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  • Articles  (112)
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  • Articles: DFG German National Licenses  (112)
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  • 1
    Electronic Resource
    Electronic Resource
    Bone photovoltaic cell in hall geometry (1981)
    Springer
    Calcified tissue international 33 (1981), S. 239-242 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Magnetic field ; IR light ; Light absorption constant ; Efficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Enhancement of photovoltage has been found in bone and its two major constituents when placed in a magnetic field in standard Hall geometry. Infrared light has been used for carrier excitation. From data obtained in this manner, values for the light absorption constant, extinction constant, mass absorption constant, and efficiency have been estimated. All these parameters increase with the increase of magnetic field. A possible explanation for the observed phenomena is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409443
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on the role of 24-hydroxylation of vitamin D in the mineralization of cartilage and bone of vitamin D-deficient rats (1981)
    Springer
    Calcified tissue international 33 (1981), S. 489-497 
    Details
    ISSN: 1432-0827
    Keywords: Vitamin D ; Vitamin D deficiency ; Cartilage ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary To test the importance of 24-hydroxylation of vitamin D3 on bone mineralization, rat pups born to vitamin D-deficient females were given either 25-hydroxyvitamin D3 or 24,24-difluoro-25-hydroxyvitamin D3 for 16 days beginning at the time of weaning. Following such treatment analysis of blood samples revealed no detectable 24R,25-(OH)2D3 and 1,25-(OH)2D3 in the rats given the difluoro compound while revealing the expected 24,24-difluoro-25-hydroxyvitamin D3 and 24,24-difluoro-1,25-dihydroxyvitamin D3. The rats given 25-hydroxyvitamin D3 had the expected levels of 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, and 1,25-dihydroxyvitamin D3. Following sacrifice at day 17, postweaning bone mineralization and modeling were studied in long bones using histological methods. Bones taken from vitamin D-deficient rats at the beginning and end of the experimental period had lesions typical of rickets. These included wide growth plates, excessive amounts of osteoid, and metaphyseal fibrosis. Following treatment with either 25-hydroxyvitamin D3 or 24,24-difluoro-25-hydroxyvitamin D3, bone mineralization returned to normal. Growth plate widths and the amount of osteoid on bone surfaces were both substantially reduced and to a similar degree in both treatment groups. Normal cartilage core formation and trabecularization of the metaphyseal primary spongiosa were also restored to a similar degree in both groups. In effect, no difference was observed in any bone parameter studied between the 25-hydroxyvitamin D3- and the 24,24-difluoro-25-hydroxyvitamin D3-treated animals. These results provide strong evidence that 24-hydroxylation of the vitamin D molecule plays little or no role in the modeling and mineralization of bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409479
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of 1,25-, 25-, and 24,25-hydroxylated vitamin D3 binding in fetal rat calvariae and osteogenic sarcoma cells (1981)
    Springer
    Calcified tissue international 33 (1981), S. 655-661 
    Details
    ISSN: 1432-0827
    Keywords: 1,25-Dihydroxyvitamin D3 ; 25-Hydroxyvitamin D3 ; 24,25-Dihydroxyvitamin D3 ; Receptors ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The hormonal metabolite of vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], exerts its biological effects by binding to a cytosolic receptor protein. Such a protein has been demonstrated in vitamin D3 target organs including fetal rat calvariae and more recently in rat osteogenic sarcoma cells. In this study we have compared the binding of 25-hydroxyvitamin D3 [25(OH)D3] and 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] to that of 1,25-(OH)2D3 in fetal rat calvariae and osteogenic sarcoma (OS) cells. Sucrose density sedimentation, DNA-cellulose chromatography, and intracellular uptake studies have been employed to evaluate these interactions. In cytosol preparations from calvariae, [3H]-1,25(OH)2D3 bound to a 3.3S macromolecule and to a much greater extent to a 5.8S macromolecule while both [3H]25(OH)D3 and [3H]24,25(OH)2D3 bound to the 5.8S macromolecule. By incubating intact calvariae and OS cells with labeled metabolites and thus establishing binding intracellularly prior to cell disruption, we have found that the 3.3S protein which has high specificity for 1,25(OH)2D3 occurs inside the cells; the 5.8S protein, however, does not occur inside the cells but is generated after cell disruption. The [3H]-1,25(OH)2D3-receptor complex adsorbed to DNA-cellulose and was eluted from this affinity resin at 0.28M KCl. In contrast, [3H]25(OH)D3 and [3H]-24,25(OH)2D3 binding activity did not adsorb to DNA-cellulose. We conclude that, in contrast to the 3.3S protein, the 5.8S macromolecule does not fulfill receptor criteria but is rather generated by the experimental manipulation of the bone cells. Our data suggest that the vitamin D3 actions on bone are mediated only via the 3.3S receptor, and hence quantitative but not qualitative differences of the effects of the various metabolites are feasible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409504
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  • 4
    Electronic Resource
    Electronic Resource
    A new semiautomatic method for quantitative static and dynamic bone histology (1982)
    Springer
    Calcified tissue international 34 (1982), S. 439-448 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Histomorphometry ; Osteocytes ; Bone dynamics ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A new semiautomatic technique combining advantages of the manual and fully automatic methods is described for obtaining quantitative static and dynamic histologic data of bone. The hardware consists of a photomicroscope, digitizing platen, digitizer, plotter/printer, floppy disc drive, and computer. The microscope is equipped with a drawing tube through which the image of the digitizing platen is projected over the optical field. The investigator selects and traces all histologic structures to be measured by moving a cursor on the digitizing platen which is visible by its projection over the histologic field. The results on accuracy and static and dynamic precision of this method show that static and dynamic parameters of bone are obtained with a degree of error (〈20%) well within the acceptable range for biologic measurements. Comparison of this method with the grid technique according to Merz and Schenck showed that for almost all micromorphometric parameters comparable absolute data are obtained. Due to the higher precision of our method, however, the number of optical fields evaluated in obtaining these comparable data could be reduced to 25% of the number of fields evaluated by the Merz and Schenck technique. The time requirements for quantitative evaluation of a histologic slide of bone by our technique are 40–50 min; 20–25 min is needed for quantitative evaluation of osteocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411282
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  • 5
    Electronic Resource
    Electronic Resource
    Quantitative bone histology in 84 normal American subjects (1982)
    Springer
    Calcified tissue international 34 (1982), S. 449-455 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Histomorphometry ; Normal values ; Bone biopsies ; Sampling error
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Quantitative bone histology was done in undecalcified sections of iliac crest bone specimens obtained from 84 normal American individuals. Samples were obtained within 12 h after death in a vertical and horizontal manner from both the right and left iliac crests. In addition to the determination of normal values of micromorphometric parameters of bone in these healthy American subjects, the following studies were carried out: (a) comparison of variance of micromorphometric parameters of bone obtained from the right versus left iliac bone (40 pairs), (b) comparison of micromorphometric parameters of bone obtained in a vertical versus horizontal manner (12 pairs), (c) evaluation of variance with increasing distance from the compact zone in bone samples obtained in a vertical manner (44 pairs), (d) analysis of variation between bone samples obtained more anteriorly versus posteriorly along the iliac crest (N=40), (e) comparison of differences in micromorphometric parameters obtained from age-matched men versus premenopausal women (N=12), and (f) plotting of histograms for assessment of distribution of micromorphometric parameters. The results show that histomorphometric data of bone cannot be easily compared when different techniques are employed for obtaining bone samples. Sampling variations are kept smaller when bone specimens are obtained in a vertical manner. Anterior/posterior variation does not cause major sampling error. If ranges of variation are taken into account, quantitative bone histology is a valuable tool for assessment of bone structure and bone cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411283
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  • 6
    Electronic Resource
    Electronic Resource
    Formation and structure of Ca-deficient hydroxyapatite (1981)
    Springer
    Calcified tissue international 33 (1981), S. 111-117 
    Details
    ISSN: 1432-0827
    Keywords: Calcium-deficient hydroxyapatite ; Amorphous calcium phosphate ; Bone ; Radial distribution function ; Carbonate apatite
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary When amorphous calcium phosphate (ACP) was transformed to crystalline hydroxyapatite (HA) in a series of aqueous slurry concentrations ranging from low to high, the higher slurry concentrations produced more Ca-deficient HA as measured by Ca/P ratio and heat-produced pyrophosphate. We feel that the excess solution phosphate produced in the higher slurry transformations results in lower Ca/P ratio HA. It has been suggested that an ACP is the precursor to bone apatite. Regulation of the in vivo ACP slurry concentration could then control the stoichiometry and, therefore, the metabolic activity of bone apatite. X-ray radial distribution function (RDF) analyses showed that CO 3 2− substitution in HA creates far greater structural distortions than do Ca deficiencies. The latter, however, do produce small, but observable, structural distortions when compared to stoichiometric HA. It now seems clear that the RDF of bone apatite can be modeled by a synthetic, Ca-deficient, CO 3 2− -containing HA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409422
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  • 7
    Electronic Resource
    Electronic Resource
    Purification, composition, and31P NMR spectroscopic properties of a noncollagenous phosphoprotein isolated from chicken bone matrix (1981)
    Springer
    Calcified tissue international 33 (1981), S. 385-394 
    Details
    ISSN: 1432-0827
    Keywords: Phosphoprotein ; Bone ; 31P-NMR ; Phosphoserine ; Phosphothreonine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Fractionation of the EDTA-soluble, noncollagenous proteins of the organic matrix of chicken bone by Sephadex G-100 molecular sieving has revealed that the majority of the organic phosphorus is present in two fractions, from one of which a homogeneous phosphoprotein has been isolated. The purified phosphoprotein has an apparent molecular weight of 12,000 and contains bothO-phosphoserine andO-phosphothreonine.31P-NMR spectroscopy demonstrates that all of the organic phosphorus exists in the form of phosphomonoesters which have an average pK2 of 6.8. The phosphoprotein is highly acidic due to its high content of dicarboxylic acids in addition to the presence of organic phosphorus. The characteristic amino acid composition of the phosphoprotein establishes its noncollagenous nature and highlights the differences among bone, dentin, and enamel phosphoproteins. The absence ofγ-carboxyglutamic acid distinguishes it from osteocalcin, the noncollagenousγ-carboxyglutamic acid-containing peptide of bone matrix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409461
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  • 8
    Electronic Resource
    Electronic Resource
    Osteopenia in juvenile diabetes (1981)
    Springer
    Calcified tissue international 33 (1981), S. 455-457 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Osteoporosis ; Diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The bone mineral status of fifty-one children with diabetes mellitus was studied by single photon absorptiometry. The mean bone mineral content was 13% below values predicted by age, sex, height, and weight. Those children whose diabetes was one year or less in duration were as osteopenic as those whose diabetes was of longer duration. The demineralized children received a higher daily insulin dose than the others. No association was noted between the degree of skeletal demineralization and sex, statural growth, renal function, and serum calcium and phosphorus. No significant changes in bone mineral content were noted longitudinally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409473
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  • 9
    Electronic Resource
    Electronic Resource
    Bone cell kinetics during longitudinal bone growth in the rat (1980)
    Springer
    Calcified tissue international 32 (1980), S. 123-133 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Cell kinetics ; Osteoprogenitor cell ; Migration ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The purpose of this work was to provide further knowledge about bone cell kinetics in the metaphysis of the growing long bone. Seventy rats were sacrificed from 1 to 120 h after injection of tritiated thymidine. Autoradiographs of 3 µm thick sections of the proximal tibial metaphysis were studied in a manner which allowed evaluation of labeled cell nuclei as a function of increasing age of metaphyseal tissue. A cell cycle duration study for osteoprogenitor cells was done. Labeled osteoprogenitor cells and osteoblasts first appeared at 1 h post-injection. The great majority of all labeled osteoprogenitor cells and osteoblasts was found within 1 mm of the growth cartilage-metaphyseal junction (GCMJ) at all times, apparently migrating with the moving GCMJ. In contrast, labeled osteoclast nuclei first appeared at 24 h post-injection within 0.3 mm of the GCMJ and remained always with the area of bone surface with which they were first associated, even as the GCMJ migrated away. By 5 days post-injection, the source of new labeled osteoclast nuclei in the metaphysis near the GCMJ was depleted, whereas that for the osteoblasts remained. The existence of two kinetically different, as well as ultrastructurally different, members of the metaphyseal osteoprogenitor cells population is postulated. A cell cycle time of 39±18 h was found for the osteoprogenitor cell population, but has limited meaning. A schema for metaphyseal bone cell movements during longitudinal bone growth is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408531
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  • 10
    Electronic Resource
    Electronic Resource
    Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) in rats (1980)
    Springer
    Calcified tissue international 32 (1980), S. 145-157 
    Details
    ISSN: 1432-0827
    Keywords: APD ; Bisphosphonate ; Bone ; Resorption ; Formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Dose-related effects of APD on bone metabolism and Ca homeostasis were studied in rats. The experimental approach consisted of longitudinal and cross-sectional observations, aiming at a kinetic interpretation. Bone and cartilage resorption was inhibited within 2–8 days at doses between 0.16 and 16 µmol/kg body weight/day. This was followed by changes in bone apposition that needed at least 23 days for a maximal effect. The time lag created a transient dissociation between resorption and apposition resulting in excess Ca and P retention, adding to increased metaphyseal bone mass. At high doses of APD (≥40 µmol/kg/day) the mineral content of new matrix decreased, associated with impairment of longitudinal growth of long bones. It is concluded that the lower doses of APD inhibited resorption of bone and cartilage, possibly by physicochemical stabilization of bone mineral, whereas the effect on bone apposition was due to a cellular homeostatic mechanism. Inhibition of growth and of matrix calcification, requiring much higher doses, may be due to a direct, toxic effect on bone cells. The modes of action of APD are discussed in relation to EHDP and Cl2MDP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408534
