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  • 1
    facet.materialart.
    Unknown
    Imprint Nacional
    Print: 1889 – 1985 (Location: A62, Keller, 41/5 - 42/1)
    Formerly as: Annaes do Observatorio do Infante D. Luis : Observacoes dos Postos Meteorologicos  (–)
    Publisher: Imprint Nacional
    Corporation: Observatório Infante D. Luís 〈Lisboa〉
    Topics: Geosciences
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  • 2
    Corporation: Observatório Central Meteorológico Infante D. Luís 〈Lisboa〉
    Topics: Geosciences
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbiology. ; Medical microbiology. ; Diseases Causes and theories of causation. ; Microbiology. ; Medical Microbiology. ; Pathogenesis.
    Description / Table of Contents: Part I. Biology and Evolution of Pseudomonas aeruginosa -- Pseudomonas aeruginosa Pangenome: Core and Accessory Genes of a Highly Resourceful Opportunistic Pathogen -- Iron Homeostasis in Pseudomonas aeruginosa: Targeting Iron Acquisition and Storage as an Antimicrobial Strategy -- Controlling Biofilm Development Through Cyclic di-GMP Signaling -- Pseudomonas aeruginosa Quorum Sensing -- Antibiotic Resistance in Pseudomonas -- Part II. Cell Envelope and Secretion Systems -- Cell Envelope Stress Response in Pseudomonas aeruginosa -- Flagella, Chemotaxis and Surface Sensing -- Antimicrobial Weapons of Pseudomonas aeruginosa -- Pseudomonas aeruginosa Antivirulence Strategies: Targeting the Type III Secretion -- Part III. Pathogenesis and Virulence -- What Makes Pseudomonas aeruginosa a Pathogen? -- Transcriptional Profiling of Pseudomonas aeruginosa Infections -- Molecular Mechanisms Involved in Pseudomonas aeruginosa Bacteremia -- Pseudomonas aeruginosa in the Cystic Fibrosis Lung -- Role of Two Component System Networks in Pseudomonas aeruginosa Pathogenesis -- Mixed Populations and Co-Infection: Pseudomonas aeruginosa and Staphylococcus aureus -- How to Manage Pseudomonas aeruginosa Infections.
    Abstract: This book covers the wide set of well-regulated virulence factors and defense mechanisms of Pseudomonas aeruginosa focusing on stress responses and the evolution of this opportunistic human pathogen. Pseudomonas aeruginosa is responsible for one out of ten hospital infections. Additionally, this Gram-negative bacterium is accountable for persistent infections in immunocompromised individuals and the leading cause of chronic lung infections in cystic fibrosis patients. This book provides insight on the metabolic versatility of Pseudomonas aeruginosa and its mechanisms for biofilm formation that make this organism highly efficient in causing infections. The book invites the readers to learn more about the intrinsic ability of Pseudomonas aeruginosa to resist a wide variety of antimicrobial agents due to the concerted action of multidrug efflux pumps, antibiotic-degrading enzymes, and the low permeability of bacterial cellular envelopes. Particular focus is put on the evolutionary role of different types of protein-secretion systems in pathogenesis, flagella and their role in chemotaxis and surface sensing, and host-pathogen interactions. This book is a useful introduction to the field for junior scientists interested in the biology and pathogenesis of Pseudomonas aeruginosa. It is also an interesting read for advanced scientists and medical specialists working within this field, providing a broader view of the topic beyond their specific area of specialization.
    Type of Medium: Online Resource
    Pages: XVII, 445 p. 69 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031084911
    Series Statement: Advances in Experimental Medicine and Biology, 1386
    DDC: 579
    Language: English
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  • 4
    Keywords: Biodiversity. ; Biotic communities. ; Conservation biology. ; Ecology . ; Zoology. ; Botany. ; Evolution (Biology). ; Biodiversity. ; Ecosystems. ; Conservation Biology. ; Zoology. ; Plant Science. ; Evolutionary Biology.
