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1

Digitale Medien

Inhibition of the metabolism of ram spermatozoa by derivatives of α-chlorohydrin (1981)

Brown-Woodman, P. D. C. ; White, I. G. ; Ridley, D. D.

New York, NY : Wiley-Blackwell

Gamete Research 4 (1981), S. 203-217

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ISSN: 0148-7280

Schlagwort(e): α-chlorohydrin ; antifertility agent ; ram ; sperm metabolism ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie

Notizen: The effects of the male antifertility agent, α-chlorohydrin, six of its derivatives, and glycidol were studied on the metabolism of washed ram spermatozoa in vitro with fructose as substrate. The α-chlorohydrin derivatives were the amino, the phosphorylated, and four glycol-bridge (ketal) compounds. All compounds except glycidol, in a concentration between 0.1 and 100 mM, reduced the aerobic glycolsis and/or oxidation of fructose. However, there was not a high correlation between the ability of these compounds to inhibit the metabolism of ram spermatozoa in vitro and their antifertility activity when administered to male rats. Other factors are clearly involved in their antifertility activity, eg, the concentration of the compounds in the epididymis and their conversion of either more or less spermicidal compounds in the body.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/mrd.1120040305

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2

Digitale Medien

Bubble formation in animals. II. Gas nuclei and their distribution in blood and tissuesThis work has been aided since July 1, 1942, by grants from the Committee on Aviation Medicine of the National Research Council carried out under contract recommended by the Commitee on Medical Reseach between the Office of Scientific Research and Development and Princeton University. Reference will not be made to progress reports or other literature of the Committee on Aviation Medicine. (1944)

Harvey, E. Newton ; Whiteley, A. H. ; McElroy, W. D. ; [weitere]

Philadelphia : Wiley-Blackwell

Journal of Cellular and Comparative Physiology 24 (1944), S. 23-34

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ISSN: 0095-9898

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jcp.1030240103

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3

Digitale Medien

Bubble formation in animals. I. Physical factorsThis work has been aided since July 1, 1942, by grants from the Committee on Aviation Medicine of the National Research Council carried out under contract recommended by the Committee on Medical Reseach between the Office of Scientific Research and Development and Princeton University. (1944)

Harvey, E. Newton ; Barnes, D. K. ; McElroy, W. D. ; [weitere]

Philadelphia : Wiley-Blackwell

Journal of Cellular and Comparative Physiology 24 (1944), S. 1-22

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ISSN: 0095-9898

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jcp.1030240102

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4

Digitale Medien

Perturbation of the switch-on of transcriptase activity in intermediate subviral particles from reovirus (1982)

Borsa, J. ; Sargent, M. D. ; Ewing, D. D. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Cellular Physiology 112 (1982), S. 10-18

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ISSN: 0021-9541

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: Intermediate subviral particles (ISVP) derived from reovirus represent a simple model system for the switch-on of transcriptase function. In such particles the endogenous transcriptase is present in a switched-off form, one step removed from the switched-on state. Switch-on of transcriptase function is an active process in this system and can be triggered by K+ ions. A variety of agents which affect gene expression in cells were tested for an effect on switch-on in ISVP. Marked effects on switch-on in ISVP were observed with a diverse group of test agents, including DMSO and other solvents, BUdR, TdR, caffeine, theophylline, and temperature. The correlation in response between ISVP and cells suggests that the ISVP system may be useful as a model for studying the biochemical mechanisms underlying the perturbative effects of such agents on gene expression in cells.

