distant future can further illuminate the nature of neutrinos and their masses.

Notizen: Abstract We provide an up-to-date account of progress toward understanding the origin of the observed baryon asymmetry of the universe. We provide a pedagogical introduction to the primary areas of research in this field, giving a detailed description of the different scenarios. The very recent developments in Grand-Unified-Theory baryogenesis, leptogenesis, electroweak baryogenesis, and the Affleck-Dine mechanism are presented. In particular, we focus on specific particle physics implementations, mostly in the context of supersymmetry, which lead to specific testable predictions.

Notizen: Abstract We review the production of high-mass lepton pairs in fixed-target experiments, including both Drell-Yan (DY) and heavy quarkonium production [J/psi, psi', Upsilon(1S), Upsilon(2S), and Upsilon(3S)]. In recent years, DY data have become standard input to the determination of parton density distributions. DY data have recently yielded the first measurement of the x dependence of the , asymmetry of the proton. Similar to the observations in deeply inelastic scattering, precision measurements of the nuclear dependence of the proton-induced DY process exhibit shadowing at small target momentum fraction, x2. There is, however, no evidence of enhanced DY production from nuclear targets. Mean transverse momenta of DY pairs are observed to increase with target mass. These data, analyzed within a new theoretical framework, provide an estimation of the energy loss of fast quarks in nuclear matter. In contrast to the DY process, there are large nuclear effects in the production of all quarkonia. These effects show strong dependence on pt and xF but do not scale with x2. Statistically less precise measurements of D meson (open-charm) production at small xF are consistent with no nuclear dependence.

Notizen: Abstract Two-particle momentum correlations between pairs of identical particles produced in relativistic heavy-ion reactions can be analyzed to extract the space-time structure of the collision fireball. We review recent progress in the application of this method, based on newly developed theoretical tools and new high-quality data from heavy-ion collision experiments. Implications for our understanding of the collision dynamics and for the search for the quark-gluon plasma are discussed.

Notizen: The field of planetary science as it developed during the lifetimes of Gene and Carolyn Shoemaker has sustained a period of exciting growth. Surveying the skies for planet-crossing asteroids and comets and studying the results of their impact upon the planets, especially the Earth, was for Gene and Carolyn an intense and satisfying quest for knowledge. It all started when Gene envisioned man going to the Moon, especially himself. After that, one thing led to another: the study of nuclear craters and a comparison with Meteor Crater, Arizona; the Apollo project and a succession of unmanned space missions to the inner and outer planets; an awareness of cratering throughout our solar system; the search for near-Earth asteroids and comets; a study of ancient craters in Australia; and the impact of Shoemaker-Levy 9 on Jupiter. The new paradigm of impact cratering as a cause for mass extinction and the opening of space for the development of new life forms have been causes to champion.

Notizen: Abstract Recent developments in the application of K-Ar and 40Ar/39Ar dating of continental weathering process demonstrate the method's suitability for dating minerals present in weathering profiles. Alunite-group sulfates and hollandite-group manganese oxides, which often precipitate through weathering reactions, were first analyzed by the K-Ar method 30 years ago. Recently these minerals were shown to be suitable to 40Ar/39Ar geochronology, despite their fine-grained habits. The bulk nature of the K-Ar technique and the complex mineral assemblages in weathering profiles restrict K-Ar dating of weathering processes. The single-crystal approach possible with the 40Ar/39Ar method allows the study of weathering profiles where alunite- and hollandite-group minerals occur as minor phases. Step-heating analysis possible with the 40Ar/39Ar method provides information about the Ar and K retention histories, the presence of hypogene contaminants, and possible 39Ar recoil during sample irradiation. Fully automated, modern 40Ar/39Ar systems enable analysis of several samples, providing a comprehensive weathering database. These results are useful in the study of continental paleoclimates and the geochemical, geomorphological, and tectonic histories of an area.