    Description / Table of Contents: Chapter 1. Biodiversity in the Gulf of Guinea Oceanic Islands: A Synthesis -- Chapter 2. Physical Geography of the Gulf of Guinea Oceanic Islands -- Chapter 3. Classification, Distribution and Biodiversity of Terrestrial Ecosystems in the Gulf of Guinea Oceanic Islands -- Chapter 4. Territory, Economy and Demographic Growth in São Tomé and Príncipe: Anthropogenic Changes in the Environment -- Chapter 5. The History of Biological Research in the Gulf of Guinea Oceanic Islands -- Chapter 6. Biogeography and Evolution in the Oceanic Islands of the Gulf of Guinea -- Chapter 7. Species Ecology in the Gulf of Guinea Oceanic Islands: Distribution, Habitat Preferences, Assemblages and Interactions -- Chapter 8. Fungi of São Tomé and Príncipe: Basidiomycete Mushrooms and Allies -- Chapter 9. The Bryophyte Flora of São Tomé and Príncipe (Gulf of Guinea): Past, Present and Future -- Chapter 10. Diversity of the Vascular Plants of the Gulf of Guinea Oceanic Islands -- Chapter 11. A Checklist of the Arachnids From the Gulf of Guinea Islands (Excluding Ticks and Mites) -- Chapter 12. The Beetles (Coleoptera) of Príncipe, São Tomé and Annobón -- Chapter 13. Butterflies and Skippers (Lepidoptera: Papilionoidea) of the Gulf of Guinea Oceanic Islands -- Chapter 14. Dragonflies and Damselflies (Odonata) of São Tomé, Príncipe, and Annobón -- Chapter 15. Diversity and Distribution of the Arthropod Vectors of the Gulf of Guinea Oceanic Islands -- Chapter 16. Terrestrial Mollusca of the Gulf of Guinea Oceanic Islands -- Chapter 17. The Fishes of the Gulf of Guinea Oceanic Islands -- Chapter 18. The Amphibians of the Gulf of Guinea Oceanic Islands -- Chapter 19. The Terrestrial Reptiles of the Gulf of Guinea Oceanic Islands -- Chapter 20. The Sea Turtles of São Tomé and Príncipe: Diversity, Distribution and Conservation Status -- Chapter 21. The Avifauna of the Gulf of Guinea Oceanic Islands -- Chapter 22. Current Knowledge and Conservation of the Wild Mammals of the Gulf of Guinea Oceanic Islands -- Chapter 23. Cetaceans of São Tomé and Príncipe -- Chapter 24. Biodiversity Conservation in the Gulf of Guinea Oceanic Islands: Recent Progress, Ongoing Challenges, and Future Directions -- Chapter 25. Environmental Education in São Tomé and Príncipe: the Challenges of Owning a Unique Biodiversity -- Chapter 26. A Thriving Future for the Gulf of Guinea Oceanic Islands.
    Abstract: This open access book presents a comprehensive synthesis of the biodiversity of the oceanic islands of the Gulf of Guinea, a biodiversity hotspot off the west coast of Central Africa. Written by experts, the book compiles data from a plethora of sources – archives, museums, bibliography, official reports and previously unpublished data – to provide readers with the most updated information about the biological richness of these islands and the conservation issues they face. The Gulf of Guinea Oceanic Islands (Príncipe, São Tomé and Annobón and surrounding islets) present extraordinary levels of endemism across different animal, fungi and plant groups. This very high endemism likely results from the long geological history of the islands and their proximity to the diversity-rich continent. Many researchers, students and conservationists from across the globe are interested in documenting biodiversity on the islands, understanding the evolutionary origins of this diversity, and mitigating the impacts of global change on this unique archipelago. This book aims to be a primer for a broad audience seeking baseline biodiversity information and to serve as a roadmap for future research efforts aiming to fill knowledge gaps in understanding and conserving the unparalleled biodiversity of the Gulf of Guinea islands.
    Type of Medium: Online Resource
    Pages: XXV, 694 p. 101 illus., 81 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031061530
    DDC: 333.95
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Cancer. ; Immunology. ; Neurology . ; Cell Biology. ; Cancer Biology. ; Immunology. ; Neurology.
    Description / Table of Contents: A View of the Endoplasmic Reticulum Through the Calreticulin Lens -- Structural Analysis of Calreticulin, an Endoplasmic Reticulum-Resident Molecular Chaperone -- The Role of Endoplasmic Reticulum Chaperones in Protein Folding and Quality Control -- Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry -- Endoplasmic Reticulum (ER) and ER-Phagy -- Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum -- Roles of Calreticulin in Protein Folding, Immunity, Calcium Signaling and Cell Transformation -- Impact of Calreticulin and Its Mutants on Endoplasmic Reticulum Function in Health and Disease -- Cancer Biology of the Endoplasmic Reticulum Lectin Chaperones Calreticulin, Calnexin and PDIA3/ERp57 -- Maintenance of Endoplasmic Reticulum Protein Homeostasis in Cancer: Friend or Foe -- IP3 Receptor Biology and Endoplasmic Reticulum Calcium Dynamics in Cancer -- Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders -- Endoplasmic Reticulum Homeostasis and Stress Responses in Caenorhabditis elegans -- Tardigrada: An Emerging Animal Model to Study the Endoplasmic Reticulum Stress Response to Environmental Extremes. .
