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  • Articles  (266)
  • Articles: DFG German National Licenses  (266)
  • Chemistry  (266)
  • Analytical Chemistry and Spectroscopy
  • Animals
  • 1980-1984  (170)
  • 1970-1974  (96)
  • 1960-1964
  • 1984  (170)
  • 1974  (96)
  • 1961
  • Medicine  (266)
  • 1
    Electronic Resource
    Electronic Resource
    The effects of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on bone and serum chemistry in rabbits (1974)
    Springer
    Calcified tissue international 16 (1974), S. 145-152 
    Details
    ISSN: 1432-0827
    Keywords: EHDP ; Bone ; Chemistry ; Serum ; Rabbits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The effects of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on bone and serum chemistry were investigated in adult rabbits. EHDP was administered by subcutaneous injection at doses of 0.25, 2.5 and 10 mg/kg body weight/day for of 28 days. Blood samples were obtained weekly from each rabbit and serum levels of total calcium, ionized calcium, inorganic phosphate and alkaline phosphatase were determined. At the end of the treatment period all rabbits were sacrificed and the tibiae removed for chemical analysis and histological evaluation. The effect of EHDP administration on serum chemistry was both dose- and time-related. The highest of the three doses, 10 mg/kg/day, resulted in a time-related decrease in total serum calcium. This dose also caused a rapid but transient reduction in serum ionized calcium. The effect of EHDP on serum inorganic phosphate was biphasic. Administration of 2.5 mg/kg/day resulted in a time-related elevation in this parameter, whereas the 10 mg/kg/day dose resulted in a time-related hypophosphatemic response. There were no significant drug-related changes in tibial fat-free dry weight, ash weight, total calcium or total phosphorus values. However, administration of 2.5 and 10 mg/kg/day EHDP resulted in increased osteoid tissue as measured histologically. These results are compared with data from other EHDP studies, and discussed in relation to the maturity and growth-state of the experimental animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02008220
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  • 2
    Electronic Resource
    Electronic Resource
    Studies in the basic mineralizing system, CaO-P2O5-H2O (1974)
    Springer
    Calcified tissue international 14 (1974), S. 3-14 
    Details
    ISSN: 1432-0827
    Keywords: Hydroxyapatite ; Mineral ; Phase ; Chemistry ; Synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Des diagrammes de phase d'équilibre ont été déterminés pour le système CaO-P2O5-H2O en utilisant des techniques de synthèse hydrothermique au cours de variatio nsde température allant de 300–600° et 2 Kb H2O de pression. De l'hydroxyapatite bien cristallisé a été synthétisé et caractérisé. De faibles variations de paramètres de la maille cristalline, liées à la température de synthèse et composition globale du matériel initial, ont été déterminées. Des conditions chimiques précises sont nécessaires pour obtenir de l'apatite, en tant que seule phase solide en équilibre dans la solution. Les résultats de diagramme de phase d'équilibre sont comparés avec ceux obtenus dans des milieux synthétiques.
    Abstract: Zusammenfassung Es wurden Gleichgewichts-Phasendiagramme für das System CaO-P2O5-H2O bestimmt, indem hydrothermale Synthese-Techniken im Temperaturbereich von 300–600° und bei einem Druck von 2 Kb H2O verwendet wurden. Es wurde gut-kristallisiertes Hydroxyapatit erzeugt und charakterisiert. Es wurden geringe Unterschiede in den Parametern der Zelleinheiten festgestellt, welche von der angewandten Temperatur und der Zusammensetzung des Startmaterials abhingen. Es waren genaue chemische Bedingungen nötig, um Apatit als die einzige feste Phase im Gleichgewicht mit der Lösung zu erhalten. Die Resultate der Gleichgewichts-Phasendiagramme werden mit früheren Untersuchungen mit der Synthesetechnik verglichen.
    Notes: Abstract Equilibrium phase diagrams have been determined for the system CaO-P2O5-H2 using hydrothermal synthesis techniques in the temperature range 300–600° and 2 Kb H2O pressure. Well-crystallized hydroxyapatite has been produced and characterized. Small variations in unit cell parameters dependent on temperature of synthesis and bulk composition of the starting materials have been determined. Precise chemical conditions were required to obtain apatite as the only solid phase in equilibrium with solution. Equilibrium phase diagram results are compared with previous synthetic investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060279
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  • 3
    Electronic Resource
    Electronic Resource
    Surgical sutures and infection: A biomaterial evaluation (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 115-126 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A standardized readily reproducible experimental model has been developed to assess the relative importance of the chemical and physical configuration of sutures as determinants of early infection in contaminated wounds. The chemical structure of the suture appeared to be the most important factor in the development of surgical infection. The incidence of infection in contaminated tissues containing either polypropylene sutures or nylon sutures was lower than the infection rate of tissues subjected to any other nonabsorbable suture. Among the absorbable sutures, polyglycolic acid (PGA) sutures evoked the least inflammatory response. The infection rate of contaminated tissues containing the PGA sutures was not significantly different from the incidence of infection of tissues subjected to the least reactive nonabsorbable sutures. The physical configuration of the suture played a relatively unimportant role in the development of early infection. The infection rate of contaminated tissues containing monofilament nonabsorbable sutures did not differ significantly from the incidence of infection of tissues subjected to multifilament sutures made from the same material. Coating the multifilament suture with either silicone, wax, or Teflon did not alter the incidence of early infection in the contaminated tissue. Finally, the presence of even the least reactive suture in contaminated subdermal tissue potentiated the development of infection.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080312
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  • 4
    Electronic Resource
    Electronic Resource
    Sheath formation in response to limited active gliding implants (animals) (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 163-173 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Experiments were conducted to further the understanding of tendon reconstructive surgery.A series of 20 dogs was used for replacement of the forepaw extensor carpi radialis tendon (a single tendon only is present in the dog) with active gliding tendon implants. The implants were attached distally and proximally so that new tendon prosthetic designs could be studied as well as new sheath development under gliding conditions.The results, recorded in this paper, show that a “gliding implant” can convert a nonspecific bed of connective tissue or scar into a specific living envelope comparable to a tendon sheath system. This system has been shown to be capable of lubricating and supporting a gliding artificial implant while augmenting normal tendon function. Degrees of active and passive gliding can take place for indefinite periods, providing the mechanical and dynamic capabilities of the new system are understood and controlled. The mature sheath will show a predictable physiologic response to unfavorable stimuli.Further evidence that the new gliding system functions as a physiologic sheath is borne out by the fact that the implant can be replaced in Stage II by a long free tendon graft. The graft is apparently supported in part by fluid nutrition and filmy adhesions between the distal and proximal anastomosis.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080317
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  • 5
    Electronic Resource
    Electronic Resource
    The mandibular staple implant for the atrophic mandible (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 365-371 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The mandibular staple is an endosseous implant that will permit the attachment of a lower deture in cases of severe alveolar bone atrophy. It is placed through a submental incision and inserted into seven parallel holes drilled into the mandible. A curved bar containing seven pins is inserted in the holes and is place against the inferior border of the mandibular symphysis. The two lateral most pins project into the mouth and the five retentive pins remain completely buried in bone. Two fasteners are screwed down on the threading of the intraoral pins. Later a bridge containing Dalbo attachments is cemented to the fasteners which allow attachment to a lower denture. A series of 25 patients have been completed with 20 successful patients for survival rate of 80%. The longest case has been in for five years and the average case has been in for 3 years. Stainless steel, titanium and ceramic coated titanium has been with apparently equal success. Patient acceptance has been excellent.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080416
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  • 6
    Electronic Resource
    Electronic Resource
    Development and evaluation of porous ceramic and titanium alloy dental anchors implanted in miniature swine (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 391-399 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A study sponsored by the National Institute of Dental Research has as its major goal the development of easily fabricated and implantable dental anchors for replacement of missing or extracted teeth. Tissue ingrowth fixes the anchors in the mandibular or maxillary bone where they can serve as a base for future attachment of prefabricated dental caps, bridges, or other dental prostheses. More immediate objectives are to determine the suitability of specific porous titanium and ceramic materials for anchor applications, to develop satisfactory designs and fabrication procedures for producing these devices, and to define material/bone interface bonding characteristics through in vivo studies. The value of the Hanford Miniature Swine as a human analog for dental research is being assessed concurrently.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080419
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  • 7
    Electronic Resource
    Electronic Resource
    Histochemical responses at a biomaterial's interface (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 49-64 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A series of nonporous glasses and glass materials designed with controlled surface ion activities to allow chemical bonding to bone are described. Surface reactivities of these materials in vitro are correlated with biological activities in vivo and in tissue culture. Direct chemical bonding of the materials to bone is demonstrated. The mechanism for development of this bond is through the production of an amorphous ion surface gel on the bioglass. This gel induces osteogenesis by a chemotactic response of osteoblasts.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080307
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  • 8
    Electronic Resource
    Electronic Resource
    Transcutaneous implants: Reactions of the skin-implant interface (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 99-113 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: One method of providing an artificial limb for an amputee might be to attach the external prosthesis directly to the skeleton but a major problem is the behavior of the tissues at the point where the prosthesis penetrates the skin surface. Preliminary experiments have been carried out using small flexible implants in porcine skin to study the principles involved. It is confirmed that the epidermis grows down into the dermis around the nonporous materials and the implant-skin junction is unstable and readily becomes infected. It was found that polytetrafluorethylene with pores of 10 μm diameter and hydron sponge with pores of 40 μm diameter became invaded by fibrous tissue and this appeared to prevent the migration of epidermis alongside the implants and a stable ring of epidermal tissue was formed near the skin surface. A review of other situations where epidermal migration is taking place suggests that epidermis is able to migrate through damaged collagenous tissue, possibly with the help of leucocytic enzymes, but that epidermal cell movement is halted when the epidermal sheet is confronted by heathly collagen bundles.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080311
