ISSN:
1573-3904
Schlagwort(e):
Antisense therapy
;
Chiral oligonucleotide analogues
;
Fmoc chemistry
;
Fmoc C-PNA amino acids
;
Solid phase synthesis
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract Due to the increasing interest in the use ofoligonucleotide analogues as antisense and antigenedrugs, we designed a chiral analogue constituted of apeptidic frame bearing nucleobases in suitablepositions (C-PNA). We recently reported the synthesisof four nonnatural α-amino acids with the DNAbases in the lateral chain. In this paper we presentan improved synthesis of the Fmoc monomers and theirpolymerisation to polypeptidic oligonucleotideanalogues using a modification of the standardprotocol for solid phase peptide synthesis.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1008801007027
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