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  • 1
    Keywords: Biotechnology. ; Biomedical engineering. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: 1.Confocal laser scanning microscopy and fluorescence correlation methods for evaluation of molecular interactions -- 2.Number and Brightness Imaging: visualization of protein oligomerization state in living cell -- 3.Single-molecule analysis on the coupling of molecular state and reaction kinetics -- 4.Imaging lipid rafts in the plasma membrane using novel probe and super-resolution microscopy -- 5.Multiplex Immunohistochemistry (IHC) -- 6.Micro-endoscopy for live small animal fluorescent imaging -- 7.Immuno-gold techniques -- 8.Correlative Light and Electron Microscopy for Nanoparticle-Cell Interaction -- 9.Diagnostic and Therapeutic Nanomedicine -- 10.Semiconductor nanocrystals for biological imaging and fluorescence spectroscopy -- 11.DNA/RNA fluorescence imaging by synthetic nucleic acids -- Section II: Label-free techniques and advanced tomographic imaging -- 12.“Magnetic resonance imaging for preclinical study -- 13.Holotomography techniques for 3D label-free imaging of live cells and tissues -- 14.Dynamic-contrast optical imaging techniques -- 15.Emerging biological and clinical applications of photoacoustic tomography -- Section III: Potential (synergic) biotechnologies to be joined with imaging techniques -- 16.Generation of genetically-engineered mouse models using CRISPR-Cas system -- 17.Highly efficient generation of cell lines stably expressing genes of interest via Cre recombinase mediated knock-in method in mouse embryonic stem (ES) cells and its application for microscopic imaging techniques -- 18.Mass spectrometry based metabolomics in translational research -- 19.Application of mass spectrometry in drug metabolism and pharmacokinetics for drug development -- 20.Discovery and Application of Chemical Probes for Translational Research -- 21.Regeneration of skin cells by mesenchymal stem cell-derived exosomes.
    Abstract: This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science. .
    Type of Medium: Online Resource
    Pages: VI, 564 p. 191 illus., 161 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360648
    Series Statement: Advances in Experimental Medicine and Biology, 1310
    DDC: 660.6
    Language: English
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  • 2
    Keywords: Sustainability. ; Digital humanities. ; Internet of things. ; Sociology, Urban. ; Urban economics. ; Architecture. ; Sustainability. ; Digital Humanities. ; Internet of Things. ; Urban Sociology. ; Urban Economics. ; Cities, Countries, Regions.
    Description / Table of Contents: Introduction - The digital polis and its practices: Beyond gated communities -- Digital polis and the ‘safe’ feminism: Focusing on the strategies of direct punishment and gated community -- Toward digital polis: Gendered data (in)justice and data activism in South Korea -- Subjection or subjectification: representation of 'networked individuals' in Korean web novels -- Digital polis and urban commons: Justice beyond the gated community -- Production and reproduction of space and culture in the virtual realm: Gated communities as the imaginary, intermediary and real spaces -- The ghettoised city and the affect of anxiety in Park Wan-soe’s ‘apartment novels’ -- Spatial and digital fortressing of apartment complexes in Seoul: Two case studies -- Inclusion, exclusion, and participation in digital polis: Double-edged development of poor urban communities in alternative smart city-making -- Online-based food hubs for community health and well-being: Performance in practice and its implications for urban design -- Third places: The social infrastructure of the smart city. .