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  • 11
    Electronic Resource
    Electronic Resource
    Decreased breaking strength of diabetic rat bone and its improvement by insulin treatment (1980)
    Springer
    Calcified tissue international 32 (1980), S. 195-199 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Diabetes ; Insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A simple instrument is described which measures the breaking strength of rat bones. The apparatus yields reproducible results and is suitable for use in measuring the strength of bones from both large and small animals. Diabetic rat femurs were more fragile and required less force to break in contrast to those from diabetic rats treated with insulin or normal rats. Daily insulin treatment significantly improved the bone cortical thickness and enhanced their capacity to withstand pressure, although these did not reach the level of the normal controls. The amount of force required to break the bone appears to be related to its cortical thickness and mass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408541
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  • 12
    Electronic Resource
    Electronic Resource
    Human vertebral bone: Relation of strength, porosity, and mineralization to fluoride content (1980)
    Springer
    Calcified tissue international 32 (1980), S. 189-194 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Fluoride ; Strength ; Porosity ; Mineralization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Radiographically normal vertebral bone cylinders from 80 male subjects were tested mechanically by static compression and analyzed for porosity, fluoride and ash content. As a group, they had low fluoride content, suggesting little prior intake, consonent with this geographic area. Nevertheless, increasing levels of fluoride were associated with bulkier bone, less porosity, and less mineral per unit of bone, which in direction though not degree suggested changes similar to those of osteomalacia and opposite from those of osteoporosis without apparent threshold. The higher fluoride hard tissue was weaker in static tests than that with less fluoride, but the increased bulk apparently offset this, resulting in bones of unchanged static strength. Hence, water fluoridation should not alter static bone strength. There has, however, been a recent report suggesting that increased mineralization of bone renders it more brittle and thus more likely to fracture on impact. Therefore, the possibility that fluoridation may increase impact resistance by lessening mineralization can be entertained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408540
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  • 13
    Electronic Resource
    Electronic Resource
    Blood/bone disequilibrium: IV. Reciprocal effects of calcium and phosphate concentrations on ion fluxes (1980)
    Springer
    Calcified tissue international 32 (1980), S. 229-236 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Ion influxes ; Calcium ; Phosphate ; Exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Quantitative measurements were made of the ion fluxes of calcium and phosphate into and from calvaria (mouse or rat) when clamped in specially designed micro-Ussing chambers. The effects of varying concentrations of calcium were examined on the influx and efflux of calcium and of its counterion, phosphate. A comparable series of experiments was performed with varying phosphate concentrations. Both ions, as their concentrations increased, depressed their own influx, increased their own efflux, and significantly increased the equilibrium concentration, E/K, supported by the calvaria. Similarly, both ions, as their concentrations increased, affected the influx or efflux of their counterion only slightly but did depress the counterion's equilibrium level, E/K, significantly. In spite of these changes it was shown that calvaria effectively buffered the medium at physiological concentrations of calcium and phosphate. The buffering capacity, however, was small, and the balance, E/K, was modified by small uptake or loss of either ion. The small size of the interacting mineral pool was confirmed by direct measurement of the rapidly exchanging fractions of both calcium or phosphate. They were only ∼1% of the total ions present. The significance of these findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408546
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  • 14
    Electronic Resource
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    Skeletal demineralization in Turner's syndrome (1982)
    Springer
    Calcified tissue international 34 (1982), S. 519-522 
    Details
    ISSN: 1432-0827
    Keywords: Turner's syndrome ; Ovarian dysgenesis ; Osteoporosis ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones of girls who received estrogen replacement therapy were less demineralized than those of the others. The bone mineral deficit became less pronounced with advancing age. It could not be determined if the apparent effect of estrogens was related to age or if the apparent improvement with age was really due to an effect of estrogen treatment. For 8 subjects followed longitudinally there was no significant change in the BMC deficit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411296
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  • 15
    Electronic Resource
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    Thallium chondrodystrophy in chick embryos: Ultrastructural changes in the epiphyseal plate (1981)
    Springer
    Calcified tissue international 33 (1981), S. 57-69 
    Details
    ISSN: 1432-0827
    Keywords: Thallium ; Chondrodystrophy ; Cartilage ; Bone ; Matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Using the transmission electron microscope, we sought to describe the morphology of thallium sulfate-induced chondrodystrophy in chick embryos. There was cell death and degeneration in all zones of growth cartilage, but the cells and matrix of the hypertrophic zone were the most severely affected. Ultrastructural changes of the hypertrophic chondrocytes consisted of alteration of the cytoplasmic contents and of the intercellular matrix; the cell membrane was smooth and without cytoplasmic extensions. The cytoplasm was filled with dilated rough endoplasmic reticulum, vacuoles of varying sizes and contents, and lipidlike bodies with electron-dense granules; mineral crystals, collagen, and degenerating mitochondria were present. The matrix showed only spotty calcification and a reduced number of dense bodies, vesicles, and granules. The cells appeared to have failed to exteriorize cell products across the plasmalemma. Failure to exteriorize cell products and to form cytoplasmic processes reduced the number of potential nucleation sites for calcification. The ultrastructure of osteocytes was much less affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409413
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  • 16
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    Studies on extractable and resistant proteoglycans from metaphyseal and cortical bone and cartilage (1981)
    Springer
    Calcified tissue international 33 (1981), S. 89-99 
    Details
    ISSN: 1432-0827
    Keywords: Soluble proteoglycans ; Resistant proteoglycans ; Collagen ; Bone ; Cartilage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Soluble proteoglycans (SPG) were extracted from bovine (BCC) and human (HCC) costal cartilages by the dissociative method using 4 M guanidinium chloride (GuHCl). Proteoglycans which are resistant to extraction (RPG) were obtained following collagenase digestion or hydroxylamine treatment of the cartilage residues. Similarly, SPG were extracted from bovine metaphyseal and cortical bone using EDTA. The RPG were extracted from the bones using hydroxylamine. Density gradient fractionation under dissociative conditions of cartilage SPG and RPG followed by chromatography on Sepharose 2B revealed that A1D1 RPG are smaller than the SPG. SPG reacted with either collagenase or hydroxylamine are also smaller than the parent SPG. A1D1 fractions obtained from BCC-SPG and RPG or from mixtures of SPG and acid-soluble collagen are free of hydroxyproline. Hydroxyproline is not completely separated from HCC-RPG. Density gradient fractionation of bone proteoglycans and Sepharose chromatography of the A1 and A1D1 fractions showed that those obtained from metaphysis are larger than those from cortical bone. This was attributed to the presence of calcified cartilage in metaphyseal bone. The A1D1 fractions of the metaphyseal proteoglycans seemed to undergo self-association since this fraction is larger than the A1 fraction from which it is derived. Cortical bone proteoglycans do not behave similarly. Density gradient purification under dissociative conditions failed to separate hydroxyproline from the proteoglycans obtained from bone. It is hypothesized that in bone proteoglycans and collagen might be linked.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409419
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  • 17
    Electronic Resource
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    Age-related changes in the orientation and particle size of the mineral phase in human femoral cortical bone (1981)
    Springer
    Calcified tissue international 33 (1981), S. 567-574 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Femur ; Age ; Mineral ; Apatite
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary It has previously been observed that after the third decade of life the tensile strength of bone decreases faster than its density [1], indicating that some microstructural change occurs in bone with advancing age. In order to try to elucidate this observation, the orientation and particle size of the mineral phase of bone have been studied with respect to age. Samples were taken from femora varying in age from 13 to 97 years. The results show that the degree of preferred orientation does not vary with age after the first decade of life. However, the percentage of small particles increased up to the fourth decade of life and thereafter decreased, a pattern of change similar to that observed for bone strength. It would seem to indicate that an increase in mineral particle size is a factor that contributes to the loss of bone strength and that an increased percentage of large particles in the later years of life could, along with osteoporosis, help to explain the increased fragility in the bones of the elderly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409493
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  • 18
    Electronic Resource
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    Uptake and loss of plutonium from osteoclasts and macrophages in the mandibular condyle of the rat (1980)
    Springer
    Calcified tissue international 30 (1980), S. 15-20 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Osteoclasts ; Macrophage ; Resorption ; Plutonium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Female rats were used to study the kinetics of plutonium transfer from the bone surfaces of the mandibular condyle to osteoclasts and macrophages. This study was made using autoradiographs prepared from plastic sections of the mineralized bones of animals which had been injected with241 Pu citrate. Measurements of the concentration of plutonium in the osteoclasts and macrophages at different times after the injection of plutonium showed that plutonium was concentrated by osteoclasts from bone surfaces and was retained with a half-time of ∼ 70 h. Subsequently, plutonium appeared to be transferred to macrophages. The results showed that plutonium was unlikely to be accumulated by macrophages as a result of their participation in bone resorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408601
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  • 19
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    Alkaline phosphatase and ATPase activities of rat bone: Separation and characterization (1980)
    Springer
    Calcified tissue international 30 (1980), S. 67-71 
    Details
    ISSN: 1432-0827
    Keywords: Alkaline phosphatase ; ATPase ; Bone ; Triton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Extraction with Triton X-100 has proved effective in solubilizing alkaline phosphatase from rat bone particles, whereas ATPase with optimum activity at pH 8 remains attached to the bone particles. The kinetic characteristics of the ATPase activity of the Triton extracts are different from those of the same enzyme attached to bone particles, but the kinetic characteristics of the particle-bound and solubilized alkaline phosphatases are similar. The results suggest that the Triton extracts do not have true ATPase activity and provide a means of separating the ATPase and alkaline phosphatase activities.
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    URL: http://dx.doi.org/10.1007/BF02408608
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    On the measurement of water compartments, pH, and gradients in calvaria (1980)
    Springer
    Calcified tissue international 31 (1980), S. 135-145 
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    ISSN: 1432-0827
    Keywords: Bone ; water compartments ; marker ; methods ; pH ; potassium ; lactate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The concept of fluid compartmentalization in bone has emphasized the need for and lack of suitable methodology for the quantitation of water “spaces” in bone, in particular intracellular water, ICF, and extracellular water, BECF. Over a dozen commonly used marker substances were studied intensively. Small columns of hydroxyapatite crystals were employed to reveal physiochemical interactions with the mineral phase, and isotope distributions in live and dead calvaria (rat pup, and adult mice) were employed to evaluate interactions with the combined organic-inorganic matrix of bone itself. The results were most discouraging. For example, for total water space, only water itself (either by direct weight or by3H2O exchange) is a reliable measure in all instances. All markers studied were passively concentrated or excluded to varying degrees. In the end, it was necessary to measure intracellular space “by difference.” An extracellular marker, polyethylene glycol (14C-, mol. wt. 4000), was incubated with viable calvariae and also with comparable calvariae having lysed cells (0.1% Triton X-100). The intracellular space thus determined by difference agreed well with correlative data obtained on mixed cell-isolates from similar specimens. In neonatal calvariae, the intracellular space was 30% of the total water present; that of adult mouse tibia, 18%; and that of adult mouse calvariae, 14.5%. Measurements of dimethyl-2,4-oxazolidinedione (DMO) distribution in live and lysed calvaria revealed an overall pH differential (inside bone vs. medium) of 0.1 unit or less. Using the best available data for ICF, BECF, and the passive concentrating effects of matrix-K+ interactions, there still remained an unexplained excess of K+ in the BECF.
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    URL: http://dx.doi.org/10.1007/BF02407174
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    Histological observations on the failure of rachitic rat bones to respond to 1,25/OH)2D3 (1980)
    Springer
    Calcified tissue international 31 (1980), S. 215-223 
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    ISSN: 1432-0827
    Keywords: Bone ; 1,25(OH)2D3 ; 25OHD3 ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Rachitic rats, maintained on diets with low or normal P contents, were given daily intraperitoneal doses of 1,25(OH)2D3 or 25OHD3 at levels of 100 or 200 ng. Plasma chemistry was measured and the ash content and histological appearance of the bones investigated. Using labeled material it was shown that the dosing levels of 1,25(OH)2D3 employed ensured a higher than normal plasma concentration of that metabolite over the period between doses. 1,25(OH)2D3 was not as effective as 25OHD3 in raising bone ash or reducing the amount of osteoid. The difference between the effects of the metabolites was evident at both dietary P levels, but more marked at the higher P level. In contrast, the metabolites reduced the width of the epiphyseal plate to an approximately similar degree, and this is possibly the reason why there are discrepancies between previous reports of the effectiveness of 1,25(OH)2D3 compared with 25OHD3 or vitamin D3. Dosing with 1,25(OH)2D3 failed to maintain a constant plasma Pi value over the period between doses in animals fed the low P diet.