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  • 9
    Electronic Resource
    Electronic Resource
    The role of porous polymeric materials in prosthesis attachment (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 145-153 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Polymeric materials are becoming increasingly popular as prosthetic materials in orthopedic surgery. One of these materials, polyethylene, is capable of being fabricated in a porous form suitable for tissue ingrowth. Porous polyethylene appears to be well suited for prosthesis attachment when bonded to its solid form of other prosthetic materials. Extensive bone growth into porous cylindrical specimens implanted in the canine femur has occurred as early as four weeks. Ingrown tissues appear normal and there is minimal inflammatory response. Mechanical strength of the porous material, though not as great as that of the solid material, does appear to be sufficient for certain orthopedic applications. Current research is directed toward determining interfacial strengths and the mechanical properties of the porous polyethylene-bone composite.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080315
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  • 10
    Electronic Resource
    Electronic Resource
    Physical characteristics of setting of acrylic bone cements (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 185-196 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An investigation was conducted to determine the general physical characteristics of self-curing acrylic resin systems in terms of their potential utilization in total hip arthroplasty.Exothermic temperature, working and setting times were monitored with thermocouples placed in acrylic masses insulated via a Teflon mold. Mechanical strengths were run in an Instron testing machine. The same trends were noted in all systems studied.As thickness or mass increased, the maximum temperature and the setting time increased. As the powder to liquid ratio increased (thereby relatively less liquid), the maximum temperature, set times and dough times decreased, while the working time was essentially unaffected. As the ambient temperature decreased, the maximum temperature decreased while the dough, working and setting times increased.The mechanical strengths of the systems cured at one atmosphere are low compared to high temperature and pressure curing. Flowability of the materials decreases quickly as final set time is approached.Although trends are similar in many self-curing acylic systems minors shifts in complex proprietary compositions can produce a wide span or working and setting times. Because the surgical team controls such parameters as the mass employed, the amount of liquid introduced, and the ambient temperature it is important that they continuously re-evaluate their handling procedures particularly if new acrylic cements would be introduced.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080319
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  • 11
    Electronic Resource
    Electronic Resource
    Preface (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. v 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080402
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  • 12
    Electronic Resource
    Electronic Resource
    Evaluation of a total hip replacement (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 271-283 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Through a survey of hip replacement arthroplasty the paper establishes the case for objective evaluation of these joints in the patient. It then outlines a simple, non-invasive technique, based on Paul's (1967) locomotion studies, to assess pre- and postoperative functional capability. Preliminary results which establish viability of the procedure are presented.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080406
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  • 13
    Electronic Resource
    Electronic Resource
    Porous titanium alloy for fixation of knee prostheses (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 319-328 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A porous titanium alloy called void metal composite (VMC) was investigated for use in knee prosthesis fixation. The interfacial ingrowth fixation of VMC intrameduallary, subchondral, and variable density implants in goat femora was evaluated biomechanically and histologically at six weeks and five months. Biomechanical tests were done under static shear and dynamic, cyclic (fatigue) loading conditions. Readily identifiable bone, strong fixation, and excellent biocompatibility were typical. Some subarticular implants appeared to induce normal hyaline cartilage overgrowth.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080411
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  • 14
    Electronic Resource
    Electronic Resource
    The normal circulation of bone and its response to surgical intervention (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 87-90 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080111
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  • 15
    Electronic Resource
    Electronic Resource
    Plastics and inflammation: An in vivo experimental study (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 97-117 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A significant variation occurred in the inflammatory response to polyethylene and polyurethane when embedded subcutaneously in experimental animals. This variation apparently is related to the composition of the plastic and adsorption of proteins. The attraction of polymorphonuclear leucocytes by plastics apparently is related to the electrostatic and/or electrokinetic imbalance that occurs at or near the site of implantation.Polyurethane and polyethylene were selected for this study since preliminary observations had shown a variation in inflammatory response when they were embedded subcutaneously in the mouse. From this study it is evident that: (1) variations occurred in the inflammatory reaction in the subcutaneous tissue of mice and rabbits following the embedding of polyethylene and polyurethane; (2) polymorphonuclear leucocytes began to emigrate within hours after these two plastics were implanted, reaching their maximum number within 24 to 48 hr; (3) polymorphonuclear leucocytes usually were absent after the 6th experimental day in mice with polyurethane, but were present for 232 days in mice with polyethylene; (4) polymorphonuclear leucocytes were present in the rabbit for only a few days following subcutaneous implantation of polyethylene and polyurethane; and (5) leucocytes around the implanted polyurethane in the rabbit began to degenerate within 48 hr. The mechanism for this degeneration is not known.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080202
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  • 16
    Electronic Resource
    Electronic Resource
    Intergranular cracking of a weak two-phase polymethyl methacrylate (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 185-188 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080207
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  • 17
    Electronic Resource
    Electronic Resource
    Preface (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. v 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080302
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  • 18
    Electronic Resource
    Electronic Resource
    Experimental analysis of ceramic-tissue interactions. A morphologic, fluoroescenseoptic, and radiographic study on dense alumina oxide ceramic in various animals (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 39-48 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Two types of dense Al2O3 ceramics (99.6% purity, 96% purity) were tested in the following fields of interest.1Wear resistibility using a pin and disk method under distilled water and human synovial fluid. Both types showed minimal initial corpuscular wear.2Biocompatibility of ceramic wear particles in mice and rats after injection by different ways. The crystal material is permanently deposited in macrophages, after transport via lymphpatic and blood vessels also in the RES without chronic inflammatory and progressive fibrotic response.3Under moderate stress conditions ceramic plates are fixed firmly by new bone formation within 2-3 months according to tetracycline label studies of bone growth in rats.4A new ceramic total hip prosthesis with two different socket designs for cement free fixation in bone is proposed and used in sheep experiments. The results of a 4 month experiment is presented showing firm fixation of the prosthesis under full stress conditions.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/jbm.820080306
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  • 19
    Electronic Resource
    Electronic Resource
    Effect of stress on tissue ingrowth into porous aluminum oxide (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 85-97 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A study of the tissue compatibility of aluminum oxide implants under different stress conditions in rabbits was performed over four- and eight-week implantation periods. The specific objectives were to examine endosteal bone ingrowth into aluminum oxide coneshaped plugs in amputated tibiae, while additional pellet-shaped implants in the tibiae and femora of rabbits with amputated and nonamputated limbs were studied to determine: (1) if the degree of loading placed on the amputated limb was sufficient to promote bone activity, (2) the degree of inertness and/or toxicity of the aluminum oxide implants, and (3) a possible cause of bone spurs.The results of the radiographic, histologic and microradiographic analyses of the in vivo implants demonstrated that there was little mineralized bone ingrowth into the coneshaped aluminum oxide implants in the amputated tibiae. The study also showed that the aluminum oxide pellet implants in the tibiae and femora of the nonamputated limbs demonstrated excellent mineralized bone ingrowth into surface and internal pores. By comparing these results with the incomplete ingrowth into corresponding pellet implants in the tibiae and femora of amputated limbs, it was determined that a lack of weight bearing and damage to the musculature and vascularity following amputation were interfering with the normal bone activity and therefore bone ingrowth.Angiographs and radiographs of the amputated tibiae demonstrated that bone spurs were present and that they originated at the site of the periosteal damage. Their cause was believed to be associated with an increase in the vascularity of the adjacent tissues.
    Additional Material: 6 Ill.
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    URL: http://dx.doi.org/10.1002/jbm.820080310
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  • 20
    Electronic Resource
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    Calcium-phosphate magnesium-aluminate osteoceramics (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 137-144 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Ceramic materials for permanent implantation in osseous tissue, called osteoceramics, were based on an equimolar mixture of Ca3(PO4)2 and MgAl2O4. Tooth roots with dense regions and with regions of controlled porosity for tissue ingrowth were made from the material. They were implanted submucosally in the mandible and maxilla of dogs. Tissue response was aceptable and strong attachment occurred. Thin sections are presented showing the interface of the alveolar bone and the prosthesis.
    Additional Material: 6 Ill.
