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  • Articles  (11,977)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Entomologia experimentalis et applicata 94 (2000), S. 183-194 
    ISSN: 1570-7458
    Keywords: Spodoptera exigua ; Sabulodes aegrotata ; Pseudoplusia includens ; avocado ; oil cells ; idioblasts ; adaptation ; food preference
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We tested the hypothesis that avocado idioblast oil cells play a defensive role against herbivorous insects. Toxicities of the intact avocado idioblast oil cells and the extracted idioblast oil were compared for three insect herbivores. Spodoptera exigua (Hübner) larvae are generalists that do not feed on avocados. By contrast, Sabulodes aegrotata (Guenée) and Pseudoplusia includens (Walker) larvae are generalist herbivores that readily feed on avocados. All bioassays were performed at a naturally occurring concentration of idioblast oil cells (2% w/w). Choice experiments showed that S. exigua larvae avoided diet treated with avocado idioblast oil cells and consume more control than treated diet. In contrast, idioblast oil cells had no significant antifeedant effects on the adapted S. aegrotata and P. includens larvae. Subsequent experiments designed to assess resistance mechanisms separated pre-ingestive (behavioral) and post-ingestive (physiological) effects of the avocado idioblast oil cells, and the extracted idioblast oil, on the two adapted herbivores. Post-ingestive adaptation was the mechanism that allows feeding. Because the impact of the avocado idioblast oil cells was greatest on the performance of non-adapted S. exigua, additional experiments determined that larvae fed diet containing the oil cells had higher mortality and reduced larval growth compared to controls. Developmental times were significantly prolonged for the survivors. Thus, increased mortality, reduced developmental rates, and antifeedant activity in the non-adapted insect indicate that defense against non-adapted herbivores may be an important function of idioblast cells in avocados.
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  • 2
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    Journal of insect behavior 13 (2000), S. 397-420 
    ISSN: 1572-8889
    Keywords: tick ; Boophilus microplus ; Ixodes ricinus ; Amblyomma variegatum ; give-up time ; avoidance ; adaptation ; sequential analysis ; water
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Life stages of different tick species avoid walking on a wet surface surrounding a dry patch by systematically returning to the dry each time they contact the wet surface beyond the border with the tip of a first leg tarsus. Sequential analysis of the border behaviors shows that repetitive contact with the water increases the probability of walks astride the border. Ticks accept this unilateral contact with the water for longer intervals and eventually walk on to the wet surface after a combination of a short patch walk followed by a border walk which is longer than the foregoing ones. Staying time on a small circular patch is shorter than on a large one, arising probably from faster adaptation of peripheral receptors following a higher frequency of border contacts. However, an equal number of border reactions on patches of different sizes and shapes suggests that a ‘counter’ in the CNS may also influence dry patch departure.
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  • 3
    ISSN: 1573-9368
    Keywords: adaptation ; barley trypsin inhibitor ; bioassay ; digestive protease activity ; Spodoptera exigua ; transgenic tobacco
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Nicotiana tabacum plants were transformed with the cDNA of barley trypsin inhibitor BTI-CMe under the control of the 35S CaMV promoter. Although the transgene was expressed and the protein was active in the homozygous lines selected, growth of Spodoptera exigua (Lepidoptera: Noctuidae) larvae reared on transgenic plants was not affected. The protease activity in larval midgut extracts after 2 days feeding on transformed tobacco leaves from the highest expressing plant showed a reduction of 25% in the trypsin-like activity compared to that from insects fed on non-transformed controls. The susceptibility of digestive serine-proteases to inhibition by BTI-CMe was confirmed by activity staining gels. This decrease was compensated with a significant induction of leucine aminopeptidase-like and carboxipeptidase A-like activities, whilechymotrypsin-, elastase-, and carboxipeptidase B-like proteases were not affected.
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  • 4
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    Aquatic ecology 34 (2000), S. 19-27 
    ISSN: 1573-5125
    Keywords: adaptation ; fitness ; food quality ; growth ; reproduction ; temporary ponds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Temporary pond Daphnia flourish on relatively poor-quality food, suggesting adaptation to stringent temporary pond conditions. We conducted laboratory life history experiments on populations of Daphnia obtusa from a shaded woodland temporary pond (short hydroperiod, dystrophic) and an open farmland temporary pond (long hydroperiod, eutrophic), and compared a suite of physical/chemical conditions in the ponds to evaluate habitat conditions. We hypothesized that the shaded woodland pond population would be more fit in terms of life history variables for individuals (age and size at first reproduction, mean brood size, mean number of neonates) and populations (generation time, net reproductive rate R 0, and intrinsic reproductive rate r) given a standard, low-quality food (trout chow and yeast). Life history traits of woodland pond animals were mixed, relative to farm pond animals, and consistent with bet-hedging for an unpredictable habitat. Values of life history traits rivaled or exceeded those of other studies using phytoplankton as food, and were influenced by the pond water used for our study. Life histories clearly differ among local and regional temporary pond Daphnia obtusa populations, and should be valuable for examining the relative influences of local selection and metapopulation dynamics on population structure.
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  • 5
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    Neuroscience and behavioral physiology 30 (2000), S. 357-363 
    ISSN: 1573-899X
    Keywords: Anoxia ; brain slices ; calcium ; phosphoinositides ; adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The involvement of the calcium and phosphoinositide intracellular regulatory systems in the molecular-cellular mechanisms of adaptation of the brain to hypoxia induced by transient anoxia were studied in slices of rat olfactory cortex. Anoxia lasting 2 min initiated the development of moderate but stable activation of intracellular regulatory systems during the reoxygenation period, with increases in binding of Ca2+ to intracellular hydrophobic domains and increases in the level of polyphosphoiositide metabolism. During this period, cells in the slices released neuromediator factors into the perfusion fluid; transfer of these to recipient slices induced similar changes in the activities of intracellular regulatory system components in the recipient slices. After anoxia lasting 10 min, NMDA-mediated pathogenic hyperactivity of the calcium and phosphoinositide systems developed. Preliminary moderate activation of these systems by transient anoxia or neuromodulator factors released by cells in response to transient anoxia prevented disruption of intracellular regulatory system activity induced by subsequent longer-lasting anoxia.
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  • 6
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    Neuroscience and behavioral physiology 30 (2000), S. 243-254 
    ISSN: 1573-899X
    Keywords: Volume transmission ; adaptation ; peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract This review presents published data and results from our own studies providing evidence for the important role of volume, non-synaptic transmission of adaptogenic signals in the mechanisms forming the long-term adaptive reactions of the brain. The importance of chemical factors involved in volume transmission and secreted by cells in this process is discussed. Special attention is paid to peptides—possible mediators of volume transmission of adaptive-type signals. Evidence has been obtained for the presence of peptides and their role in the mechanism of development of adaptive brain reactions of different origins, especially those arising in response to tetanic stimulation of neurons and transient hypoxic stress. An original method for testing for the effects of neuromodulator factors released by cells in donor slices subjected to these treatments on recipient slices was used to show that these factors had pronounced effects on synaptic transmission and could induce long-term potentiation of synaptic transmission, protecting against functional derangements due to prolonged anoxia. Blockade of protein synthesis in donor slices subjected to adaptogenic treatments suppressed the appearance of these effects. The review concludes with a discussion of the mechanisms of interaction of the synaptic and volume transmission of signals involved in forming long-term adaptive brain reactions.
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  • 7
    ISSN: 1573-6857
    Keywords: adaptation ; Drosophila ; hydrocarbons ; latitude ; longitude ; natural populations ; polymorphism ; temperaturey ; vapour pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 7-tricosene (7T) and 7-pentacosene (7P) are the major components of cuticular hydrocarbons in Drosophila simulans and D. melanogaster males. A chemical study of 16 isofemale lines of D. melanogaster sampled at the first and eighth generations in laboratory conditions showed the stability of chromatographical profiles. Then a large scale study of male 7T/7P polymorphism was performed with 85 populations of D. melanogaster and 29 of D. simulans collected all over the world. There were significant correlations of the values of the balanced ratio (7T − 7P)/(7T + 7P) with geo-climatic parameters, such as latitude, longitude, mean temperature, temperature range and vapour pressure. Parallel variations were also reported for the homologous linear alkanes (23 and 25 Carbon atoms) but not for the longer branched alkanes (27 and 29 Carbon atoms). No correlation was significant for the D. simulans populations studied. In this species a similar polymorphism of 7T/7P was found but restricted to a few populations from West Equatorial Africa.
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  • 8
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    Evolutionary ecology 14 (2000), S. 627-643 
    ISSN: 1573-8477
    Keywords: adaptation ; Bergmann's rule ; clutch size ; egg size ; physiological constraint ; temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Organisms and parts of an organism like eggs or individual cells developing in colder environments tend to grow bigger. A unifying explanation for this Bergmann's rule extended to ectotherms has not been found, and whether this is an adaptive response or a physiological constraint is debated. The dependence of egg and clutch size on the mother's temperature environment were investigated in the yellow dung fly Scathophaga stercoraria. Smaller eggs were laid at warmer temperatures in the field and the laboratory, where possible confounding variables were controlled for. As clutch size at the same time was unaffected by temperature, this effect was not due to a trade-off between egg size and number. Temperature-dependent egg sizes even persisted within individuals: when females were transferred to a cooler (warmer) environment, they laid third-clutch eggs that were larger (smaller) than their first-clutch eggs. The fitness consequences of these temperature-mediated egg sizes were further investigated in two laboratory experiments. Neither egg and pre-adult survivorship nor larval growth rate were maximized, nor was development time minimized, at the ambient temperature corresponding to the mother's temperature environment. This does not support the beneficial acclimation hypothesis. Instead, this study yielded some, but by no means conclusive indications of best performance by offspring from eggs laid at intermediate temperatures, weakly supporting the optimal temperature hypothesis. In one experiment the smaller eggs laid at 24°C had reduced survivorship at all ambient temperatures tested. Smaller eggs thus generally performed poorly. The most parsimonious interpretation of these results is that temperature-mediated variation in egg size is a maternal physiological response (perhaps even a constraint) of unclear adaptive value.
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  • 9
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    Evolutionary ecology 14 (2000), S. 563-570 
    ISSN: 1573-8477
    Keywords: adaptation ; compensation ; damage ; general vigor ; herbivory ; plant fitness ; tolerance ; stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Tolerance of an environmental factor is the ability to maintain fitness in the face of stress imposed by that factor. A tolerant genotype minimizes the decline in fitness from that achieved in a relatively benign environment to that produced in environments with more stressful levels of the factor. Hence, tolerance is a phenotypically plastic characteristic of a genotype that can be assessed only by measuring the genotype's fitness in more than one environment. The genotype's tolerance is characterized by the shape of the fitness reaction norm along the environmental gradient whereas the overall height of the function represents its general vigor.
