ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The purpose of this study was to determine the effect of sintering conditions onmicroporosity of and cell proliferation and bone ingrowth on biphasic calcium phosphate (BCP)bioceramics. Discs were prepared from a calcium-deficient apatite preparation that upon sintering at1050oC and above, results in a BCP with 60% hydroxyapatite (HA)/ 40% beta-tricalciumphosphate (β-TCP) ratio. The discs were divided into groups which were sintered under differentconditions of heating rate (programmed vs. non-programmed) and temperature (1050°C vs.1200°C). The discs were characterized in terms of composition (HA/β-TCP ratio), surfacemorphology, surface area, surface microporosity, per cent microporosity, and dissolution properties.The in vitro effect of sintering conditions on cell proliferation was determined using an establishedmouse fibroblast cell line (L929). Results demonstrated the following: (a) the HA/β-TCP ratioremained 60/40 regardless of sintering conditions; (b) the % microporosity, surface microporosity,surface area of the BCP and cell proliferation on the BCP significantly decreased with increasingsintering temperature, and (c) the extent of dissolution decreased with decreasing per centmicroporosity. The in vivo study indicated no tissue adverse reaction and direct bone contact withthe implant surface, confirming the biocompatibility of the BCP bioceramics. Resorption of theBCP and bone ingrowth was directly related to the sintering temperature: the higher thetemperature, the lower the resorption and the bone ingrowth. Results of this study indicate that percent microporosity of the BCP bioceramics affects its dissolution properties and cell response. Thestudy demonstrates that optimum per cent microporosity elicits optimum cell response and shouldbe considered to provide osteogenic/osteoinductive property to bioceramics
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1139.pdf
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