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    URL: http://dx.doi.org/10.1002/jbm.820080314
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  • 21
    Electronic Resource
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    Study of early sheath development using static nongliding implants (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 155-162 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Clinical studies will permit only small sections of tendon sheaths to be removed for biopsy at restricted levels as the sheaths were to be used for tendon grafting. In active gliding programs, biopsy has been limited to small sheath sections in immediate relation to the distal or proximal anastomosis where gliding motion may be induced or minimal. In the passive gliding programs, biopsy has been limited to the most proximal segments where considerable folding of the sheath occurs or cul-de-sac buckling of the implant may produce irritation.As these were the only practical clinical sources of sheath sections for biopsy and study, the authors felt that a comparison study of sheath development in animals would broaden our understanding in humans. With this objective in mind, three canine laboratory studies were carried out where, for pure purposes of investigation, entire sheath sections were removed at designated time intervals for study.The flexible implants were well accepted, affording the opportunity to observe development of early sheaths in a controlled connective tissue environment, free from the stress of joint motion.The semi-rigid implants showed equal acceptance in side-by-side tissue level of the same dog as the flexible implant. This influenced changes in artificial tendon development from extrusion to the more exacting mold fabrication. It seemed evident that the degree of increase in stiffness of the new artificial tendons to gain a superior surface for gliding and increased strength would not change tissue acceptance providing flexibility was maintained.The cellular response in this study did not seem to represent a foreign body phenomena but an orderly acceptance of the soft tissue environment to the smooth surface of the inert implant.It is concluded that this study confirmed in animals the clinical findings of Mayer, Bunnell, Milgram, and Carroll.The consistent orderly development of the new sheaths formed in response to the static implants is impressive. The authors believe the appearance of these histologic sections are likely correlations with the development of new sheaths around the Hunter Tendon Prosthesis during the three-four week postoperative period when the hand is resting in a functional dressing.
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    URL: http://dx.doi.org/10.1002/jbm.820080316
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  • 22
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    The potential for poly-α-amino acids as biomaterials (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 197-207 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Poly-α-amino acids have been investigated for possible use in a wide variety of biomedical applications. These range from dialysis membranes to artificial skin substitutes to degradable sutures. The large number of available α-amino acids potentially provides an extremely large number of poly-α-amino acids. The majority of materials investigated to date are copolymers composed of two components, one of which usually provides the desired property for the given application.This paper deals with the further examination of a series of γ-benzyl-L-glutamate-L-leucine copolymers. Evidence is provided on the effect of these copolymers on the biological environment as determined by implantation in rats up to 200 days. In vitro tests were also performed and the effect of these tests on the stress-strain properties of one of the copolymers is presented.Preliminary evidence on biodegradable copolymer films is also included. These materials have free γ-carboxyl groups on the glutamate components.
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    URL: http://dx.doi.org/10.1002/jbm.820080320
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    The load-deformation characteristics of connective tissues (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 427-434 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Following the classification of tissues according to their “dominant” and “interactive” components the paper surveys their load-deformation behavior, highlighting in particular the significance of time dependence. This leads to a discussion of the implant/tissue interaction in which the complexity that could be created by varying load and deformation time rates at the interface is explored.
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    URL: http://dx.doi.org/10.1002/jbm.820080422
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    Morphologic observations of neosheath development of undifferentiated connective tissue development around artificial tendons (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 175-184 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The management of severe flexor tendon injuries of the hand has been dramatically improved by tendon sheath reconstruction with an artificial tendon, followed by conventional tendon grafting. The purpose of this study was to investigate the nature of neosheath formation.In 25 chickens, the flexor tendons and sheaths in a toe were excised and replaced with a United States Army artificial tendon. An artificial tendon was also placed in the back, and four weeks later, tendons and surrounding tissue as well as normal tendon sheaths were excised and submitted for light, transmission electron microscopy and scanning electron microscopy.In all instances, neosheaths formed around the silastic coated artificial tendon. The neosheaths formed in the foot and back were similar to normal sheath, having the same cellular and fibrous composition. Reconstruction of the normal anatomy with an artificial tendon explains why this surgical technique gives superior results to other less physiologic procedures in patients with severe hand injuries.
    Additional Material: 9 Ill.
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    URL: http://dx.doi.org/10.1002/jbm.820080318
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    MultiphaseTrademark of Standard Pressed Steel Company in Jenkintown, Pennsylvania. MP35N alloy for medical implants (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 219-226 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The biomaterials engineer of today has an extremely limited choice of approved metallic implant alloys with which to conduct his studies. There is essentially no incentive for larger companies to initiate basic research in the biomaterials field. New alloys which would have the best chance of developing as biomaterials would be “spin-off” alloys from somewhat related industries and currently in production. MP35N is just such a spin-off alloy with a background of years of in-vitro testing and use in corrosive environments. When compared to the desired implant material requirements, the material properties required of MP35N for present applications readily indicate its potential use as a biomaterial.It is a castable alloy which exhibits good as-cast ductility. In the wrought condition, yield strength levels from 60,000 to over 310,000 psi are possible with accompanying good ductility characteristics. Excellent stress corrosion cracking resistance and improved fatigue strength over present cast implant material are also characteristic of MP35N. Results, to date, from in-vivo tests indicate tissue compatibility of MP35N at least comparable to HS-21 (Vitallium).Possible medical applications for MP35N would include hip and knee joints, bone plates, heart pacer electrodes, suture wire and clips, and Endosseous blade implants.
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    URL: http://dx.doi.org/10.1002/jbm.820080322
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    Press fit implant arthroplasty of the hip and knee (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 285-288 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The bone-implant interface and the accompanying difficulties with fixation continue to be a major area of research activity. Biological fixation would appear to be the ideal method of fixation. Press-fit metal implants may be part of a larger answer that may include sintering, coatings, or both.
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    Masthead (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984) 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180101
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    A note from the Editor (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. v 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180102
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  • 29
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    The mechanical strength of maxillary complete dentures (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 413-425 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A complete study of the static and dynamic strength of complete maxillary dentures was undertaken. First, the denture base material was investigated in its various forms from the point of view of tension, creep, relaxation, fatigue, and the effect of a corrosive environment. Complete dentures were tested under static compression, and the distribution of stresses along the midline of the upper dentures was determined by means of strain rosettes and by reciprocating compression, the determination of their fatigue strength. The results were found to conform with experience as far as lifetime of complete dentures is concerned.
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    Mechanical properties of bone cement: A review (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 435-462 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Many authors have examined the mechanical properties of bone cement and the various factors that affect its mechanical behavior. This article presents a comprehensive survey on the reported mechanical properties of bone cement. Variables that influence the mechanical properties, such as handling characteristics, strain rate, loading modes, additives, porosity, blood inclusion, in vivo environment, temperature, etc. have also been reviewed. The importance of specifying these variables in reporting test results on the mechanical properties of bone cement is pointed out. Previous attempts to improve the mechanical properties of bone cement are also summarized. Future research areas important for fully characterizing the physical properties of PMMA are also suggested.
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    Water sorption and mechanical properties of 2-hydroxyethyl-methacrylate and methylmethacrylate copolymers (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 137-146 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Randomly cross-linked copolymers of 2-hydroxyethyl-methacrylate (HEMA) and methyl-methacrylate (MMA) have been prepared and studied in the dry and swollen state. Tensile and indentation tests indicate that by changing the composition of copolymers, it is possible to obtain materials with a wide range of mechanical properties and corresponding glass transition temperatures. Water diffusion coefficients in sorption and desorption experiments have been calculated and compared.
    Additional Material: 6 Ill.
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    Healing pattern of small caliber Dacron grafts in the baboon: An animal model for the study of vascular prostheses (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 281-292 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Although dogs have been used widely to study the healing of large caliber synthetic grafts, hypercoagulability probably makes the dog a poor model for studies of small caliber vascular prostheses. The baboon's coagulation system is similar to man's, but large caliber baboon grafts were reported to endothelialize rapidly. In this study the healing pattern of 4mm internal diameter Dacron carotid interpositon grafts in baboons was determined using specimens harvested at time points between 2 weeks and 18 months post-implantation and examined with light and scanning electron microscopy. The luminal surface of baboon grafts in the acute healing phase (〈1 month) was comparable to that reported in the literature for dogs. Baboon grafts did not completely endothelialize until 10-12 weeks post-implantation. For work with small caliber vascular protheses, the dog appears to have no advantage over the baboon as an animal model on the basis of graft healing.
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    Masthead (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984) 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180401
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    Some aspects of macrophage behavior at the implant interface (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 395-401 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The macrophage plays a pivotal role in both wound healing and cellular response to implants, including percutaneous devices. Within twenty-four hours macrophages were found in close contact with the implant surface. Eventually fibroplasts and connective tissue proliferate, and finally the implant will be encapsulated. The presence of macrophages is essential for the activation of collagen synthesis by fibroplasts. Implant shape and surface can profoundly affect macrophage behavior. At rough implant surfaces macrophages with giant cells are present for many months with the possibility of chronic granulomatous reactions. Superior tissue compatibility should be associated with smooth, well contoured implants with no acute angles.
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    Casting properties of Ni-Ti shape memory alloy (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 427-434 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A Ni-45 wt % Ti (Ni-50 at % Ti) alloy was cast into molds of magnesia and silica investments by use of a dental argon-arc pressure casting machine with a copper crucible. The castings exhibited shape memory properties. The shape recovery process was sharper in the specimens cast in magnesia investment molds than in those cast in silica (phosphate-bonded) investment molds. The latter casting had a hard region of the periphery, suggesting that shape recovery process may be affected by reaction of molten metal with silica. Furthermore, the alloy possessed the adequate mechanical properties for consideration as crown-and-bridge prostheses.
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    Release of corrosion products by F-75 cobalt base alloy in the rat. I: Acute serum elevationsPresented in part at Society for Biomaterials, 9th Annual Meeting, Birmingham, AL, April 28, 1983. (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 513-522 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The release of corrosion products by implants has become a matter of concern. Using a microsphere model, the release of chromium, cobalt, and nickel, secondary to implantation of various surface area exposures of F-75, a cast cobalt-chromium alloy, was studied over a 30 day period in the rat. Dose related elevations were observed in the serum concentration of chromium and cobalt but not of nickel, with the maxima being achieved at 3 days after metal implantation followed by declines in concentration. The chromium elevation, approximately twelvefold for a surface area to body weight (SA/BW) ratio of 300 x is similar to that previously reported in patients receiving total hip replacement arthoplasties. However, the cobalt elevation, twentyfold for a SA/BW ratio of 300 x, has not been previously observed. These serum concentration changes are as yet unexplained, but are probably not due to fibrous capsule maturation or alloy repassivation.
