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  • 1
    facet.materialart.
    Unbekannt
    Imprint Nacional
    Print: 1889 – 1985 (Ort: A62, Keller, 41/5 - 42/1)
    Vormals: Annaes do Observatorio do Infante D. Luis : Observacoes dos Postos Meteorologicos  (–)
    Verlag: Imprint Nacional
    Körperschaft: Observatório Infante D. Luís 〈Lisboa〉
    Thema: Geologie und Paläontologie
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    facet.materialart.
    Unbekannt
    Print: 1901 – 1985 (Ort: A51, 39/2)
    Körperschaft: Observatório Central Meteorológico Infante D. Luís 〈Lisboa〉
    Thema: Geologie und Paläontologie
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Epigenetics. ; Developmental biology. ; Evolutionary developmental biology. ; Molecular Evolution. ; Zoology. ; Evolutionary genetics. ; Epigenetics. ; Developmental Biology and Stem Cells. ; Evolutionary Developmental Biology. ; Molecular Evolution. ; Zoology. ; Evolutionary Genetics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. An Introduction to Epigenetics, Development, Ecology and Evolution. Chapter 2. Epigenetic Regulation: The Cross-Talk among Development, Adaptive Strategies, and Microevolutionary Change -- Chapter 3. Epigenetics and Phenotypic Plasticity in Animals -- Chapter 4. Role of Environmentally Induced Epigenetic Transgenerational Inheritance in Evolutionary Biology -- Chapter 5. Transgenerational Epigenetic Programming -- Chapter 6. Epigenetics, Evolution and Development of Birds -- Chapter 7. Epigenetics and the Extreme Stress Response -- Chapter 8. Epigenetic Adaptation to Local Ecologies as a First Step toward Gene: Culture Co-evolution.
    Kurzfassung: Epigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and 'co-act' with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.
    Materialart: Online-Ressource
    Seiten: XII, 232 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031137716
    DDC: 572.865
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Beschreibung / Inhaltsverzeichnis: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.
    Kurzfassung: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges Alina L. Capatina, Dimitris Lagos, and William J. Brackenbury Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk Jerry J. Fan and Xi Huang Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu Ion Transport and Radioresistance Bastian Roth and Stephan M. Huber Ion Transporting Proteins and Cancer: Progress and Perspectives Mustafa B. A. Djamgoz.
    Materialart: Online-Ressource
    Seiten: X, 277 p. 30 illus., 20 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031039942
    Serie: Reviews of Physiology, Biochemistry and Pharmacology, 183
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Agriculture. ; Botany. ; Soil science. ; Agriculture. ; Plant Science. ; Soil Science.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Man And The Soil - Plant - Atmosphere System -- Chapter 2: Water, The Universal Solvent For Life -- Chapter 3: The Soil As A Water Reservoir For Plants -- Chapter 4: Plant: The Solar Energy Collector -- Chapter 5: Atmosphere: The Fluid Envelope That Covers The Planet Earth -- Chapter 6: The Equilibrium State Of Water In The Systems -- Chapter 7: The Movement Of Water In The Systems -- Chapter 8: Soil Water As A Nutrient Solution -- Chapter 9: Aspects Of The Soil Atmosphere -- Chapter 10: How Heat Is Propagated In The Soil -- Chapter 11: Water Infiltration Into The Soil -- Chapter 12: Water Redistribution After Infiltration Into The Soil -- Chapter 13: Evaporation And Evapotranspiration: The Vapor Losses To The Atmosphere -- Chapter 14: How Do Plants Absorb Soil Water ? -- Chapter 15: The Water Balance In Agricultural And Natural Systems -- Chapter 16: How Plants Absorb Nutrients From The Soil -- Chapter 17: How Soil, Plant And Atmophere Properties Vary In Space And Time In The Spas: An Approach To Geoestatistics -- Chapter 18: Spatial And Temporal Variability Of Spas Attributes: Analysis Of Spatial And Temporal Series -- Index -- .
    Kurzfassung: This textbook presents the concepts and processes involved in the soil-plant-atmosphere system as well as its applications in the water cycle in agriculture. Although reaching the frontier of our knowledge in several subjects, each chapter starts at the graduation level and proceeds to the post-doctoral level. Its more complicated subjects, as math and physics, are well explained, even to readers not well acquainted with these tools. Therefore, it helps students read, understand, and developing their thoughts on these subjects. Instructors also find it an easy book with the needed depth to be adopted in courses related to Soil Physics, Agricultural Management, Environmental Protection, Irrigation and Agrometeorology. It serves also as “lexicon” to engineers and lawyers involved in agricultural, environmental cases.