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    URL: http://dx.doi.org/10.1007/BF02407184
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    Calcium homeostasis and bone pathology in magnesium deficient rats (1980)
    Springer
    Calcified tissue international 31 (1980), S. 231-238 
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    ISSN: 1432-0827
    Keywords: Magnesium ; Bone ; Calcium ; Parathyroid gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Calcium homeostasis and bone pathology were studied in weanling rats fed a low (70 ppm) magnesium diet for 2–21 days. The rats developed significant, progressive hypercalcemia after 6 days on the diet. The increase in blood calcium was accompanied by progressive hypoactivity of the parathyroid gland (PTG), as determined by histologic and morphometric analyses. Thus hyperactivity of the PTG could not have been responsible for the hypercalcemia observed. Histologic examination of femora and humeri from magnesium-deficient rats showed progressive subperiosteal hyperplasia, consisting of undifferentiated osteoprogenitor cells and fibrous tissue, after 7 days of deficiency. The presence of unmineralized osteoid tissue in the metaphyses indicated that mineralization was not proceeding normally. The alterations in differentiation of osteoprogenitor cells, together with the failure of mineralization, resulted in significantly lower rates of bone formation (as measured by fluorochrome labeling) in the magnesium-deficient rats. Basophilic cementing lines and inactive osteocytes in the cortices of bones from magnesium-deficient rats indicated that bone resorption was also severely reduced in magnesium deficiency. We postulate that bone magnesium depletion (66% by day 21) has a direct negative effect on osteoblastic and osteocytic activity, and may explain, in part, the decreased responsiveness of bone to parathyroid hormone (PTH) that has been observed in magnesium-deficient animals.
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    URL: http://dx.doi.org/10.1007/BF02407186
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    Limitations of radioactive microspheres as tracers for bone blood flow and extraction ratio studies (1980)
    Springer
    Calcified tissue international 31 (1980), S. 261-265 
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    ISSN: 1432-0827
    Keywords: Bone ; blood flow ; microspheres ; fluorine ; strontium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Radioactive microspheres have been used for measuring bone blood flow and the extraction ratios of bone-seeking radionuclides, but we have shown that the technique is not completely valid. Bone uptake of18F and85Sr was compared with that of microspheres simultaneously injected into the heart or aorta of rats and rabbits under a variety of conditions. In single-passage experiments with quick killing to avoid recirculation, attention was focused on the tibiae and femora which could be dissected quickly to avoid post-mortem migration. For the rest of the skeleton, the effect of the latter was minimized by allowing recirculation for 5 min and comparing blood flow determinations in conjunction with a cardiac output measurement. The apparent extraction ratio of18F was variable and always exceeded unity in the single-passage experiments. With recirculation, there were significant differences between the extraction ratios for some bones, and the ratios sometimes exceeded unity. Extraction ratios for85Sr were similarly variable, but lower. When85Sr was compared directly with18F, the relative extraction ratio was 0.8, with little variation between bones or animals. It is concluded that the flux of microspheres entering the vasculature of bone is not representative of blood flow, owing to the removal of some microspheres in pre-osseous capillary beds. Microspheres are therefore not a satisfactory standard for the determination of extraction ratios.
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    URL: http://dx.doi.org/10.1007/BF02407191
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    Tumoral calcinosis: Evidence for concurrent defects in renal tubular phosphorus transport and in 1α,25-dihydroxycholecalciferol synthesis (1980)
    Springer
    Calcified tissue international 32 (1980), S. 1-6 
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    ISSN: 1432-0827
    Keywords: Ectopic calcification ; 1,25-dihydroxyvitamin D ; hyperphosphatemia ; Bone ; Renal tubule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A 50-year-old Latin American man with tumoral calcinosis presented with hyperphosphatemia (6.62±1.04 SD mg/dl), elevated renal threshold phosphorus concentration (TmP) (7.3 mg/GFR), and 1,25-dihydroxyvitamin D [1,25-(OH)2D] (69 pg/ml) hypercalciuria (239 mg/day), and a high fractional intestinal calcium (Ca) absorption (0.74). Sodium cellulose phosphate therapy (20 g/day) lowered urinary Ca, and partially reduced serum phosphorus (P) and TmP to 5.91±0.63 mg/dl and 6.2 mg/GFR, respectively. Serum 1,25-(OH)120D remained elevated at 58–64 pg/ml. Amphojel therapy (4 oz/day) decreased urinary P to 23±21 mg/day and lowered serum P to 5.75±0.36 mg/dl (P〈0.05). TmP increased to a value of 8.0 mg/GFR while serum 1,25-(OH)2D continued to remain elevated at 53 pg/ml. This case illustrates the probable operation of dual abnormalities in tumoral calcinosis represented by augmented renal conservation of P and an elevation in the circulating concentration of 1,25-(OH)2D.
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    URL: http://dx.doi.org/10.1007/BF02408515
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    Use of tracer microspheres to measure bone blood flow in conscious dogs (1980)
    Springer
    Calcified tissue international 32 (1980), S. 69-76 
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    ISSN: 1432-0827
    Keywords: Bone ; Marrow ; Blood flow ; Microspheres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Blood flow was measured in mature and immature dogs by means of tracer microspheres. Microspheres of 15 µm were found to be the most suitable size in the dog. Total body nonentrapment in the awake, standing dog is likely to be less than 10%. Cortical bone flood flow, devoid of periosteum and marrow, is 2.5 ml/100 g/min in mature dogs and 7.0 ml/100 g/min in immature dogs,P〈0.005. Blood flow in cancellous bone is greater than that in cortical bone in mature (P〈0.001) and immature (P〈0.02) dogs. Flow is different in different regions of a long bone because of different proportions of cortical and cancellous bone, probably because of interrelationships of function (surfaces undergoing remodeling) and, therefore, of energy metabolism and blood flow.
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    URL: http://dx.doi.org/10.1007/BF02408523
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    Paradoxical effect of 1.25 dihydroxycholecalciferol on osteoblastic and osteoclastic activity in the skeleton of the eelAnguilla anguilla L (1980)
    Springer
    Calcified tissue international 32 (1980), S. 83-87 
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    ISSN: 1432-0827
    Keywords: 1.25 (OH)2D3 ; Fish ; Bone ; Osteoblasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Female mature eels (300 to 500 g) received one intraperitoneal injection of 1.25 (OH)2D3 (10 µg). Their vertebral bone was compared, 8 h and 24 h after the injection, with vertebral bone of control mature female eels receiving solvent alone (ethanol). Sexual maturation in female eels induces a bone decalcification with hypercalcaemia and hyperphosphataemia. The control eels showed marked osteoclastic resorption and osteocytic osteolysis and the degree of mineralization of the intercellular substance decreased. Injection of 1.25 (OH)2D3 into these female mature eels provoked as early as 8 h : 1) an increase in hypercalcaemia and hyperphosphataemia ; 2) a major conversion of lining cells to osteoblasts and a stimulation of osteoblastic activity with new bone formation ; 3) diminished osteoclastic resorption without changing osteocytic osteolysis or bone matrix mineralization.
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    URL: http://dx.doi.org/10.1007/BF02408525
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    A quantitative histologic analysis of the growing long bone metaphysis (1980)
    Springer
    Calcified tissue international 32 (1980), S. 113-122 
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    ISSN: 1432-0827
    Keywords: Rat ; Bone ; Metaphysis ; Quantitative ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The purpose of this work was to analyze the proximal tibial metaphysis of the 170 g rat in a quantitative histologic fashion which would allow some relation to tissue age to be established. Stained 3 µm thick tissue sections were analyzed with the aid of a Merz grid on an eyepiece reticule and a light microscope. Tissue mass and cell distribution were studied in all areas. The rate of change in tissue mass during aging of the metaphysis was calculated. Two regions of the metaphysis were identified. One, corresponding to the primary spongiosa, less than 4.45 days of age, is a region of high turnover of hard tissue and high numbers of osteoblasts and osteoprogenitor cells. The other, corresponding to the secondary spongiosa, is a region of relatively low net tissue turnover and low numbers of osteoblasts and osteoprogenitor cells. Osteoclasts were found relatively more uniformly distributed through the metaphysis than were osteoblasts and osteoprogenitor cells. The rate of bone formation in the primary spongiosa is 50 times that found in the Haversian bone of the rib of 5-year-old humans and about 500 times that found at the cortical-endosteal surface of ribs of 5-year-old humans. It is argued that both cell distribution and tissue distribution in the metaphysis support the concept that osteoblasts and osteoclasts, rather than osteocytes, are responsible for the maturation of the metaphysis. The inhomogeneous distribution of both cells and tissue in the metaphysis has definite meaning for the interpretation of findings concerning the incorporation of radionuclides into the skeleton.
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    URL: http://dx.doi.org/10.1007/BF02408530
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    Plasma proteins in human cortical bone: Enrichment ofα 2 HS-glycoprotein,α 1 acid-glycoprotein, and IgE (1982)
    Springer
    Calcified tissue international 34 (1982), S. 229-231 
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    ISSN: 1432-0827
    Keywords: Plasma proteins ; IgE ; IgD ; α 1Acid-glycoprotein ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Human cortical bones were extracted with EDTA, and the residue after EDTA extraction was digested with bacterial collagenase. Ten plasma proteins were identified and quantitated in the EDTA extracts. Three of them—IgE, IgD, andα 1acid-glycoprotein—had not previously been described in bone or dentine. Five plasma proteins identified in collagenase digests are albumin, IgG, IgA, IgE, andα 1acid-glycoprotein. IgE,α 1acid-glycoprotein, andα 2HS-glycoprotein were found to be concentrated in the bone more than other plasma proteins by factors between 11 and 525. The identification of plasma proteins was facilitated by the addition of polyethylene glycol in agarose gel. The presence of plasma proteins both in EDTA extracts and in collagenase digests suggests their structural role in bone.
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    URL: http://dx.doi.org/10.1007/BF02411242
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    Effect of 1,25-dihydroxyvitamin D3 on osteopenia induced by prednisolone in adult rats (1982)
    Springer
    Calcified tissue international 34 (1982), S. 253-257 
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    ISSN: 1432-0827
    Keywords: Prednisolone ; Calcium ; Bone ; Corticoid osteopenia ; Vitamin D metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Adult male rats were fed a diet containing 0.15% calcium, 0.3% phosphorus, and either 100, 50, or 20 mg of prednisolone per kg of diet. All these levels of prednisolone led to osteopenia, decreased intestinal absorption of calcium, slightly lower serum calcium and phosphorus, and a decreased level of serum 1,25-dihydroxyvitamin D3. Exogenous parenteral 1,25-dihydroxyvitamin D3 corrected steroid-induced changes in serum calcium and phosphorus, but could not completely correct the low intestinal calcium transport; nor did it prevent the development of osteopenia. The prednisolone-induced osteopenia seems at least in part to be caused by impaired intestinal calcium transport. The impaired calcium transport may be the result of low levels of 1,25-dihydroxyvitamin D3 and a direct effect of presnisolone on the intestine.
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    URL: http://dx.doi.org/10.1007/BF02411246
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    Role of vitamin D in maternal skeletal changes during pregnancy and lactation: A histomorphometric study (1982)
    Springer
    Calcified tissue international 34 (1982), S. 245-252 
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    ISSN: 1432-0827
    Keywords: Vitamin D ; Vitamin D deficiency ; Bone ; Pregnancy ; Lactation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The effect of vitamin D on bone changes during the reproductive cycle in female rats has been investigated. One group of female rats was maintained on a vitamin D-deficient diet and another group on a vitamin D-replete diet from weaning. Both groups were mated with normal males and changes in their bones were determined histomorphometrically during pregnancy, lactation, and after weaning. All vitamin D-deficient rats had bone changes typical of rickets. Pregnancy caused significant reductions in mineralized tissue of trabecular and cortical bone in the vitamin D-deficient rats. Lactation caused further significant reductions in mineralized tissues of cortical and trabecular bone in both the vitamin D-deficient and vitamin D-replete animals, with the greatest changes seen at weaning. Some restoration of mineralized tissues occurred following weaning. There was an increase in tetracycline-labeled bone surface in the vitamin D-replete animals during lactation, likely due to an increase in bone formation rates. In the vitamin D-deficient animals during lactation, there was a decrease in tetracyclinelabeled bone surface, likely due to severely depressed bone mineralization. These results indicate that the mobilization of calcium from bone to maintain pregnancy and lactation occurs by a mechanism independent of vitamin D.
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    Bone histomorphometric reproducibility in normal patients (1981)
    Springer
    Calcified tissue international 33 (1981), S. 369-374 
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    ISSN: 1432-0827
    Keywords: Histomorphometry ; Bone ; Reproducibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary To study bone histomorphometry reproducibility in normal subjects, we performed during orthopedic surgery bone biopsies in 16 post-menopausal women. Each woman had four bone biopsies, two at the usual site in the iliac crest, one on the left and one on the right side, and two other biopsies just behind the usual site, one at each side. We performed measurements of trabecular bone volume, relative osteoid volume, osteoid surfaces, osteoclastic resorption surfaces and calcification front. The average values of the 16 patients were compared, on the one hand, two by two, by a student test, and on the other hand, by a variance analysis. By these two methods the results showed no significant difference between the average values of the 16 patients at each location for any of the histomorphometric parameters studied. However, there was a location variation which was estimated by the intra-individual variation for a given patient. On the other hand, we calculated from the variance analysis the location variance for a group of 10 to 100 patients. In any case all the parameters had a location variation which was high for osteoclastic resorption surfaces and relative osteoid volume when expressed in % of the absolute value of these parameters. The variation of the trabecular bone volume was 0–46. 15% (95% confident limit interval) in a single patient and the hypothetical value of the location variation was 41.6% for a group of 10 patients and 13.0% for a group of 100 patients.