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  • 10
    ISSN: 1573-5079
    Keywords: adaptation ; biosynthesis ; bacteriochlorophyll a formation ; 3-acetyl group formation ; chlorophyll b formation ; degradation ; 7-formyl group formation ; isocyclic ring E formation ; oxygenase- and hydratase-catalysed cyclization ; origin of 133- and 173-carboxyl groups
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Chlorophylls, magnesium-containing tetrapyrrolic pigments of photosynthesis, are widely-distributed in Nature and participate in both light harvesting and in the transduction of light energy to chemical energy for the photosynthetic fixation of carbon dioxide. We briefly discuss the extensive role of various isotopic labelling techniques in elucidating the pathway of tetrapyrrole-pigment biosynthesis and we acknowledge the classic and meticulous research of David Shemin who, approximately 50 years ago, introduced isotopic tracer techniques with 15N and 14C isotopes to study the biosynthesis of the carbon/nitrogen macrocycle of haem, an iron tetrapyrrole. The main focus of this review is the application of mass spectrometry and 18O labelling to the study of the incorporation of oxygen atoms from molecular oxygen or water into the periphery of the chlorophyll macrocycle during biosynthesis and their loss during degradation and light acclimation. In particular, we review the mechanism of formation of the isocyclic ring of chlorophylls, in higher plants, green algae and various photosynthetic bacteria, which concomitantly incurs formation of the 131-oxo group that is present in all photosynthetically-active chlorophylls. In addition we discuss the formation of the ubiquitous 133- and 173-carboxyl groups and also the formation of the 7-formyl group of chlorophyll b and the 3-acetyl group of bacteriochlorophyll a.
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  • 11
    ISSN: 1573-5079
    Keywords: adaptation ; electron transport ; global warming ; Rubisco
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract To determine how parameters of a Farquhar-type photosynthesis model varied with measurement temperature and with growth temperature, eight cool and warm climate herbaceous crop and weed species were grown at 15 and 25 °C and single leaf carbon dioxide and water vapor exchange rates were measured over the range of 15 – 35 °C. Photosynthetic parameters examined were the initial slope of the response of assimilation rate (A) to substomatal carbon dioxide concentration (Ci), A at high Ci, and stomatal conductance. The first two measurements allow calculation of VCmax, the maximum rate of carboxylation of ribulose bisphosphate carboxylase and Jmax, the maximum rate of photosynthetic electron transport, of Farquhar-type photosynthesis models. In all species, stomatal conductance increased exponentially with temperature over the whole range of 15 – 35 °C, even when A decreased at high measurement temperature. There were larger increases in conductance over this temperature range in the warm climate species (4.3 ×) than in the cool climate species (2.5 ×). The initial slope of A vs. Ci exhibited an optimum temperature which ranged from 20 to 30 °C. There was a larger increase in the optimum temperature of the initial slope at the warmer growth temperature in the cool climate species than in the warm climate species. The optimum temperature for A at high Ci ranged from 25 to 30 °C among species, but changed little with growth temperature. The absolute values of both the initial slope of A vs. Ci and A at high Ci were increased about 10% by growth at the warmer temperature in the warm climate species, and decreased about 20% in the cool climate species. The ratio of Jmax — VCmax normalized to 20 °C varied by more than a factor of 2 across species and growth temperatures, but differences in the temperature response of photosynthesis were more related to variation in the temperature dependencies of Jmax and VCmax than to the ratio of their normalized values.
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  • 12
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    Biologia plantarum 43 (2000), S. 99-103 
    ISSN: 1573-8264
    Keywords: adaptation ; alkaline phosphatase ; chlorophyll content ; copper uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Copper tolerance in Scenedesmus biguja was studied by comparing the physiological properties and Cu uptake in wild type and copper tolerant strain. A concentration dependent reduction in growth rate, pigment, protein, sugar, and amino acid contents, oxygen evolution, and alkaline phosphatase activities was noticed in both strains at 1 and 200 μg(Cu) dm−3. The reduction in all parameters was higher in the wild type than in the tolerant strain. The tolerant strain showed also enhanced alkaline phosphatase activity, and insignificant loss of potassium and sodium. The Cu uptake was influenced by the Cu concentrations the algae had been exposed to during their previous growth: the lower the Cu concentration in the culture medium, the higher the activity of the uptake and the capacity of the cells to accumulate Cu.
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  • 13
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    Journal of bioeconomics 2 (2000), S. 41-86 
    ISSN: 1573-6989
    Keywords: adaptation ; basic needs ; fitness ; social indicators
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Economics
    Notes: Abstract The ground‐zero premise (so to speak) of the biological sciences is that survival and reproduction is the basic, continuing, inescapable problem for all living organisms; life is at bottom a ‘survival enterprise’. It follows that survival is the ‘paradigmatic problem’ for human societies as well; it is a prerequisite for any other, more exalted objectives. Although the term ‘adaptation’ is also familiar to social scientists, until recently it has been used only selectively, and often very imprecisely. Here a more rigorous and systematic approach to the concept of adaptation is proposed in terms of ‘basic needs’. The concept of basic human needs has a venerable history – tracing back at least to Plato and Aristotle. Yet the development of a formal theory of basic needs has lagged far behind. The reason is that the concept of objective, measurable needs is inconsistent with the theoretical assumptions that have dominated economic and social theory for most of this century, namely, ‘value‐relativism’ and ‘cultural determinism’. Nevertheless, there have been a number of efforts over the past 30 years to develop more universalistic criteria for basic needs, both for use in monitoring social well‐being (‘social indicators’) and for public policy formulation. Here I will advance a strictly biological approach to perationalizing the concept of basic needs. It is argued that much of our economic and social life (and the motivations behind our revealed preferences and subjective utility assessments), not to mention the actions of modern governments, are either directly or indirectly related to the meeting of our basic survival needs. Furthermore, these needs can be specified to a first approximation and supported empirically to varying degrees, with the obvious caveat that there are major individual and contextual variations in their application. Equally important, complex human societies generate an array of ‘instrumental needs’ which, as the term implies, serve as intermediaries between our primary needs and the specific economic, cultural and political contexts within which these needs must be satisfied. An explicit framework of ‘Survival Indicators’, including a profile of ‘Personal Fitness’ and an aggregate index of ‘Population Fitness’, is briefly elucidated. Finally, it is suggested that a basic needs paradigm could provide an analytical tool (a ‘bio‐logic’) for examining more closely the relationship between our social, economic and political behaviors and institutions and their survival consequences, as well as providing a predictive tool of some value.
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  • 14
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    Journal of computational analysis and applications 1 (1999), S. 43-62 
    ISSN: 1572-9206
    Keywords: Linear method ; convolution class ; nonparametric deconvolution ; statistics ; adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We expand upon the known results on sharp linear Fourier methods of approximation where the approximation is the best in terms of both rate and constant among all polynomial procedures of approximation. So far these results have been studied due to their mathematical beauty rather than their practical importance. In this paper we show that they are the core mathematics underlying best statistical methods of solving noisy ill-posed problems. In particular, we suggest a procedure for recovery of noisy blurred signals based on samples of small sizes where a traditional statistics concludes that the complexity of such a setting makes the problem not worthy of a further study. Thus, we present a problem where a combination of the classical approximation theory and statistics leads to interesting practical results.
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  • 15
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    Archives of microbiology 171 (1999), S. 214-217 
    ISSN: 1432-072X
    Keywords: Key words Cyanobacteria ; Periplasmic proteins ; Salt ; adaptation ; Synechocystis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Periplasmic proteins were obtained from control cells and salt-adapted cells of the cyanobacterium Synechocystis sp. PCC 6803 using the method of cold osmotic shock. Two of these proteins (PP 1, apparent mol. mass 27.6 kDa, and PP 3, apparent mol. mass 39.9 kDa) were accumulated in high amounts in the periplasm of salt-adapted cells, while the major periplasmic protein (PP 2, apparent mol. mass 36.0 kDa) was accumulated independently from salt. After isolation from gels and partial sequencing, the proteins could be assigned to proteins deduced from the complete genome sequence of Synechocystis. Neither salt-induced periplasmic proteins (PP 1, Slr0924 and PP 3, Slr1485) exhibited sequence similarity to proteins of known function from databases. The major protein (PP 2-Slr0513) showed significant sequence similarities to iron-binding proteins. All proteins included typical leader sequences at their N-terminus.
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  • 16
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    Molecular and cellular biochemistry 196 (1999), S. 31-42 
    ISSN: 1573-4919
    Keywords: thiols ; antioxidant ; redox ; adaptation ; oxidative stress ; skeletal muscle ; dietary supplement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Glutathione plays a central role in the maintenance of tissue antioxidant defenses and in the regulation of redox sensitive signal transduction. In muscle cells, the level and redox status of GSH regulates activity of the redox sensitive transcription factor NF-κB. Physical exercise may cause oxidation of GSH in tissues such as the blood, skeletal muscle and liver. Endurance training strengthened GSH dependent tissue antioxidant defenses in most studies. Although studies investigating the effect of sprint training are few, current results show that sprint training may also have a beneficial effect on tissue GSH homeostasis. Skeletal muscle GSH level appears to be tightly regulated by the state of physical activity. Regular exercise enhances and chronic inactivity decreases the level of GSH in this tissue. N-acetyl-L-cysteine (NAC) and α-lipoic acid (LA) are two antioxidant dietary supplements that are able to enhance cellular GSH levels. Because LA can be recycled to its potent dithiol form, dihydrolipoate, by enzymes present in the human cell it has a clear advantage over NAC. Recently an improved form of LA, a positively charged analogue (LA-Plus), has been discovered. LA-Plus has more potent immuno-modulatory activity compared to LA. Both LA and NAC have been shown to have beneficial effects in protecting tissue GSH homeostasis against exercise induced oxidative stress.
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  • 17
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    Journal of bioeconomics 1 (1999), S. 19-34 
    ISSN: 1573-6989
    Keywords: Darwinian world view ; evolution ; evolutionary economics ; development ; subjectivism ; natural selection ; analogy ; adaptation ; evolutionary progress ; preferences ; genetic endowment ; growth of consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Economics
    Notes: Abstract Bioeconomics—the merging of views from biology and economics—on the one hand invites the 'export' of situational logic and sophisticated optimization developed in economics into biology. On the other hand, human economic activity and its evolution, not least over the past few centuries, may be considered an instance for fruitfully applying ideas from evolutionary biology and Darwinian theory. The latter perspective is taken in the present paper. Three different aspects are discussed in detail. First, the Darwinian revolution provides an example of a paradigm shift which contrasts most significantly with the 'subjectivist revolution' that took place at about the same time in economics. Since many of the features of the paradigmatic change that were introduced into the sciences by Darwinism may be desirable for economics as well, the question is explored whether the Darwinian revolution can be a model for introducing a new paradigm in economic theory. Second, the success of Darwinism and its view of evolution have induced economists who are interested in an evolutionary approach in economics to borrow, more or less extensively, concepts and tools from Darwinian theory. Particularly prominent are constructions based on analogies to the theory of natural selection. Because several objections to such analogy constructions can be raised, generalization rather than analogy is advocated here as a research strategy. This means to search for abstract features which all evolutionary theories have in common. Third, the question of what a Darwinian world view might mean for assessing long term economic evolution is discussed. Such a view, it is argued, can provide a point of departure for reinterpreting the hedonistic approach to economic change and development. On the basis of such an interpretation bioeconomics may not only go beyond the optimization-cum-equilibrium paradigm currently prevailing in economics. It may also mean adding substantial qualifications to the subjectivism the neoclassical economists, at the turn of the century, were proud to establish in the course of their scientific revolution.
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  • 18
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    Biology and philosophy 14 (1999), S. 65-82 
    ISSN: 1572-8404
    Keywords: adaptation ; explanation ; evolution ; preadaptation ; specialization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Notes: Abstract The concept of preadaptation, though useful, continues to trouble evolutionary scientists. Usually, it is treated as if it were really adaptation, prompting such diverse theorists as Gould and Vrba, and Dennett to suggest its removal from evolutionary theory altogether. In this paper, I argue that the as-if sense is ill-founded, and that the sense of preadaptation as a process may be defended as unequivocal and generally useful in evolutionary explanations, even in such problem areas as human evolution.