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    In situ immunoradiometric assay of fibrinogen adsorbed to artificial surfaces (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 547-559 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An in situ immunoradiometric assay was devised to quantitate human fibrinogen deposited on hemodialysis membrane, Cuprophane, from in vitro exposure to fibrinogen solution and from ex vivo extracorporally clinical use. The method requires a monospecific 125I-labeled antifibrinogen-IgG purified by DEAE chromatography and immunoadsorption. The labeled antifibrinogen IgG was shown to react specifically with fibrinogen adsorbed and immobilized (by glutaraldehyde) on Cuprophane. Other plasma proteins such as human albumin, IgG, or α-thrombin, adsorbed singly or coadsorbed with fibrinogen on the surface did not seem to affect the fibrinogen-antifibrinogen reaction. The presence of blood cells such as platelets and granulocytes with fibrinogen on Cuprophane reduced only slightly the uptake of 125I-antifibrinogen-IgG. The examination of fibrinogen-fibrin deposition on clinically used Cuprophane by this technique and by autoradiography of the same material following 125I-antifibrinogen-IgG conjugation indicated that the deposition of fibrinogen was heavy and heterogeneous. We concluded that this in situ method may be useful to monitor fibrinogen-fibrin deposition and adsorption of other plasma proteins that occur under in vitro, ex vivo, and in vivo conditions.
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    The healing of hamster skin ulcers treated with n-butyl-2-cyanoacrylate (Histoacryl blue) (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 601-607 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This study was undertaken to examine the effectiveness of a commercially available n-butyl-2-cyanoacrylate (Histoacryl blueTri-Hawk International, 1570 Barré, Montréal, H4L 4M6 Quebec.) as a local treatment for cutaneous ulcers. Two ulcers, approximately 0.5 cm2 each, were made on the backs of 30 hamsters. The right side was covered with a thin film of tissue adhesive, while the left side was left untreated as a control. Animals were sacrificed at various times post-operatively, the tissue excised, processed, and examined with the light microscope. Results showed that cyanoacrylate decreased the inflammatory exudate early in the experiment, and epithelial migration occurred slightly earlier in experimental tissue. Scab formation was absent in experimental sites until the layer of adhesive was lost. After 2 days, healing was comparable in both experimental and control, and the sites were indistinguishable histologically at day 5.
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  • 39
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    Masthead (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984) 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180601
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  • 40
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    Cytocompatibility of albuminated polyester fabrics (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 895-909 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An alternative to the usual technique of preclotting porous textile vascular prostheses prior to surgical implantation is to render them impermeable to blood by impregnation with a cross-linked albumin filler matrix. This material subsequently becomes the foundation for cellular development. The compatibility of such impregnated fabrics with newly formed endothelial cells has been evaluated by an in vitro organotypic culture method. This technique enables the characterization and numeration of cells that develop on blood contact surfaces and enables determination of their rate of development. Woven, knitted, and velour fabrics were evaluated folllowing coating with albumin and either storage in Tyrode solution or 40% ethanol or desiccation by critical point drying. Preclotted cardiovascular repair fabrics prepared according to conventional surgical protocol served as controls. The identification of the newly formed cells was confirmed histologically. The most extensive and rapid cellular development was observed on the woven fabric and is believed may have resulted from the smoother surface topography of this substrate. Good cellular development was noted particularly on fabrics which had been stored in Tyrode solution. Ethanol had a deleterious effect on the apparent compatibility.
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  • 41
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    Adsorption and reactivity of human prothrombin to artificial surfaces (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 695-705 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Human prothrombin in Tyrode's solution, in mock plasma (albumin, fibrinogen, and IgG mixture), and in citrated plasma adsorbs to Cuprophane, polyvinylchloride, and polyacrylonitrile surfaces. The adsorption of prothrombin is maximal in Tyrode's solution and minimal in plasma. The surface concentrations of prothrombin are highest on polyacrylonitrile, second on polyvinylchloride, and lowest on Cuprophane at all prothrombin concentrations tested in the bulk solution. Qualitative tests show that prothrombin adsorbed to polyvinylchloride can be activated by Taipan snake venom to generate thrombin that clots fibrinogen. However, more quantitative tests indicate that only part of the adsorbed prothrombin on all three materials can be activated to form thrombin exhibiting amidolytic activity. The partial reactivity of adsorbed prothrombin is further confirmed by release of 125I-peptide from surface bound 125I-prothrombin after treatment with Australian Taipan snake venom. Prothrombin bound to Cuprophane seems to promote granulocyte adhesion, but has no effect on platelet adhesion.
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    Toxic reactions evoked by glutaraldehyde-fixed pericardium and cardiac valve tissue bioprosthesis (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 727-736 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Bovine pericardial tissue and tissue-derived bioprosthesis fixed in glutaraldehyde and stored in either glutaraldehyde or formaldehyde can induce cytotoxic reactions even after prolonged washing due to the slow leaching of the chemicals used for crosslinking and sterilizing. Sequential rinsing for up to 60 min was still not sufficient to eliminate cytotoxic effects. On the other hand, satisfactory results were obtained when cardiac valves made from glutaraldehyde fixed pericardium were stored in a solution containing 0.02% of propyl-hydroxy-benzoate and 0.18% methyl-hydroxy-benzoate. The valves stored in this solution and rinsed three times for 1 min in normal saline showed few signs of residual cytotoxicity. Rinsing in a solution containing glycine was partially effective in neutralizing the cytotoxic effect, and this or similar approaches offer good possibilities. The use of Chang cells grown in culture provides an excellent quantitative assay for the assessment of residual cytotoxicity and for evaluating the host response to different methods of fixation, storage, and rinsing of tissue derived bioprosthesis.
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    The influence of dentine on the in vitro cytotoxicity testing of dental restorative materials (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 771-779 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Few in vitro systems for testing dental restorative materials have taken into account the protection afforded by the residual dentine in vivo. In turn opinions differ as to whether an increase in residual dentine thickness increases this protection. In this study an increase in the depth of dentine powder beneath zinc oxide eugenol (ZOE) reduced its toxicity, while this was not the case with the glass ionomer cement. Compaction of the powder had no effect, suggesting that protection was due to binding of the toxicant to the dentine rather than it acting as a physical barrier. Protein was shown to be very important in moderating the cytotoxicity of ZOE. These results suggest that in vivo the irritancy of some materials may be related to the depth of residual dentine but not others. The effect of exposure period and volume of these materials on their cytotoxicity was also investigated. Increasing the volume of ZOE while retaining the same surface area increased the toxicity of ZOE, while with the glass ionomer it had no effect.
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    Molecular weight characterization of virgin and explanted polyester arterial prostheses (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 881-894 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The macromolecular properties of 17 virgin commercial arterial prostheses and a series of explanted prostheses, both manufactured from poly(ethylene terephthalate) (PET) yarns, have been studied by gel permeation chromatography (GPC) and by differential scanning calorimetry (DSC). Only small differences were found between the average molecular weights and the degree of crystallinity of the unused reference grafts. A broadening of the DSC curves was observed for the prostheses containing texturized yarns compared with those made solely from flat, untexturized yarns. This broadening may be due to greater heterogeneity of the crystal sizes caused by the texturizing process and to the use of two or more different yarns with dissimilar thermal histories in the same prosthesis. Average molecular weights of the explant series were significantly lower than those of the corresponding reference grafts but almost time independent. The polydispersity index and the degree of crystallinity of the explants remained constant as a function of time. These results are discussed in regard to others available in the literature.
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    In vivo biocompatibility studies. V. In vivo leukocyte interactions with biomerR. E. Marchant received the Student's Award for this manuscript from the Society for Biomaterials, 1984, Washington, DC. (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1169-1190 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A cage implant system was utilized to quantitatively and qualitatively characterize in vivo leukocyte interactions with cast Biomer. Scanning electron microscopy (SEM) in conjunction with cytochemical staining procedures were used to investigate the cellular events at the leukocyte/Biomer interface as well as in the inflammatory exudate over a 21-day implantation period. SEM was used to characterize leukocyte morphology on the Biomer surface and the cytochemical stains were used to differentially count leukocytes and to demonstrate intracellular alkaline and acid phosphatase activity. The results showed that the population density of leukocytes on the Biomer surface diminished with implantation time. The population density of multinucleated foreign body giant cells remained constant with time, while the numbers of nuclei per giant cell increased. The differential analysis revealed that macrophages preferentially adhered to the Biomer surface compared to other leukocytes in the exudate. The phagocytic capability of all adherent leukocytes, including giant cells, decreased with time and this corresponded to changes in leukocyte morphology observed with SEM.
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    Materials, clinical and morphological evaluation of custom-made bioreactive-glass-coated canine hip prostheses (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1017-1030 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Bioreactive-glass-coated hip prostheses were implanted in dogs for periods of time ranging from 3 to 17 months. The prostheses were tailor-made for each animal through the use of standard radiographs. However, such a procedure does not necessarily yield a close apposition between the glass layer and bone. As a result, the initial stability of the component can be lost before bone bonding is established. Secondary to this phenomenon, the micromotion can lead to a continuous disruption of the top film on the glass despite the evidence of various reaction layers on the glass surface.
