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  • Artikel  (17)
  • Springer  (12)
  • Nature Publishing Group  (5)
  • Chemie und Pharmazie  (17)
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  • Artikel  (17)
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  • 1
    Digitale Medien
    Digitale Medien
    Effect of Thyroxine on the Swelling of Mitochondria isolated from Various Tissues of the Rat (1956)
    [s.l.] : Nature Publishing Group
    Nature 178 (1956), S. 1119-1119 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Not all tissues respond in the same degree to the in vivo administration of thyroxine. Gordon and Heming8 found that the oxygen consumption of slices of liver, kidney, diaphragm and heart from thyrotoxic rats was significantly greater than normal, while that of slices of spleen, brain and testis ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/1781119a0
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    The Oldoway Human Skeleton (1932)
    [s.l.] : Nature Publishing Group
    Nature 129 (1932), S. 903-903 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] WE are glad to find from Dr. Leakey's letter in NATURE of May 14 that he is in agreement with us in regarding the Oldoway skeleton as an artificial burial, and regret that, in common with everyone else whom we have consulted in this matter, we interpreted his original letter in NATURE of Oct. ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/129903a0
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    The Oldoway Human Skeleton (1932)
    [s.l.] : Nature Publishing Group
    Nature 129 (1932), S. 312-313 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] A LETTER appeared in NATURE of Oct. 24, 1931, signed by Messrs. Leakey, Hopwood, and Reck, in which, among other conclusions, it is stated that “there is no possible doubt that the human skeleton came from Bed No. 2 and not from Bed No. 4”. This must be taken to mean that the skeleton is to be ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/129312b0
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Tyrosine kinase receptor indistinguishable from the c- met protein (1989)
    [s.l.] : Nature Publishing Group
    Nature 339 (1989), S. 155-156 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] P190 is a heterodimer of two disulphide-linked subunits: a 50K a-chain which is exposed at the cell surface and a 145K /3-chain that spans the plasma membrane and includes sites for tyrosine phosphorylation5'6. Recently, it has been proposed that the protein encoded by the c-met proto-oncogene may ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/339155a0
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Misidentified cell (1989)
    [s.l.] : Nature Publishing Group
    Nature 337 (1989), S. 311-312 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] SIR—Because the cell line TE671 is said to originate from an early culture of a human medulloblastoma1, it has been widely used to investigate this tumour type and as a model for primitive neural cells in general. And because the cell line can be infected by the AIDS virus HIV2 (in a way ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/337311c0
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    The disposition of inhaled lysine theophylline in volunteers (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 635-637 
    Details
    ISSN: 1432-1041
    Schlagwort(e): theophylline ; inhalation ; saliva-serum distribution ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Six healthy volunteers received an iv infusion of 317 mg lysine theophylline (equivalent to 197 mg anhydrous theophylline) in order to calculate theophylline clearance by standard methods. They subsequently received a 20 minute inhalation of nebulised lysine theophylline. Serum and salivary theophylline concentrations were measured and all saliva was collected for the first hour. From these concentrations estimates were made of the distribution of theophylline into the blood and saliva with 40% to 94% identified in the blood. Very high salivary concentrations were reached during the inhalation phase with saliva: serum concentration ratios of between 60 and 1600.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543500
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Personality and theophylline pharmacokinetics (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 429-431 
    Details
    ISSN: 1432-1041
    Schlagwort(e): theophylline ; asthma ; personality measures ; pharmacokinetics ; volunteers ; patients
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Thirteen volunteers received an iv dose of theophylline followed by blood sampling for 8 h to calculate pharmacokinetic parameters. Ten patients with asthma undergoing chronic dosing with slow release aminophylline underwent 12 h of blood sampling to calculate theophylline clearance. Both groups completed an Eysenck Personality Inventory (EPI) from which was derived scores for neuroticism (N) and extroversion (E). Using multiple regression analysis no independent effect of either N or E score on theophylline clearance or half-life could be demonstrated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00544362
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    The relationship between clearance of theophylline and age within the adult age range (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 177-179 
    Details
    ISSN: 1432-1041
    Schlagwort(e): theophylline clearance ; age ; adult age range ; normal subjects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Twenty volunteers aged between 20 and 57 years were given 197 mg of theophylline (as lysine theophylline) by iv infusion over 5 minutes to test the hypothesis that within the adult age range theophylline clearance declines with age. Samples were assayed for theophylline using the EMIT assay and clearance was determined by standard methods. Clearance values were 0.73 ml/min/kg below age 38 years and 0.75 ml/min/kg at and above age 38 years. Multiple regression analysis using age as a continuous variable showed no relationship between age and clearance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00547418
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Transport of K+ and other cations across phospholipid membranes by nonesterified fatty acids (1994)
    Springer
    The journal of membrane biology 141 (1994), S. 21-28 
    Details
    ISSN: 1432-1424
    Schlagwort(e): Fatty acids ; Liposomes ; Cation transport ; Membrane transport
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The rate of change of internal pH and transmembrane potential has been monitored in liposomes following the external addition of various cation salts. Oleic acid increases the transmembrane movement of H+ following the imposition of a K+ gradient. An initial fast change in internal pH is seen followed by a slower rate of alkalinization. High concentrations of the fatty acid enhance the rate comparable to that seen in the presence of nigericin in contrast to the effect of FCCP (carbonyl cyanide p-(tri-fluoromethoxy)phenyl hydrazone) which saturates at an intermediate value. The ability of nonesterified fatty acids to catalyze the movement of cations across the liposome membrane increases with the degree of unsaturation and decreases with increasing chain length. Li and Na salts cause a similar initial fast pH change but have less effect on the subsequent slower rate. Similarly, the main effect of divalent cation salts is on the initial fast change. The membrane potential can enhance or inhibit cation transport depending on its polarity with respect to the cation gradient. It is concluded that nonesterified fatty acids have the capability to complex with, and transport, a variety of cations across phospholipid bilayers. However, they do not act simply as proton/cation exchangers analogous to nigericin nor as protonophores analogous to FCCP. The full cycle of ionophoric action involves a combination of both functions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00232870
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Untersuchung von Milch (1937)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 110 (1937), S. 359-361 
    Details
    ISSN: 1618-2650
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01394164
    Standort Signatur Erwartet Verfügbarkeit
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