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  • 19
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    Biology and philosophy 14 (1999), S. 211-233 
    ISSN: 1572-8404
    Keywords: adaptation ; evolutionary psychology ; reasoning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Notes: Abstract I discuss two types of evidential problems with the most widely touted experiments in evolutionary psychology, those performed by Leda Cosmides and interpreted by Cosmides and John Tooby. First, and despite Cosmides and Tooby's claims to the contrary, these experiments don't fulfil the standards of evidence of evolutionary biology. Second Cosmides and Tooby claim to have performed a crucial experiment, and to have eliminated rival approaches. Though they claim that their results are consistent with their theory but contradictory to the leading non-evolutionary alternative, Pragmatic Reasoning Schemas theory, I argue that this claim is unsupported. In addition, some of Cosmides and Tooby's interpretations arise from misguided and simplistic understandings of evolutionary biology. While I endorse the incorporation of evolutionary approaches into psychology, I reject the claims of Cosmides and Tooby that a modular approach is the only one supported by evolutionary biology. Lewontin's critical examinations of the applications of adaptationist thinking provide a background of evidentiary standards against which to view the currently fashionable claims of evolutionary psychology.
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  • 20
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    Genetica 107 (1999), S. 181-187 
    ISSN: 1573-6857
    Keywords: IS element ; β-glucoside ; β-galactoside ; E. coli ; selfish DNA ; adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The concept of transposable elements (TEs) as purely selfish elements is being challenged as we have begun to appreciate the extent to which TEs contribute to allelic diversity, genome building, etc. Despite these long-term evolutionary contributions, there are few examples of TEs that make a direct, positive contribution to adaptive fitness. In E.coli cryptic (silent) catabolic operons can be activated by small TEs called insertion sequences (IS elements). Not only do IS elements make a direct contribution to fitness by activating cryptic operons, they do so in a regulated manner, transposing at a higher rate in starving cells than in growing cells. In at least one case, IS elements activate an operon during starvation only if the substrate for that operon is present in the environment. It appears that E. coli has managed to take advantage of ISelements for its own benefit.
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  • 21
    ISSN: 1573-5117
    Keywords: crustacean ; subterranean environment ; adaptation ; metabolism ; hypoxia ; recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The locomotory and ventilatory activities, oxygen consumption, and the intermediary and energy metabolism modifications of a spring and a cave population of the aquatic amphipod crustacean Gammarus minus were investigated in normoxia, severe hypoxia ( $$P_{{\text{O}}_{\text{2}} } $$ 〈 0.03 kPa) and subsequent recovery. The aims of this study were to compare (1) the reactions of both populations to these experimental conditions, (2) these results with those obtained on the hypogean amphipod Niphargus, and (3) the degree of adaptation to hypoxia showed by both populations of G. minus. Despite their different origins, both populations of G. minus presented identical responses in all experimental conditions. The lethal time for 50% of the population was about 6 h, and the oxygen consumption about 44 μmol O2/g dw per h in normoxic conditions. The metabolic effects of severe hypoxia and subsequent recovery were significant compared to normoxic conditions, but also similar between both populations for alanine, arginine phosphate, ATP, glycogen and lactate levels. This study (i) underlines the statement that a high resistance to lack of oxygen is not universally found in subterranean organisms, but is more related to oxygen availability and/or to the energetic state of each subterranean ecosystem, and (ii) highlight the diversity of adaptive responses to an environmental constraint expressed by hypogean crustaceans.
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  • 22
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    Hydrobiologia 413 (1999), S. 1-9 
    ISSN: 1573-5117
    Keywords: ecological genetics ; adaptation ; Rhizophora ; mangroves ; cuticular waxes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We have examined possible adaptation in cuticular alkane composition in the halophytic mangrove genus Rhizophora. Relative composition of the dominant alkanes varied: 1. among the three sympatric species from the Atlantic-East-Pacific region, 2. with geographic region within species and, 3. among populations within geographic region. For R. mangle, longer chain alkanes were more important in the semi-arid regions of north-west Africa and the Pacific coast of north-central Mexico. Mantel tests showed that inter-population taxonomic distances for the major alkanes were correlated with taxonomic distances for annual rainfall and mean maximum temperature, but not with weighted geographic distance. Since alkane carbon chain length should affect the biophysical properties of waxes, with longer chain lengths increasing crystallinity and impermeability, our data provides support for the hypothesis that observed differentiation is due to natural selection, rather than stochastic processes in this species. The same pattern was not observed for R. racemosa or R. harrisonii. Since these two species occupy less saline conditions and are more restricted in their latitudinal range, selection pressure may be less important than other evolutionary forces such as genetic drift. There was some evidence that alkane composition was more closely correlated with mean minimum temperatures in R. racemosa, that might set the latitudinal limits in this species.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 25-41 
    ISSN: 1573-1596
    Keywords: adaptation ; agriculture ; climate change ; Kazakhstan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract Agriculture in Kazakhstan is sensitive to climate, and wheat yields could be reduced up to 70% under climate change. With the transition from a socialist economy to a free market economy, decisions are being made now that will affect Kazakhstan's ability to cope with climate change. A team of Kazakh and American researchers examined the cost-effectiveness and barriers to implementations of adaptation options for climate change. Twelve adaptation options that increase flexibility to respond to climate change were identified using a screening matrix. Four options, forecasting pest outbreaks, developing regional centers for preserving genetic diversity of seeds, supporting a transition to a free market, and reducing soil erosion through the use of changed farming practices, were examined. The Adaptation Decision Matrix (ADM) was then applied to estimate benefits using expert judgment (using an arbitrary numerical scale, not monetary values) and benefits estimates were compared to costs to determine cost-effectiveness. The ADM uses subjective measures of how well adaptation options meet policy objectives. Controlling soil erosion was estimated to have the highest benefits, but the high costs of implementation appears to make it relatively cost-ineffective. Supporting a transition to a free market was ranked as the most cost-effective measure, with regional centers second. However, use of different scales to quantify benefits or different weights can result in regional centers being more cost-effective than the transition to a free market. Regional centers was also judged to have fewer barriers to implementation than a transition to a free market. These results will be incorporated in Kazakhstan's National Action Plan. The ADM and other tools are relatively easy to apply, but are quite subjective and difficult to evaluate. The tools can be quite useful by decision makers to analyze advantages and disadvantages between different adaptation options, but should be supplemented with additional, particularly quantitative analysis.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 137-165 
    ISSN: 1573-1596
    Keywords: adaptation ; agriculture ; climate change ; decision-making ; variability
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    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract This work presents a framework for viewing agricultural adaptation, emphasizing the multiple spatial and temporal scales on which individuals and institutions process information on changes in their environment. The framework is offered as a means to gain perspective on the role of climate variability and change in agricultural adaptation, and developed for a case study of Australian agriculture. To study adaptation issues at the scale of individual farms we developed a simple modelling framework. The model highlights the decision making element of adaptation in light of uncertainty, and underscores the importance of decision information related to climate variability. Model results show that the assumption of perfect information for farmers systematically overpredicts adaptive performance. The results also suggest that farmers who make tactical planting decisions on the basis of historical climate information are outperformed by those who use even moderately successful seasonal forecast information. Analysis at continental scales highlights the prominent role of the decline in economic operating conditions on Australian agriculture. Examples from segments of the agricultural industry in Australia are given to illustrate the importance of appropriate scale attribution in adapting to environmental changes. In particular, adaptations oriented toward short time scale changes in the farming environment (droughts, market fluctuations) can be limited in their efficacy by constraints imposed by broad changes in the soil/water base and economic environment occuring over longer time scales. The case study also makes the point that adaptation must be defined in reference to some goal, which is ultimately a social and political exercise. Overall, this study highlights the importance of allowing more complexity (limited information, risk aversion, cross-scale interactions, mis-attribution of cause and effect, background context, identification of goals) in representing adaptation processes in climate change studies.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 199-213 
    ISSN: 1573-1596
    Keywords: adaptation ; climate change ; impact assessment ; response options ; vulnerability
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    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract This paper outlines what is meant by "adaptation" to climate change, and how it might be addressed in the IPCC Assessments. Two roles of adaptation in the climate change field are identified: adaptation as part of impact assessment (where the key question is: what adaptations are likely?), and adaptation as part of the policy response (where the central question is: what adaptations are recommended?). The concept of adaptation has been adopted in several fields including climate impact assessment and policy development, risk management, and natural hazards research. A framework for systematically defining adaptations is based on three questions: (i) adaptation to what? (ii) who or what adapts? and (iii) how does adaptation occur? The paper demonstrates that, for adaptation purposes, climate extremes and variability are integral parts of climate change, along with shifts in mean conditions. Attributes for differentiating adaptations include purposefulness, timing, temporal and spatial scope, effects, form and performance. The framework provides a guide for the treatment of adaptation in the IPCC assessments, both in the assessment of impacts and in the evaluation of adaptive policy options.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 215-225 
    ISSN: 1573-1596
    Keywords: climate ; adaptation ; impacts
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    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract There is a critical need to collectively understand, to develop adaptation options to enhance the benefits, and to reduce the social and economic vulnerabilities induced by climate variability and change. This paper uses key questions to help build a framework for adaptation by first organizing the questions into adaptation science, management and option components, including their respective sub-categories. The process of adaptation depends on many factors, including who or what adapts, what they adapt to, how they adapt and what and how resources are used. This conceptual model is designed to organize concepts regarding adaptation, to help stimulate ideas, and to explore the linkages among parts of the adaptation cycle. Predictive models need to be developed to determine the outcomes of planned adaptation strategies. For the best and most realistic evaluation of climate problems, adaptation and impacts should be considered together. This joint approach improves the assessment of the significance and dangers of the current and future climate, as well as the determination of solutions (e.g., how to prepare for a changing climate) and their priorities. Challenges of adaptive management are discussed in terms of a framework with linkages to adaptation science and options. Adaptation research and applications work continue to build on the foundation of science and management frameworks to address the risks and uncertainties in the decision-making process and to identify adaptation options.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 227-237 
    ISSN: 1573-1596
    Keywords: adaptation ; climate change ; climate variability ; data ; climate applications ; El Niño ; UNFCCC
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    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract An extensive foundation of high quality data and information on the climate and on the biological, environmental and social systems affected by climate is required in order to understand the climate impact processes involved, to develop new adaptation practices, and to subsequently implement these practices. Experience of the impacts of current and past variability of climate and sea level is a prime source of information. Many practices are in use to reduce climate impacts, for example in engineering design, agricultural risk management and climate prediction services, though their roles as adaptations to climate change are not widely appreciated. While there are good data sets on some factors and in some regions, in many cases the databases are inadequate and there are few data sets on adaptation-specific quantities such as vulnerability, resilience and adaptation effectiveness. Current international action under the United Nations Framework Convention on Climate Change (UNFCCC) pays little attention to adaptation and its information requirements. Furthermore there are trends toward reduced data gathering and to restrictions on access to data sets, especially arising from cost and commercialisation pressures. To effectively respond to the changes in climate that are now inevitable, governments will need to more clearly identify adaptation as a central feature of climate change policy and make a renewed shared commitment to collecting and freely exchanging the necessary data.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 239-252 
    ISSN: 1573-1596
    Keywords: climate change ; coastal zones ; adaptation ; vulnerability ; IPCC Technical Guidelines
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    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract This paper evaluates the IPCC Technical Guidelines for Assessing Climate Change Impacts and Adaptations with respect to the guidance offered for coastal-adaptation assessment. It appears that the IPCC Technical Guidelines focus strongly on implementation. This paper uses both conceptual and empirical information is used in this paper to show that coastal adaptation embraces more than selecting one of the "technical" options to respond to sea-level rise (retreat, accommodate or protect). Coastal adaptation is a more complex and iterative process with a series of policy cycles. To be effective, an expanded adapta-tion framework involving four steps is suggested, including (i) information collection and awareness raising; (ii) planning and design; (iii) implementation; and (iv) monitoring and evaluation. The incom-plete coverage of these four steps in existing coastal-adaptation assessments constrains the development of adaptation strategies that are supported by the relevant actors and integrated into existing management. Researchers and policy-makers are recommended to work together to establish a framework for adaptation that is integrated within current coastal management processes and practices and takes a broader view on the subject.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 319-329 
    ISSN: 1573-1596
    Keywords: uncertainty ; risk ; adaptation ; extreme events ; (credible) information ; integrated assessment
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    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract This paper draws ten lessons from analyses of adaptation to climate change under conditions of risk and uncertainty: (1) Socio-economic systems will likely respond most to extreme realizations of climate change. (2) Systems have been responding to variations in climate for centuries. (3) Future change will effect future citizens and their institutions. (4) Human systems can be the sources of surprise. (5) Perceptions of risk depend upon welfare valuations that depend upon expectations. (6) Adaptive decisions will be made in response to climate change and climate change policy. (7) Analysis of adaptive decisions should recognize the second-best context of those decisions. (8) Climate change offers opportunity as well as risk. (9) All plausible futures should be explored. (10) Multiple methodological approaches should be accommodated. These lessons support two pieces of advice for the Third Assessment Report: (1) Work toward consensus, but not at the expense of thorough examination and reporting of the "tails" of the distributions of the future. (2) Integrated assessment is only one unifying methodology; others that can better accommodate those tails should be encouraged and embraced.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 307-318 
    ISSN: 1573-1596
    Keywords: adaptation ; climatic change ; economic welfare ; costs and benefits
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    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract The potential damages of climate change and climate variability are dependent upon the responses or adaptations that people make to their changing environment. By adapting the management of resources, the mix and methods of producing goods and services, choices of leisure activities, and other behavior, people can lessen the damages that would otherwise result. A framework for assessing the benefits and costs of adaptation to both climate change and climate variability is described in the paper. The framework is also suitable for evaluating the economic welfare effects of climate change, allowing for autonomous adaptation by private agents. The paper also briefly addresses complications introduced by uncertainty regarding the benefits of adaptation and irreversibility of investments in adaptation. When investment costs are irreversible and there is uncertainty about benefits, the usual net present value criterion for evaluating the investment gives the wrong decision. If delaying an adaptation project is possible, and if delay will permit learning about future benefits of adaptation, it may be preferable to delay the project even if the expected net present value is positive. Implications of this result for adaptation policy are discussed in the paper.