Notizen: Abstract The detailed morphology of impact craters is now believed to be mainly caused by the collapse of a geometrically simple, bowl-shaped "transient crater." The transient crater forms immediately after the impact. In small craters, those less than approximately 15 km diameter on the Moon, the steepest part of the rim collapses into the crater bowl to produce a lens of broken rock in an otherwise unmodified transient crater. Such craters are called "simple" and have a depth-to-diameter ratio near 1:5. Large craters collapse more spectacularly, giving rise to central peaks, wall terraces, and internal rings in still larger craters. These are called "complex" craters. The transition between simple and complex craters depends on 1/g, suggesting that the collapse occurs when a strength threshold is exceeded. The apparent strength, however, is very low: only a few bars, and with little or no internal friction. This behavior requires a mechanism for temporary strength degradation in the rocks surrounding the impact site. Several models for this process, including acoustic fluidization and shock weakening, have been considered by recent investigations. Acoustic fluidization, in particular, appears to produce results in good agreement with observations, although better understanding is still needed.

Notizen: Abstract An unexpected excess of events with high Q2 reported by the H1 and ZEUS collaborations at HERA in early 1997 provoked speculation that the production of first-generation leptoquarks had been observed. In this article we review the anomalous HERA events, give a brief summary of the motivation for leptoquarks, and discuss the most recent searches at HERA and the Tevatron for first-, second-, and third-generation leptoquarks as well as generation-changing leptoquarks. We conclude with a short discussion of future prospects for leptoquark searches.

Notizen: Abstract This chapter presents an experimental overview of collective flow phenomena in heavy-ion collisions in the incident energy regime from 100 AMeV to 160 AGeV. The characteristic features of various types of flow are described. The discussion of common dependences on the collision system and bombarding energy focuses on the different time scales of the underlying physics processes. Special emphasis is placed on the presence of structures in the excitation functions. The sensitivity of the available data to changes of nuclear-matter properties, e.g. equation of state, medium effects, and phase transitions, is discussed.

Notizen: Abstract During protein folding, many of the events leading to secondary and tertiary structure occur in milliseconds or faster. Modern nuclear magnetic resonance and laser detection techniques, coupled with fast initiation of the folding reaction, are probing these events in great detail. Theory, ranging from analytical models to molecular dynamics calculations, is beginning to match up with experiment. As a result, timescales, from such elementary steps as the addition of a residue to a helix to strange kinetics of collapsing protein backbones, can now be measured and interpreted.

Notizen: Abstract Neutron scattering represents a versatile technique for chemists, as it explores the structure and dynamics of materials at the atomic scale. This review gives an outline of the neutron scattering formalism and describes diffraction and inelastic and quasielastic scattering techniques. Applications to chemistry are illustrated by examples from recent work on crystalline and liquid organic materials, including heterogeneous systems, bulk polymers and polymer solutions. There is particular emphasis on systems where hydrogen bonding plays a significant role. With more powerful sources and improved instrumentation in prospect, there is considerable potential for future extension of these methods to increasingly complex materials.

Notizen: Abstract Atoms and small molecules react with transition metal clusters in ways that are analogous to the physisorption and chemisorption reactions observed on the corresponding extended metal surface. However, often underlying these similarities are size-dependent variations in the reaction mechanisms and rates, the interpretation of which requires a detailed understanding of the structures of both the bare metal cluster substrates and the cluster-molecule complexes. Although polyatomic transition metal clusters cannot be characterized by the traditional methods of molecular spectroscopy, the combination of other physical and chemical probes can provide qualitative and semiquantitative structural information. These techniques, when combined with equilibrium geometries calculated using ab initio or semiempirical methods, provide a detailed picture of the structural origin of metal cluster reactivity and its variation with size.

