ISSN:
0749-1581
Keywords:
Selective relaxation time
;
Biselective relaxation time
;
Cross-relaxation time
;
Interproton distance
;
Stereochemistry
;
Guinesines
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Both selective (T1S) and biselective relaxation times (T1BS) were measured for the sulphur containing alkaloids, guinesine-A, -B and -C (Ia, Ib and Ic). Their configurations and conformations were determined using the interproton distances (rij) derived from the cross-relaxation times (σij), which were obtained from the observed T1S and T1BS values. Their configurations are concluded to be 3′,4′-cis-2,3′-erythro (Ia), 3′,4′-cis-2,3′-threo (Ib) and 3′,4′-trans-2,3′-erythro (Ic), which are consistent with the results from x-ray analyses and 1H NOE experiments. The preferred conformations in CDCl3 solution are also proposed for these alkaloids.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260290802
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