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    Mitigation and adaptation strategies for global change 4 (1999), S. 343-361 
    ISSN: 1573-1596
    Keywords: adaptation ; climate change ; socioeconomic impacts ; Egypt
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    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract Assessment of the vulnerability and expected socioeconomic losses over the Nile delta coast due to the impact of sea level rise is carried out in details. Impacts of sea level rise over the Governorates of Alexandria and Port Said in particular, are evaluated quantitatively. Analysis of the results at Alexandria Governorate indicate that, if no action is taken, an area of about 30% of the city will be lost due to inundation. Almost 2 million people will have to abandon their homeland; 195,000 jobs will be lost and an economic loss of over $3.5 Billion is expected over the next century. At Port Said Governorate results indicate that beach areas are most severely affected (hence tourism), followed by urban areas. The agriculture sector is the least affected sector. It is estimated that the economic loss is over $ 2.0 Billion for 0.50 m SLR and may exceed $ 4.4 Billion for 1.25 m SLR. Options and costs of adaptation are analyzed and presented. Multi-criteria and decision matrix approaches, based on questionnaire surveys are carried out to identify priorities for the two cases. Analysis of these techniques of two options; the current policy (hard protection measures on some vulnerable areas) and no action (stopping these activities) have the lowest scores. Beach nourishment and integrated coastal zone management (ICZM) have the highest scores, however ICZM has high cost measures. The most cost-effective option is the land-use change, however with relatively very high cost measure. It is recommended that an ICZM approach be adopted since it provides a reasonable trade off between costs and cost effectiveness.
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    Hydrobiologia 405 (1999), S. 49-55 
    ISSN: 1573-5117
    Keywords: biotic ; abiotic ; pond ; stream ; niche ; adaptation
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    Topics: Biology
    Notes: Abstract Forty-one amphibian habitats of various types in northern Israel were examined, in which water availability ranged from one month in the year to all year round. Larvae of all six species of amphibians native to the region, Salamandra salamandra, Triturus vittatus (Urodela), Hyla arborea, Bufo viridis, Rana ridibunda and Pelobates syriacus (Anura), were studied. The distribution of the species was governed by biotic and abiotic factors in the habitats, but not by the type of water body. Thus, larvae of all six species were found in temporary winter ponds, but only Salamandra and Bufo in streams and springs during the winter, and Rana during the summer. Ambient temperature, duration of water availability and elevation of the water body were major factors in species distribution. Species distribution also varied according to season. Species diversity increased from winter to summer. The growth rate of small larvae was found to be slower than that of larger larvae.
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    ISSN: 1573-0778
    Keywords: adaptation ; antibody production rate ; hybridoma ; intracellular amino acids ; osmotic pressure
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    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The time length required for the adaptation of AFP-27 hybridoma cells to high osmotic pressure and the effect of a gradual increase of osmotic pressure on monoclonal antibody production were investigated. When the cells were subjected to an increase of osmotic pressure from 300 mOsmol kg-1 to 366 mOsmol kg- 1, the intracellular content of osmoprotective free amino acids reached a maximum level 6 h after the osmotic pressure was increased to 366 mOsmol kg-1. The same time period of 6 h incubation at 366 mOsmol kg-1 was required to obtain a high growth rate of AFP-27 cells at 440 mOsmol kg-1 when the cells were subjected to a two-step increase of osmotic pressure from 300 mOsmol kg-1 to 366 mOsmol kg-1 and then to 440 mOsmol kg-1. The time length for the physiological adaptation of the cells to 366 mOsmol kg-1 was consequently estimated to be 6 h. Osmotic pressure during batch cultivation was gradually increased from 300 mOsmol kg-1 to 400 mOsmol kg-1 with an adaptation time of at least 6 h. The specific growth rates following a gradual increase of osmotic pressure were higher than those at a constant osmotic pressure of 400 mOsmol kg-1, while the specific monoclonal antibody production rate increased with the increase in the mean osmotic pressure. As a result, the cells grown under a gradual increase of osmotic pressure produced higher amounts of monoclonal antibodies than did those grown under constant osmotic pressure.
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    Evolutionary ecology 13 (1999), S. 469-483 
    ISSN: 1573-8477
    Keywords: adaptation ; artificial neural networks ; behaviour ; genetic algorithms ; habitat choice ; individual-based model ; state dependence ; stochastic dynamic programming
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    Topics: Biology
    Notes: Abstract Even though individual-based models (IBMs) have become very popular in ecology during the last decade, there have been few attempts to implement behavioural aspects in IBMs. This is partly due to lack of appropriate techniques. Behavioural and life history aspects can be implemented in IBMs through adaptive models based on genetic algorithms and neural networks (individual-based-neural network-genetic algorithm, ING). To investigate the precision of the adaptation process, we present three cases where solutions can be found by optimisation. These cases include a state-dependent patch selection problem, a simple game between predators and prey, and a more complex vertical migration scenario for a planktivorous fish. In all cases, the optimal solution is calculated and compared with the solution achieved using ING. The results show that the ING method finds optimal or close to optimal solutions for the problems presented. In addition it has a wider range of potential application areas than conventional techniques in behavioural modelling. Especially the method is well suited for complex problems where other methods fail to provide answers.
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    ISSN: 1573-8221
    Keywords: nitric oxide ; heat-shock proteins ; hypotension ; adaptation
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    Topics: Biology , Medicine
    Notes: Abstract The role of HSP70 and nitric oxide in antihypotensive effects of thermal adaptation was studied. Western blot analysis and electron paramagnetic resonance were used to determine the contents of HSP70 and nitric oxide. Protective effect of adaptation was evaluated by the limitation of blood pressure drop after heat shock. The formation of protective effects, accumulation of HSP70, and development of the ability to decrease nitric oxide overproduction had similar dynamic patterns and appeared at the same period. Quercetin, an inhibitor of HSP70 synthesis, prevented the development of protective effects. The data suggest that HSP70 accumulated during adaptation prevents heat shock-induced hypotension by restricting NO over-production and interfering with its cytotoxic effects.
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    ISSN: 1573-8221
    Keywords: Ca2+ transport ; α-crystallin ; adaptation ; stress
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    Topics: Biology , Medicine
    Notes: Abstract α-Crystallin, an endogenous low-molecular-weight protein with chaperone activity, exerted protective effects on membrane systems of Ca2+ transport into the sarcoplasmic reticulum of skeletal muscles. Protective action of α-crystallin depended on the body state. This effect was not observed in the control and after adaptation to stress, while after stress, especially against the background of adaptation, α-crystallin increased the rate of Ca2+ transport into the sarcoplasmic reticulum and thermal resistance of Ca2+ pump. The mechanisms of α-crystallin activation during stress are discussed.
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    Bulletin of experimental biology and medicine 128 (1999), S. 794-796 
    ISSN: 1573-8221
    Keywords: stress ; adaptation ; behavioral and somatic indices ; rats
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    Topics: Biology , Medicine
    Notes: Abstract We developed a model of stress (free swimming in a cage) which allows to assess the immediate and long-term effects of emotional stress. This stress induced typical changes in the open field test and ulceration of gastric mucosa. Unlike standard immobilization stress the proposed technique excludes a traumatic factor, it is well reproducible and simple.
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    ISSN: 1573-8221
    Keywords: August and Wistar Rats ; stress ; ulcer formation ; adaptation ; behavior
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    Topics: Biology , Medicine
    Notes: Abstract The incidence of gastric ulceration induced by acute emotional stress in Wistar rats is 3 times higher than in August rats, and the mean number of gastric ulcers in Wistar rats 6.3-fold surpassed that in August rats. Wistar rats predisposed to stress-induced ulceration displayed suppressed locomotor and exploratory activities in the open field test, while August rats had more stable behavioral patterns and enhanced exploratory activity after stress. Short-term preadaptation to hypobaric hypoxia for 6 days attenuated stress-induced gastric ulceration, whereas long-term adaptation (40 days) aggravated the severity of gastric ulcers in August and Wistar rats. The interstrain differences in stress-induced ulceration persisted after adaptation. The data suggest that these differences are related to genetically determined peculiarities of production and metabolism of NO and glucocorticoids in August and Wistar rats.