    Abstract: This book provides a comprehensive overview of the biology of the endoplasmic reticulum (ER) and the associated ER proteins, it discusses their structure, function and signaling mechanisms in the cell and their role in disease. This book also offers insights into the practical aspects of research and demonstrates the use of non-mammalian models to study the structure and function of the ER. Written by leading experts in the field, the book enables readers to gain a thorough understanding of current ER biology. It is intended for scientists and clinical researchers working on the endoplasmic reticulum in all its various roles and facets in health and disease. .
    Type of Medium: Online Resource
    Pages: VIII, 327 p. 27 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030676964
    Series Statement: Progress in Molecular and Subcellular Biology, 59
    DDC: 571.6
    Language: English
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  • 6
    Keywords: Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Description / Table of Contents: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Abstract: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Type of Medium: Online Resource
    Pages: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602672
    Series Statement: Advances in Experimental Medicine and Biology, 1322
    DDC: 615
    Language: English
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  • 7
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.
    Abstract: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges Alina L. Capatina, Dimitris Lagos, and William J. Brackenbury Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk Jerry J. Fan and Xi Huang Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu Ion Transport and Radioresistance Bastian Roth and Stephan M. Huber Ion Transporting Proteins and Cancer: Progress and Perspectives Mustafa B. A. Djamgoz.
    Type of Medium: Online Resource
    Pages: X, 277 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031039942
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 183
    DDC: 610.72
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Botany. ; Soil science. ; Agriculture. ; Plant Science. ; Soil Science.
    Description / Table of Contents: Chapter 1: Man And The Soil - Plant - Atmosphere System -- Chapter 2: Water, The Universal Solvent For Life -- Chapter 3: The Soil As A Water Reservoir For Plants -- Chapter 4: Plant: The Solar Energy Collector -- Chapter 5: Atmosphere: The Fluid Envelope That Covers The Planet Earth -- Chapter 6: The Equilibrium State Of Water In The Systems -- Chapter 7: The Movement Of Water In The Systems -- Chapter 8: Soil Water As A Nutrient Solution -- Chapter 9: Aspects Of The Soil Atmosphere -- Chapter 10: How Heat Is Propagated In The Soil -- Chapter 11: Water Infiltration Into The Soil -- Chapter 12: Water Redistribution After Infiltration Into The Soil -- Chapter 13: Evaporation And Evapotranspiration: The Vapor Losses To The Atmosphere -- Chapter 14: How Do Plants Absorb Soil Water ? -- Chapter 15: The Water Balance In Agricultural And Natural Systems -- Chapter 16: How Plants Absorb Nutrients From The Soil -- Chapter 17: How Soil, Plant And Atmophere Properties Vary In Space And Time In The Spas: An Approach To Geoestatistics -- Chapter 18: Spatial And Temporal Variability Of Spas Attributes: Analysis Of Spatial And Temporal Series -- Index -- .
    Abstract: This textbook presents the concepts and processes involved in the soil-plant-atmosphere system as well as its applications in the water cycle in agriculture. Although reaching the frontier of our knowledge in several subjects, each chapter starts at the graduation level and proceeds to the post-doctoral level. Its more complicated subjects, as math and physics, are well explained, even to readers not well acquainted with these tools. Therefore, it helps students read, understand, and developing their thoughts on these subjects. Instructors also find it an easy book with the needed depth to be adopted in courses related to Soil Physics, Agricultural Management, Environmental Protection, Irrigation and Agrometeorology. It serves also as “lexicon” to engineers and lawyers involved in agricultural, environmental cases.
    Type of Medium: Online Resource
    Pages: XXI, 456 p. 272 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030193225
    DDC: 630
    Language: English
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  • 9
    Keywords: Conservation biology. ; Ecology . ; Biodiversity. ; Environmental policy. ; Environmental education. ; Conservation Biology. ; Biodiversity. ; Environmental Policy. ; Environmental and Sustainability Education.
    Description / Table of Contents: Preface -- 1 A land of illusions and thin air -- 2 The cosmovision of the ancient inhabitants of the desert, a look through the cave painting -- 3 Life in Cuatro Ciénegas, a historical tour of the Coahuila desert between the XVI and XIX centuries, its people, and their relationship with the environment -- 4 Water as a socializing element. Hydraulic culture in New Spain between the 16th and the 18th centuries -- 5 Environmental conservation, water and wetland governance in Mexico -- 6 Cuatro Ciénegas, an aquifer at risk of overexploitation -- 7 Demise of Churince -- 8 Plants as a canary in the mine: A wetland response to ecosystem failure -- 9 Can bacterial populations go extinct? Evolutionary biology and bacterial studies in Cuatro Ciénegas shed light on the extinction process -- 10 Children can save the world, CBTa 22, Rural High school as a social experiment for a sustainable future -- 11 Conservation of the most diverse oasis of the world and the future of our path in the deserts: Lessons from Cuatro Ciénegas to the world -- Index.