Zusätzliches Material: 14 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jcp.1041120104

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5

Digitale Medien

Morphological and ultrastructural characterization of mammalian spermatozoa processed for flow cytometric DNA analyses (1984)

Garner, D. L. ; Johnson, L. A. ; Lake, S. ; [weitere]

New York, NY : Wiley-Blackwell

Gamete Research 10 (1984), S. 339-351

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ISSN: 0148-7280

Schlagwort(e): spermatozoa ; flow cytometry ; DNA staining ; nuclear morphology ; ultrastructure ; mammals ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie

Notizen: The morphological and ultrastructural changes that occur during preparation of porcine, bovine, and murine spermatozoa for flow cytometric quantification of the relative DNA content of the X- and Y-chromosome-bearing sperm populations were examined. Ejaculated spermatozoa from the boar and bull were washed using a series of dimethyl sulfoxide (DMSO) solutions prior to fixation, whereas the epididymal mouse spermatozoa were washed only in phosphate-buffered saline (PBS). Spermatozoa from all three species were then fixed in ethanol and processed for fluorochrome staining by a treatment regimen consisting of sulfhydryl reduction and proteolysis. The processed sperm nuclei were stained for DNA with the fluorochrome, 4′-6-diamidino-2-phenylindole (DAPI) before quantification by flow cytometry. Scanning and transmission electron micrographs of sperm heads taken at various steps of the preparation and staining procedures show 1) that the rigorous washing procedure disrupted the plasma and outer acrosomal membranes, 2) that ethanol fixation resulted in removal of the outer membranes and disintegration of the nuclear envelope, and 3) that thiol and proteolysis treatment removed the remaining cellular organelles including the tail and rapidly induced partial decondensation of the tightly packed chromatin. Sequential micrographs showed that the nuclear matrix of all three species increased in thickness about twofold during the preparation and staining. Consequently, the harsh procedures currently used for quantitative staining of DNA for high-resolution flow cytometric analyses destroy most cellular organelles and thereby prevent simultaneous characterization of DNA content and other sperm cell constituents.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/mrd.1120100402

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6

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Regulation of leucine metabolism in man: a stable isotope study (1981)

D. E. Matthews ; D. M. Bier ; M. J. Rennie ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 214(4525): 1129-31.

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Publikationsdatum: 1981-12-04

Beschreibung: Leucine catabolism is regulated by either of the first two degradative steps: (reversible) transamination to the keto acid or subsequent decarboxylation. A method is described to measure rates of leucine transamination, reamination, and keto acid oxidation. The method is applied directly to humans by infusing the nonradioactive tracer, L-[15N,1-13C]leucine. Leucine transamination was found to be operating several times faster than the keto acid decarboxylation and to be of equal magnitude in adult human males under two different dietary conditions, postabsorptive and fed. These results indicate that decarboxylation, not transamination, is the rate-limiting step in normal human leucine metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matthews, D E -- Bier, D M -- Rennie, M J -- Edwards, R H -- Halliday, D -- Millward, D J -- Clugston, G A -- AM-25994/AM/NIADDK NIH HHS/ -- HD-10667/HD/NICHD NIH HHS/ -- RR-00954/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1129-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302583" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Adult ; Carbon Isotopes ; Humans ; Kinetics ; Leucine/*metabolism ; Male ; Models, Biological ; Nitrogen Isotopes ; Oxidation-Reduction

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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7

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Anti-T-cell reagents for human bone marrow transplantation: ricin linked to three monoclonal antibodies (1983)

D. A. Vallera ; R. C. Ash ; E. D. Zanjani ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 222(4623): 512-5.

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Publikationsdatum: 1983-11-04

Beschreibung: Three new reagents that react against human T cells were synthesized by covalently linking the toxin ricin to monoclonal antibodies recognizing differentiation antigens on the surface of T lymphocytes. Each of these immunotoxins selectively inhibited T-cell proliferation when the cells were incubated in the presence of lactose. Multipotent human stem cells were inhibited only at much higher concentrations. Mixtures of all three immunotoxins were more effective than any one alone. These reagents have the potential for preventing graft-versus-host disease in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vallera, D A -- Ash, R C -- Zanjani, E D -- Kersey, J H -- LeBien, T W -- Beverley, P C -- Neville, D M Jr -- Youle, R J -- CA-25097/CA/NCI NIH HHS/ -- CA-31618/CA/NCI NIH HHS/ -- CA-31685/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):512-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6353579" target="_blank"〉PubMed〈/a〉

Schlagwort(e): *Antibodies, Monoclonal ; Antigen-Antibody Complex ; Bone Marrow/immunology ; *Bone Marrow Transplantation ; Hematopoietic Stem Cells/immunology ; Humans ; *Immunosuppressive Agents ; Lymphocyte Activation ; Ricin/*immunology ; T-Lymphocytes/*immunology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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8

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Lymphadenopathy associated virus infection of a blood donor--recipient pair with acquired immunodeficiency syndrome (1984)

P. M. Feorino ; V. S. Kalyanaraman ; H. W. Haverkos ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 225(4657): 69-72.