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    Bulletin of experimental biology and medicine 127 (1999), S. 477-479 
    ISSN: 1573-8221
    Keywords: physical exercise ; stress ; kinin system ; elastase ; adaptation
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    Topics: Biology , Medicine
    Notes: Abstract In rats, adaptation to strenuous exercise was accompanied by phasic changes in the activities of the kallikrein-kinin system, elastase-like proteinases, and proteinase inhibitors, and total antioxidant activity in the serum, myocardium, liver, and cerebral cortex. After 30-min physical exercises, activity of the kallikrein-kinin system decreased in the serum and increased in tissue with parallel activation of elastase-like proteinases in the myocardium and cerebral cortex. After 3-h exercises the activity of the kallikrein-kinin system showed some indications of exhaustion, especially in the myocardium and cerebral cortex. Activities of elastase-like proteinases tended to normal due to activation of α1-proteinase inhibitor and normalization of total antioxidant activity.
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    ISSN: 1573-8221
    Keywords: Ca transport ; cytoplasm ; stress ; adaptation
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    Topics: Biology , Medicine
    Notes: Abstract Acute stress reduces and adaptation to stress enhances thermal resistance of Ca2+ pump of the sarcoplasmic reticulum fraction. Soluble cytoplasmic factors increase the rate of Ca2+ transport into myocardial sarcoplasmic reticulum and its thermal resistance in the stressed, stress-adapted, and control rats, the activating effect being most pronounced during acute stress. Structural and functional mechanisms underlying the protective effect of soluble cytoplasmic factors on membrane-bound enzymes are discussed.
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    Bulletin of experimental biology and medicine 127 (1999), S. 151-154 
    ISSN: 1573-8221
    Keywords: adaptation ; opiatergic system ; isoproterenol-induced damage ; myocardium
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    Topics: Biology , Medicine
    Notes: Abstract Adaptation to hypoxia and short-term immobilization stress, as well as preconditioning with Rhodiolae rosea extract produces pronounced antiarrhythmic and cardioprotective effects in the model of adrenergic damage to the heart. Preliminary blockade of opioid receptor significantly decreases the protective effect of adaptation. Using selective opiate receptor antagonists (naltrindole, ICI 174,864, and norbinaltorphimine) we show that the antiarrhythmic effect of adaptation is mediated predominantly via activation ofk-receptors, and to a lesser extent μ-and σ-receptors.
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    ISSN: 1573-8264
    Keywords: adaptation ; osmoprotectant ; osmotin ; potato ; proline ; salinity
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    Topics: Biology
    Notes: Abstract Potato (Solanum tuberosum L. cv. Bintje) was transformed with a cDNA clone encoding an osmotin-like protein. Transgenic and non-transgenic in vitro plants were subjected to NaCl for 3 weeks. The shoot and root development was slightly affected by salinity indicating that the salt condition used was a mild stress. The endogenous proline content of the osmotin-like transformed clone only raised slightly as compared to the non-transformed genotype, where a marked increase in proline content could be observed as a result to salt stress. These data provide evidence for the involvement of osmotin-like proteins in the mechanisms of salt tolerance in potato plants.
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    ISSN: 1570-7458
    Keywords: integrated pest management ; genotypes ; rm ; plant breeding ; adaptation ; Acari
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Eight cultivars of the ornamental crop Gerbera jamesonii Bolus (Asteraceae) were compared in host plant suitability for the two spotted spider mite Tetranychus urticae Koch (Acarina: Tetranychidae). This was done by determining the intrinsic rate of population increase, rm, of spider mites on leaf discs of plants from each of the cultivars. Large differences in rm values were found, ranging from 0.088/day on cultivar Bianca to 0.242/day on cultivar Sirtaki. This variation in rm was mainly caused by differences in developmental time of the spider mites. We assessed the performance of spider mites on young and old leaves of the two gerbera cultivars Bianca and Sirtaki. On Sirtaki the spider mites had a shorter developmental time and higher peak oviposition rate on young leaves than on old leaves. However, on Bianca such an effect was not found. We also determined the performance of two spider mite strains on the resistant gerbera cultivar Bianca. We compared the rm of a strain that had been reared on this cultivar for approximately half a year with the rm of a strain that was reared on bean. The rm of the strain that was reared on cultivar Bianca increased to 0.208/day, which is however still substantially lower than the rm on the susceptible cultivar Sirtaki.
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    Plant systematics and evolution 210 (1998), S. 57-86 
    ISSN: 1615-6110
    Keywords: Alliaceae ; Allium ; Nuclear DNA amount ; adaptation ; evolution ; infrageneric classification
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    Topics: Biology
    Notes: Abstract The 4C DNA amounts of 86 species fromAllium subgg.Allium, Rhizirideum, Bromatorrhiza, Melanocrommyum, Caloscordum andAmerallium show a 8.35-fold difference ranging from 35.60 pg (A. ledebourianum, 2n = 16) to 297.13 pg (A. validum 2n = 56). At diploid level the difference is 3.57-fold betweenA. ledebourianum (35.60 pg) andA. ursinum (127.14 pg). This shows that a significant loss and/or gain of DNA has occurred during evolution. On average subgg.Rhizirideum andAllium have less DNA amount than subgg.Melanocrommyum andAmerallium. The distribution of nuclear DNA amounts does not show discontinuous pattern and regular groups. The evolution of genome size has been discussed in relation to polyploidy and genomes, heterochromatin, adaptive changes in morphological characteristics, phenology and ecological factors, and infrageneric classification.
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    Biology and philosophy 13 (1998), S. 529-540 
    ISSN: 1572-8404
    Keywords: adaptation ; optimization ; fitness ; functional ; historical ; evolutionary explanation ; Wright ; Millikan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Notes: Abstract The purely theoretical notion of fitness or optimality that is employed for instance in optimization theory has come under attack from those who think that only a more historically based notion of fitness could have a central role in evolutionary explanation. They argue that the key notion is proven usefulness rather than theoretical usefulness. This paper articulates a notion of theoretical usefulness and defends its role in functional evolutionary explanations.
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    Biology and philosophy 13 (1998), S. 359-391 
    ISSN: 1572-8404
    Keywords: adaptation ; algorithm ; atavism ; contingency ; deep homology ; Dennett ; development ; disparity ; epicurean selectionism ; evolution ; exaptation ; Gould ; metaphors ; punctuated equilibrium ; selectionism ; spandrels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Notes: Abstract In his recent book on Darwinism, Daniel Dennett has offered up a species of a priori selectionism that he calls algorithmic. He used this view to challenge a number of positions advocated by Stephen J. Gould. I examine his algorithmic conception, review his unqualified enthusiasm for the a priori selectionist position, challenge Dennett's main metaphors (cranes vs. skyhooks and a design space), examine ways in which his position has lead him to misunderstand or misrepresent Gould (spandrels, exaptation, punctuated equilibrium, contingency and disparity), and discuss recent results in developmental biology that suggest that an a priori position does not fill the demands of an evolutionary biology. I conclude by insisting that evolutionary biology is many leveled, complicated, and is carried on an ever shifting and expanding empirical base that when disregarded results in caricature.
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    ISSN: 1573-5125
    Keywords: adaptation ; Chironomus riparius ; larval migration ; metal pollution ; seasonal dynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Chironomus riparius is one of the insect species which inhabit polluted rivers in large densities, indicating a high adaptive capacity. Previous studies showed that this capacity is expressed by the occurrence of adapted strains in metal polluted rivers. Differences in life history between metal-exposed and non-exposed midges have been demonstrated in laboratory experiments, and therefore a comparative field study of seasonal dynamics was carried out at two metal polluted sites and one reference site. Just downstream from a massive metal discharge, seasonal dynamics were almost identical to the upstream reference site. Circa four generations per year were produced. Further downstream, lower larval densities were recorded, especially during the second half of the sampling period. The influx of upstream C. riparius larvae into polluted sites was estimated by measuring larval drift just upstream from the point source of metal contamination and indicated a massive input to the standing stock downstream. It is concluded that drift of non-tolerant larvae is dominating the seasonal dynamics of midges downstream. Accordingly, genetic uniformity of chironomids inhabiting upstream and downstream sites is expected most of the time. However, research performed during the last decade, demonstrated that genetically adapted strains of C. riparius may develop at certain stages in the seasonal cycle. However, a stable metal-adapted C. riparius population at the first downstream site, is most likely present on rare occasions only.
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    Genetica 102-103 (1998), S. 525-533 
    ISSN: 1573-6857
    Keywords: adaptation ; mutation-selection-drift ; nearly neutral mutations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Most theoretical models in population genetics fail to deal in a realistic manner with the process of mutation. They are consequently not informative about the central evolutionary problem of the origin, progression, and limit of adaptation. Here we present an explicit distribution of phenotypes expected in an ensemble of populations under a mutation-selection-drift model that allows mutations with a distribution of adaptive values to occur randomly in time. The model of mutation is a geometrical model in which the effect of a new mutation is determined by a random angle in n dimensional space and in which the adaptive value (fitness) of an organism decreases as the square of the deviation of its phenotype from an optimum. Each new mutation is subjected to random genetic drift and fixed or lost according to its selective value and the effective population number. Time is measured in number of fixation events, so that, at any point in time, each population is regarded as genetically homogeneous. In this mutation-selection-drift model, among an ensemble of populations, the equilibrium average phenotype coincides with the optimum because the distribution of positive and negative deviations from the optimum is symmetrical. However, at equilibrium, the mean of the absolute value of the deviation from the optimum equals √ $$\sqrt {n/8Ns} $$ , where n is the dimensionality of the trait space, N is the effective population size, and s is the selection coefficient against a mutation whose phenotype deviates by one unit from the optimum. Furthermore, at equilibrium, the average fitness across the ensemble of populations equals 1 - (n + 1)/8N. When n is sufficiently large, there is a strong mutation pressure toward the fixation of slightly deleterious mutations. This feature relates our model to the nearly neutral theory of molecular evolution.
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  • 49
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    GeoJournal 45 (1998), S. 77-83 
    ISSN: 1572-9893
    Keywords: globalization ; national tradition ; Russian human geography inertia ; adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography
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  • 50
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    Reviews in fish biology and fisheries 8 (1998), S. 57-91 
    ISSN: 1573-5184
    Keywords: adaptation ; artificial neural networks ; fish ; fitness ; game theory ; genetic algorithms ; hearing ; ideal free distribution ; learning ; life history theory ; memory ; migration ; olfaction ; optimal foraging theory ; optimization ; sensory organs ; spatial modelling ; stochastic dynamic programming ; vision
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Our ability to model spatial distributions of fish populations is reviewed by describing the available modelling tools. Ultimate models of the individual's motivation for behavioural decisions are derived from evolutionary ecology. Mechanistic models for how fish sense and may respond to their surroundings are presented for vision, olfaction, hearing, the lateral line and other sensory organs. Models for learning and memory are presented, based both upon evolutionary optimization premises and upon neurological information processing and decision making. Functional tools for modelling behaviour and life histories can be categorized as belonging to an optimization or an adaptation approach. Among optimization tools, optimal foraging theory, life history theory, ideal free distribution, game theory and stochastic dynamic programming are presented. Among adaptation tools, genetic algorithms and the combination with artificial neural networks are described. The review advocates the combination of evolutionary and neurological approaches to modelling spatial dynamics of fish.