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    Studies of diffusion in calvaria (1981)
    Springer
    Calcified tissue international 33 (1981), S. 441-444 
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    ISSN: 1432-0827
    Keywords: Bone ; Diffusion ; H2O ; Ions ; Vitamin D ; Diphosphonate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The rates of diffusion of small ions and neutral molecules through isolated calvaria have been determined. Compared with data published on self-diffusion and diffusion through cartilage, H2O, 3-O-methylglucose, lactate, sulfate, and methylamine diffuse at approximately 2/3 the expected rate. Diffusion of H2O and sulfate was unaffected by the administration of the diphosphonate 1-hydroxyethane-1,1-diphosphonate (EHDP), although phosphate fluxes are markedly diminished. Diffusion of water was nearly doubled by vitamin D deficiency. A 1-week treatment with 1,25(OH)2D3 had no effect on H2O diffusion while returning calcium influx to normal. It is concluded that bone matrix permits a flow of small neutral and ionized molecules nearly comparable to that in cartilage. When changes in calcium and phosphate influx are observed, they can be ascribed to the exchange properties of bone mineral and not to changes in matrix permeability.
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    Density of a sample bovine cortical bone matrix and its solid constituent in various media (1981)
    Springer
    Calcified tissue international 33 (1981), S. 499-504 
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    ISSN: 1432-0827
    Keywords: Bone ; Collagen ; Density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The density of a bovine cortical bone matrix sample was found in water, several ethanol-water solutions, and in the dried state. Previously the density of the same mineralized bone was found fresh and when desiccated. The volume in each state was estimated from the dimensional changes axially, tangentially, and radially. Confirmation was found by determining the density of dried specimens upon immersion in xylene. The amount of imbibed xylene provided an estimate of the free pore volume in the dried matrix. The volume fraction of the solid constituent, S, in the wet matrix was found to be 0.57, from which the density of S in various solutions was calculated. Density of wet matrix in 0.15 M saline: 1.180 g/cc; for dried matrix, 1.246 g/cc. Density of wet S in saline: 1.33 g/cc; for dried S, 1.42 g/cc, which matches published values for collagen molecules. Dimensional changes between wet and dried state of matrix match published values for artificially cross-linked rat tail tendon fibers. Axially: 1.04, by area: 2.27; by volume: 2.62. Estimate of intrafibrillar volume, assuming 80% of mineral is within fibrils: 0.73 cc/g dry collagen.
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    Radiographic evidence of disuse osteoporosis in the monkey (M. nemestrina) (1981)
    Springer
    Calcified tissue international 33 (1981), S. 631-639 
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    ISSN: 1432-0827
    Keywords: Bone ; Osteopenia ; Noninvasive monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Radiological techniques were utilized for monitoring progressive changes in compact bone in the tibia of monkeys during experimentally induced osteopenia. Bone mass loss in the tibia during restraint was evaluated from radiographs, from bone mineral analysis, and from images reconstructed from gamma ray computerized tomography. The losses during 6 months of restraint tended to occur predominantly in the proximal tibia and were characterized by subperiosteal bone loss, intracortical striations, and scalloped endosteal surfaces. Bone mineral content in the cross section of the tibia declined 17–21%. Tomography demonstrated endosteal widening and reduced mineral content per unit of thickness of cortical bone. In 6 months of recovery, the mineral content of the proximal tibia remained depressed. Effects of the dynamic environment on local-regional changes in various skeletal areas are discussed.
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    URL: http://dx.doi.org/10.1007/BF02409501
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    Inhibition of active bone resorption by copper (1981)
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    Calcified tissue international 33 (1981), S. 35-39 
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    ISSN: 1432-0827
    Keywords: Copper ; Resorption ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary An investigation of the role of copper in bone metabolism was undertaken. Explanted calvaria from 6-day-old mice were grown for 48 h in medium with and without the addition of copper sulfate. Active resorption was found to be significantly inhibited in the presence of copper sulfate concentrations of 10−6M and above. Copper sulfate concentrations of 10−5M and above inhibited hydroxyproline, protein, and DNA synthesis. Lower concentrations were ineffective. The effect of 5 × 10−6M copper sulfate on resorption was reversible. Several other compounds were tested for similar effects and at 5 × 10−6M were found to inhibit bone resorption in the order: copper sulfate 〉 brown gold chloride 〉 sodium aurothiomalate 〉 zinc sulfate 〉 sodium sulfate. The copper sulfate effect was twice that of sodium aurothiomalate, and sodium sulfate was not significantly inhibitory. The results suggest that the high serum copper levels associated with rheumatoid arthritis may reflect the activity of a hypothetical control mechanism of bone resorption. In the diseased state this would act to restore the normal rate of bone resorption.
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    Osteogenesis in osteopetrotic mice (1982)
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    Calcified tissue international 34 (1982), S. 37-42 
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    ISSN: 1432-0827
    Keywords: Bone ; Osteopetrosis ; Osteoclast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Ectopic bone arising in grafts of compatible normal intact bone marrow in microphthalmic osteopetrotic recipients was examined in the light microscope and was found to be unaffected by the deficiency that curtails resorption of primitive woven bone in osteopetrotic animals.
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    URL: http://dx.doi.org/10.1007/BF02411206
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    Effects of vitamin D metabolites and analogs on bone collagen synthesis in vitro (1982)
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    Calcified tissue international 34 (1982), S. 103-110 
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    ISSN: 1432-0827
    Keywords: Bone ; Collagen ; Vitamin D metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The effects of selected vitamin D3 metabolites and analogs on bone collagen synthesis in vitro were examined in organ cultures of neonatal mouse calvarial bone. The incorporation of [3H]proline into the collagenase-digestible fraction of newly synthesized protein was progressively inhibited by 1α,25-dihydroxyvitamin D3 (1α,25-(OH)2D3) (10−12 M to 10−7 M) in 24-h cultures, and incorporation into noncollagen protein was also blunted at the higher doses employed. The synthetic analog 1α-hydroxyvitamin D3 (1α-OHD3) was almost 300-fold less potent an inhibitor of collagen synthesis than was 1α,25(OH)2D3, and the natural metabolites 25-hydroxyvitamin D3 (25OHD3) and 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3), 1000-fold less potent, although the dose-response curve for each of these compounds was not parallel with that for 1α,25(OH)2D3. The 24S,25(OH)2D3 enantiomer was four-fold less potent than 24R,25-(OH)2D3 or 25OHD3, and vitamin D3 showed less than 2% the activity of 25OHD3. The responses were unaffected by the substitution of 0.4% bovine albumin for 5% horse serum in the medium, and no stimulation of collagen synthesis was observed in response to 25-hydroxylated metabolites between 2×10−14 and 2×10−6 M or in cultures treated for up to 96 h with 24R,25(OH)2D3 (2×10−10M). The overall results emphasize the similarity of the structural requirements for the inhibition of matrix synthesis and the stimulation of resorption by active vitamin D metabolites in bone. In addition, these studies support the importance of the 1-hydroxyl function to the biologic activity of vitamin D in the skeleton.
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    URL: http://dx.doi.org/10.1007/BF02411216
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    Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia (1982)
    Springer
    Calcified tissue international 34 (1982), S. 125-130 
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    ISSN: 1432-0827
    Keywords: X-Linked hypophosphatemic rickets ; Osteomalacia ; 1,25-Dihydroxyvitamin D ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary In order to determine whether a defect in vitamin D metabolism might play a role in the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia (XLH), we compared the serum 1,25-dihydroxyvitamin D [1,25(OH)2D] level in 52 normal subjects and 37 patients with XLH. In untreated patients, adults were found to have values similar to age-matched controls, while youths had values similar to growth-rate-matched controls but significantly lower than the levels of age-matched controls who were growing at a normal rate. In contrast, treated XLH patients of all ages had serum levels significantly lower than both controls and untreated XLH patients. Further, the serum levels of 1,25(OH)2D in these treated patients had a significant inverse linear correlation with serum 25-(OH)D concentrations. We propose that subjects with XLH have serum 1,25(OH)2D levels within appropriate age- and growth-rate-matched normal ranges. However, in the presence of hypophosphatemia, we would have anticipated elevated levels of 1,25(OH)2D; viewed in this light the serum 1,25(OH)2D levels are inadequate, suggesting the presence of a relative deficiency of this active vitamin D metabolite.
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    Blood:Bone disequilibrium. V. Effects of a diphosphonate (EHDP) on phosphate fluxes in rat calvaria (1982)
    Springer
    Calcified tissue international 34 (1982), S. 145-148 
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    ISSN: 1432-0827
    Keywords: Bone ; Diphosphonate ; Phosphate fluxes ; Solubility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Calvaria taken from rats (normal or thyroparathyroidectomized) given a diphosphonate (EHDP 10 mg/kg daily for 7 days) were placed in special Ussing chambers for the measurement of phosphate fluxes to and from bone. When compared with appropriate controls, the experimental calvaria showed a marked decrease in influx, K, a significant increase in the projected equilibrium concentration, E/K, where E is the efflux and a significnant increase in the calcium concentration in the medium. It is concluded that this large increase in passive “solubility” is caused by the diphosphonate's ability to stabilize the small amount of regulator phase (brushite or brushite-apatite mixture) present in bone.
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    URL: http://dx.doi.org/10.1007/BF02411225
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    Parathyroid hormone and calcitonin interactions in bone: Irradiation-induced inhibition of escape in vitro (1982)
    Springer
    Calcified tissue international 34 (1982), S. 197-203 
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    ISSN: 1432-0827
    Keywords: Parathyroid hormone ; Calcitonin ; Bone ; Escape ; Irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Calcitonin (CT) inhibits hormonally stimulated bone resorption only transiently in vitro. This phenomenon has been termed “escape,” but the mechanism for the effect is not understood. One possible explanation is that bone cell differentiation and recruitment of specific precursor cells, in response to stimulators of resorption, lead to the appearance of osteoclasts that are unresponsive to CT. To test this hypothesis, cell proliferation in neonatal mouse calvaria in organ culture was inhibited by irradiation from a cobalt-60 source. At a dose of 6000 R, [3H]thymidine incorporation into intact calvaria was inhibited approximately 90%. Irradiation had no effect on the resorptive response to 0.1 U/ml parathyroid hormone (PTH). However, irradiation induced a dose-dependent inhibition of the escape response which was maximal at 6000 R. A dose of 6000 R did not affect the binding of125I-salmon CT to calvaria and decreased PTH stimulation of cyclic AMP release from bone without affecting the cyclic AMP response to CT. Although irradiation caused a dose-dependent inhibition of DNA synthesis, the dose-response curves for that effect and inhibition of escape were not superimposable. A morphologic study of hormonally treated calvaria demonstrated that irradiation prevented the early increase in number of osteoclasts in PTH-treated calvaria that had been observed previously in unirradiated bones. Autoradiography showed that irradiation also prevented the PTH-stimulated recruitment of newly divided mononuclear cell precursors into osteoclasts. This may be correlated with the effect of irradiation to prevent the loss of responsiveness to CT in the presence of PTH.
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    URL: http://dx.doi.org/10.1007/BF02411233
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    Changes in plasma bone GLA protein during treatment of bone disease (1982)
    Springer
    Calcified tissue international 34 (1982), S. 121-124 
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    ISSN: 1432-0827
    Keywords: Bone ; Calcium ; Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Bone Gla protein (BGP) was measured in the plasma by radioimmunoassay (RIA) during treatment of 59 patients with bone diseases including Paget's disease (N=9), primary hyperparathyroidism (N=25), chronic renal failure (N=20), and cancer involving bone (N=5). Plasma BGP was increased above normal in all patients. BGP decreased in the patients with Paget's disease following the acute and chronic administration of salmon calcitonin. Plasma BGP was higher in women then in men with primary hyperparathyroidism. Following parathyroidectomy, BGP decreased in both sexes but the decrease was significant in women only. Plasma BGP was increased in patients with renal osteodystrophy and did not change after hemodialysis. In the patients with bone cancer, plasma BGP decreased during treatment of the attendant hypercalcemia with salmon calcitonin. Although plasma BGP and serum alkaline phosphatase (AP) levels were generally correlated in these studies, there were examples of dissociation between the two. The measurement of plasma BGP appears to provide a specific index of bone metabolism that may in some circumstances be more sensitive than serum alkaline phosphatase measurement. However, further studies are necessary to establish the clinical value of plasma BGP measurement by RIA in the management of patients with bone diseases.