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    Determination of extractable methylene dianiline in thermoplastic polyurethanes by HPLC (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 961-968 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Polyurethanes are finding increasing utilization in biomedical applications. Recently, the reported finding of methylene dianiline (4,4′-diaminodiphenylmethane, MDA) in the aqueous extracts of autoclaved 4,4′-diphenylmethane diisocyanatebased polyurethanes promoted our investigation of the origin and extent of extractable methylene dianiline in polyurethanes. A high-pressure liquid chromatography procedure using precolumn derivatization is utilized to selectively monitor the appearance of this diamine in the aqueous extracts of polyurethanes subjected to water immersion, heat aging, and various sterilization techniques. No MDA was found in the aqueous extracts of the treated polyurethane except for the case of prolonged steam autoclaving. The appearance of 3-5 ppb MDA in the extract under these conditions is attributed to hydrolysis of the polymer. The stability of the polyurethanes under most conditions renders these materials useful in biomedical applications.
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    The binding of metal salts and corrosion products to cells and proteins in vitroThis paper was presented in part at the seventh annual meeting of the Society for Biomaterials, 1981. (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1005-1015 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The binding of metal ions from salts and from corrosion products of 316 LVM stainless steel and MP-35 to blood cells and serum proteins was studied in vitro. In the first series of experiments, metal salts were added to whole blood and then the blood separated into red cells, white cells, and serum. Nickel from nickel chloride or corrosion products of stainless steel bound in very small quantities to blood cells. Cobalt from cobalt chloride bound to both red cells and white cells. Chromium from chromic chloride (Cr3+) bound to cells in very small quantities whereas chromium from potassium dichromate (Cr6+) and corrosion products showed very high to binding to red cells and some binding to white cells. In a second series of experiments the blood was separated into its components and then the metal salts were added and the binding pattern was identical. In a third series of experiments serum which had interacted with the metal salts or corrosion products was separated into its components by isolectric focusing on polyacrylamide gels. Almost all of the metal, whatever the source, was detected in the albumin region of the gels indicating strong binding to albumin. These studies on the cell and protein binding of the metals help to explain the dissemination of corrosion products from the site of the implant and subsequent systemic responses by some individuals.
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    Polyester prostheses as substitutes in the thoracic aorta of dogs. II. Evaluation of albuminated polyester grafts stored in ethanol (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1059-1072 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: In an attempt to find an alternative procedure to the preclotting of porous textile vascular prostheses, the feasibility of an albumin coating and ethanol preservation technique has been evaluated by implanting albuminated polyester prostheses as substitutes in the thoracic aorta of dogs. Nine different grafts representing woven, knitted, and velour constructions were implanted for periods ranging from 4 h to 6 months. At the sacrifice, the grafts were excized for measurement of the thrombogenicity of the flow surface, for pathological examination by light microscopy and SEM, and for quantifying the changes in the textile structure during implantation. Also the kidneys were removed and examined for infarcts caused by trapped circulating emboli. The healing characteristics of the nine different grafts proved similar and followed the same sequence of events as preclotted control grafts. The albumin coating and ethanol preservation resulted in a somewhat slower rate of healing. Yet, given sufficient time, a more completely healed graft was achieved as evidenced by the presence of endothelial-like cells throughout the length of the graft. In addition, the albumin is believed to reinforce the textile structure by reducing the tendency to stretch and dilate in vivo.
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    The antithrombotic effect of prostaglandin E1 immobilized on albuminated polymer matrix (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1115-1124 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: For intravascular implantation, a biofunctional surface seems to retard surface thrombosis upon synthetic materials. Prostaglandins, like PGI2, PGE1, and PGD2, etc., are believed to stimulate membrane-bound adenyl cyclase and thereby raise intracellular levels of c-AMP within platelets, which inhibit platelet adhesion and aggregation. A new procedure is suggested for the immobilization of prostaglandin E1 on an albuminated polymer matrix, through glutaraldehyde coupling. Materials thus prepared show dramatic antiplatelet effects, with regard to platelet adhesion, when compared with albumin-immobilized surfaces. The affinity of various modified surfaces toward platelet adhesion is studied, using washed platelets suspended in Tyrode's solution. Octane contact angle studies are used to develop an understanding of the varied nature of bound substrates at equilibrium on polymer surfaces. These are studied at the solid/liquid interface, which is closest to in vivo conditions. The plasma recalcification time demonstrates the anticoagulant properties of various surfaces. A possible role of PGE1 in reducing platelet activity in the presence and absence of vitamin C is discussed. This technique may be used in the development of nonthrombogenic surfaces on existing biomedical polymers. Simultaneous pharmaceutical modification of the blood with vitamin C may enhance the blood compatibility of the surface.
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    Metallographic examinations of retrieved intramedullary bone pins and bone screws from the human body (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 27-38 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Substantial improvements have been made by the surgical manufacturing industry in the development of implants and by the orthopedic surgeon in the use of prosthetic appliances. In spite of these advancements, some prosthetic devices completely fail of do not provide satisfactory performance. Hostile environmental conditions of the human body are highly influential in limiting the service life of the implants, so the material selection and the design and fabrication must be made with extreme care. Examinations we have made of intramedullary pins retrieved from femurs reveal examples of fretting and/or crevice corrosion and in-service failures that nucleated in microscopic surface gouges. Self-tapping screws, essential for securing bone implants, failed due to fractures originating in the thread roots. Failures by merely exceeding the ultimate strength of the material and by the more involved process of stress corrosion cracking are shown.An evaluation laboratory for failure analyses of prostheses is recommended.
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    The foreign body reaction - an experimental protocol (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 65-76 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A comprehensive protocol is presented for the in vivo evaluation of soft tissue foreign body reactions to surgical implants. A number of methods of evaluation and quantitation of the tissue reaction to implants are presented and discussed. A strong plea is made for semi-quantitation of tissue reactions, rather than relying on subjective, qualitative methods.
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    Clinical problems in total hip replacements (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 227-244 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Total hip replacements are based on a long chain of efforts of partial exchange of joint compartments. Inplants of material of both biological and nonbiological origin have been applied over the past 50 years. Smith-Pedersen, Judet, Moore, and Thompson are names to be remembered. It was primarily from the idea of firm fixation and low friction between the joint surfaces that today's constructions emerged. Immediate superior clinical results encouraged a strong trend towards hip-arthroplasties. The orthopedic surgeon can now choose amongst several prosthetic designs, the most common being metal to metal or plastics with or without bone cement. But, after ten years a number of threatening problems have become evident, calling for critical analysis of total joint replacements. Biomechanical, chemical, and morphological disturbances, both in the early and late phases, show that the body has difficulties in tolerating the artificial joint. This survery presents some of the most obvious risks and failures in total hip replacements.
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    Total surface replacement of the hip joint (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 245-260 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The surface replacement hip prosthesis reported represents an attempt to improve upon some aspects of the present design of total hip. The prosthesis comprises a cap fitted over the femoral head and a liner fixed into the socket, both being cemented with methyl methacrylate. The chief advantage of this design is preservation of bone stock. The prostheses were inserted bilaterally into six dogs, and whilst ten joints failed, one case was strikingly successful at two years follow-up. It was concluded that the design showed sufficient advantages over current total hips and that there was sufficient possibility of success in some application, to merit further study.
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    The total Walldius knee endoprosthesis in combination with retropatellar facet replacement (Polyethylene). Indication, operative procedure, and clinical results in a two year follow-up study (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 289-298 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Total replacement of the knee joint often remains unsatisfactory because of severe femor-patellar osteoarthritis.Twenty-four Walldius knee prostheses were inserted in 21 cases. Since March 1971 we have used a combination of this type of hinge prosthesis with a high-density polyethylene retropatellar facet prosthesis developed by our group in cooperation with the Badische Anilin- & Soda Fabrik AG (BASF).Fourteen knees of this combined type have been implanted and resulted in considerably less complaints than the original Walldius knee. The postoperative range of motion with an average of 66° does not differ in both groups.
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    A simple shoulder replacement (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 329-330 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Although degenerative arthritis of the shoulder is quite rare, it does occur. Pain relief was obtained in three such cases by the insertion of a polyethylene glenoid liner made for this purpose and used in conjunction with a standard metal prosthesis for humeral head replacement. Good pain relief and fair motion was obtained.
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    An in vitro test system for estimation of blood compatibility of biomaterials (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 341-356 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An in vitro test cell is described which permits exposure of artificial surfaces in sheet or film form to native human blood in the absence of a blood-air interface. Evaluation of Cuprophane, polyethylene, Silastic, and silicone-coated glass in the in vitro cell showed Cuprophane and silicone-coated glass to produce the least activation of the intrinsic coagulation system, while Silastic produced the greatest degree of activation. Polyethylene gave results intermediate between those obtained with the other materials. Each of these four different materials was evaluated in the elliptical cell test system multiple times with blood from 13 different donors.Our data suggest that with the present test system and the proper experimental design, one might expect that, “on the average,” performance of 36 tests on each of two materials will be sufficient for a 10% difference in their compatibility with blood to be statistically significant at the 5% level. The number of tests is 26 for significance at the 10% level.