    Abstract: This book takes readers on a journey through the history of water in the Coahuila desert. It starts by describing the beauty and mysteries of the landscape, and then explores the rock art of the original desert cultures in Coahuila, offering readers a glimpse of the sacred nature of water in the desert, as well as the rituals surrounding it. Moving on to the colonial times and the post- independence development of the region, it discusses early water management, and explores how water is managed in modern times, as well as the legal complications of the law, and how these faulty laws, designed for less arid regions, have affected a highly diverse wetland, the Cuatro Ciénegas oasis. The book then examines the biological consequences of the water loss for the aquatic plants and animals in Churince – a now extinct system within Cuatro Ciénegas. Further, it addresses how even bacteria can become extinct in this hyper-diverse microbial oasis. Lastly, after this despair and sense of loss, the book provides hope, offering suggestions for how we can transform the future, from a social and educational point of view as well as through good science and changes in policy.
    Type of Medium: Online Resource
    Pages: XVI, 191 p. 63 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030832704
    Series Statement: Cuatro Ciénegas Basin: An Endangered Hyperdiverse Oasis,
    DDC: 333.9516
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Evolution (Biology). ; Plant ecology. ; Plant physiology. ; Plants Development. ; Evolutionary Biology. ; Plant Ecology. ; Plant Physiology. ; Plant Development.
    Description / Table of Contents: Chapter 1 - Introduction: Plant-herbivore interaction -- Section I - The evolution of Plant Defense -- Chapter 2 - Natural selection of plant defense against herbivores in native and non-native ranges -- Chapter 3 - Plant demographic effects of herbivores -- Chapter 4 - Towards a unifying quest for an understanding of tolerance mechanisms to herbivore damage and its eco-evolutionary dynamics -- Chapter 5 - The extended microbiota: how microbes shape plant-herbivore interactions -- Chapter 6 - How plants defend themselves is based on what they remember -- Chapter 7 - Ecological genomics of insect-plant interactions: The case of gall inducing insects -- Chapter 8 - The ecology of inbreeding depression in plant defense -- Chapter 9 - The role of trichomes in plant-herbivore interactions -- Chapter 10 - Resource allocation and defense against herbivores in wild and model plants -- Section II - Community ecology of interactions -- Chapter 11 - Intra-specific variation in plant-arthropod traits and interactions along ecological gradients: evidence from latitudinal studies -- Chapter 12 - Ecosystem engineering by insect herbivores: non-trophic interactions in terrestrial ecosystems -- Chapter 13 - What is a better source? Sex-biased herbivory and its effects on tritrophic interactions -- Chapter 14 - Natural herbivore regulation in tropical agroecosystems: importance of farming practices and landscape structure -- Chapter 15 - Functional Plant Traits and Plant-herbivore Interactions -- Chapter 16 - The evolutionary context of interactions between herbivorous insects, pathogenic fungi and their host plants -- Chapter 17 - Plant domestication and trophic interactions -- Chapter 18 - Defaunation, domestication, and dispersal in plant communities -- Chapter 19 - Meta-analysis of the diversity and structure of understory plant communities in tropical forests impacted by Defaunation -- Chapter 20 - To escape or to defend? The role of enemies in bare and edaphically challenging environments -- Chapter 21 - Plant defense evolution: a macroevolutionary approach in the genus Datura -- Chapter 22 - The evolution and diversification of a neotropical generalist herbivorous: The history of the grasshopper Genus Sphenarium Charpentier, 1842 -- Chapter 23 - Evolution among weevils and their host plants: interaction between the genera Trichobaris LeConte and Datura L -- Chapter 24 - Host chemical divergence is a better predictor of herbivore diversity than latitude -- Chapter 25 - Concluding remarks.
    Abstract: Plant-herbivore interactions are a central topic in evolutionary ecology. Historically, their study has been a cornerstone for coevolutionary theory. Starting from classic ecological studies at the phenotypic level, it has since expanded to molecular and genomic approaches. After a historical perspective, the book’s subsequent chapters cover a wide range of topics: from populations to ecosystems; plant- and herbivore-focused studies; in natural and in man-modified ecosystems; and both micro- and macro-evolutionary levels. All chapters include valuable background information and empirical evidence. Given its scope, the book will be of interest to both students and researchers, and will hopefully stimulate further research in this exciting field of evolutionary biology.
    Type of Medium: Online Resource
    Pages: XIX, 376 p. 48 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030460129
    DDC: 576.8
    Language: English
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