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    Tensile properties of antler bone (1982)
    Springer
    Calcified tissue international 34 (1982), S. 301-305 
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    ISSN: 1432-0827
    Keywords: Antler ; Bone ; Collagen ; Tension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The tensile deformation characteristics of compact bone from deer antler were measured in both the “dry” and “wet” states and compared with published values for bovine compact bone. The tensile strength in the wet state (108±5.1 MN/m2) was comparable to the value for bovine compact bone tested at the same strain rate. The modulus value was very low: 7.5±0.9 GN/m2. The work to fracture was comparatively high, about 3 times that for bovine compact bone. Fractographic examination revealed fibrillar and osteonal shear for samples fractured in the dry state. In the samples tested in the wet state, some regions exhibited pull-out of lamellar segments from within a Haversian system. The results are explained in terms of the higher collagen content and lesser degree of mineralization in the antler.
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    The effects of long-term immobilization on the histomorphology of human cortical bone (1982)
    Springer
    Calcified tissue international 34 (1982), S. 337-342 
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    ISSN: 1432-0827
    Keywords: Bone ; Histomorphology ; Immobilization ; Quadriplegia ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The cortical bone histomorphometrics, total visible osteon density, and mean osteonal cross-sectional area were determined for the major long bones and sixth ribs of two individuals with neurological deficit. One was a multiple sclerosis patient who had been in a wheelchair for 15 years. The other was a quadriplegic as a result of poliomyelitis. Statistically significant differences in osteon densities occurred only in the case of the quadriplegic. Nevertheless, in that subject, the total visible osteon densities for bones of the right arm were not statistically different from those of their age-matched (control) radii. Medical history records revealed that there had been partial use of this limb. These results support the belief that mechanical stress is an important factor in the maintenance of normal cortical bone remodeling. In addition, since there were subnormal osteon densities and normal mean osteonal cross-sectional areas, immobilization appears to be characterized by reduced activation frequency with a normal amount of bone turnover per BMU.
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    Activation of serum complement inhibits collagen synthesis in fetal rat bone in organ culture (1982)
    Springer
    Calcified tissue international 34 (1982), S. 370-375 
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    ISSN: 1432-0827
    Keywords: Complement ; Bone ; Collagen ; Prostaglandins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Activation of rabbit serum complement caused a marked reduction in collagen synthesis but a much smaller change in noncollagen protein synthesis in fetal rat calvaria maintained in organ culture. In the periosteum of the fetal rat calvarium, both collagen and noncollagen protein synthesis were reduced, whereas in the central bone, presumably enriched in osteoblasts, only collagen synthesis was inhibited. This large decrease in bone collagen synthesis could not be attributed to enhanced degradation of newly synthesized collagen or its release into the culture medium. Activation of complement also stimulated the production of PGE in fetal rat calvaria. Antagonists of prostaglandin cyclooxygenase decreased prostaglandin synthesis but did not restore collagen synthesis in complement-treated bones, suggesting that complement decreases osteoblast collagen synthesis by a mechanism largely independent of prostaglandin production.
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    URL: http://dx.doi.org/10.1007/BF02411270
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    Occurrence of actin-like protein in extracellular matrix vesicles (1982)
    Springer
    Calcified tissue international 34 (1982), S. 376-381 
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    ISSN: 1432-0827
    Keywords: Matrix vesicles ; Bone ; Actin ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Preliminary indications of the occurrence of actin and myosin in crude matrix vesicle preparations have been reported previously. In the present study extracellular matrix vesicles from rat alveolar bone were isolated. They were further purified by a sucrose density gradient. SDS-polyacrylamide gel electrophoresis of the purified vesicles revealed the presence of a polypeptide with a molecular weight of 43 K daltons and with electrophoretic mobility identical to that of blood platelet actin. The limited proteolysis of both 43 K dalton vesicular polypeptide and actin byStaphylococcus aureus-V8-protease revealed three fragments with identical electrophoretic mobility. In addition, the vesicular preparations inhibited the activity of DNase I, a property typical of actin monomers. Filamentous material extracted from matrix vesicles showed ultrastructural features of F-actin. Reaction of this material with heavy meromyosin resulted in arrowhead formation, which is characteristic of acto-heavy meromyosin. The occurrence of actin in extracellular matrix vesicles may account for their budding from the osteoblastic plasma membrane, their possible motility in the matrix, and maintenance of the spherical shape.
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    Abnormal skeletal response to parathyroid hormone in dogs with chronic uremia (1982)
    Springer
    Calcified tissue international 34 (1982), S. 403-407 
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    ISSN: 1432-0827
    Keywords: Cyclic AMP ; Parathyroid hormone ; Bone ; Chronic uremia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The release of cyclic AMP from bone in response to stimulation with PTH 1–34 was examined in 20 dogs with long-term chronic renal failure (CRF) produced by unilateral nephrectomy and contralateral partial renal artery ligation. After 9 to 15 months of uremia, the tibiae were removed and perfused in vitro. Seven dogs with CRF served as controls, 7 dogs with CRF were treated with 24,25(OH)2D3 — 2.5 µg per day, and 6 CRF dogs underwent thyroparathyroidectomy (TPTX) 42 h before they were sacrificed. The release of cyclic AMP from bone in response to PTH 1–34 in the CRF dogs was severely reduced compared to the response observed in 7 dogs with normal renal function (net accumulation of cyclic AMP release 86±8.5 versus 426±59.0 pmol/30 min). Long-term treatment of uremic dogs with 24,25(OH)2D3 had no effect on the release of cyclic AMP by bone. However, the release of cyclic AMP was restored to normal levels in the CRF dogs that underwent thyroparathyroidectomy. All CRF dogs had secondary hyperparathyroidism and the fact that TPTX returned the cyclic AMP response to normal values suggests that desensitization to PTH of the adenylate cyclase system of bone exists in chronic uremia.
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    Stress-wave attenuation in thin structures by ultrasonic through-transmission (1980)
    Springer
    Journal of nondestructive evaluation 1 (1980), S. 277-286 
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    ISSN: 1573-4862
    Keywords: Ultrasonics ; through-transmission ; composite materials ; attenuation ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The steady-state amplitude of the output of an ultrasonic through-transmission measurement is analyzed and the result is given in closed form. Provided that the product of the input and output transduction ratios, the specimen-transducer reflection coefficient, the specimen-transducer phase-shift parameter, and the material phase velocity are known, this analysis gives a means for determining the through-thickness attenuation of an individual thin sample. Multiple stress-wave reflections are taken into account, and so signal echoes do not represent a difficulty. An example is presented for a graphite fiber epoxy composite (Hercules AS/3501-6). Thus, the technique provides a direct method for continuous or intermittent monitoring of through-thickness attenuation of plate structures which may be subject to service structural degradation.
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    A new digital correlation flaw detection system (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 57-63 
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    ISSN: 1573-4862
    Keywords: ultrasonics ; correlation ; pseudorandom codes ; random signals ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A new portable digital random signal flaw detection system is described which uses a digital delay line to replace the acoustic delay line of the original random signal system. Using this new system, a comparison was made between the two types of transmit signals which have been used in previous systems—m-sequences and random signals. This comparison has not been possible with these previous correlation flaw detection systems. Results indicated that for high-speed short code operation, the m-sequences produced slightly lower range sidelobes than typical samples of a clipped random signal. For normal long code operation, results indicated that system performance is essentially equivalent in resolution and signal-to-noise ratio using either m-sequences or clipped and sampled random signals. Further results also showed that for normal long code operation, the system produces outputs equivalent in resolution to pulse-echo systems, but with the added benefit of signal-to-noise ratio enhancement.
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    Potential and limits of holographic reconstruction algorithms (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 85-111 
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    ISSN: 1573-4862
    Keywords: Holographic reconstruction ; ultrasound ; NDE ; Rayleigh-Sommerfeld formula
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract For the purpose of ultrasonic nondestructive testing of materials, holography in connection with digital reconstruction algorithms has been proposed as a modern tool to extract crack sizes from ultrasonic scattering data. Defining the typical holographic reconstruction algorithm as the application of the scalar Kirchhoff diffraction theory to backward wave propagation, we demonstrate its general incapability of reconstructing equivalent sources, and hence, geometries of scattering bodies. Only the special case of a planar measurement recording surface, that is to say, a hologram plane, and a planar crack with perfectly rigid boundary conditions parallel to the hologram plane and perpendicular to the incident field yields a nearly perfect correlation between crack size and reconstructed image; the reconstruction algorithm is then referred to as the Rayleigh-Sommerfeld formula; it therefore represents the optimal case matched to that special geometrical situation and, hence, may be interpreted as a quasi-matched spatial filter. Using integral equation theory and physical optics, we compute synthetic holographic data for a linear cracklike scatterer for both plane and spherical wave incidence, the latter case simulating a synthetic aperture impulse echo situation, thus illustrating how the Rayleigh-Sommerfeld algorithm or its Fresnel approximation increasingly fail for cracks inclined to the hologram plane and excited nonperpendicularly. Furthermore, we point out how the physical data recording process may additionally influence the reconstruction accuracy, and, finally, guidelines for a careful and serious application of these holographic reconstruction algorithms are given. The theoretical results are supported by measurements.
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    Interior imaging using spatial frequency sampling (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 203-207 
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    ISSN: 1573-4862
    Keywords: ultrasonics ; synthetic aperture ; spatial frequency ; interior imaging ; acoustic microscopy ; defect detection ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A new acoustic synthetic aperture geometry is demonstrated in which the image field is sampled in the spatial frequency domain. This means the sampled field is recorded in a particularly convenient form for presentation to the back propagation algorithms used to reconstruct the field at the object plane. The method has applications in interior visualization. It is difficult to image the interior of solid objects using lens based imaging systems because a different lens geometry must be used for each distinct object material. The system presented here overcomes such problems since both the angular variation of the transmission coefficient at the object-water interface and the aberrations introduced by the velocity mismatch at the object surface may be readily compensated for in the back propagation routine. Experimental results are presented illustrating the detection of four half wavelength diameter defects, spaced by three wavelengths, at a depth of eight wavelengths below the surface of an aluminum block.
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    Spherical wave decomposition approach to ultrasonic field calculations (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 241-247 
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    ISSN: 1573-4862
    Keywords: ultrasonic field ; numerical methods ; transducer design ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A simple, flexible, accurate, and comprehensive numerical method is presented for theoretically analyzing the diffraction field of a continuous wave transducer of arbitrary size, shape, and frequency. Using the extensively studied circular transducer for comparison, numerical results are shown for an unfocused transducer with uniform velocity excitation as well as for a focused transducer with Gaussian velocity excitation. Data concerning the execution time, program size, and convergence of the method are also presented for its implementation as a design tool on a minicomputer system.
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    Quantitative use of Rayleigh waves to locate and size subsurface holes (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 55-63 
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    ISSN: 1573-4862
    Keywords: ultrasonics ; Rayleigh waves ; subsurface defects ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An ultrasonic inspection method is used to obtain the circumference of a subsurface hole and the depth of the hole below the surface. A pitch-catch Rayleigh wave transducer set-up was used to launch a Rayleigh surface wave at the flaw and to capture and record the scattered waves. The frequency spectrum of the scattered waves can be used to obtain the depth of the hole. The ligament of material between the hole and the surface is sent into resonance, and this feature can be extracted from the scattered waves' frequency spectrum. The frequency is a function of the ligament length; thus the hole depth can be obtained. The circumference of the hole is found from a time of flight measurement. A Rayleigh wave is formed that travels around the hole's surface. The length of time required for the wave to travel around the hole is a measure of the circumference.
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    The influence of skin depth on crack measurement by the ac field technique (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 65-76 
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    ISSN: 1573-4862
    Keywords: crack measurement ; ac field technique ; arbitrary skin depth ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A general solution is given to describe the ac field around surface-breaking cracks for arbitrary values of the ratio of skin depth δ to crack depthd. This solution allows accurate interpretation of crack depth from voltage readings taken by a Crack Microgauge instrument in cases where δ andd are comparable. It is shown to agree with asymptotic formulae obtained for the cases where δ/d is very small and very large. Provided that the probe length Δ is large compared with δ, the calculations show that a very good approximation to the crack depth may be obtained, irrespective of the ratio δ/d, by using the thin-skin asymptotic formula $$d = \frac{1}{2}\Delta (V_2 - V_1 )/V_1 $$ whereV 1 andV 2 are probe voltages registered at positions just off and across the crack, respectively. The problem is solved for a crack of infinite aspect ratio which has no opening, but it can be applied with confidence at the centerline of cracks of fairly large aspect ratio.
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    Infrared scanning thermography for a quantitative detection of cavities in a plane slab and a rectangular prism (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 99-109 
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    ISSN: 1573-4862
    Keywords: thermography ; infrared scanning ; calibration ; inverse problems ; cavity detection ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An approach for treating nondestructive testing as the solution of inverse problems in mathematical physics has been used for the detection of cavities. The approach is developed based on the use of an additional boundary condition of scanned temperature on the surface to solve for the cavity geometry. For the present study, the condition at the cavity side is taken to be that of a specified temperature, and the experiment is carried out to meet this condition. Two specimens are tested in this paper, a plane slab and a rectangular prism. In both bodies the cavity is rectangular in shape. For the testing of the plane slab, the method is able to detect the cavity wall with high accuracy, whereas the cavity depth error is larger (6%). The detection of the cavity position in the rectangular prism has an error ranging from −9.7 to 7.7%. Errors in the experiment are attributed to the uncertainties in the measurements of temperature and the Biot number. The former is read off from the analog data output of the infrared scanner. The latter is not measured separately, but is computed from the scanned data and thus becomes a portion of the total nondestructive testing output. A final note is also made in this paper to relate how the presented method can be used in actual practice.