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    Antithrombin activity of a polyelectrolyte synthesized from cis-1,4-polyisoprene (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 375-379 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A polyelectrolyte synthesized from cis-1,4-polyisoprene, containing aminosulfonate and carboxylate groups was shown to have an anticoagulant activity of about 1/30 compared with heparin. Because the substance prevents the coagulation of plasma in the presence of thrombin it is assumed that it acts as an antithrombin.
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    Couple corrosion among alloys for skeletal prostheses (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 407-419 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Using a metallographic technique to identify and count corrosion pits, the tendency for passive film breakdown has been studied under conditions that simulate a crevice and a combination of two different materials. Potential corrosion couples were formed among: 316L stainless steel, cast Co—Cr—Mo alloy, wrought Co—Cr—W—Ni alloy, Ti-6% Al-4% V alloy, a Co—Ni—Cr—Mo (multiphase) alloy and graphite. Only 316L stainless steel seems significantly prone to pitting corrosion in a crevice condition. Dissimilar metals in the crevice configuration did not seem to accelerate the corrosion of stainless steel.
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    Grafting of polymeric side chains to soft tissues (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 451-470 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This paper describes a novel approach for obtaining covalent bonding to tissues by chemical grafting of polymeric side chains to the collagenous backbone. Soft tissues such as calfskin or ratskin can be modified by acrylic, methacrylic, or vinyl monomers containing a variety of functional groups using ceric ions, persulfate-bisulfite or comonomers forming donor-acceptor complexes as initiators. Reactions take place within 20 min to 3 hr under experimental condition which, with suitable changes, might be tolerated clinically. The resulting products are insoluble in solvents for the respective homopolymers. It is likely that the polymeric side chain is attached chemically to the collagenous backbone. With ratskin, the grafting takes place mainly at the surface, resulting in a change in wettability and water sorption of the substrate. Modified hydrophilic, hydrophobic or even oil repellent surfaces can be prepared by judicious choice of monomer used. Thus, hydrophobic, oleophobic subdermal ratskin surfaces are obtained on reaction with flourinated monomers. Treated ratskins appear more resistant to fungal attack than the original substrate. It is conceivable that the polymeric side chains can serve as adhesive liners since the modified surface may improve the ability of the substrate to adhere to restorative materials.
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    A histopathological report on the nature of the epithelium and underlying connective tissue which surrounds oral implants (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 373-383 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This report is concerned with the two tissue types (oral epithelium and fibrous connective tissue) which surround oral implants and the possible adhesion of cells of these tissues to the implant surface. A review of the literature reveals that there is disagreement as to which of these two tissue types encase the deeper portions of Vitallium implants. Using techniques developed for studying the dental epithelial attachment, the following observations are submitted.1A PAS-possitive material is in abundance at the interface between the junctional epithelium and the implant post and present, but to a lesser degree, between the fibrous connective tissue and the implant surface.2An Oracine-positive material is present at the interface of both tissue types and the implant surfaces.3Collagen fibers subjacent to the junctional epithelium are oriented at functional angles to the basement membrane.4A histological artifact has been frequently observed which is the result of the tearing of the end of the epithelium away from its basement membrane.5Bacterial plaque adhering to the exposed portion of the implant posts extends in an apical direction and terminates abruptly along a very distinct line.From these observations it seems likely that an adhesion exists at the interface between the junctional epithelial cells and the penetrating implant surface.
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    A preliminary report on thirty-five geometric total knee arthroplasties (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 299-309 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This paper reviews the first 35 cases of geometric total knee arthroplasties performed on 32 patients at The George Washington University Medical Center. The procedure was done in 25 patients with rheumatoid arthritis, 5 patients with osteoartritis, and 2 patients with traumatic arthritis. Ages ranged from 38-83 years with an average of 58 years. This is a short-term follow-up with the longest of one year duration and the shortest two months. Fourteen patients had previous knee surgery including one that had three previous procedures. Indications and contraindications are outlined and the surgical procedure is described with an effort to point out certain technique problems. Twenty patients had complete relief of pain, ten had slight pain with activity. One has severe patellofemoral pain on weight-bearing and one has constant pain. Twenty patients had varying degrees of instability prior to surgery and none following the procedure and a 50° valgus deformity has been corrected satisfactorily. It was observed that patients with restricted motion and pain gained significant motion and pain relief while those with good motion and pain gained less overall and in some instances lost. Peroneal nerve palsies, patellar tendon avulsions, and wound complications are presented. We feel on the basis of this limited experience that this total knee system offers to the patient in need of a salvage procedure a stable, essentially pain-free knee that has increased mobility and function.
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    Materials in maxillofacial prosthetics (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 349-363 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Maxillofacial prosthetic materials are classified in two main groups: extraoral and intraoral prosthetic materials.Among extraoral prosthetic materials vinyl chloride polymers, poly (methyl methacrylate), silicone, and polyurethane are discussed for use in facial prosthetics. At present silicones and polyurethane materials are considered most desirable for their strength, even though both are somewhat difficult to color.Intraoral prosthetic materials include silicones, poly (methyl methacrylate), Tantalum, Ticonium, Vitallium, and Titanium mesh materials. Here again, silicone is particularly valued for its tissue tolerability. Metallic mesh materials have the advantage of permitting granulated tissue to migrate through the mesh.The criteria for ideal materials in maxillofacial prosthetics are as follows: extraoral prostheses should not irritate the surrounding tissues, yet it should be strong enough about the periphery to endure. It should be translucent, light weight, easy to process, and easy to manipulate prior to processing. It should be resistant to various chemicals such as ether, oil and to sunlight, heat, and cold.Implantable prosthetic materials must not be physically modified by the soft tissue; must not be capable of inciting inflammatory or foreign body reaction; must be chemically inert, noncarcinogenic, capable of resisting strain, easy to construct, and easy to sterilize.Progress toward meeting these criteria depends upon cooperation between laboratory and clinical researchers.
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    Porous titanium dental implants (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 401-407 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Titanium implants have been designed which utilize a solid core and porous exterior. The technique for implants containing posts utilizes a cast chromium-cobalt splint for fixation and the buried implants are held in place by the overlying gingiva until tissue growth into the porosity results in stabilization.Clinically successful post implants with apparent bone ingrowth and healthy gingiva surrounding the post have been achieved for periods up to three months.
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    Masthead (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974) 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080501
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    Masthead (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974) 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080601
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    The effect of implantation on the physical properties of silicone rubber (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 357-367 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Medical grade silicone rubber manufactured by Dow Corning Corporation was implanted subcutaneously in beagle dogs. At specified time intervals, the implants were removed at which time physical properties and weight changes were determined. A change in the physical properties was observed after six months implantation. Tensile strength decreased 7%, elongation 10% and the modulus at 200% extension increased 8%. After two years implantation, tensile strength had decreased 8%, elongation 15%, and 200% modulus increased 16%. After two weeks implantation, a 0.4% weight gain was seen, and after four weeks implantation the samples had gained 0.7%. However, after four weeks the weight gains stabilized and from four weeks to two years, they never exceeded 0.91%. The increase was due mainly to lipid absorption. No phospholipid or protein was detected. A chloroform/methanol extraction of the samples before implantation demonstrated 1.7% extractable silicone polymer. Samples not extracted before implantation, but extracted after implantation also demonstrated 1.7% extractable silicone polymer. This data suggests extractable silicone polymer does not leach from the medical grade silicone rubber during implantation.The data also suggests that the rubber is not being degraded to extractable silicone polymers during implantation. There were no significant differences in percent lipid up-take or the lipid profiles between samples which had extractable silicone polymer extracted before implantation and/or those which were not extracted before implantation.It should be pointed out that the slight changes in physical properties measured in this study should not be great enough to alter the performance of the rubber in the subcutaneous environment.
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    Some effects of pore diameter on single pore bony ingression patterns in Teflon (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 399-406 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Teflon implants containing a single cylindrical pore were surgically embedded in the femural bones of rabbits. A total of eight different pore sizes were used for each experimental animal. Their diameters ranged from 274 to 670 μm, with approximately 50 μm intervals between sizes. The amount of bone tissue ingression and its spatial distribution was assessed for each pore diameter at weekly intervals over a sixteen-week period by bone labeling with Tetracycline injection. From these data an optimum pore diameter of between 400 to 450 μm was observed for maximum bone ingression. The distribution of new bone growth was characterized as an apposition pattern which emanated from the walls and the open end of the pore. No rejection phenomena were observed at the Teflon tissue interfaces.
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    Investigation of the phase composition of six dental amalgams by X-ray diffraction (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 443-450 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The integrated intensities of certain reflections of the γ, γ1, and γ2 phase have been determined as a function of the mercury content of 6 amalgams after annealing for 20 hr at 37°C. This dependency could be described satisfactorily by means of the regression model: \documentclass{article}\pagestyle{empty}\begin{document}$$ I_i = I_{i^0 } - \alpha _i W $$\end{document}. Here Ii is the integrated peak intensity for phase i at a mercury fraction of W by weight, whereas Ii0 and αi are constants of the material, whereby i = 0, 1, 2 stands for the γ, γ1, and γ2 phase respectively. Considerable differences between the αi and Ii0 parameters of the different amalgams were detected.
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    Compressive strength of implanted porous replamineform hydroxyapatite (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 39-45 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Porous replamineform hydroxyapatite is a nontoxic, nonallergenic synthetic ceramic currently under investigation as an implant for restoration of atrophic edentulous ridges. Previous studies have demonstrated its capacity to permit the ingrowth of bone into its pores. Evaluation of the material was carried out to determine its eventual compressive strength following implantation. Bony penetration results in a significant increase in strength, judged to be sufficient for support of dentures.