Notizen: Abstract Recent studies on fast (〈10 ns) and ultrafast (〈10 ps) photothermal and photoacoustic phenomena occurring at solid-liquid interfaces are discussed, including related topics, with emphasis placed on interfaces between aqueous solutions and metals under electrochemical potential control. Details of transient reflecting grating measurements for metal-liquid interfaces are considered as they relate to mesoscopic interface structures and nano-environments. Dependencies of fast photothermal phenomena on the electrochemical potential and types of anions in the solutions are shown. Ultrafast photothermal phenomena observed by transient reflectivity measurements are considered in connection with interface femtochemistry and hot electron reactions. Technical progress in measuring fast and ultrafast photothermal phenomena is reviewed for solid-liquid interfaces, including colloidal solutions.

Notizen: Abstract Except for ortho- and para-H2, little is known about nuclear spin isomers (or spin modifications) of molecules. The main reason is the lack of practical enrichment techniques. Recently, a few enrichment methods were developed, which opened up new possibilities in the field. These methods are briefly reviewed. Substantial progress in the field has been made by the introduction of light-induced drift as a gas-phase separation tool. This is illustrated by extensive data on CH3F, which reveal that the gas-phase ortho-para conversion is governed by intramolecular mixing of the nuclear spin states. The role of direct ortho-para transitions is small. Various aspects of the conversion were investigated in detail: pressure and collision partner dependence, isotope effect, and temperature dependence. The most decisive information on the spin conversion mechanism is derived from the observation of level-crossing resonances in an electric field and the quantum Zeno effect induced by collisions.

Notizen: This paper reviews the way in which, in the Italy of the years immediately after World War II, interest in the dynamics of molecular processes was awakened. The narrative begins with the work of a small number of chemists and physicists who, in the initial stage, interacted closely. In the course of the years, their interests diverged and younger people joined the newly formed groups. Even now, after half a century, a common approach can still to be seen regarding how to attack problems and perform experiments. Experimental work is discussed, bringing out the common viewpoint of fields as diverse as mass spectrometry, isotope effects, chemical kinetics, molecular beams, molecule-molecule interactions, molecule-ion interactions, molecule-surface interactions, and plasma chemistry.

Notizen: Abstract This review focuses on time-dependent methods suitable for simulating the quantum dynamics of processes in large clusters and condensed-phase environments. A number of mean field, quantum-classical, and quantum statistical approximations that avoid the conventional exponential scaling with the number of degrees of freedom are reviewed. In addition, rigorous semiclassical and path integral approaches are described that are feasible in certain physical situations. Select chemical applications illustrating the capabilities of these methods are discussed.

Notizen: Abstract Recent progress in combining the techniques of time-resolved molecular spectroscopy with shock compression science is reviewed. Shock wave spectroscopy probes the response of molecules to high-speed, large-amplitude mechanical transients and is an important way of studying physical chemical phenomena that involve large-amplitude displacements. A brief discussion of the continuum model for shock compression and a molecular model for the shock front is presented. Methods for generating and detecting shock effects are reviewed. Several applications of shock spectroscopy are reviewed, including high explosives, the nanoshock technique that uses ultrafast lasers, and shock compression of biological molecules.

Notizen: Abstract This article reviews recent progress in our understanding of gas-phase neutral reaction dynamics as made possible by improvements in the crossed molecular beam scattering technique for measuring reactive differential cross sections. A selection of crossed-beam studies on systems that play a fundamental role in our basic understanding of reaction phenomena are discussed to illustrate the capabilities of the experimental method. The examples include benchmark atom-diatom abstraction and insertion reactions, and four-atom radical reactions for which state-to-state, state-resolved, or state-averaged differential cross sections have recently been measured. The results are discussed in the light of the latest related theoretical developments regarding the treatment of potential energy surfaces and the dynamics of the systems. Recent results on crossed-beam studies of chemically relevant reactions of carbon, nitrogen, and oxygen atoms are also reviewed, and the latest developments in the technique are noted.

