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  • 1
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    Inhibition of adipogenesis by Wnt signaling (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-11
    Description: Wnts are secreted signaling proteins that regulate developmental processes. Here we show that Wnt signaling, likely mediated by Wnt-10b, is a molecular switch that governs adipogenesis. Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors CCAAT/enhancer binding protein alpha (C/EBPalpha) and peroxisome proliferator- activated receptor gamma (PPARgamma). When Wnt signaling in preadipocytes is prevented by overexpression of Axin or dominant-negative TCF4, these cells differentiate into adipocytes. Disruption of Wnt signaling also causes transdifferentiation of myoblasts into adipocytes in vitro, highlighting the importance of this pathway not only in adipocyte differentiation but also in mesodermal cell fate determination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, S E -- Hemati, N -- Longo, K A -- Bennett, C N -- Lucas, P C -- Erickson, R L -- MacDougald, O A -- 5P60 DK20572/DK/NIDDK NIH HHS/ -- R01-DK51563/DK/NIDDK NIH HHS/ -- T32-DK07245/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2000 Aug 11;289(5481):950-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0622, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10937998" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Adipocytes/*cytology/*metabolism ; Animals ; Axin Protein ; CCAAT-Enhancer-Binding Proteins ; Cell Differentiation ; Cell Lineage ; Cytoskeletal Proteins/metabolism ; DNA-Binding Proteins/antagonists & inhibitors/genetics/metabolism ; Gene Transfer Techniques ; Genetic Vectors ; Mesoderm/cytology ; Mice ; Mice, Nude ; Muscles/cytology/metabolism ; Nuclear Proteins/antagonists & inhibitors/genetics/metabolism ; Proteins/genetics/metabolism ; Proto-Oncogene Proteins/genetics/*metabolism ; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors/genetics/metabolism ; *Repressor Proteins ; Retroviridae/genetics/physiology ; *Signal Transduction ; TCF Transcription Factors ; *Trans-Activators ; Transcription Factor 7-Like 2 Protein ; Transcription Factors/antagonists & inhibitors/genetics/metabolism ; Wnt Proteins ; *Zebrafish Proteins ; beta Catenin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Autocrine regulation of mammary cell differentiation (1990)
    Springer
    Protoplasma 159 (1990), S. 112-117 
    Details
    ISSN: 1615-6102
    Keywords: Mammary gland ; Cell differentiation ; Autocrine control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Milk secretion and mammary function in dairy animals are regulated by local mechanisms sensitive to the frequency or efficiency of milking. Acute local control of milk secretion occurs through autocrine feedback inhibition by a milk protein. Sustained changes in milking frequency and milk secretion are associated with longer-term adaptations in the degree of differentiation and, ultimately, the number of mammary epithelial cells. Differentiation of cultured mammary cells is suppressed by a milk fraction containing the inhibitor, suggesting that intra-mammary regulation of differentiation in vivo is elicited by the same autocrine regulator subsequent to its acute effect on milk secretion. The autocrine factor may affect mammary cell differentiation by modulating the number of cell surface hormone receptors for prolactin, thereby changing their sensitivity to circulating hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01322594
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    Paper (German National Licenses)
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  • 3
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    Regulation of osteoblastogenesis and bone mass by Wnt10b (2005)
    National Academy of Sciences
    Details
    Publication Date: 2005-02-22
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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