    Abstract: This edited collection provides an alternative discourse on cities evolving with physically and virtually networked communities—the ‘digital polis’—and offers a variety of perspectives from the humanities, media studies, geography, architecture, and urban studies. As an emergent concept that encompasses research and practice, the digital polis is oriented toward a counter-mapping of the digital cityscape beyond policing and gatekeeping in physical and virtual gated communities. Considering the digital polis as offering potential for active support of socially just and politically inclusive urban circumstances in ways that mirror the Greek polis, our attention is drawn towards the interweaving of the development of digital technology, urban space, and social dynamics. The four parts of this book address the formation of technosocial subjectivity, real-and-virtual combined urbanity, the spatial dimensions of digital exclusion and inclusion, and the prospect of emancipatory and empowering digital citizens. Individual chapters cover varied topics on digital feminism, data activism, networked individualism, digital commons, real-virtual communalism, the post-family imagination, digital fortress cities, rights to the smart city, online foodscapes, and open-source urbanism across the globe. Contributors explore the following questions: what developments can be found over recent decades in both physical and virtual communities such as cyberspace, and what will our urban future be like? What is the ‘digital polis’ and what kinds of new subjectivity does it produce? How does digital technology, as well as its virtuality, reshape the city and our spatial awareness of it? What kinds of exclusion and cooperation are at work in communities and spaces in the digital age? Each chapter responds to these questions in its own way, navigating readers through routes toward the digital polis. Chapter "Introduction - The digital polis and its practices: Beyond gated communities" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 208 p. 32 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811996856
    Series Statement: Advances in 21st Century Human Settlements,
    DDC: 304.2
    Language: English
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  • 3
    Call number: MOP 46493 / Mitte
    Type of Medium: Monograph available for loan
    Pages: 194 S.
    Location: MOP - must be ordered
    Branch Library: GFZ Library
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  • 4
    Keywords: Computer science ; Software engineering ; Computers ; Law and legislation ; Management information systems ; Computer Science ; Management of Computing and Information Systems ; Software Engineering ; Legal Aspects of Computing ; Information Systems Applications (incl. Internet)
    Description / Table of Contents: This book is open access under a CC BY license. This book constitutes the refereed proceedings of the 13th IFIP WG 2.13 International Conference on Open Source Systems, OSS 2017, held in Buenos Aires, Argentina, in May 2017. The 16 revised full papers and 3 short papers presented were carefully reviewed and selected from 32 submissions. The papers cover a wide range of topics related to free, libre, and open source software (FLOSS), including: licensing, strategies, and practices; case studies; projects, communication, and participation; tools; and project management, development and evaluation
    Pages: Online-Ressource (XIV, 220 pages) , 37 illustrations
    ISBN: 9783319577357
    Language: English
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 157 (1946), S. 262-263 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the last few years much work has been done, mostly in the United States, on the effect of sulphonamide drugs on the synthetic activities of intestinal bacteria. These studies have yielded valuable information about the synthesis of vitamins and other substances in the gut and their ...
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2012-03-09
    Description: Dyneins are microtubule-based AAA(+) motor complexes that power ciliary beating, cell division, cell migration and intracellular transport. Here we report the most complete structure obtained so far, to our knowledge, of the 380-kDa motor domain of Dictyostelium discoideum cytoplasmic dynein at 2.8 A resolution; the data are reliable enough to discuss the structure and mechanism at the level of individual amino acid residues. Features that can be clearly visualized at this resolution include the coordination of ADP in each of four distinct nucleotide-binding sites in the ring-shaped AAA(+) ATPase unit, a newly identified interaction interface between the ring and mechanical linker, and junctional structures between the ring and microtubule-binding stalk, all of which should be critical for the mechanism of dynein motility. We also identify a long-range allosteric communication pathway between the primary ATPase and the microtubule-binding sites. Our work provides a framework for understanding the mechanism of dynein-based motility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kon, Takahide -- Oyama, Takuji -- Shimo-Kon, Rieko -- Imamula, Kenji -- Shima, Tomohiro -- Sutoh, Kazuo -- Kurisu, Genji -- England -- Nature. 2012 Mar 7;484(7394):345-50. doi: 10.1038/nature10955.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan. takahide.kon@protein.osaka-u.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22398446" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/metabolism ; Adenosine Triphosphate/metabolism ; Allosteric Regulation ; Binding Sites ; Crystallography, X-Ray ; Cytoplasmic Dyneins/*chemistry/metabolism ; Dictyostelium/*chemistry ; Hydrolysis ; Microtubules/metabolism ; Models, Biological ; Models, Molecular ; Movement ; Protein Structure, Tertiary ; Structure-Activity Relationship
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2020-05-16
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology
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  • 8
    Publication Date: 2012-07-07
    Print ISSN: 0268-3768
    Electronic ISSN: 1433-3015
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Springer
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  • 9
    Publication Date: 2012-03-07
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 10
    Publication Date: 2011-08-22
    Print ISSN: 0108-7673
    Electronic ISSN: 2053-2733
    Topics: Chemistry and Pharmacology , Geosciences , Physics
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