Notizen: Abstract This review provides a discussion of recent techniques for simulation of phase equilibria of complex fluids. Monte Carlo methods are emphasized over molecular dynamics methods. We describe recent developments, such as the use of expanded-ensemble, tempering, or histogram reweighting techniques. Our discussion of such developments is aimed at a general audience and is intended to provide an overview of the main advantages and limitations of each particular technique. References are provided to allow interested readers to identify and trace back most recent applications of a particular simulation technique. We conclude with general guidelines regarding selection of suitable simulation methods for particular problems and systems of interest.

Notizen: Abstract In this overview we discuss the vibrational spectrum of phosphaethyne, HCP, in its electronic ground state, as revealed by complementary experimental and theoretical examinations. The main focus is the evolution of specific spectral patterns from the bottom of the potential well up to excitation energies of approximately 25,000 cm-1, where large-amplitude, isomerization-type motion from H-CP to CP-H is prominent. Distinct structural and dynamical changes, caused by an abrupt transformation from essentially HC bonding to mainly PH bonding, set in around 13,000 cm-1. They reflect saddle-node bifurcations in the classical phase space-a phenomenon well known in the nonlinear dynamics literature-and result in characteristic patterns in the spectrum and the quantum-number dependence of the vibrational fine-structure constants. Two polar opposites are employed to elucidate the spectral patterns: the exact solution of the Schrodinger equation, using an accurate potential energy surface and an effective or resonance Hamiltonian (expressed in a harmonic oscillator basis set and block diagonalized into polyads), which is defined by parameters adjusted to fit either the measured or the calculated vibrational energies. The combination of both approaches-together with classical mechanics and semiclassical analyses-provides a detailed spectroscopic picture of the breaking of one bond and the formation of a new one.

Notizen: This chapter discusses the impact of two-state models of nonadiabatic coupling by Landau, Zener, Stuckelberg, Rosen, and Teller on the current theory of nonadiabatic interaction. In particular, the idea of analytical continuation of classical dynamical variables into complex-valued phase space and time is emphasized. The development of the basic models over the past 30 years has provided us with a useful means of investigating the nonadiabatic molecular dynamics; this is illustrated by the references to our earlier and most recent work.

Notizen: Abstract Polyelectrolytes are electrolytes asymmetric both in charge and size. Their properties in solution are dominated by Coulombic forces, and without a detailed understanding of these interactions, no interpretation of experimental data is possible. This paper is a review of recent developments in the theory of highly asymmetric electrolytes of spherical shape resembling surfactant micelles. Three different models are discussed: (a) the cell model, which is focused on the small ion-macroion interaction; (b) the model that treats the solution as an effective one-component fluid of macroions; and (c) the isotropic model, where the solution is represented as a mixture of charged spheres. Traditionally, the electrostatic interactions are accounted for via the solution of the Poisson-Boltzmann equation. This theory, however, ignores the fluctuations around the most probable distribution and may yield poor results for systems with multivalent ions. This paper focuses on developments beyond the Poisson-Boltzmann theory; the results of computer simulations and integral equation theories represent the major part of the review.

Notizen: Abstract Recent applications of density functional theory to biologically relevant metal centers are reviewed. The emphasis is on reaction mechanisms, structures, and modeling. The accuracy of different functionals is discussed for standard benchmark tests of first- and second-row molecules and for transition metal systems. Modeling aspects of the protein metal complexes are discussed regarding both the size of the model being treated quantum mechanically and the treatment of the protein surrounding it. To illustrate the effects, structures computed without the effects of the protein are compared with experimental structures from enzymes, and results from simple dielectric models of the protein for electron transfer processes are described. The choice of spin state is discussed for multimetal complexes. Examples of mechanisms studied recently by density functional theory are described, such as O2 and methane activation in methane monooxygenase and O2 formation in photosystem II.