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    Analysis of ultrasonic wave scattering for characterization of defects in solids: I. Spherical inclusions and reciprocity (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 175-182 
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    ISSN: 1573-4862
    Keywords: ultrasonic wave scattering ; inclusions ; reciprocity ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract This paper, as part of a series on elastic wave scattering, presents results of measurements and calculations on scattering of ultrasonic waves by a solid spherical inclusion (tungsten carbide) embedded in titanium alloy by the diffusion bonding process. Both direct scattering and mode-converted scattering angular distributions are reported for shear and compressional incident waves. The consequences upon the signals when transmitter and receiver were interchanged are explored in a reciprocity rule.
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    Volumetric inspection of moderately thick austenitic stainless steels by multifrequency eddy currents (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 23-33 
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    ISSN: 1573-4862
    Keywords: austenitic stainless steel ; austenitic stainless steel welds ; eddy current inspection ; eddy current testing ; electromagnetic testing ; ferromagnetic steel inspection ; flaw characterization ; flaw detection ; NDE ; multifrequency eddy current inspection ; weld inspection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract This paper describes the initial phase of a project to develop eddy-current methods to inspect welds joining sections of austenitic stainless steel pipe having walls up to 13 mm (0.5 in.) thick. The objective of this phase was to demonstrate the feasibility of detecting and characterizing flaws in austenitic stainless steel base metals. These materials and welds present challenging eddy-current problems because of their relatively large thickness and ferromagnetism. Multiparameter analysis shows that a reflection coil probe operated with three discrete driver frequencies and phase detection can locate and size a cracklike defect in a single conductor in the presence of variations in conductor resistivity, permeability, and thickness and in the probe-conductor spacing (liftoff). Experiments were performed with a modular three-frequency instrument. Flat-plate specimens of types 304L and 347 stainless steel machined to 12.7 to 15.9 mm thickness simulated pipe walls; saw-cut slots 10 to 30% of nominal specimen thickness simulated cracklike defects. The same slots were used in duplicate experiments as near-side (directly under the test probe) or far-side (in the face opposite the probe) defects. Flaw detection and characterization capability was demonstrated by a series of experimental measurements fitted to specimen properties by least squares techniques. The quality of the fit determined the expected accuracy of measurement. Comparison of accuracy estimates determined the best choice of operating frequencies. From the 1,2,5 sequence of frequencies between 0.5 and 20 kHz, the optimum set of operating frequencies was selected to be 0.5, 2, and 10 kHz. Estimates of measurement accuracy for combined near- and far-side defect cases were: plate thickness, 0.74 mm; probe liftoff, 0.03 mm; defect location (depth of material above defect), 3.48 mm; and defect size (vertical slot depth), 1.09 mm. A few property values were back-calculated from instrument readings; the errors in these values were somewhat larger than the measurement accuracy estimates because of instrument drift and the absence of calibration circuits.
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    Defect identification and sizing by the ultrasonic satellite-pulse technique (1980)
    Springer
    Journal of nondestructive evaluation 1 (1980), S. 263-276 
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    ISSN: 1573-4862
    Keywords: Ultrasonics ; scattering ; diffraction ; defect characterization ; cracks ; voids ; pattern recognition ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Shape and size are the most important defect characteristics that need to be determined for the reliable prediction of the remaining service lifetime of a defective structure or part. The analytical and supporting experimental results presented in this paper concern a general, pattern recognition-based, ultrasonic defect identification and sizing method. The satellite-pulse technique (SPT) is based on the interpretation, in terms of defect types (shapes) and dimensions, of the separation in time of arrival between the readily detected specularly reflected pulse and its generally ignored tip-diffracted or tangentially scattered “satellite” contained in the received waveform. Calibration procedures were also developed that enable the ultrasonic examiner to read the time scale of the oscilloscope for equivalent crack depth or void diameter as appropriate.
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    Acoustic emission and inclusion fracture in 7075 aluminum alloys (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 35-41 
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    ISSN: 1573-4862
    Keywords: acoustic emission ; crack growth ; 7075 aluminum ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract For slow crack growth (da/dn ≈0.1 µm per load cycle) in 7075-T6 aluminum, quantitative agreement was found between the amplitude distribution of burst acoustic emissions and the area size distribution of intermetallic inclusions ≈10 (µm)2 in area as measured on thepolished fracture face. This observation permits the prediction of the amplitude distribution of acoustic emissions due to crack growth in a particular sample of 7075-T6 aluminum directly from a simple, standard metallographic observation performed on the material in question. It was also found that a reduction of the yield stress from that of 7075-T6 aluminum (503 MPa) to that of 7075-0 aluminum (103 MPa) completely eliminated burst acoustic emission activity due to crack advance in the amplitude range studied.
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    Static finite element stress intensity factors for annular cracks (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 119-124 
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    ISSN: 1573-4862
    Keywords: Stress intensity factor ; annular crack ; finite element methods ; fatigue ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Results of finite element static stress intensity factor calculations for an annular crack around a spherical inclusion (void) are presented and compared with those from approximate analytical methods.
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    URL: http://dx.doi.org/10.1007/BF00566309
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    Note on ultrasonic tomography (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 147-149 
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    ISSN: 1573-4862
    Keywords: Ultrasonic tomography ; residual stress ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Ultrasonic tomography is being explored as a potential tool to map residual stresses in solids. The angular scanning required in tomography imposed limitations on the stress configuration adaptable to such a treatment. These are discussed in the following note.
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    Ill-posed and well-posed problems in inverse elastodynamic scattering for nondestructive evaluation (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 161-172 
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    ISSN: 1573-4862
    Keywords: elastodynamic inverse scattering ; ultrasonics ; data reduction ; ill-posed problems ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The practical significance of ill-posedness in a data reduction problem is reviewed. Inverse elastodynamic scattering is shown to be ill-posed in general, although suitably restricted problems may be well-posed. These results underscore the need to analyze carefully the errors of data reduction problems in NDE, and to focus attention on final results of an NDE exercise, rather than on intermediate steps.
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    Effects of sinusoidal crack-face perturbations on scattering of elastic waves (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 153-159 
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    ISSN: 1573-4862
    Keywords: ultrasonics ; scattering ; cracks ; periodic surface perturbation ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The scattering of a plane longitudinal wave from a two-dimensional crack, with a sinusoidal surface perturbation whose amplitude and wavelength are much smaller than the length of the crack, is investigated. The amplitude of the cylindrical body waves in the far field are calculated from a Kirchhoff approximation that utilizes the solution to the reflection from the sinusoidal surface profile of a semiinfinite solid. The results are compared to those for a flat crack, and conditions for significant differences of the amplitude as a function of the angle of observation are discussed. Characteristic changes in the scattered field produced by profiles with different amplitudes and periods are explained.
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    Parasitic voltages induced by artificial flaws when measured using the ac field technique (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 195-202 
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    ISSN: 1573-4862
    Keywords: ac potential difference ; fatigue crack measurement ; slots ; artificial flaws ; parasitic voltages ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The development of a successful and accurate instrument for measuring surface-breaking cracks in metals using the ac field technique has raised several interesting theoretical problems. Measurements with the instrument, known as the Crack Microgauge, do not rely on any prior calibration against an artificial flaw such as a saw-cut in a test block, but some users accustomed to such a calibration from other devices have nevertheless wished to use the instrument in that fashion and have in some instances reported erroneous results. In this paper, we develop a simple theory to explain and quantify this phenomenon. We calculate the parasitic voltages induced in the instrument probe due to the finite opening possessed by an artificial flaw, and we use these results to reinterpret the instrument readings. Controlled experimental measurements on artificial flaws of rectangular cross-section made in aluminum and in steel are found to be in good agreement with the theory. It is shown, however, that application of the theory requires additional information about the internal phase shift associated with the instrument. To enhance the accuracy of the theory, the effect of the corners of the artificial flaws was also considered, although it was not very influential in this work.
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    The ac field around a plane crack in a metal surface when the skin depth is large (1982)
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    Journal of nondestructive evaluation 3 (1982), S. 19-24 
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    ISSN: 1573-4862
    Keywords: ac potential difference ; eddy current ; fatigue crack measurement ; skin effect equation ; large skin depth ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract This paper considers the solution of the skin-effect or Helmholtz equation, ∇2ψ=k 2ψ, for the two-dimensional flow of a uniform alternating current perturbed by a plane crack of uniform depth. Herek is the ratio of crack depthd to skin depth δ. When the skin depth is large compared with the crack depth andk f 0, the quasi-static approach to this problem ignores the terms on the right-hand side and constructs solutions from Laplace's equation which are essentially dc solutions and are correct to orderk. In this paper we consider behavior near the limit when the skin depth is large and give solutions which are correct to orderk 2. In an example we relate the results to the interpretation of readings from an ac potential difference instrument applied to the measurement of surface-breaking cracks.
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    Characterization of localized surface elastic defects by nonspecular reflection at the Rayleigh angle (1982)
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    Journal of nondestructive evaluation 3 (1982), S. 93-98 
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    ISSN: 1573-4862
    Keywords: bounded ultrasonic beam reflectivity ; Rayleigh angle ; beam profile ; surface defects ; nonspecular reflection ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The relationships between characteristics of elastic defects and nonspecular features of bounded ultrasonic beams reflected at the Rayleigh angle from a liquid-solid interface are investigated. The results can serve as a theoretical basis for interpretation of Rayleigh angle nonspecularly reflected beam profiles as characterization of localized surface elastic defects.
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    On the optimum applied field for magnetic particle inspection using direct current (1982)
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    Journal of nondestructive evaluation 3 (1982), S. 125-136 
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    ISSN: 1573-4862
    Keywords: magnetic particle inspection ; magnetic leakage fields ; finite difference method ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Experimental measurements of leakage fields from cylindrical defects were obtained in a geometry which permitted simultaneous measurement of the magnetic induction of the material. The results obtained are compared with calculations using a nonlinear finite difference method. Both the experiments and the calculations indicate that the magnitude of the leakage field continues to grow nearly in proportion with the applied field well into the saturation region of the magnetic material. The implications for magnetic particle inspection are discussed.
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    Time domain Born approximation (1982)
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    Journal of nondestructive evaluation 3 (1982), S. 45-53 
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    ISSN: 1573-4862
    Keywords: Born approximation ; ultrasonic scattering ; NDE ; time domain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The time domain Born approximation for ultrasonic scattering from volume flaws in an elastic medium is described. Results are given both for the direct and the inverse problem. The time domain picture leads to simple intuitive formulas, which we illustrate by means of several simple examples. Particular emphasis is given to the front surface echo and its use in reconstructing the properties of the flaw.
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    Remaining fatigue life prediction in the initiation regime using SAW NDE (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 3-9 
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    ISSN: 1573-4862
    Keywords: harmonic generation ; fatigue ; microcracks ; aluminum ; surface acoustic waves ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Harmonic generation of surface acoustic waves (SAW) is shown to be a useful tool for the detection of the initiation of surface cracks during fatigue of high strength aluminum alloys. A model that relates the length and density of microcracks to the amplitude of a SAW harmonic signal is described, and an associated coefficient of generation efficiency for the second harmonic amplitude is derived. A correlation between experimentally measured harmonic amplitude and remaining fatigue life is then demonstrated, which allows the mean remaining fatigue lifetime to be estimated to within 5% over the last 50% of the fatigue life for an Al 7075 alloy if the cyclic stress amplitude, but not the duration of fatigue, is known.
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    Ultrasonic diffraction technique for characterization of fatigue cracks (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 11-19 
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    ISSN: 1573-4862
    Keywords: ultrasonic diffraction ; fatigue cracks ; crack closure ; crack surfaces ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract This paper describes an ultrasonic diffraction technique for characterizing fatigue cracks. The angular field of energy scattered from a crack tip was computed. Using the theoretically predicted and experimentally verified optimum range of angles, we measured the crack profiles by the ultrasonic diffraction technique. Ultrasonic measurements agreed very well with direct destructive measurements. In addition, fatigue crack closure was detected and information on crack surfaces was obtained.
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    Methods for determining the depth of near-surface defects (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 21-36 
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    ISSN: 1573-4862
    Keywords: ultrasonics ; surface defects ; defect depth ; deconvolution ; correlation ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract In previous work by the authors,(1,6) it was demonstrated that the presence of near-surface defects could be detected reliably, even though the defect echo was contained within the near-surface echo. The algorithm consists of examining the variation in the composite (near-surface plus defect) response after it has been deconvolved from a near-surface response known to be defect-free. This paper presents two algorithms that have been developed subsequent to the work presented in ref. (6) for estimating thedepth of a near-surface defect, given that its presence has already been detected. One algorithm uses complex frequency domain techniques, and the other uses time domain analysis. Both procedures operate on the surface-plus-defect signal, using reference signals containing surface-only and defect-only responses. The defect signal is extracted from the composite signal. Defect depth is then computed from the time difference between the centers of the front-surface and extracted defect responses. A mean absolute depth error of 0.015 in. was obtained by applying the algorithms to experimental data containing depths from 0.020 to 0.130 in. below the near-surface.