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    Bulletin of experimental biology and medicine 125 (1998), S. 533-539 
    ISSN: 1573-8221
    Keywords: range of nerve bonds ; isolation from nervous effects ; heart ; hypoxia ; adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A concept of functional isolation of the heart from nervous effects as a mechanism of heart adaptation to extreme states has been formulated. In moderate hypoxia, isolation of the cardiovasomotor center from nonhypoxic afferention provides the compliance of myocardial hyperfunction to the intensity of hypoxia and limits heart participation in different forms of activity of the organism. In thermal hypoxia, myocardial isolation from sympathetic and parasympathetic effects ensures its minimal function and economy of energy due to transfer to the autorhythmical mode of function and rules out heart participation in circulatory reactions. Functional isolation of the heart in hypoxia is caused by energy deficiency and depends on the training of an organism and coordination of the sympathetic and parasympathetic effects. High prevalence of isolation of cells, organs, and systems from regulating effects in health and disease is demonstrated and its mechanisms, levels, and impact are disclosed. Both the “extension” of nervous bonds and hyperfunction and the “narrowing” of nervous bonds and hypofunction of biological systems are aimed at adaptation of an organism.
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    Bulletin of experimental biology and medicine 126 (1998), S. 882-885 
    ISSN: 1573-8221
    Keywords: hemorrhagic shock ; adaptation ; stress ; antioxidant protection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Modeling of hemorrhagic shock in rats adapted to immobilization stress required the removal of greater volumes of blood than that in control rats. The antioxidant system activation in adapted rats was accompanied by an increase in resistance to blood loss. The antishock effect of preliminary adaptation to stress was shown for the first time.
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    ISSN: 1573-8221
    Keywords: adaptation ; nitric oxide ; NO donor ; NO synthetase inhibitor ; stress ; gastric ulcer ; protection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The iron dinitrosyl complex (a NO donor), adaptation to stress, and their combination suppress the stress-induced ulcer formation. Nω-nitro-L-arginine, a NO synthetase inhibitor, reduce the antistress effect of adaptation. Severe stress induces a sharp decrease in the NO production in the liver and brain. After adaptation to stress, the NO production in the liver and brain does not differ significantly from control levels. However, adaptation attenuates a decrease in the NO production in the liver caused by severe stress.
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    Bulletin of experimental biology and medicine 126 (1998), S. 1203-1204 
    ISSN: 1573-8221
    Keywords: individual resistance to hypoxia ; hepatic monooxygenases ; cold ; adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Hepatic monooxygenase activity was studied in rats with various resistance to hypoxia during adaptation to cold. Cold-induced change in the concentrations of cytochromes P-450 and b5 and the activity of microsomals metabolism of amidopyrine and aniline were shown to be associated with individual resistance to hypoxia. The content of microsomal cytochromes in highly resistant rats did not change on the fifth day of cold exposure. However, the intensity of metabolic reactions decreased. In low-resistance rats, a cold-induced decrease in the concentration of the cytochromes was not accompanied by significant changes in metabolic rates of amidopyrine and aniline.
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    Process Safety Progress 17 (1998), S. 61-67 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Risk assessments have been performed to determine the risk associated with the transportation of hazardous wastes through a city. In the course of these assessments, a number of modeling issues arose relating to transportation accident rates, the characterization of incidents, the effect of thermal radiation, the impact of exposure to toxic chemicals, and the threshold for acceptable risk. This paper discusses these issues.
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    Process Safety Progress 17 (1998), S. S3 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
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    Process Safety Progress 17 (1998), S. 98-103 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This paper presents the design of ribbon wound pressure vessels useful for Ammonia, Urea and Methanol plants. The design is to create a thin shell of 1/5 the total wall thickness required, weld it to the end pieces, and wind 4 to 8 mm thick ribbons of 80 mm width at an angle of 15 to 30 degrees on the inner shell, using a prestress. The ribbons are welded at the ends and an even number of layers are wound cross-helically on to the shell. With more than 7000 vessels over the pressure range of 50 to 350 atmospheres in use in the various chemical industries in China over the past 30 years, their safety record has been excellent. Of particular interest has been the application of this technology in the Ammonia and Urea plants, where the design allows fabrication of these vessels at substantial reduction in cost, and early delivery, when compared to the mono wall technology.
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    Process Safety Progress 17 (1998), S. 20-22 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Most audits try to look at a representative selection of the plant procedures and equipment. An alternative is a survey, a look in depth at selected procedures (such as those for testing alarms and trips, issuing permits-to-work, controlling modifications, taking samples or testing relief devices) or selected equipment (such as level glasses or equipment for handling LPG). If the procedure or equipment is well-chosen, surveys may make a bigger contribution to safety, per person-hour, than a conventional audit.
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    Process Safety Progress 17 (1998), S. 39-42 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Under OSHA 1910.119, all Process Safety Management (PSM) facilities are required to keep their pressure relief system design information current. This article demonstrates why a pressure relief system design verification effort must be based on an equipment list, rather than a relief device list, in order to ensure that every piece of equipment is adequately protected. The formerly common practice of simply checking the design bases of all existing relief devices is deficient is deficient since this technique does not systematically ensure that every piece of equipment is protected.The “Berwanger Method” is a step by step process for designing or analyzing a pressure relief system to meet OSHA 1910.119 Process Safety Information (PSI) and Process Hazard Analysis (PHA) mandates. The method uses a relational database which tracks the relationships between protected equipment, potential overpressure scenarios, and protective devices.The challenge facing an operating company does not end once the design basis has been “verified” - the design basis information must also be maintained and be readily accessible to avoid costly reinvention of the wheel down the road. The “Berwanger Method” also addresses these maintenance issues.
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    Process Safety Progress 17 (1998), S. 49-60 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This paper reports on a comprehensive literature search and small scale experimental work on the reaction characteristics of phosphorous trichloride and water. More than 30 tests were conducted, including both closed and open test cells. The water to phosphorus trichloride molar ratio was varied from 1 to 25. When in contact, water and phosphorus trichloride will form two liquid layers with a reaction starting at the interface. The impact of variables on reaction rates including the interface surface area, layer depth, and stirring were investigated experimentally. A reaction rate model that fits all the measured data is presented. Case studies illustrating the use of this data for emergency relief systems and vent containment design are presented in reference. [1].
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    Process Safety Progress 17 (1998), S. 68-73 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Two major accidents in the 80's: the summit Tunnel Fire, England and Piper Alpha disaster, an offshore platform in the North Sea; and very recently, possible explosion of the Boeing, TWA flight 800 at New York, makes it imperative that further research into the mechonisms of the ignition of flammable vapor/air mixture in contact with hot surfaces needs to be done. There have been a number of studies of ignition by hot surfaces, but in all these studies the ignition sources were wire, sphere or strip, i.e., most of them were flat surfaces. But to the authors' knowledge, other variables which affect the ignition mechanism such as irregular geometrical shapes have not been studied. The purpose of this paper is to examine how the degree of confinement (or, configuration), size and orientation, of the heated surface affects the ignition temperature of the flammable vapors. The results were obtained by experimentnal and by computational fluid dynamics.
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    Process Safety Progress 17 (1998), S. S3 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
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    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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    Process Safety Progress 17 (1998), S. 9-15 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The design and deflagration pressure relief vents is based on correlations developed for various types of combustible materials and for enclosures of different strengths. The primary guideline for deflagration vent design in the US is NFPA 68 Guide for Venting of Deflagrations [5]. That document gives guidance for the design of vents for enclosures containing flammable gases, specifically hydrogen, coke oven gas, propane, and methane. Application of the guide to other gases is achieved using the KG value. Values of KG are published for a relatively small number of gases, as seen in Table D-1 of NFPA 68. This work present KG data on several additional gases obtained in a laboratory scale test vessel along with analysis of the results with respect to published values of fundamental burning velocity.
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    Process Safety Progress 17 (1998), S. 23-31 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In May 1996, the Flammable and Combustible Liquids Code Committee of the National Fire Protection Association (NFPA) proposed for adoption by the Association a new edition of NFPA 30, Flammable and Combustible Liquids Code. This new edition was the culmination of two and one-half years' work by the Committee and included one of the most significant changes to that document in some twenty years: the incorporation of mandatory fire protection criteria for warehouses and other inside areas that store flammable and combustible liquids in containers and portable tanks.
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    Process Safety Progress 17 (1998), S. 32-38 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This paper describes the development of a risk ranked Inspection Recommendation procedure that is used by one of Exxon's chemical plants to prioritize repairs that have been identified during equipment inspection.As part of the Company's Safety Management Practices initiative in the late 1980's a procedure was put into place to ensure that an Inspector's repair recommendations were properly addressed by the organization. The initial procedures were successful at “systematizing” the documentation and stewardship-to-completion of the Inspector's recommendation, however, there were complications with the original process: (1)The Inspector made a simple High, Medium or Low assessment of the priority/criticality of the recommendation. Frequently, this resulted in disagreements with Operations about the true priority of the recommendation.(2)If there was agreement on the priority of the recommendation, there was still disagreement on the relative rank within the priority-which high priority was the highest priority?(3)With limited funds to spend on repairs, it was (and is) important to make sure that the money was being spent on the highest risk items that had the greatest risk reduction/cost benefit ratio.To address these concerns, the procedure was modified to incorporate a risk assessment of the recommendation by both the Inspector and Operations. In the new procedure, the Inspector describes the deficiency that he/she finds and assesses the probability of failure within a certain time-frame. Operations must assess the consequences, from an environmental, safety and economics standpoint, were the failure to occur. These assessments are combined in the typical risk equation (risk = probability × consequences) to arrive at a severity index which serves to rank the recommendation relative to the other recommendations. Because Operations participates in the assessment there is very little disagreement about the priority of the recommendation. The severity index puts the recommendations in order so it is quite clear which are the highest priority recommendations. This process has helped to focus the entire organization on those deficiencies that represent the greatest risk with the result that less time and money is spent correcting items that have a low risk/cost benefit ratio, allowing these savings to be used to reduce the higher risks in the plant.
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    Process Safety Progress 17 (1998), S. 124-126 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A simple analytical method is presented for estimating the hybrid minimum ignition energy (HMIE) of dust-gas mixtures, based on the assumed generality of Bartknecht's well-known test data for mixtures of propane with a series of dusts in air. Since the HMIE equation requires input data which might be unavailable, the use of conservative default methods is discussed.
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    Process Safety Progress 17 (1998), S. 138-148 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A large and potentially hazardous decrease in aldehyde autoignition temperature (AIT) occurs with increased pressure. The AIT-pressure curve determined in a 5 L stainless steel sphere was similar for propionaldehyde and butyraldehyde in air, falling from about 185°C at atmospheric pressure to 90°C at 140 psia. Reduction of oxygen concentration had little effect on propionaldehyde AIT. At 100°C and 140 psia, autoignitions accompanied by at least a doubling of pressure were observed above 4% oxygen. In the presence of a few grams of free liquid, propionaldehyde vapor ignited in air at initial conditions significantly below the AIT. The mechanism appears to involve rapid Fe-catalyzed exothermic liquid-phase oxidation leading to autoignition of the adjacent heated gas layer. An acetaldehyde vapor-air mixture in the presence of free liquid and rust exploded at room temperature when air pressure was increased to 95 psia; this result is discussed with reference to a cylinder overpressurization that occurred while making up an ostensibly sub-LFL calibration mixture with compressed air. Propionaldehyde's limiting oxygen concentration (LOC) was investigated in the near-autoignition region using the same 5L apparatus; the findings are discussed with reference to an overpressurization incident in an air-liquid partial oxidation reactor. The general results are used to illustrate the application of LOC in partial oxidation processes subject to autoignition and to discuss elements of the current ASTM draft test method for LOC, which does not address test difficulties associated with condensable and/or reactive gas systems.
