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  • Artikel  (70)
  • Springer  (65)
  • Nature Publishing Group  (5)
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  • 1
    Digitale Medien
    Digitale Medien
    Effect of Thyroxine on the Swelling of Mitochondria isolated from Various Tissues of the Rat (1956)
    [s.l.] : Nature Publishing Group
    Nature 178 (1956), S. 1119-1119 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Not all tissues respond in the same degree to the in vivo administration of thyroxine. Gordon and Heming8 found that the oxygen consumption of slices of liver, kidney, diaphragm and heart from thyrotoxic rats was significantly greater than normal, while that of slices of spleen, brain and testis ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/1781119a0
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Tyrosine kinase receptor indistinguishable from the c- met protein (1989)
    [s.l.] : Nature Publishing Group
    Nature 339 (1989), S. 155-156 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] P190 is a heterodimer of two disulphide-linked subunits: a 50K a-chain which is exposed at the cell surface and a 145K /3-chain that spans the plasma membrane and includes sites for tyrosine phosphorylation5'6. Recently, it has been proposed that the protein encoded by the c-met proto-oncogene may ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/339155a0
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Misidentified cell (1989)
    [s.l.] : Nature Publishing Group
    Nature 337 (1989), S. 311-312 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] SIR—Because the cell line TE671 is said to originate from an early culture of a human medulloblastoma1, it has been widely used to investigate this tumour type and as a model for primitive neural cells in general. And because the cell line can be infected by the AIDS virus HIV2 (in a way ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/337311c0
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Transport of K+ and other cations across phospholipid membranes by nonesterified fatty acids (1994)
    Springer
    The journal of membrane biology 141 (1994), S. 21-28 
    Details
    ISSN: 1432-1424
    Schlagwort(e): Fatty acids ; Liposomes ; Cation transport ; Membrane transport
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The rate of change of internal pH and transmembrane potential has been monitored in liposomes following the external addition of various cation salts. Oleic acid increases the transmembrane movement of H+ following the imposition of a K+ gradient. An initial fast change in internal pH is seen followed by a slower rate of alkalinization. High concentrations of the fatty acid enhance the rate comparable to that seen in the presence of nigericin in contrast to the effect of FCCP (carbonyl cyanide p-(tri-fluoromethoxy)phenyl hydrazone) which saturates at an intermediate value. The ability of nonesterified fatty acids to catalyze the movement of cations across the liposome membrane increases with the degree of unsaturation and decreases with increasing chain length. Li and Na salts cause a similar initial fast pH change but have less effect on the subsequent slower rate. Similarly, the main effect of divalent cation salts is on the initial fast change. The membrane potential can enhance or inhibit cation transport depending on its polarity with respect to the cation gradient. It is concluded that nonesterified fatty acids have the capability to complex with, and transport, a variety of cations across phospholipid bilayers. However, they do not act simply as proton/cation exchangers analogous to nigericin nor as protonophores analogous to FCCP. The full cycle of ionophoric action involves a combination of both functions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00232870
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    The Relationship Between Childhood Growth, Bone Mass, and Muscle Strength in Male and Female Adolescents (1997)
    Springer
    Calcified tissue international 60 (1997), S. 405 -409 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Key words: Bone mineral density — Bone mineral content — Childhood growth — Dual X-ray absorptiometry — Muscle strength.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. In this population-based study, the relationship between childhood weight and height, and adolescent bone mass and muscle strength have been studied in 39 girls and 48 boys. Total body and femoral neck bone mass measurements (bone mineral content, BMC and bone mineral density, BMD) were made by dual X-ray absorptiometry. Quadriceps muscle strength was measured. Mean age at the time of measurement was 15.1 years for girls and boys. Results were individually linked to data on childhood (birth to 6 years of age) weight and height, taken from community health records. Childhood weight was found to be predictive of adolescent total body BMC (TBMC). However, this was not the case when correlating childhood weight and total body BMD (TBMD), suggesting that growth determines the size of the skeleton, whereas the density within that bone envelope is to a greater extent governed by other factors. Further, in a multiple regression model we found that the combined effect of childhood weight and height was significantly correlated with adolescent quadriceps muscle strength.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002239900253
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Polymorphisms of the Vitamin D Receptor, Infant Growth, and Adult Bone Mass (1997)
    Springer
    Calcified tissue international 60 (1997), S. 233 -235 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Key words: Bone density — Vitamin D receptor — Polymorphism — Growth — Genetic.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. Family and twin studies have demonstrated a strong genetic component to the development of peak bone mass. Early fetal and infant environment has also been shown to influence bone mass through an effect on skeletal size and mineral content. We report a retrospective study that has examined whether early infant growth is regulated by genetic factors shown to be associated with bone mass. We have determined the vitamin D receptor (VDR) gene alleles for 66 women (mean age 65.5 years) on whom detailed birth records were available. There was a statistically significant trend (P= 0.04) for VDR genotype against weight at the age of 1 year, with the ``tt'' homozygote group having 7% higher weight. We conclude that early fetal or infant environment may interact with an individual's underlying genotype to program early skeletal growth, and that this may track through later life to influence adult characteristics. Further prospective studies are required, however, to fully clarify the precise environmental and genetic mechanisms underlying these findings.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002239900220
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    The Oldoway Human Skeleton (1932)
    [s.l.] : Nature Publishing Group
    Nature 129 (1932), S. 903-903 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] WE are glad to find from Dr. Leakey's letter in NATURE of May 14 that he is in agreement with us in regarding the Oldoway skeleton as an artificial burial, and regret that, in common with everyone else whom we have consulted in this matter, we interpreted his original letter in NATURE of Oct. ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/129903a0
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    The Oldoway Human Skeleton (1932)
    [s.l.] : Nature Publishing Group
    Nature 129 (1932), S. 312-313 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] A LETTER appeared in NATURE of Oct. 24, 1931, signed by Messrs. Leakey, Hopwood, and Reck, in which, among other conclusions, it is stated that “there is no possible doubt that the human skeleton came from Bed No. 2 and not from Bed No. 4”. This must be taken to mean that the skeleton is to be ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/129312b0
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    cGMP stimulates active K+ uptake in rat submandibular slices (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 362-364 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The 8-bromo derivative of cGMP was found to stimulate the ouabain-sensitive uptake of K+ and to reduce the net release of K+ induced by acetylcholine in rat submandibular gland slices incubated in vitro.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01963123
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Genetic transformation of the pathogenic fungus Wangiella dermatitidis (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 444-450 
    Details
    ISSN: 1432-0614
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract Genetic transformation of Wangiella dermatitidis was studied using three plasmid vectors (pAN7-1, pWU44, and pKK5) and both electroporation and polyethyleneglycol-mediated methods. pAN7-1 contains the E. coli hygromycin B (HmB) phosphotransferase (hph) gene. Expression of the hph gene confers resistance to antibiotic HmB. Selection for resistance, indicative of transformation, resulted in 10–203 HmB-resistant colonies/μg pAN7-1 on medium containing 100 μg HmB/ml. Strains of W. dermatitidis used in this study have innate sensitivity to HmB at a critical inhibitory concentration of 20–40 μg/ml. Vectors pWU44 and pKK5 contain a URA5 gene from Podospora anserina. A ura5 auxotroph of W. dermatitidis was transformed to prototrophy with pWU44 or pKK5 by complementation. Transformation frequencies for these two plasmids were between 17–50 transformants/μg vector DNA. Southern blotting analysis and polymerase chain reaction detection of DNA from putative transformants confirmed transformation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00169942
    Standort Signatur Erwartet Verfügbarkeit
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