ISSN:
1573-3904
Keywords:
Antisense therapy
;
Chiral oligonucleotide analogues
;
Fmoc chemistry
;
Fmoc C-PNA amino acids
;
Solid phase synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Due to the increasing interest in the use ofoligonucleotide analogues as antisense and antigenedrugs, we designed a chiral analogue constituted of apeptidic frame bearing nucleobases in suitablepositions (C-PNA). We recently reported the synthesisof four nonnatural α-amino acids with the DNAbases in the lateral chain. In this paper we presentan improved synthesis of the Fmoc monomers and theirpolymerisation to polypeptidic oligonucleotideanalogues using a modification of the standardprotocol for solid phase peptide synthesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008801007027
Permalink