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    Process Safety Progress 17 (1998), S. F3 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
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    Process Safety Progress 17 (1998), S. 157-170 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Risk analysis in chemical process industries is an elaborate exercise involving several steps from preliminary hazard identification to development of credible accident scenarios, to preparation of strategies for prevention or control of damage.All this requires substantial inputs of time and money. In order to get an approximate yet workable assessment of risk at much lesser costs, indices have been developed which link typical findings of elaborate risk analysis to scales of risk. The scales, in turn, provide workable measures of hazards/risks/safety.In the past, indices have been reported for swift risk assessment - the noteworthy among them include Dow fire and explosion index, Mond fire, explosion and toxicity index, IFAL index, and mortality index. A few rapid ranking techniques have also been proposed.This paper presents a new system of methodologies for Hazard Identification and Ranking (HIRA). The system consists of two indices: one for fire and explosion hazards and another for the hazard due to likely release of toxic chemical. The magnitudes of these indices indicate the severity of the likely accident; in terms of the size of the impacted area.HIRA has been applied to a typical chemical process industry - a sulfolane plant - and its performance has been compared with that of the Dow's and the Mond's indices. The study reveals that HIRA is more sensitive and accurate than the other indices.
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    Process Safety Progress 17 (1998), S. 200-208 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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    Process Safety Progress 17 (1998), S. 213-218 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: On October 31, 1987 a crane lifting a heat exchanger convection section failed and severed a 4″ loading line and a 2″ pressure relief line to an HF alkylation reactor settler drum at a petroleum refinery in Texas City, Texas. Vapors were emitted under pressure for about two hours and the vessel was plugged and drained aproximately 44 hours later. A plume from this accidental release passed through residential areas, damaging some vegetation (brown lawns), and spawning a class action law suit. An extensive analysis was conducted to determine the total inventory loss and to model the blowdown process and the concentrations of HF in the plume. Since the discharge rate was decreasing with time, a peak concentration of HF in the emitted vapors occurred just before the water spray mitigation system became fully operative. Consequently, the mitigation efforts were more effective late in the response when concentrations were already low. The predicted plume concentrations are consistent with observed vegetation damage effects, with concentrations below Emergency Response Planning Guideline Level 3 past 3/4 mile from the source. These results support a policy of sheltering in place during such an event.
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    Keywords: Chemistry ; Chemical Engineering
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    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A fifty-five gallon steel drum of a liquid organic peroxide pressurized and ruptured in the mix room of a manufacturing plant. The head of the drum blew off and the ejected material ignited. The resulting fire was extinguished by the building sprinkler system and operating personnel. Although there were no injuries, the fire caused significant damage in the mix room. The investigation of this incident, its likely cause, and the corrective actions will be discussed.
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    Process Safety Progress 17 (1998), S. 238-242 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The Brazoria County Petrochemical Council, 13 companies that are working together to enhance relations between industry and the community, united in a joint effort at complying with the EPA's Risk Management Program. One of the significant issues the group had to address was the need to develop meaningful hazard assessment for presentation to the public. The EPA's “Table Look-Up Approach” found in the Offsite Consequence Analysis Guidance document is certainly a good tool; however, the built-in conservatism results in over-estimates of potential hazard areas. Much more meaningful results are shown to be obtained using one of the hazard release models.The value of using a credible scenario with realistic meteorological data is demonstrated through the consistently smaller areas predicted by the PHAST Model for planning purposes. Realistic scenarios/failure modes and realistic model parameters are important so that the risk to the public is not overstated. Proprietary models such as PHAST are invaluable in providing more meaningful consequences for planning purposes.
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    Process Safety Progress 17 (1998), S. 263-271 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Some of the hazards encountered by process plant operators involve the operation of in-line valves to control, start, and to stop flow. Torque required to operate valves may vary according to valve wheel size, in-line pressure, and valve flange position (open/closed). This study determined how valve wheel size, in-line pressure and valve position (open/closed) affect torque required to actuate a valve. Data were gathered with each combination of size, pressure and position for 336 valves in an operating petrochemical process facility. The results indicate that the main effects of valve wheel size, the in-line pressure, and open/closed valve position significantly affect operational torque requirements. In addition, the interaction between position and pressure was significant for operational torque. The implication of these results is that operators are exposed to operational torque requirements that exceed maximum acceptable capabilities that have been determined in previous studies.
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    Process Safety Progress 17 (1998), S. 288-296 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An ammonia storage tank was built at the BASF Antwerp site in 1969 on land reclaimed from the sea. After several years of operation uneven foundation settlement, of up 2, occurred. In order to assure stability of this area for the next operation period (at least 10 years) measures were taken to ensure continued safe operation. One key measure was strain gauge monitoring at the location of maximum stress.
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    Process Safety Progress 17 (1998), S. 297-301 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The Baker-Strehlow methodology was developed to provide an objective approach to prediction of blast pressures from vapor cloud explosions. The complete methodology was first published in 1994 [1]. Since then, it has evolved through ongoing research and use in VCE hazard analyses, facility siting studies and accident investigations. This article gives a brief overview of a paper on recent developments in the Baker-Strehlow methodology presented at the 31st Loss Prevention Symposium in Houston on March 9-13, 1997. Because the entire paper is too lengthy to be presented here, the following discussions may be lacking in some details. A copy of the complete paper can be obtained from the American Institute of Chemical Engineers (AIChE).Since the Baker-Strehlow method was first published, it has been used extensively in VCE hazard assessments in refineries and chemical plants. As expected, many practical lessons have been learned during the course of the hazard assessments, and the Baker-Strehlow method has evolved as a result. The changes have been evolutionary, not revolutionary. In keeping with the goals of the original study in which the methodology was developed, all changes have been incorporated with the intent of achieving an objective methodology to provide consistent prediction of VCE blast effects.The revisions to the Baker-Strehlow method resulting from experience gained during plant walk-downs and hazard assessments include: Systematic identification of “potential explosion sites” or “PESs,”Selection of the level of confinement for mixed zones of 2D and 3D confinement,Deciding on flame expansion when confinement is elevated above the vapor cloud,Selecting the reactivity for a fuel that is a mixture of fuels with differing reactivities,Predicting blast loads when there are multiple PES's within a vapor cloud considering different ignition source locations.
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    Process Safety Progress 17 (1998), S. 83-85 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Safety, health and loss prevention are major areas of interst for the American Institute of Chemical Engineers (AIChE). There has been an evolution of these concerns over the years in the Institute just as it has in industry. This article chronicles this evolution.
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    Process Safety Progress 17 (1998) 
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    Process Safety Progress 17 (1998), S. 1-8 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Recent guidelines released by the U.S. EPA define a worst-case scenario as a release under stable atmospheric conditions defined as Pasquil-Gifford stability class F. Unfortunately, very few tests at F stability have been available heretofore to provide a basis for models. Recent test data with propane releases by the German research organization TUV provide a set of 60 experiments conducted specifically to define the effects of atmospheric stability class on dispersion. Of these, 25 tests were at F stability. A comparable number were at each other stability class A through E. In addition 23 tests were at wind speeds under 1.5 m/s in stable atmospheres. This paper reports on adjustments made to our models based on these new data by reducing the originally-postulated sensitivity to stability class. In spite of considerable scatter in the TUV data, particularly between two different types of propane analyzers, the model allows us to extract information by averaging over the tests.
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    Process Safety Progress 17 (1998), S. 16-19 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A multi-disciplinary team developed a guideline for determining access restriction zones around vented solids handling equipment. The guideline provides a method for ensuring the discharge from a vented explosion will not cause injury to personnel. The steps in this method include: calculating the extent of external hazards from vented explosions; identifying potential areas where personnel could be exposed to a hazard; identifying ways to eliminate or reduce the hazard area; and establishing and documenting any access restrictions needed. Hazard zone calculations use the latest knowledge from research into fireball size, flame length and external pressure equations in VDI 3673. The guideline provides guidance for using this information. Options for mitigating or reducing external hazards from vented explosions are also described. As part of the project, the team audited several solids handling systems to look for potential oversights in existing restricted access areas. Some of the team's learnings from these audits are reviewed.
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    Process Safety Progress 17 (1998), S. 43-48 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This paper defines situation awareness (SA) and discusses its importance to operator-machine system safety and functioning in the context of process control activities. Specifically, identified are relationships of human detection of critical process cues converying the status of automated control systems and operator interpretation of the meaning and relevance of such information to the potential for negative incidents in chemical processing. Beyond individual operator SA in interacting with control systems, intra- and inter- work team SA are discussed for supporting individual attainment of process control responsibilities. Factors critical to team SA are discussed. “Road blocks” to team SA are also analytically examined. Lastly, methods for assessing individual and team SA are reviewed and vehicles for relating outcomes of these methods to changes in process control operator and team behavior to improve human-machine system safety and performance are relayed.
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    Process Safety Progress 17 (1998) 
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    Keywords: Chemistry ; Chemical Engineering
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    Process Safety Progress 17 (1998), S. 74-81 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The knowledge of the ingition behavior of dust-air mixtures due to electrical sparks (MIE, Minimum Ignition Energy) and hot surfaces (MIT, Minimum Ignition Temperature) is important for risk assessments in chemical production plants. The ignition behavior determines the extent and hence the cost of preventive protection measures.This paper describes the use of the minimum ignition energy and minimum ignition temperature as very important safety indexes in practice.Based on the latest results from large scale experiments on pneumatic filling of silos with polymeric materials and new results of full scale filling tests using Flexible Intermediate Bulk Containers (FIBC) manufactured from a variety of materials, guidance can be given to ensure safe operation in different situations such as filling, emptying operations, type of powder handled.The aim of this paper is to assist people dealing with product. It reflects the present state of the art and current knowledge of the assessment and measures associated with powder handling.
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    Process Safety Progress 17 (1998), S. 104-106 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In mid-1997, an Advanced Process Control (APC) scheme was implemented at a resins manufacturing complex with the goal of minimizing flare fuel gas usage while maintaining sufficient energy (BTU/SCF flare gas) to be in environmental regulatory compliance. Prior to APC implementation, the flare system was manually controlled by plant operators with minor attention paid to the minimization of fuel gas usage. Since implementation, APC has saved the plant thousands of dollars in fuel gas costs and reduced unnecessary combusted fuel gas emissions.Hazard analysis techniques were used in the development of the control scheme. An overview of the APC used, the economic evaluation, and the hazard analysis techniques used in the project are presented here.
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    Process Safety Progress 17 (1998), S. 107-123 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In the risk assessment parlance, especially with reference to chemical process industries, the term “domino effect” is used to denote “chain of accidents,” or situations when a fire/explosion/missile/toxic load generated by an accident in one unit in an industry causes secondary and higher order accidents in other units. The multi-accident catastrophe which occurred in a refinery at Vishakhapatnam, India, on September 14, 1997, claiming 60 lives and causing damages to property worth over Rs 600 million, is the most recent example of the damage potential of domino effect.But, even as the domino effect has been documented since 1947, very little attention has been paid towards modeling this phenomena. In this paper we have provided a conceptual framework based on sets of appropriate models to forecast domino effects, and assess their likely magnitudes and adverse impacts, while conducting risk assessment in a chemical process industry. The utilizability of the framework has been illustrated with a case study.