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    Accept/reject decisions and failure prediction for structural ceramics: Application to failure from voids (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 37-52 
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    ISSN: 1573-4862
    Keywords: failure prediction ; accept/reject decisions ; ceramic materials ; ultrasonics ; fracture ; probabilistic model ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A general probabilistic method for reaching accept/reject decisions and failure prediction based on nondestructive evaluation procedures is described. The method is illustrated for ceramic materials that fail by the activation of microcracks located at void surfaces. The inspection procedure used for the analysis is the long wavelength ultrasonic method. The analysis indicates influences on the decision level and on the false-reject probability of variations in the signal-to-noise ratio and in the preexistent void population. The ultrasonic inspection is shown to exert a relatively minor influence on the false-reject probability, even for low signal-to-noise ratios, low stresses, and a widely dispersed void population, because of the intrinsic variability of the selected failure process. More encouraging results concerning the utility of NDE are anticipated to apply to other failure mechanisms in ceramics.
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    Analytical representation of transient ultrasonic phased-array near- and far-fields (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 53-66 
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    ISSN: 1573-4862
    Keywords: ultrasonic transducers ; phased array ; ultrasonic imaging ; impulse response ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The present contribution provides a method for the derivation of analytical near- and far-field expressions for the pressure step-function response of nonuniformly excited ultrasonic transducers modeled as pistons of arbitrary shape in an infinite rigid baffle. Explicit inversion of the Laplace transformed ultrasonic field using Cagniard's idea results in elementary functions or definite integrals of elementary functions, depending on the assumed nonuniform aperture distribution. The basic signal distortion is illustrated in terms of three-dimensional space-time plots of the pressure unit step-function response of a rectangular uniform aperture. The corresponding results for a phased-array transducer are also given. In addition, we investigate the pressure profile on the axis perpendicular to a uniform rectangular piston and its horizontal radiation pattern for different bandwidths of the exciting impulse.
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    Acoustic measurements of stress fields and microstructure (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 67-77 
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    ISSN: 1573-4862
    Keywords: stress fields ; microstructure ; J integral ; stress intensity factor ; harness acoustic velocity ; acoustic elasticity ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A very precise system for measuring two-dimensional velocity fields in solid samples has been used for nondestructive measurements of both externally applied and residual inhomogeneous stresses in solids,J integrals, stress intensity factors of cracks, and hardness of quenched steel. The longitudinal velocity measurement is based on precise determination of the propagation transit time through the stressed solid specimen using a small diameter, water-coupled acoutic transducer, which is scanned mechanically over the sample. Changes in velocity are then related to changes of stress in the sample by the theory of acoustoelasticity. Similar measurements show a high degree of correlation between longitudinal velocity changes and changes in microstructure in steel samples. Applications to problems of solid mechanics and material science illustrate the utility of this nondestructive measuring technique.
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    The relationship between radiating body forces and equivalent surface stresses: Analysis and application to EMAT design (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 79-85 
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    ISSN: 1573-4862
    Keywords: ultrasonic waves ; EMAT ; surface stress ; NDE ; Green's function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An analysis of the radiation from a body force shows that it is equivalent to the radiation from a series of surface stresses defined by the moments of the body force taken with respect to the depth coordinate. As the body force becomes localized near the surface, the zeroth moment of the force dominates the radiation and is often thought of as an equivalent surface stress. However, under certain conditions, this can vanish, and the other moments must be considered. It is found that, as the order of the moment of a particular force component increases, the resulting radiation patterns alternate between those characteristic of a compressive surface stress and those characteristic of a shear surface stress, which have considerably different angular variations. Results of experiments in the development of EMAT transducers for nondestructive testing that support these results are cited, and important consequences in the design of inspection systems are indicated.
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    An acoustic emission energy analysis and its use to study damage in laminated composites (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 225-233 
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    ISSN: 1573-4862
    Keywords: Acoustic emission ; energy analysis ; composite materials ; strength ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A new technique which uses the output of a true RMS voltmeter to measure the acoustic emission energy output of a transducer is presented. To demonstrate its use in a typical case, this procedure is used to measure acoustic emission energy during tensile tests on [0°/±30°/90°]s glass-epoxy laminate uniaxial and 10° off-axis tensile coupons. The test results were compared with numerical predictions of laminate response and acoustic emission energy. The experiments indicate that acoustic emission energy can be used to indicate the onset of ply and interlaminar failure.
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    Defect characterization in the short-wavelength regime (1980)
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    Journal of nondestructive evaluation 1 (1980), S. 235-247 
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    ISSN: 1573-4862
    Keywords: Ultrasonics ; acoustic waves ; scattering ; diffraction ; defect characterization ; silicon nitride ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The scattering of acoustic waves by different types of spherical defects in a silicon nitride matrix is calculated by using Ying and Truell's scattering theory. The theoretical scattering results are interpreted using a ray tracing approach. Experiments were carried out at a high frequency (150–450 MHz) to characterize defects in silicon nitride. Time and space averaging, Wiener filtering, diffraction, and propagation loss corrections were used to remove the effect of the transducer response and propagation loss in the material from the scattered signal. Our experimental results indicate the presence of a new type of defect in silicon nitride. They give the type and size of voids, cracks, and Si inclusions in good agreement with measurements obtained after sectioning.
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    Quantitative characterization of flaws near a surface using inverse born approximation (1982)
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    Journal of nondestructive evaluation 3 (1982), S. 183-188 
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    ISSN: 1573-4862
    Keywords: Ultrasonics ; Born inversion ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Quantitative reconstruction of volumetric flaws near a surface of an elastic solid has been carried out experimentally by analyzing the scattered ultrasonic waves. The inverse Born approximation (developed for flaws in bulk materials) was tested for the first time in the determination of the size, shape, and orientation of near-surface flaws. We have studied spherical solid inclusions at various depths below the surface. In addition we examined an approximately 2:1 prolate spheroidal inclusion which was located one major axis below the surface. The determination of the flaw's size, shape, and orientation in terms of an equivalent ellipsoid is realized by performing nonlinear least-squares iteration of the one-dimensional Born inversion results obtained at various scattering directions within a finite aperture. The reconstruction is in good agreement with the actual parameters of the flaw.
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    Rayleigh wave propagation in a solid with a cold-worked surface layer (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 43-49 
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    Keywords: Rayleigh wave dispersion ; higher mode generation ; cold-working ; rail ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The propagation of the Rayleigh surface wave is experimentally studied along the top surface of used railroad rail under conditions where ultrasonic pulses have carrier frequencies ranging from 0.4 to 3.0 MHz and approximately 10 µs duration. The generation of the first higher (M 21 or Sezawa) mode as well as the fundamental (M 11) mode and their dispersion properties are observed. These phenomena are attributable to the presence of the cold-worked surface layer caused by the wheel passage. It is shown that a theoretical model of a single layer overlying a half space, whose elastic constants are determined by a destructive method, yields results which agree with the dispersion curves obtained experimentally. On the basis of this one-layered model, an inversion method to estimate the layer thickness and its elastic constants is discussed.
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    Resonance testing of cast iron (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 65-74 
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    ISSN: 1573-4862
    Keywords: NDE ; cast iron ; vibration analysis ; modulus ; strength
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An outline is given of the existing nondestructive vibration tests for cast irons and their drawbacks in terms of the dimensional accuracy of the components. A proposal is made for a new test based on the change of resonant frequency with vibration amplitude exhibited by cast irons. This proposal is evaluated using material data obtained from dynamic tests of a wide range of cast iron specimens. A test rig is described suitable for testing cylindrical cast bars, and typical results are presented in relation to material strength. There is also a brief description of preliminary testing on cast products.
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    Detection of strength limiting defects in cellular glasses by dielectric measurements (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 113-118 
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    ISSN: 1573-4862
    Keywords: Capacitance ; dielectric constant ; voids ; cellular glasses ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Cellular (foamed) glasses are a prime candidate for certain structural applications, such as support of the silvered glass concentrator mirrors in solar thermal energy systems. An economical nondestructive measurement of strength-limiting defects in these materials would permit development of designs in which the material is subjected to a higher working stress level and maintains the same probability of failure. This would result in weight and cost savings for any application. A method of measuring the capacitance of well-defined regions of a specimen was investigated. Large voids were found to produce significant localized changes in the capacitance of the specimen. The feasibility of locating the large, strength limiting defects in this porous material has been demonstrated for one type of cellular glass. Means of producing an image from this type of data and an implementation scheme for on-line production measurements are discussed.
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    Nondestructive testing of materials using 14 MeV neutrons and a pulse-shape analyzer system (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 139-146 
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    ISSN: 1573-4862
    Keywords: Material defects ; 14 MeV neutrons ; pulse-shape analyzer system ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A 14 MeV neutron generator and fast neutron spectrometer consisting of an organic scintillation detector and a pulse-shape analyzer are used for the nondestructive testing of materials. The 14.6 MeV peak (in the 12.7–15.7 MeV region) is observed to change as a function of both the kind of testing material and the defect condition inside the material. The number of neutron counts under the 14.6 MeV peak for lighter testing materials (e.g., plastic, brass, and aluminum) with a defect will increase, as compared to the number of neutron counts under the same peak region of an identical testing material but with no defect. For heavier testing materials (e.g., steel and lead), the inverse is observed. The method is feasible even with defects of size 0.25 cm3 (i.e., a cylindrical cavity 0.4 cm in diameter and 2.0 cm in length), although quantitative evaluation of the size of the defect as a function of the change of the number of neutron counts under the 14.6 MeV peak region is difficult due to instability of the 14 MeV neutron output.
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    Surface acoustic wave measurements of surface cracks in ceramics (1981)
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    Journal of nondestructive evaluation 2 (1981), S. 219-229 
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    ISSN: 1573-4862
    Keywords: acoustics ; surface acoustic waves ; Rayleigh waves ; ceramics ; surface cracks ; residual stresses ; crack extension ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An investigation of scattering from surface cracks has been conducted. In particular, the change in the reflection coefficient of a Rayleigh wave incident on a surface indentation crack has been measured as the sample is stressed to fracture. The acoustic measurements have been correlated with the stable crack extension that precedes final failure. The crack extension behavior of as-indented specimens was found to differ appreciably from that of annealed specimens. Cracks in the annealed samples exhibited partial crack tip closure, but little stable extension, whereas cracks in the as-indented samples displayed both crack closure and irreversible crack growth. This behavior has been rationalized by invoking concepts based upon the residual stresses created by indentation.
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    Probe characterization in ac field measurements of surface crack depth (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 9-17 
    Details
    ISSN: 1573-4862
    Keywords: ac potential difference ; probe characterization ; induction effect ; slots ; fatigue crack ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract In the ac field method of crack depth measurement by the Crack Microgauge, the area of the loop formed in the probe gives rise to an induced voltage, which can introduce errors into the depth measurement. In this paper, a method for measuring the probe area is given, and the quality of the probe is thereby characterized. The underlying theory was given previously, and it is applied here to the probe characterization problem. The probe area is determined by two voltage measurements taken on an artificial rectangular flaw machined in an arbitrary metal. By measurements on several such specimens with the same probe, it is confirmed that the area so obtained is a characteristic of the probe and is independent of the specimen material. Thereafter, measurements on various rectangular flaws with probes of different characteristic area were taken, and very good agreement between predicted and real depths was achieved. Both theory and experiments show that probe characterization is of particular importance when this method is used to measure surface crack depths in metals of low permeability such as aluminum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566950
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    Change in impedance of a single-turn coil due to a flaw in a conducting half space (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 37-43 
    Details
    ISSN: 1573-4862
    Keywords: eddy current ; impedance ; lift-off ; flaw ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The problem of detection and characterization of a flaw in a conducting half-space using an eddy-current coil oriented parallel to the interface is examined. An expression is derived for a first order approximation for the change in complex impedance due to a flaw located within the conducting medium. The overall impedance is a function of the radius and lift-off distance of the test coil and the conductivity of the material. An analytical expression is derived for the change in impedance as a function of the electric fields at the position of the flaw. It is found to be an integral over the volume of the flaw of the electric fields found with and without the flaw being present. The limiting case of a degenerate point flaw may be examined in greater detail by allowing the field in the presence of the flaw to be approximated by the unperturbed field. For flaws small enough that the field does not vary much over its volume, the field may be even further approximated by using just the value of the field at the position of the centroid of the flaw. Plots are shown to illustrate the behavior of the change in impedance as a function of the radial range of the flaw and the depth of the flaw centroid, using previously derived expressions for the fields for the unflawed case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566953
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    Electromagnetic acoustic transducer for in-plane and plane-normal velocity measurements (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 85-91 
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    ISSN: 1573-4862
    Keywords: displacement-field ; acoustic radiation ; wave propagation ; absolute velocity ; EMAT ; mode selective ; nonresonant frequency response ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A new electromagnetic acoustic transducer (EMAT) is developed that measures velocities and absolute surface displacements in-plane and plane-normal to the direction of wave propagation. This transducer is flexible in shape and design to conform with irregular surfaces and has unique characteristics of nonresonant frequency response. Tests show that the sensitivity of this EMAT can be increased by increasing the applied magnetic field. Because this transducer is mode selective and nonresonent, its response can be related uniquely to the wave motion. This property is highly desirable for research purposes, though generally not wanted in field monitoring situations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00568964
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    Two-dimensional radiographic imaging analysis (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 221-227 
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    ISSN: 1573-4862
    Keywords: Radiography ; point-spread function ; corner location ; edge location ; unsharpness ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Two-dimensional imaging properties of locally isotropic and isoplanatic point spread functions are described in a general radiographic context. In particular, the radiographic response to a two-dimensional wedge-shaped object is shown to possess several properties which enable the identification of the wedge corner on the image, thereby alleviating the need for image enhancement techniques. Extensions to the location of flat-edged boundaries are also discussed. The potential dimensioning application of this analysis lies in the precise and objective location of points of interest on radiographs of more complex two-dimensional objects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00565866
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    Loss of specular reflection due to nonlinear crack-face interaction (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 229-239 
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    ISSN: 1573-4862
    Keywords: Crack-opening displacement ; crack closure ; ultrasonics ; Kirchoff approximation ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The interaction between rough crack faces is modeled by nonlinear relations between the crack-face tractions and the crack-opening displacements. These relations account for crack closure and for the related resistance to crack-face sliding. The relations are used to investigate reflection and transmission of an incident pulse by an infinite flaw plane. The problem statement is reduced to a set of inhomogeneous nonlinear ordinary differential equations for the displacement discontinuities, [u] and [v], across the flaw plane. These equations have been solved numerically. The reflection and transmission of an incident pulse by a crack with interacting crack faces. Both incident longitudinal and transverse waves have been considered. The loss of specular reflection as compared to a perfect (traction-free) crack is exhibited by specific examples.