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Publikationsdatum: 1984-07-06

Beschreibung: A retrovirus isolated from three patients with the acquired immunodeficiency syndrome (AIDS) in the United States was morphologically and antigenically identical to lymphadenopathy associated virus isolated in France. Two of these isolates were from a blood donor-recipient pair, each of whom developed AIDS. Lymphadenopathy associated virus was isolated from the blood donor's lymphocytes 12 months after his onset of AIDS symptoms and from the blood recipient's lymphocytes 1 month after her onset of AIDS symptoms. Two isolates from the blood donor-recipient pair and an isolate from an epidemiologically unrelated homosexual man were examined by competitive radioimmunoassay to determine their antigenic relatedness to each other and to other human retroviruses. The major core proteins (p25) of the isolates were antigenically identical and all three isolates were identical to prototype lymphadenopathy associated virus isolated in France.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feorino, P M -- Kalyanaraman, V S -- Haverkos, H W -- Cabradilla, C D -- Warfield, D T -- Jaffe, H W -- Harrison, A K -- Gottlieb, M S -- Goldfinger, D -- Chermann, J C -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):69-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328663" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Acquired Immunodeficiency Syndrome/*microbiology/transmission ; Adult ; Antibodies, Viral/immunology ; *Blood Donors ; Blood Transfusion/adverse effects ; Deltaretrovirus/immunology ; Female ; Humans ; Male ; Retroviridae/*immunology ; Retroviridae Infections/*immunology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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9

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Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients (1984)

D. Pickar ; R. Labarca ; M. Linnoila ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 225(4665): 954-7.

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Publikationsdatum: 1984-08-31

Beschreibung: Plasma-free homovanillic acid, a major metabolite of dopamine, was measured in chronically ill schizophrenic patients both before and during treatment with the antipsychotic phenothiazine, fluphenazine. Neuroleptic treatment was associated with a significant time-dependent decrease in plasma homovanillic acid from pretreatment values, which were significantly elevated when compared with those of age- and sex-matched healthy control subjects. Further, both the absolute concentrations as well as the neuroleptic-induced reductions in plasma homovanillic acid determined over 5 weeks of neuroleptic treatment were statistically significantly correlated with ratings of psychosis and improvement in psychosis, respectively. These findings suggest that the delayed effects of neuroleptic agents on presynaptic dopamine activity may more closely parallel their therapeutic actions than do their immediate effects in blocking postsynaptic dopamine receptors and that a decrease in dopamine "turnover" may be responsible for their antipsychotic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickar, D -- Labarca, R -- Linnoila, M -- Roy, A -- Hommer, D -- Everett, D -- Paul, S M -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):954-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474162" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Adult ; Dopamine/metabolism ; Female ; Fluphenazine/pharmacology/*therapeutic use ; Homovanillic Acid/*blood ; Humans ; Male ; Phenylacetates/*blood ; Schizophrenia/blood/*drug therapy ; Time Factors

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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10

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Co-release of ACTH and beta-endorphin immunoreactivity in human subjects in response to central cholinergic stimulation (1983)

S. C. Risch ; N. H. Kalin ; D. S. Janowsky ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 222(4619): 77.

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Publikationsdatum: 1983-10-07

Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Risch, S C -- Kalin, N H -- Janowsky, D S -- Cohen, R M -- Pickar, D -- Murphy, D L -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):77.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6312560" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Adrenocorticotropic Hormone/*blood ; Cholinergic Fibers/*physiology ; Endorphins/*blood ; Humans ; Physostigmine/pharmacology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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