    Materialart: Online-Ressource
    Seiten: XXI, 456 p. 272 illus., 8 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030193225
    DDC: 630
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Schlagwort(e): Plants Evolution. ; Plant ecology. ; Evolution (Biology). ; Conservation biology. ; Ecology . ; Plant physiology. ; Plant Evolution. ; Plant Ecology. ; Evolutionary Biology. ; Conservation Biology. ; Plant Physiology.
    Beschreibung / Inhaltsverzeichnis: Section I - The natural history of the plant diversity in the Chihuahuan desert -- Chapter 1 - Vegetation and species richness in the Chihuahuan Desert -- Chapter 2 - Biogeography and phylogeography of the plants of Chihuahuan Desert -- Chapter 3 - The Chihuahuan Desert, climate change and paleovegetation during the mid-Holocene and Last Maximum Glacial -- Chapter 4 - Plants in the desert: diversity and life-forms -- Section II - Cuatro Cienegas Basin, a refugia within the Chihuahuan desert -- Chapter 5 - Reproductive biology of Grusonia bradtiana (Cactaceae) from the Chihuahuan desert -- Chapter 6 - How did Fouquieria come to the Chihuahuan Desert? -- Chapter 7 - Between Aridity and Opulence: Resources of the Mexican Desert -- Chapter 8 - Ecological importance of Bajadas in the Cuatrocienegas region: a floristic diversity and vegetation analysis -- Chapter 9 - Gypsophilous species of Cuatro Ciénegas -- Chapter 10 - The ages of life: the changing forms and the history of Coryphantha werdermanni throughout its development -- Chapter 11 - Cuatrocienegas: a refugee for the living rock cactus, Ariocarpus fissuratus -- Chapter 12 - Reproductive biology and conservation of the living rock Ariocarpus fissuratus -- Chapter 13 - Effect of reproductive modes on the population dynamics of an endemic cactus from Cuatro Ciénegas -- Chapter 14 - Conservation status, germination and establishment of the divine cactus, Lophophora williamsii (Lem. ex Salm-Dyck) J. M. Coult., at Cuatrocienegas -- Chapter 15 - Genetic and ecological characterization of Arundo donax and Phragmites australis in the Cuatro Ciénegas Valley -- Section III - Perturbation caused by the overexploitation of the aquifer, conservation and management -- Chapter 16 - Disturbance and the formation and colonization of new habitats in the terminal part of the Churince System -- Chapter 17 - Riparian species and habitats in a semiarid disturbed zone: an unlikely movable feast in the Churince System -- Chapter 18 - Morphological variations of Samolus ebracteatus var. coahuilensis in different microenvironments in the Churince System, in the Cuatrociénegas Basin, Coahuila -- Chapter 19 - Germination of riparian species in natural and experimental conditions -- Chapter 20 - Ecological dynamism of disturbance-induced micro environments in the Churince System, Cuatro Ciénegas, using time series network analyses.
    Kurzfassung: Environmental and specific diversity in the Chihuahuan desert in general, and in the Cuatro Ciénegas Basin in particular, has long been recognized as outstanding. This book provides a global ecological overview, together with in-depth studies of specific processes. The Chihuahuan desert is the warmest in North America, and has a complex geologic, climatic and biogeographical history, which affects today’s distribution of vegetation and plants and generates complex phylogeographic patterns. The high number of endemic species reflects this complex set of traits. The modern distribution of environments, including aquatic and subaquatic systems, riparian environments, gypsum dunes and gypsum-rich soils, low levels of phosphorous and organic matter, and high salinity combined with an extreme climate call for a range of adaptations. Plants are distributed in a patchy pattern based on punctual variations, and many of them respond to different resources and conditions with considerable morphological plasticity. In terms of physiological, morphological and ecological variability, cacti were identified as the most important group in specific environments like bajadas, characterized by high diversity values, while gypsophytes and gypsovagues of different phylogenies, including species with restricted distribution and endemics.
    Materialart: Online-Ressource
    Seiten: XIII, 327 p. 89 illus., 55 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030449636
    Serie: Cuatro Ciénegas Basin: An Endangered Hyperdiverse Oasis,
    DDC: 581.38
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Schlagwort(e): Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Beschreibung / Inhaltsverzeichnis: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Kurzfassung: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Materialart: Online-Ressource
    Seiten: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Ausgabe: 1st ed. 2021.
    ISBN: 9789811602672
    Serie: Advances in Experimental Medicine and Biology, 1322
    DDC: 615
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Schlagwort(e): Food science. ; Food Safety measures. ; Sustainability. ; Food Science. ; Food Safety. ; Sustainability.
