ISSN:
1573-9686
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Technology
Notes:
Abstract Copolymers formed from 20%-γ-L-benzylglutamate-80%-L-leucine (GL-14), 50%-γ-L-benzylglutamate-50%-L-leucine (GL-11), 80%-γ-L-benzylglutamate-20%-L-leucine (GL-41), 80%-γ-L-benzylglutamate-20%-L-phenylalanine (GP-41), and 100%-γ-L-benzylglutamate (G-1), where all percentages are in mole percent, were cast as thin films and tested for their ability to cause platelet retention in columns and to initiate coagulation, as measured by the partial thromboplastin times and Factor VII assays. Benzene, dichloroethane, and dioxane were used as casting solvents. Solvent and composition altered material properties as measured by X-ray diffraction, scanning electron microscopy and contact angle measurements. The effect of composition was non linear, regardless of solvent. GL-11 was the composition most capable of initiating coagulation as measured by the PTT test and Factor VII assays. The measured PTT values were observed to be greatest in those materials where the “polar” energy, averaged over the entire surface, was greatest. Platelet adhesion and the activation of Factor VII also appeared to correlate best with “polar” energy. There was no relationship of measured coagulation time to structural measurements determined by X-ray diffraction. The results imply short range interactions of partially charged molecules as a major determinant in activating the coagulation system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02364218
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