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  • 1990-1994  (47)
  • 1935-1939  (14)
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  • 1
    ISSN: 1432-1041
    Keywords: Pharmacokinetics ; Caucasians ; Repirinast ; Antiallergic drug ; single dose ; oral administration ; metabolite ; BAY w 8199
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of BAY w 8199, the active metabolite of the prodrug repirinast (BAY u 2372), has been investigated after oral administration of 150, 300 and 450 mg repirinast to twelve healthy male Caucasians. Plasma BAY w 8199 concentrations were very variable between subjects. The mean peak level (geom. mean; 1s-range) was 0.14 (0.08–0.25), 0.19 (0.13–0.29) and 0.24 (0.14–0.42) mg/l after the 150, 300 and 450 mg doses, respectively. Peak levels were reached 0.5–2.5 h after drug intake. Terminal half-lives were calculated as 5.9 h (150 mg), 8.0 h (300 mg) and 9.8 h (450 mg). The dose proportionality of the plasma profiles of BAY w 8199 and of its excretion in urine was demonstrated by testing several parameters. About 7.4% of each dose (calculated as BAY w 8199) was excreted in urine over 36 h. The renal clearance of about 27 l/h suggests that BAY w 8199 is excreted by tubular secretion in addition to glomerular filtration.
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 594 (1990), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 62 (1993), S. 2271-2273 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Epitaxial iron disilicide thin layers have been grown on silicon by gas source molecular beam epitaxy (GSMBE) in the temperature range 450–550 °C. Fe(CO)5 and SiH4 are used as sources for the silicide growth on a heated Si(111) surface. The growth phases are characterized in situ by means of high-resolution electron energy loss spectroscopy, ultraviolet and x-ray photoelectron spectroscopies. The formation of an epitaxial metallic γ-FeSi2 layer at the interface with the silicon substrate is revealed and no complete relaxation of this strained metastable interface layer is observed, as the growth proceeds with the semiconducting equilibrium β-FeSi2 phase. The coexistence in the GSMBE grown heterostructures of the metallic (CaF2) and semiconducting (orthorhombic) FeSi2 structures is confirmed by cross-section transmission electron microscopy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 62 (1993), S. 3010-3012 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: For the first time clear evidence for two-dimensional Shubnikov–de Haas oscillations in modulation-doped CdTe/CdMnTe quantum-well structures is reported. The structures were grown by molecular-beam epitaxy using ZnBr2 as a novel source material for the n-type doping of II-VI epitaxial layers. From an analysis of the Shubnikov–de Haas oscillations a carrier density of 9×1011 cm−2 and an effective mass of 0.1 m0 could be deduced. Due to band filling the Fermi energy in the subbands is shifted above the conduction-band edge. This can be detected as a Stokes shift of absorption compared to photoluminescence recombination. From the Fermi energy shift the carrier concentration can be estimated, which agrees well with values determined by Hall-effect measurements.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 48 (1992), S. 795-798 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 47 (1991), S. 1808-1811 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 48 (1992), S. 912-913 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Microchimica acta 1 (1937), S. 144-153 
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary 1. On account of its transparency, a spot test plate made of Jena glass („Jenaer Glastüpfelplatte“) is suitable for all spot tests, no matter what colour the reaction products have. 2. It has been found that the greatest sensitivity is reached by working on a spot test plate which rests on a white or black background. A silver coloured paper gives a rather convenient background, both for bright and dark precipitates and hues. 3. By making spot tests with suitable standard solutions, on this plate, one can perform semi-quantitative analyses. 4. It is possible, on this plate, to determine the concentration of hydrogen ions with satisfying accuracy. 5. The new spot tests plate may be advantageously used for fluorescence tests and several microscopical examinations.
    Abstract: Résumé 1° La plaque de touche en verre d'Iéna (Jenaer Glastüpfelplatte) possède, grâce à sa transparence, toutes les qualités requises pour les réactions de touches, quelle que soit la couleur des produits de réaction. 2° On a constaté que la sensibilité maximale est atteinte en travaillant sur un fond blanc ou noir. Un papier couleur d'argent peut servir de fond, également convenable, pour les précipités (et colorations) clairs et foncés. 3° Au moyen de solutions types appropriées on peut exécuter, sur cette plaque, des analyses de touche sémi-quantitatives. 4° Sur la plaque en verre décrite, il est possible de déterminer la concentration des ions d'hydrogène, avec une précision satisfaisante. 5° Aussi, l'emploi de cette plaque offre des avantages pour les analyses par fluorescence et pour certaines recherches microscopiques.
    Notes: Zusammenfassung 1. Wegen ihrer Durchsichtigkeit eignet sich die Jenaer Glastüpfelplatte für sämtliche Tupfreaktionen, gleichgültig welche Farbe die Reaktionsprodukte besitzen. 2. Die größte Empfindlichkeit wurde beim Arbeiten mit weißer bzw. schwarzer Unterlage festgestellt. Als Untergrund sowohl für helle als auch für dunkle Niederschläge und Färbungen ist ein silberfarbiges Papier recht geeignet. 3. Durch Tüpfeln auf der Jenaer Glastüpfelplatte sind bei Verwendung entsprechender Vergleichslösungen halbquantitative Analysen ausführbar. 4. Die Bestimmung der Wasserstoffionenkonzentration ist auf der Glastüpfelplatte mit guter Genauigkeit möglich. 5. Für Fluoreszenzprüfungen und manche mikroskopische Untersuchungen wird die Glastüpfelplatte ebenfalls mit Vorteil verwendet.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 100 (1993), S. 155-159 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Although feline salivary glands have been used in investigations on secretion and microlithiasis and both processes involve calcium, nothing is known about its distribution in these glands. Therefore we have demonstrated the presence of calcium by a histochemical technique using glyoxal bis(2-hydroxyanil) and a biochemical technique using dry ashing. The histochemical technique stained serous acinar cells weakly and rarely found mucous acinar cells strongly in the parotid gland, mucous acinar cells moderately to strongly and serous acinar cells weakly in the sublingual gland, and central and demilunar acinar cells moderately to strongly in the submandibular gland. The biochemical technique revealed less calcium in the parotid than in the submandibular and sublingual glands. Both techniques revealed a decrease of calcium in submandibular and sublingual glands following parasympathetic stimulation. The histochemical distribution of calcium, which corresponds to that of acinar secretory glycoprotein, and the loss of calcium following parasympathetic stimulation, which causes release of secretory granules, indicate the presence of calcium in secretory granules. The concentration of calcium in the different types of acinar cell corresponds to the acidity of the secretory glycoprotein and suggests that calcium is present as a cationic shield to allow the condensation of polyionic glycoprotein in secretory granules.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 25 (1937), S. 24-25 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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