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    Process Safety Progress 17 (1998) 
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    Process Safety Progress 17 (1998), S. 149-154 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This article deals with fire protection for water miscible flammable liquids stored in plastic containers packaged in boxes located on pallets. A series of fire tests was conducted with palletized rack storage arrangements using in-rack sprinkler protection at various levels. The intent of the paper is to present data from this test series for these types of commodities. The paper will identify various existing water miscible flammable liquid products stored in this fashion and provide background information for protecting this type of storage as it relates to NFPA 30 Flammable and Combustible Liquids Code. The test data indicates that further research work is needed in the area of plastic containers for use with the storage of combustible and flammable liquids. Included in the paper are discussions concerning possible protection strategies and suggestions for future research which would benefit those involved in risk management of this type of commodity.
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    Process Safety Progress 17 (1998), S. 176-183 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The safest method to prevent fires and explosions of flammable mixtures in the first place. This method requires detailed knowledge of the flammability region as a function of the fuel, oxygen, and nitrogen concentrations. A triangular flammability diagram is the most useful tool to display the flammability region, and to determine if a flammable mixture is present during plant operations.This paper describes how to draw and use a flammability diagram. A procedure to estimate the flammability region using the available and sometimes limited data is discussed. The paper also shows how to use the flammability diagram with plant operations involving inerting and purging, and from bringing vessels into and out of service. A compilation of flammability diagrams for 30 materials, based on previously published data is provided.An automated apparatus for acquiring data for a flammability diagram is described. The apparatus consists of a 20-L sphere with an automated gas mixing system, a fuse-wire ignition system, and a high speed pressure measurement and data acquisition system. Data derived from the apparatus includes flammability limits, maximum pressure during combustion, and the maximum pressure rate. The effect of fuse-wire ignitor dynamics on the results is studied. A flammability diagram for methane drawn from data obtained from the apparatus, is presented.
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    Process Safety Progress 17 (1998), S. 86-97 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Regulatory issues related to material safety have made the accurate measurement and/or prediction of flash points essential. The flash point is one of the major physical properties used to determine the fire and explosion hazards of a liquid. Flash points are used by virtually all governmental entities worldwide to define “flammable” and “combustible” materials for shipping and safety regulations.A model is described here for the calculation of closed cup flash points for multicomponent, single liquid phase, mixtures. The model is based upon rigorous vapor/liquid equilibrium calculations supplemented with information about the lower flammable limits (LFL's) and heats of combustion (ΔHc's) for the mixture's constituent components. The closed cup flash points predicted with this model are typically within ± 5°C of the experimentally reported values. Such a model is useful as a means of verifying experimental data and as a tool for screening product formulations prior to experimental flash point determination. The model should considerably enhance the safety evaluation portion of the product development cycle, thus leading to shortened product time-to-market cycles. While flash points calculated with this model are in excellent agreement with experiment, experimental determination is still encouraged for critìcal safety applications.
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    Process Safety Progress 17 (1998), S. 134-137 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: National Advisory Committee's Acute Exposure Guideline Levels (AEGLs) for ammonia are critically evaluated. The technical bases for concern about AEGL-2 and AEGL-3 values derived by the committee are summarized recommendations made.
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    Process Safety Progress 17 (1998), S. 127-133 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An explosion and flash fire in a fixed bed reactor occurred at a municipal wastewater treatment plant (WWTP). Two employees were injured in the accident. The accident occurred in an ozone treatment building where ozone was used to treat odors from the offgas of the sludge concentration units. Excess ozone manually was routed to the fixed bed reactor (ozone destruct unit) where the ozone is catalytically transformed into oxygen before being discharged to the atmosphere.An investigation of the accident was conducted to determine the root cause of the explosion and flash fire and identify corrective actions which the WWTP management could undertake to prevent a recurrence. This investigation included site inspections, interview with the injured employees, sampling and analysis of various materials, an explosion dynamics analysis, and a root cause analysis.It was concluded that cooling oil from one of the ozone generation units entered the main ozone gas line due to a crack in one of the reactor's dielectric tubes. The cooling oil was vented into the ozone destruct unit when an employee opened a ball valve on the main ozone gas line. The cooling oil, essentially a saturated hydrocarbon mixture, reacted exothermically when it contacted the manganese dioxide catalyst. The exothermic reaction resulted in an explosion which propelled the access panel outwards and dispersed the catalyst pellets. A flash fire followed the explosion. The flash fire burned two employees and caused thermal damage to a nearby control panel.Although this accident was the first of its kind at this facility, this was not the first time that the ozone generator had experienced a failure of a dielectric tube. Thus, there was a significant probability that a dielectric tube failure could leak cooling oil into the main ozone gas line. This failure event could, in turn, result in another explosion and flash fire. The WWTP staff neither designed nor fabricated the ozone generator-destructor system. Therefore, it did not seem appropriate for the WWTP staff to modify the ozone system. Instead, it was recommended that the ozone destruct unit be taken out of service. The WWTP management acted on this recommendation.
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    Process Safety Progress 17 (1998), S. 171-175 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An explosion occurred in a petroleum product storage tank at a refinery. The liquid petroleum product was a heavy oil used as an asphalt extender. There were no injuries, but the cleanup was costly. The storage tank was one of several which received the product stream from a dehydration unit. The accident occurred shortly after the refinery was brought back on-line following a shutdown for schduled maintenance.This was the first incident of this kind to occur at this facility. Analysis of the process data and eyewitness observations indicated that the dehydration tower, which was supposed to be maintained at a minimum of 100°C during the shutdown, was allowed to drift below 100°C for an unknown period of time. This deviation enabled liquid water to enter the storage tank. Three operational factors contributed to the accident. Corrective actions were recommended to prevent a recurrence of a similar incident.
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    Process Safety Progress 17 (1998), S. 184-189 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Dust explosions have been with us for a long time. The first record of a dust explosion occurred in Turin, Italy, on December 14, 1785 [1]. The detailed record of this event is left to us by Count Morozzo. The event took place in Mr. Giacomelli's bakery. We know from his account that the weather was unseasonably dry, that a boy who worked in the bakery was using a shovel to stir and transfer the flour to a chute from a store room to the bakery and he had a lighted lamp to work by. The rest, as the saying goes, is history. No one was killed, and the building was saved by the sagacious fact of having plenty of windows. Since that first record, of course, there have been many explosions with much loss of life and significant economic consequences.
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    Process Safety Progress 17 (1998), S. 190-195 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The RSST DIERS vent sizing methodology is revised to provide realistic design equations for reactive systems consistent with available large-scale experience. Using easy to obtain RSST data such as rate of temperature rise and rate of pressure rise excellent agreement is illustrated for hybrid, vapor and gassy reactive systems.
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    Process Safety Progress 17 (1998), S. 196-199 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: From the 1960s onwards, the chemical and oil industries developed and used a number of new safety techniques which, in time, became second nature to those who applied them. They included the use of QRA for deciding priorities, Hazop and audits for identifying problems, inherently safer design for avoiding hazards, and more thorough investigation of incidents for identifying underlying causes. However, it has not yet become second nature to remember the accidents of the past and the actions needed to prevent them happening again.I joined industry in 1944 and moved to production in 1952. Then, and for at least 15 years afterwards, safety was a non-technical subject that could be left to arts graduates and elderly foremen. There was concern that people should not be hurt - great attention was paid to the lost-time accident rate - but there was no realization, that it was a subject worthy of systematic study by experienced technologists.This view changed at the end of the 1960s. A new generation of plants had been built, operating at higher temperatures and pressures and containing larger inventories of hazardous chemicals; the result was a series of fires and explosions and a worsening fatal accident rate. Figure 1 shows the situation in ICI, at the time the UK, s largest chemical company. Other companies experienced a similar state of affairs.As a result in 1968, I was appointed one of the company's first technical safety advisers, an unusual appointment at the time for someone with my experience, and if the reason for my appointment had not been so obvious I would have wondered what I had done wrong. I and my colleagues tried to apply the same sort of systematic thinking to safety that we applied in our other professional work. We developed some new concepts and techniques and adopted others. A common feature of our ides, realized only in restrospect, was that they consisted of more than mere problem-solving techniques. Once people had got used to these new concepts and used them a few times, they began to look at a whole range of problems in a different way.
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    Process Safety Progress 17 (1998), S. W3 
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    Keywords: Chemistry ; Chemical Engineering
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    Process Safety Progress 17 (1998), S. 259-262 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Case histories of 65 incidents in runaway reactions and emergency relief in Taiwan were analyzed and classified into several categories according to their causes, materials involved, equipment types, reaction types, and ignition sources. The cases in reactors and storage tanks were examined in more detail owing to the higher probability or larger potential hazard in these two types of equipments. The most common consequence of the incidents are explosions, fires, and atmospheric release of toxic chemicals. The most severe case was a thermal explosion from an organic peroxide storage area which caused the death of 33 persons. Popping and direct releasing of process chemicals to the atmosphere from relieving devices cause the greatest environmental concerns to the community close to the plants. Runaway reactions in batch type reactors occur frequently due to various operational mistakes. Heat of reaction is the most frequent ignition source of runaway reactions and emergency relief.
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    Process Safety Progress 17 (1998), S. 272-277 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: EPA's Risk Management Program regulation, promulgated in June 1996 as 40 CFR Part 68 requires subject industries to submit Risk Management Plans by June 1999. This plan requires hazard assessment of the operations of a facility using worst case scenarios and alternative releases. EPA has provided an Off-site Consequence Analysis (OCA) guidance to help facilities in their hazard assessment.OxyChem will be significantly impacted by the RMP rule. This paper outlines OxyChem's general experience and its strategy in planning to comply with this rule. OxyChem's approach in the development of the scenarios required by the rule is described in this paper. Limitations involved in the use of EPA's look-up tables or a single modeling solution for conducting all of the OCA are discussed. A three tiered OCA approach is presented as a possible alternative.
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    Process Safety Progress 17 (1998), S. 209-212 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: HFC-227ea (CF3CHFCF3;1, 1, 1, 2, 3, 3, 3-heptafluoropropane) is an effective replacement for Halon 1301 in fire suppression systems, providing rapid extinguishment of flames through a combination of physical and chemical mechanisms. The vast majority of applications for HFC-227ea involve the protection of Class A hazards, which are characterized by low fuel loadings and low energy output, with fire sizes often in the range of 5-10 kW. Mid- and large-scale testing has demonstrated that HFC-227ea, at its minimum design concentration of 7.0% v/v, is effective at extinguishing fires typical of those expected to occur in electronic data processing (EDP) facilities, telecommunication facilities and anechoic chambers. The levels of HF produced following extinguishment of typical Class a fires with HFC-227ea were well below the estimated mammalian LC50 and the human Dangerous Toxic Load (DTL), and do not appear to present a threat to electronic equipment.
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    Process Safety Progress 17 (1998), S. 219-224 
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Sandia National Laboratories (Sandia) has refined a process for developing inherently safer system designs based on methods used by Sandia to design detonation safety into nuclear weapons. The process was created when Sandia realized that standard engineering practices did not provide the level of safety assurance necessary for nuclear weapon operations, with their potential for catastrophic accidents. A systematic approach, which relies on mutually supportive design principles integrated through fundamental physical principles, was developed to ensure a predictably safe system response under a variety of operational and accident-based stesses. Robust, safe system designs result from this thematic approach to safety, minimizing the number of safety critical features. This safety assurance process has two profound benefits: the process avoids the need to understand or limit the ultimate intensity of off-normal environments and it avoids the requirement to analyze and test a large array of accident environment scenarios (e.g., directional threats, sequencing of environments, time races, etc) to demonstrate conformance to all safety requirements.
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