    Beschreibung / Inhaltsverzeichnis: Introduction., Chapter 1 - Insects as food and feed -- Chapter 2 - The global market of insects as food and feed -- Chapter 3 - Insects as food and feed: analysis of regulatory experiences in selected non-EU countries -- Chapter 4 - The EU regulatory framework for insects as food and feed and its current constraints -- Conclusions -- References.
    Kurzfassung: Forecasts point out an exponential growth in the global population, which raises concerns over the ability of the current agri-food production systems to meet food demand in the long term. Such a prospect has led international organizations and the scientific community to raise awareness about, and call for, the need to identify additional sources of food to feed the world. From this perspective, insects qualify as a suitable and more environmentally friendly alternative to meat and other foods that are sourced from animal proteins. However, uptake of the production and commercialization of insects as food has been facing regulatory hurdles, consumer skepticism and rejection in many markets. This is particularly true in the context of western societies in which insects do not always constitute part of the local traditional diets. Production and Commercialization of Insects as Food and Feed: identification of the Main Constraints in the European Union analyses and discusses the regulatory state-of-the-art for the production and commercialization of insects as food and feed in the European Union. The EU has been taking concrete legislative steps with a view to opening up its market for insect foods, although some key regulatory constraints still exist today which ultimately prevent the industry sector from growing, consolidating and thriving. The main regulatory constraints in the EU for insects as food include the fragmentation of the EU market as a result of the adoption of different policy solutions by EU Member States for novel foods and the lengthy and complex authorization procedures. Also, ad hoc safety and quality requirements tailored to the needs and specificities of the insect food sector are currently missing. This work constitutes the first comprehensive overview of the evolution and current state-of-the-art of the regulatory framework for insect foods in the EU, based on a multidisciplinary approach that combines science, policy and law. It proposes a legislative roadmap which the EU should follow in order to make its regulatory framework fit for insect foods in the long term by providing a detailed comparison between the current EU legal framework and other regulatory systems of western countries with a view to singling out the markets which are better equipped to address the production and the commercialization of insect foods. The text provides an updated overview of the overall market and of European consumers’ perspectives on the use of insect foods. With the proper legislative steps and consolidation, the EU can be a global leader for insects as food and feed both as a market and as a standard-setting body.
    Materialart: Online-Ressource
    Seiten: XV, 94 p. 67 illus., 66 illus. in color. , online resource.
    Ausgabe: 1st ed. 2021.
    ISBN: 9783030684068
    DDC: 641.3
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Beschreibung / Inhaltsverzeichnis: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression -- Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening -- Ion channels in Lung Cancer -- Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer -- Transportome Malfunctions and the Hallmarks of Pancreatic Cancer -- How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer -- Ion Channels in Glioma Malignancy -- Membrane Transporters and Channels in Melanoma -- Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.
    Kurzfassung: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, and Ahmed Ahidouch Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening Valerio Farfariello, Natalia Prevarskaya, and Dimitra Gkika Ion Channels in Lung Cancer Etmar Bulk, Luca Matteo Todesca, and Albrecht Schwab Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer Giuliano Ciarimboli, Gerit Theil, Joanna Bialek, and Bayram Edemir Transportome Malfunctions and the Hallmarks of Pancreatic Cancer Qi Ling and Holger Kalthoff How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer Christian Stock Ion Channels in Glioma Malignancy Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, and Fabio Franciolini Membrane Transporters and Channels in Melanoma Ines Böhme, Roland Schönherr, Jürgen Eberle, and Anja Katrin Bosserhoff Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application Nagore Del-Río-Ibisate, Rocío Granda-Díaz, Juan P. Rodrigo, Sofía T. Menéndez, and Juana M. García-Pedrero.
    Materialart: Online-Ressource
    Seiten: IX, 427 p. 50 illus., 25 illus. in color. , online resource.
    Ausgabe: 1st ed. 2021.
    ISBN: 9783030909208
    Serie: Reviews of Physiology, Biochemistry and Pharmacology, 181
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Physiology.
    Beschreibung / Inhaltsverzeichnis: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression -- Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression -- Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer -- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues -- Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?.
    Kurzfassung: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression Line O. Elingaard-Larsen, Michala G. Rolver, Ester E. Sørensen, and Stine F. Pedersen Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression Ebbe Boedtkjer Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer Larry Fliegel Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, and Alessandra Fiorio Pla Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism? Christian Stock.
    Materialart: Online-Ressource
    Seiten: XV, 175 p. 40 illus., 20 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030998004
    Serie: Reviews of Physiology, Biochemistry and Pharmacology, 182
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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