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    Long-term compressive creep deformation and damage in acrylic bone cements (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 25-37 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Compressive creep tests were performed on five commercially available acrylic bone cements under conditions simulating in vivo usage. Measured creep strains are quite large, generally exceeding elastic strains. Large variations in creep response were noted among the various cements, with a carbon-reinforced cement by far the most resistant to creep. The empirical model ∊ = a exp(bσ)tn was found to predict creep strains within about 10% of the measured values. Microscopic examination of some specimens after testing revealed significant cracking, resulting from long-term loading, that could be a contributing cause of time-dependent failure.
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    Isolation of serum protein organometallic corrosion products from 316LSS and HS-21 in vitro and in vivo (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 99-114 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An investigation into blood-borne organometallic compounds that arise from the corrosion of metals used in orthopedic prosthetic devices was conducted using an in vivo rat model with an implantation time of 10 days and an in vitro human serum model with an incubation time of 5 days. Both models involved 316LSS and HS-21Haynes Stellite 21: Stellite Division of Cobalt Corporation, Kokomo, Indiana (An alloy of very similar composition to ASTM F-75) in the spherical powder form of 55 ± 5 μm microns in diameter at three different surface areas to body weight ratios. Gel chromatography on cross-linked dextran (G-200) was used to fractionate the serum proteins which bound the metal ions (chromium, cobalt, and nickel) released and identify them. Atomic-absorption-spectrophotometry analysis measured the concentration of the metal ions in each serum protein peak as well as whole serum from both models, and red cell and tissue from the in vivo model. Within the serum proteins, the metal ions were bound to two of the principal serum protein peaks. Similar distributions of the metals among the serum protein peaks were not noted.
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    Letters to the editor (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 123-125 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180112
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    Histological evaluation of porous titanium cardiac pacemaker electrode tips (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 47-60 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An investigation of the tissue reaction to five porous titanium alloy pacemaker electrode tips inserted in sheep hearts was made. Attachment of the electrode tips to the endocardial wall was facilitated by fibrous tissue ingrowth into the porous material. Vascularized fibrocollagenous tissue was found within the pores of the tips. One tip was found to be infected. The presence of occasional multinucleated foreign-body giant cells within the porosity was related to the particulate features of the porous tip. The electrode tips had a reduced sensing impedance compared with conventional solid platinum tips. The present findings are consistent with previous observations relating to porous cobalt-chromium alloy and porous platinum-iridium alloy tips and suggest that porous titanium alloy may be a suitable pacemaker electrode tip material.
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    The glutaraldehyde-stabilized porcine aortic valve xenograft. II. Effect of fixation with or without pressure on the tensile viscoelastic properties of the leaflet material (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 79-98 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: We have examined the tensile viscoelastic properties of circumferential and radial strips of porcine aortic valve leaflets following fixation in glutaraldehyde and formaldehyde, with or without pressure. After aldehyde treatment, the radial strips remained weaker and less stiff than circumferential strips and responded slightly differently to the treatment. After fixation, with or without pressure, the radial strips showed large changes in stress-strain and hysteresis responses due to initial loading, and there was a twofold reduction in tensile strength and final stiffness. For strips in both directions, fixation without pressure produced doubled extensibility and a ramping stress-strain curve. Permanent (plastic) deformation of 5-20% occurred as a result of cyclic loading, stress relaxation, and creep experiments. Pressure fixation, however, produced little change in stress-strain results other than a simple shift to lower strain and produced no plasticity. Both methods of fixation reduced stress relaxation and creep. Mechanical test results are consistent with a loss of ground substance matrix during fixation. Reductions in tensile strength after fixation may be due to “riveting” of collagen geometry, producing local stress concentrations.
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    Masthead (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984) 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180201
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    Editorial (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. iii 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180202
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    On the true wear rate of ultrahigh molecular weight polyethylene in the total knee prosthesis (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 207-224 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The objective of this investigation was to assess the magnitude of the true wear of the polyethylene components of several total knee replacements. Five different prostheses were tested by total joint simulation for the equivalent of 1 month of use. The true wear rates of the tibial components were measured by quantitative recovery of the polyethylene debris. After testing, the tibial components were examined in the scanning electron microscope, and the molecular weight distributions were analyzed. The wear rates were found to range from 0.3 to 1.8 mg per month. The soluble fraction molecular weights ranged from 179,000 to 393,000 with 53-78% soluble. The wear rates, significantly larger than those observed for total hip prostheses, are dominated by the high contact stresses in these prostheses. The wear results in dimensional changes, which are of the same order of magnitude as those due to creep. The debris had two components: fine fibrous particles, found in all cases, and coarse granules, found when the wear rate is relatively high. Evidence for fatigue cracking was found at the surfaces of the tibial component with the highest wear rate. This behavior is consistent with other investigations of the material itself and indicates that continuous deterioration of the polyethylene should be expected in this class of prosthesis.
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    Masthead (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984) 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180301
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    Reduction in complement activation from biomaterials by removal of air nuclei from the surface roughness (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 255-269 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The activation of the rabbit complement system by each of three different synthetic materials is reported. Samples of each type of material were subjected to one of two different priming procedures. One priming procedure was intended to remove the air nuclei from the surface roughness of the materials; the other procedure was just the normal one. It was found that the removal of the air nuclei during priming reduced the complement activation by each of the two materials of lower surface tension, but not by a statistically significant amount for the material of highest surface tension, cellophane. For the denucleated samples of the three materials, the amount of complement activation was found to correlate with the critical surface tension of the materials; if the samples of the materials were normally primed, there was no correlation of the amount of complement activation with the critical surface tension of the material.
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    In vivo biocompatibility studies. II. Biomer: Preliminary cell adhesion and surface characterization studies (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 309-315 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Additional Material: 7 Ill.
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    Streaming potential and streaming current measurements to estimate surface conduction and electric double layer structure of biomaterials (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 317-320 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
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    Design criteria for percutaneous devices (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 357-382 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A theoretical model of a percutaneous device is described. The model is split into several components, each with its own function. Special structures such as horns, hair, feathers, fingernails, hoofs, teeth, and antlers are taken as examples where nature has solved the problems of “percutaneous devices.” These structures have been regarded in relation to dimensional and structural differences of epidermis, dermis, and subcutis. Theoretical guidelines are described for the design of a prosthetic percutaneous device.
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    Some factors that influence prolonged interfacial continuity (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 383-393 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Bringing a percutaneous implant through the integument with the intentions of leaving it as a functional device for prolonged periods of time has not yet become a reality. If we are ever to achieve prolonged uninfected implants, attention must be directed toward a variety of failure mechanisms. Some of these mechanisms have defined our scrutiny, and our awareness of others are poorly understood. Some of the causes for failure of a percutaneous implant are the forces, either extrinsic or intrinsic, that cause shearing and tearing at the skin-implant interface. Extrinsic forces are defined as those forces applied either to the skin or the implant by the external environment. Intrinsic forces are those that have to do directly or indirectly with the body's growth and cell maturation, such as the retraction of maturing scar tissue and the surface migration of squamous epithelium. An intact skin-implant interface is important to attain in order to close the portal which might allow microbial invasion. The integument must remain intact, since a suppurative wound makes the implant's removal mandatory.
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    Infection of percutaneous devices: Prevention, monitoring, and treatment (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 403-411 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Infection continues to pose the major obstacle to long-term percutaneous access. Development of methods to prevent infection or techniques to determine early onset of infection at a time when antibiotic therapy may prove successful would be of enormous value. Our laboratory has been working toward developing and testing a noninvasive semiquantitative swab culture technique (SQ) to monitor percutaneous leads for infection. This technique was found to have a 76% sensitivity having identified 47 of 62 organisms detected by a quantitative tissue culture technique (Q) at the time of system explant. Furthermore, 47 of 61 organisms identified by the SQ technique accurately detected those isolated by the Q techniques. Accordingly, the SQ technique has a 77% specificity. This technique was capable of detecting organisms a median of 14 days prior to overt clinical infection. Prompt initiation of oral antibiotic treatment based on SQ results has doubled system survival compared with untreated systems. Clearly, the SQ technique has proven useful to monitoring percutaneous devices.
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    Bond strength and hardness of light-activated composite resins (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 789-796 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The bond strength of visible light-activated composites to etched enamel was measured as a function of exposure time. Studies have shown that the bottom surface may not be as hard as the top after customary cure times. Therefore this study also measured hardness and related it to enamel bonding. Plexiglas molds were used to simulate extracoronal applications where light is not attenuated by enamel. Bond strength and hardness of the bottom surfaces reached maximum values after the same exposure times with two of the three composites. More exposure time than normally recommended by manufacturers was needed to obtain maximum bond strength to enamel.