Notizen: Abstract The basic principles and recent advances in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry are reviewed. A brief history of electrospray ionization is provided, along with a complete technical description of the technique, electrospray ionization variations, and advantages. Next, the fundamental principles of Fourier transform ion cyclotron resonance mass spectrometry are covered, including ion cyclotron motion, ion cyclotron resonance excitation, and image current detection. Instrumentation and methods used to couple these techniques are then described. Topics include ion source configuration, ion transport through a strong magnetic field gradient, and ion trapping methods. The article concludes with selected applications that highlight the strengths of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.

Notizen: Nowadays in order to contribute to the competitive strength of the organization empowerment is seen as a useful tool. But the organization must know what it wants to empower. Therefore it must be able to map the desired skills and competence levels for the workforce and to compare these with the actual situation. This article gives an overview of how to set up skills and competence management.

Notizen: This paper seeks to investigate the constitutive meaning of creativity as a construct through the relation between creativity and other constructs and to assess the possible effects of organizational climate on managers' creativity in Lebanon. The present study examines the construct validity of the KEYS instrument in order to gain further insights into the factors stimulating or hindering creativity in Lebanon and to create an environment infrastructure that encourages and reinforces creativity in developing countries.

Notizen: This paper presents some of the major learning points of a study in innovation practices in Indian organizations. It explains the current concerns and imperatives of Indian organizations since the liberalization, privatization and globalization processes started in 1991. We attempt to formulate the logical distinctions between different clusters and hypothesize the phenomenon of innovation. We identify the innovative outcomes and the constraining forces. A model is proposed to understand the strategic implications. Value innovations require an organizational commitment to create a strong momentum for inside-in changes and the deeper the commitment, the more likely organizations are to advance in bringing inside-out value creating outcomes and attaining superior positions in the competition pace.

Notizen: This paper explores the impact of affirmative action on the culture of small business enterprises in South Africa. The functions of organizational culture are explored and utilized to reach a deeper understanding of the desired impact of affirmative action. Managers are identified as holding key roles as change agents. Recommendations include managing change from a culture perspective directed at creating participative management processes and shifting the enterprise's essential values.

Notizen: Discusses flexibility and the ability to adapt as an essential attribute of leadership that is beyond technical competence. Defines flexibility as a process of continually examining situations and, when warranted, quickly adapting to changing circumstances. Examines the power of flexibility as it relates to changes in science, medicine and business practice. Defines flexibility as a tool to be used only by the brave and not as a shield for cowards who fear the harsh realities of decision making. Depicts flexibility as an essential behaviour that promotes and supports quality leadership. Provides guidance, techniques and examples that can be used to enhance leadership skills. Establishes a sound philosophy to increase the probability for long-term success and professional fulfillment. Includes quotes from contemporary as well as historical leaders.

Notizen: The concept of empowerment has received a great deal of attention in recent years. However, the empowerment knowledge base is predominantly large company-oriented with little evidence of understanding what empowerment means in a small business context. It is inappropriate to treat the small firm as a microcosm of a large organisation. The small business is qualitatively as well as quantitatively different and this article propounds that it is questionable whether the concept of empowerment and its various dimensions as portrayed in the literature are readily transferable to small businesses. It is suggested that empowering management approaches are key features of successful growth-oriented small firms but the current body of empowerment literature fails to encapsulate the idiosyncrasies and informalities of the small business operation, and thus convey understanding of the unique and novel forms of empowerment which facilitate sustainable development. Case study insight is used to support these propositions.

Notizen: This paper discusses the attitude and views of travel consultants on the impact of Internet related technologies on their future employment and their abilities to cope with the threat of dis-intermediation. The authors anticipate that changes in the travel distribution process brought about by the Internet and other technologies will result in retail travel agencies experiencing lower business volume and hence difficulty in maintaining business viability. Against this background, a number of questions need to be addressed. What is the attitude of consultants towards new technologies in travel distribution? Are travel consultants prepared to meet the new challenges? What will be the role of travel consultants? Using a survey of 102 travel consultants, the paper shows the lack of awareness and negative attitude displayed by travel consultants in this rapidly changing distribution environment. The paper further suggests measures and training programs that could be undertaken to address the situation.