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    URL: http://dx.doi.org/10.1007/BF00565867
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    Love wave propagation in a solid with a cold-worked surface layer (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 51-55 
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    ISSN: 1573-4862
    Keywords: Love wave dispersion ; surface layer ; work hardening ; rail ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract In this paper, experiments show Love wave generation along the top surface of used railroad rail, where the shear wave velocity has been slightly reduced by the cold-working of wheel passage for years. The rf pulses used in the experiments have about 10 µs duration and a relatively narrow frequency spectrum. The group velocity of the Love wave is found to have a strong dependence on the carrier frequency over the tested range of 0.45–3.1 MHz. Application of the seismological one-layered model to the experimental measurements yields an NDE technique for the elastic properties and the thickness of the cold-worked surface layer. The results are interpreted on the basis of a destructive observation by micro-Vickers hardness testing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614997
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    Digital ultrasonic image construction using electronic ordered dither techniques (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 75-84 
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    ISSN: 1573-4862
    Keywords: digital signal processing ; microprocessor based system ; binary display ; ordered dither ; ultrasonic C-scan ; image magnification ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The use of a digital microprocessor based system for the acquisition of ultrasonic C-scan information is investigated. The C-scan information is displayed on a binary display device using electronic ordered dither techniques to represent gray levels. The digital system with a binary display increases system flexibility and yields better reproducibility and constant image quality independent of the display medium. Images may be stored on magnetic tape or disk for later retrieval and image processing. The techniques which are described allow for image magnification and a reduction in scan time by replacing the mechanical linkage between the scanner and the display with digital signals. A detailed comparison is made between two dither signals, and the advantages of each are discussed. The combination of digital signal processing and imaging techniques produces results which utilize the capabilities of ultrasonic inspection to the point where the transducer becomes the limiting factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00615000
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    SOL-X: An on-line nondestructive method for measuring grain size with x-rays (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 133-138 
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    ISSN: 1573-4862
    Keywords: X-rays ; diffraction ; grain size determination ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract It is shown that the grain size of commercial materials can be estimated by x-rays with little or no sample preparation. The method is readily automated and can be employed on-line, for example, in a rolling mill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566311
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    Computerized evaluation of acoustic images utilizing a method of averaging (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 173-188 
    Details
    ISSN: 1573-4862
    Keywords: ultrasonics ; acoustic imaging ; computer image analysis ; failure prediction ; inhomogeneous materials ; accept/reject criteria ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A computerized technique is presented which has been developed for analyzing acoustic images of an inhomogeneous material. The acoustic imaging system is briefly described with emphasis on its adaptation to billets of graphite for atmospheric reentry body use. Ultrasonic images of such inhomogeneous material contain a nonuniform distribution of anomalies and few, if any, geometrically regular features which can be assessed to establish material integrity. Results obtained with our new algorithms show, for certain discriminants, a high degree of correlation between the numerical accept/reject values obtained from acoustic image processing and the time-to-failure of the graphitic material in simulated atmospheric reentry tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00570729
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    Propagation of elastic waves in honeycomb panels for application to rapid inspection techniques (1981)
    Springer
    Journal of nondestructive evaluation 2 (1981), S. 209-217 
    Details
    ISSN: 1573-4862
    Keywords: honeycomb panels ; acoustic inspection ; leaky waves ; SH and Lamb waves ; line scan ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract This paper considers the properties of elastic waves guided by an aluminum plate bonded to a honeycomb core for application to rapid inspection of honeycomb panels. Current acoustic inspection techniques involve the transmission of a signal between a pair of small transducers located on opposite sides of the panel. Scanning the transducers in raster fashion results in a high resolution inspection of the panel, but is very time consuming. An alternative technique would simultaneously inspect all points along a line between two widely spaced transducers located on the same side of the panel. Scanning the pair once over the panel permits rapid inspection, although with decreased resolution. Studies presented here indicate that such a method of inspection is feasible and that the flexural mode is probably the most useful.
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    URL: http://dx.doi.org/10.1007/BF00570733
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    Acoustoelastic response of polycrystalline aggregates exhibiting transverse isotropy (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 1-8 
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    ISSN: 1573-4862
    Keywords: acoustoelasticity ; transverse isotropy ; polycrystalline aggregate ; cubic crystal ; third-order elastic constants ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Acoustoelasticity is an ultrasonic technique which has been used for the determination of active and residual stresses in common structural materials. This paper examines the effect of texture on the acoustoelastic response in polycrystalline bodies. In particular materials which are transversely isotropic aggregates of cubic crystals are studied. The second- and third-order elastic constants of the polycrystal are derived from the elastic properties of the constituent crystals, and the crystalline orientation relative to the body's symmetry axis. The acoustoelastic relations between velocity and deformation are then presented for the aggregate. Finally, evaluation of the acoustoelastic response for several ideal textures using data for aluminum single crystals shows that the response is highly dependent on the texture.
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    URL: http://dx.doi.org/10.1007/BF00566949
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    Photothermal examination of an adhesive layer (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 111-113 
    Details
    ISSN: 1573-4862
    Keywords: photoacoustic microscopy ; delamination ; layered structure ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An adhesive layer, by which a piezoceramic foil is attached to an aluminum membrane for telephone application, is examined in a nondestructive way by thermal waves. The basic principles of the method are outlined, and its detecting power is demonstrated by evaluation of a well-defined delamination.
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    URL: http://dx.doi.org/10.1007/BF00568967
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    Finite element modeling of absolute eddy current probe signals (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 147-154 
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    ISSN: 1573-4862
    Keywords: finite element modeling ; eddy current ; absolute probe ; steam generator tubing ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Finite element analysis techniques are applied to the problem of predicting signals from an absolute eddy current probe in the tube sheet region of a PWR steam generator for the purpose of optimizing the probe coil geometry and determining the feasibility of using such a probe to characterize the condition of the tube and tube sheet crevice.
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    URL: http://dx.doi.org/10.1007/BF00566556
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    Relationships between crack opening displacement, alloy variables, and crack detection sensitivity (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 189-200 
    Details
    ISSN: 1573-4862
    Keywords: Acoustic harmonic generation ; critical angle acoustics ; fatigue crack detection ; alloy microstructure ; load amplitude ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Alloy grain size is known to influence both the propagation path and the closure stress of surface fatigue cracks in many alloys. The general trend is for the path to be more tortuous and the closure stress to be larger, the larger the grain size. By use of Ti Al-4V and Al 7075-T6, the effects of grain size on the nondestructive detection of surface cracks which might arise from closure stress and path irregularity variables were evaluated. Titanium specimens were inspected using an acoustic harmonic generation technique, and it was discovered that the major source of harmonic signals was grain sized crystallographic cracks. Harmonic signals were larger during fatigue in an 8-µm compared to a 4-µm grain sized alloy, as there were more grain sized cracks in the large grain material. Crack closure was found to be extremely important in determining the reflected acoustic amplitude obtained in inspecting small (100–1000 µm) cracks in Al 7075-T6 using a critical angle technique. Average received amplitudes were an order of magnitude smaller for cracks at zero load than for those opened by a tensile stress. The scatter in the reflected amplitude was also large, apparently as the result of variations in the degree of the closure from crack to crack. For the 7075 material, the important effect of larger grain size was to increase the irregularity of the crack path, making the small cracks more visible acoustically at azimuthal angles not normal to the crack plane.
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    URL: http://dx.doi.org/10.1007/BF00565864
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    Nondestructive evaluation of jades by means of 14 MeV neutron activation (1982)
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 137-145 
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    ISSN: 1573-4862
    Keywords: jadeite authentication ; 14 MeV neutrons ; jades ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Fourteen MeV neutron activation of jades was used to test the authenticity of jades: to ascertain whether they are genuine jadeite and whether their greenish colour is genuine, both of which are important criteria for the high market value of jadeite. For given activation and measurement conditions of the jades, the gamma-ray spectrum was observed to change as a function of the type of the jades; the counting ratio of the photopeaks from the two most prominent constituent elements varies greatly as a function of the type of the jades. The ratio of counts for the Compton edges of the 1.779 MeV gamma-ray of28Al, from28Si(n,p)28Al reaction, and the 1.434 MeV gamma-ray of52V, from52Cr(n,p)52V reaction, varied as a function of the type of the jades and also as a function of the color. These results can be applied for a fast and nondestructive evaluation of jades.
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    URL: http://dx.doi.org/10.1007/BF00566555
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    Frequency domain methods for reducing transducer variability (1980)
    Springer
    Journal of nondestructive evaluation 1 (1980), S. 101-109 
    Details
    ISSN: 1573-4862
    Keywords: ultrasonic transducers ; NDE ; deconvolution ; signal processing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract A major objective of quantitative nondestructive evaluation is to formulate defect detection, classification, and sizing algorithms that are insensitive to variations in transducer characteristics, material type, and defect depth. With the data used in this research, ultrasonic signals were found to vary significantly with changes in the transducer and only secondarily with changes in material and depth. It is shown that the method for minimizing signal variations due to transducer and material changes is to deconvolve the test signal with respect to the transducer response from a reference defect in a block of the same material. Since depth variation primarily affects signal amplitude and has minor impact on shape, detection, classification, and sizing, insensitivity to depth is achieved by avoiding the use of amplitude-dependent parameters. The notion of a “standard transducer” is introduced. Its mathematical properties and methods of realization are given. It is shown how the effects of variability from different test transducers can be removed by signal processing. When these procedures are applied to the test transducer, the effect is to cause it to resemble the standard transducer and, thereby, to place all ultrasonic waveforms on a common basis.
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    URL: http://dx.doi.org/10.1007/BF00566118
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    Ultrasonic attenuation and velocity in AS/3501-6 graphite fiber composite (1980)
    Springer
    Journal of nondestructive evaluation 1 (1980), S. 137-148 
    Details
    ISSN: 1573-4862
    Keywords: composite material ; ultrasonic velocity ; ultrasonic attenuation ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The ultrasonic group velocity and attenuation were measured as a function of frequency for longitudinal and shear waves in the Hercules epoxy matrix (3501-6) and in the principal directions of the unidirectional Hercules graphite fiber epoxy composite (AS/3501-6). Tests were conducted in the frequency ranges 0.25–14 MHz and 0.5–3 MHz for longitudinal and shear wave modes, respectively. While the attenuation increased with frequency for all wave modes, the group velocity was independent of frequency for all wave modes. In studying the effects of transducer-specimen interface couplant and pressure, it was found that for each transducer, there exists a frequency-dependent “saturation pressure” corresponding to the maximum output amplitude of the signal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566121
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    On the acoustic emission due to the fracture of brittle inclusions (1980)
    Springer
    Journal of nondestructive evaluation 1 (1980), S. 149-155 
    Details
    ISSN: 1573-4862
    Keywords: acoustic emission ; fracture ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The far-field characteristics of the emission from a theoretical model for the fracture of brittle inclusions are presented in detail. The model is a circular crack growing at constant speed from zero size until it attains a prescribed size. The far-field radiation pattern is the same as that of a simple combination of force doublets, and some qualitative similarities between force doublets and acoustic dipoles are noted. The initial shape of the far-field pulses due to the growing stage and the stopping is determined, but difficulties arise in accounting for the diffraction of a surface wave on the crack faces generated by the stopping of the crack.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00567088
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