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    Correlation of tissue reaction to corrosion in osteosynthetic devicesThe opinions or assertions contained herein are the private opinions of the authors and are not the official views of the Department of The Air Force. (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 817-828 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This study evaluated the interaction of osteosynthetic plates to adjacent tissue. Eleven patients had 13 plates removed with simultaneous biopsies of the adjacent soft tissue. Four patients had pain localized to the area of the plate and 11 patients had routine removal or removal for fracture nonunion. Each plate was graded on a 0-5 point scale for the amount and severity of corrosion present at the screw - plate interface. The adjacent tissue was fixed in formalin and stained with hematoxylin and eosin. The tissue reaction was graded on a 0-5 point scale based on the inflammatory response. A positive correlation of corrosion and tissue reaction was found that was significant at p ≤ 0.005 in the assymptomatic group. The other good correlation showed that tissue reaction tends to decrease with time at p ≤ 0.005. There was no correlation of corrosion with tissue reaction in the symptomatic removal group. All patients with pain adjacent to the plates were relieved by implant removal. The findings suggest that stainless steel is minimally toxic to human tissue in most circumstances and that the toxic products are well tolerated. There was a significant group (4/11) that showed a different pattern of tissue response which did not appear to be toxic response. We do not recommend routine implant removal to prevent metal toxicity; however, there is a group of patients who have pain in the area of the implant that may be caused by an allergic reaction and is relieved by implant removal.
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    Academic focus: Graduate study in dental materials science at New York university college of dentistry (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 867-870 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
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    Extracorporeal removal of mercury by hemoperfusion through agarose - polymercaptal microsphere beads (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 617-629 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Uniform agarose - polymercaptal microsphere beads (APMMB) of 1.0-mm diameter were prepared by encapsulating thousands of polymercaptal microspheres of 0.8-μm average diameter within an agarose matrix. Those beads show a high avidity and affinity for mercury and readily remove mercury compounds bound to serum proteins. In vivo detoxification trials in dosed rabbits and dogs showed the effectiveness of the APMMB for removal of mercury compounds by hemoperfusion. The rate for mercury removal is enhanced by addition of cysteine. The biocompatibility of the APMMB, measured by the depletion of the formed elements and various soluble components of the blood, is also demonstrated.
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    Equilibrium adsorption of human serum albumin and human fibrinogen on hydrophobic and hydrophilic surfaces (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 685-693 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The adsorption of human serum albumin and human fibrinogen on flat surfaces was quantitatively determined by measuring the decrease in UV absorption in the adsorption solution. The applicability of the method is discussed for hydrophilic and hydrophobic materials. The values of equilibrium adsorption are presented - albumin on polyethylene, and fibrinogen on polyethylene, carbon, poly(2-hydroxyethyl methacrylate), and cellophane.
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    An in vivo method for the biological evaluation of metal implantsPresented in part at the 9th Annual Meeting of the Society for Biomaterials, 1983. (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 829-844 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The peritoneal cavity of the rat was used as an implantation site in order to study the quantitative, cellular response and the qualitative, histopathological response to three metals (Ag, Sn, Cu). The effects of the metals on the cells were correlated with the cellular concentrations of the metal as determined by chemical analysis. Small variations in the cell population and a minimal foreign body reaction was observed with an implanted control material (silicone polymer). Large increases in the number of cells and an intense foreign body reaction was observed with Cu implants. Decreases in the number of cells were seen with Sn and Ag implants, but only Sn elicited a foreign body reaction. Implantation of Ag failed to elicit a foreign body reaction. Significant concentrations of all three metals were detected in the retrieved cells.
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    Difference of bond bonding behavior among surface active glasses and sintered apatite (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 845-859 
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    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Three types of surface active glasses and sintered apatite were implanted in femurs of rabbits for 8 and 16 weeks and subjected to the push-out test to measure the bone bonding strength. The apatite surface layers of these materials, which were formed under in vitro treatment, were studied using IR, NMR, and AES. The difference in the bonding strength among these materials was shown statistically. The results of in vitro experiments explained the differences. It was concluded that the crystal chemistry and formation rate of the surface apatite layer significantly influenced the bonding strength. Materials that formed a surface apatite layer having a bone-like crystal chemistry and fast formation rate showed high bone bonding strength.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180714
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  • 93
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    Announcement (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1191-1192 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180918
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  • 94
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    The activation of the complement system by polymer materials and their blood compatibility (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 969-978 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The activation of the complement system by polymer materials and their blood compatibility. One of the negative effects of the clinical application of various blood-containing biomedical devices is the activation of the complement system induced by a foreign surface. A method of determining the hemolytic activity of human serum complement before and after contact with polymers was chosen in order to elucidate the relationship between polymer surface types and the degree of complement activation. The complement activation of each donor proved to depend both on his own complement reactivity and the type of polymer surface. The role played by each constituent was estimated using the rate constants for spontaneous (ksp) and induced (kind) complement activation. The negative correlation (-0,88, p 〈 0,001) between the degree of irreversible adsorption of 131I-serum albumin and relative kind was determined. Thus, we propose the use of kind for the criterion of conformation alterations of protein macromolecules induced by the adsorption/desorption processes on blood/surface interface, leading to complement activation.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180902
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  • 95
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    Morphological characteristics of tendon cells cultured on synthetic fibers (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1073-1087 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Filamentous carbon is currently being used as an implant material for tendon and ligament repair in humans. This material acts as a scaffold for the organization of new fibrous tissue growth. Primary cultures of rat tendon fibroblast cells (1° RTF cells) were grown on carbon, Dacron, polyethylene and Nylon fibers in vitro. The morphological characteristics of these cells were examined. The process of cell migration from tendon explant to fiber substrate was similar for all four materials. Three morphological categories of cells were observed on these materials. (1) spherical dividing cells, (2) spindle-shaped migrating cells, (3) sheath-like migrating or stationary cells. The morphological characteristics and orientational behavior of cultured fibroblasts on these fiber materials were strongly influenced by the diameters of the fibers and by fiber surface characteristics such as longitudinal striations. The possible mechanisms of cell response to substrate geometric configuration are discussed along with the clinical significance of these experiments.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180910
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  • 96
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    In vivo validation of a cell culture test for biocompatibility testing of urinary catheters (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1125-1135 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Biocompatibility tests have been compared for their suitability as routine safety tests for urinary catheters. Latex catheters from five manufacturers were tested by each of the following four methods: (1) a cell culture cytotoxicity assay of catheter extracts, (2) intracutaneous injection of the extracts into rabbits, (3) intramuscular implant of catheter pieces into rabbits, (4) catheterization of sheep (mucous membrane irritation). The rabbit intracutaneous and intramuscular tests are both current pharmacopoeial methods for ascertaining the suitability of polymers for medical use. The four tests each showed a cell or tissue response ranging from no detectable change to severe damage, according to the catheter batch or brand, and they each identified the same samples as most toxic and least toxic. However, they differed in sensitivity. The sheep test and the cell culture assay discriminated between catheters of intermediate toxicity and ranked as toxic catheters not identified as such by the two pharmacopoeial tests. The sheep test most closely approximates clinical usage, but is impractical for routine use. The cell culture assay is a suitable alternative. It also has the advantages of a clearly defined endpoint, good sensitivity, reproducibility, speed, and reduced animal usage.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180914
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  • 97
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    Extracorporeal removal of specific antibodies by hemoperfusion through the immunosorbent agarose-polyacrolein microsphere beads: Removal of anti-bovine serum albumin in animals (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 1153-1167 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: We describe (1) the production of a unique immunosorbent system, agarose-polyacrolein microsphere beads (APAMB) for removal of a specific antibody, anti BSA, and (2) its efficacy in animal trials. This is a model system for hemoperfusive removal of specific antibodies or antigens directly from whole blood. The agarose beads (1.0 mm mean diameter) contain thousands of microspheres of 0.2 m̈m mean diameter. The microspheres which contain the ligand are encapsulated within an agarose matrix to confer physical strength, biocompatibility, spacial configuration, and porosity allowing rapid entry of plasma for reaction. Any antigen may be linked covalently to spacers on the polyacrolein microspheres to remove a specific antibody, or vice versa. Thus the APAMB remove specific molecules in contrast to the charcoal or ion exchange resins currently in use. Removal of antibody is efficient and rapid, therefore, short hemoperfusive times may be used. The beads are biocompatible; there are negligible decreases in RBC, WBC and platelets. Electrolytes and other soluble components also are minimally affected. Therapy, at the least palliative, of autoimmune disorders i.e., multiple myeloma, macroglobinemia, autohemolytic anemias, idiopathic thrombocytopenia, myasthenia gravis, rheumatoid arthritis, thyroiditis, glomerulonephritis, etc, is potentially available with this or its further improved versions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180916
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  • 98
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    Pyrolytic biocarbon materials (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 209-217 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Carbon is one of the most attractive biomaterials in many respects. Recent developments in high strength carbon materials for the aerospace industry have led to new forms of carbon which have good structural properties. Several of these, based on a vapor-de-posited pyrolytic graphite matrix, are described. A needle-like silicon-carbide strengthened pyrolytic graphite has been implanted in rabbits and chimpanzees with encouraging results. Applications are being sought.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080321
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  • 99
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    Masthead (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974) 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080401
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  • 100
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    Splat-cooled alloys in the Ag-Sn-Cu system (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 3-10 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Strength, dimensional change during setting, and corrosion resistance have been measured for amalgams prepared from splat-cooled alloys of different compositions in the Ag-Sn-Cu system. The amalgam with optimum values of these properties was made from the alloy containing 60 at. % Ag, 25 at. % Sn, and 15 at. % Cu. Tensile strengths for amalgams from this alloy were about 8000 psi, dimensional change during setting near zero, and corrosion resistance was good.X-Ray diffraction showed that the γ1 and γ2 phases formed during the early stages of setting but that the γ2 phase had essentially disappeared after about 24 hr. At the latter time Cu6Sn5 was present.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080103
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