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  • 1
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    Seismicity on the Western Greenland Ice Sheet: Surface Fracture in the Vicinity of Active Moulins (2015)
    Wiley
    Details
    Publikationsdatum: 2015-05-20
    Beschreibung: We analyzed geophone and GPS measurements collected within the ablation zone of the western Greenland Ice Sheet during a ~35 day period of the 2011 melt season to study changes in ice deformation before, during, and after a supraglacial lake drainage event. During rapid lake drainage, ice flow speeds increased to ~400% of winter values, and icequake activity peaked. At times 〉 7 days after drainage, this seismicity developed variability over both diurnal and longer periods (~10 days), while coincident ice speeds fell to ~150% of winter values and showed nightly peaks in spatial variability. Approximately 95% of all detected seismicity in the lake basin and its immediate vicinity was triggered by fracture propagation within near-surface ice (〈330 m deep) that generated Rayleigh waves. Icequakes occurring before and during drainage frequently were collocated with the down flow (west) end of the primary hydrofracture through which the lake drained, but shifted farther west and outside the lake basin after the drainage. We interpret these results to reveal vertical hydrofracture opening and local uplift during the drainage, followed by enhanced seismicity and ice flow on the down-stream side of the lake basin. This down-stream region collocates with InSAR-measured speedup in previous years, and could reflect the migration path of the melt water supplied to the bed by the lake. The diurnal seismic signal can be associated with nightly reductions in surface melt input that increase effective basal pressure and traction, thereby promoting elevated strain in the surficial ice.
    Print ISSN: 0148-0227
    Thema: Geologie und Paläontologie , Physik
    Publiziert von Wiley im Namen von American Geophysical Union (AGU).
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  • 2
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    Seismic multiplet response triggered by melt at Blood Falls, Taylor Glacier, Antarctica (2012)
    Wiley
    Details
    Publikationsdatum: 2012-07-10
    Beschreibung: Meltwater input often triggers a seismic response from glaciers and ice sheets. It is difficult, however, to measure melt production on glaciers directly, while subglacial water storage is not directly observable. Therefore, we document temporal changes in seismicity from a dry-based polar glacier (Taylor Glacier, Antarctica) during a melt season using a synthesis of seismic observation and melt modeling. We record icequakes using a dense six-receiver network of three-component geophones and compare this with melt input generated from a calibrated surface energy balance model. In the absence of modeled surface melt, we find that seismicity is well-described by a diurnal signal composed of microseismic events in lake and glacial ice. During melt events, the diurnal signal is suppressed and seismicity is instead characterized by large glacial icequakes. We perform network-based correlation and clustering analyses of seismic record sections and determine that 18% of melt-season icequakes are repetitive (multiplets). The epicentral locations for these multiplets suggest that they are triggered by meltwater produced near a brine seep known as Blood Falls. Our observations of the corresponding p-wave first motions are consistent with volumetric source mechanisms. We suggest that surface melt enables a persistent pathway through this cold ice to an englacial fracture system that is responsible for brine release episodes from the Blood Falls seep. The scalar moments for these events suggest that the volumetric increase at the source region can be explained by melt input.
    Print ISSN: 0148-0227
    Thema: Geologie und Paläontologie , Physik
    Publiziert von Wiley im Namen von American Geophysical Union (AGU).
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  • 3
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    Inactivation of TNF signaling by rationally designed dominant-negative TNF variants (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-09-27
    Beschreibung: Tumor necrosis factor (TNF) is a key regulator of inflammatory responses and has been implicated in many pathological conditions. We used structure-based design to engineer variant TNF proteins that rapidly form heterotrimers with native TNF to give complexes that neither bind to nor stimulate signaling through TNF receptors. Thus, TNF is inactivated by sequestration. Dominant-negative TNFs represent a possible approach to anti-inflammatory biotherapeutics, and experiments in animal models show that the strategy can attenuate TNF-mediated pathology. Similar rational design could be used to engineer inhibitors of additional TNF superfamily cytokines as well as other multimeric ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steed, Paul M -- Tansey, Malu G -- Zalevsky, Jonathan -- Zhukovsky, Eugene A -- Desjarlais, John R -- Szymkowski, David E -- Abbott, Christina -- Carmichael, David -- Chan, Cheryl -- Cherry, Lisa -- Cheung, Peter -- Chirino, Arthur J -- Chung, Hyo H -- Doberstein, Stephen K -- Eivazi, Araz -- Filikov, Anton V -- Gao, Sarah X -- Hubert, Rene S -- Hwang, Marian -- Hyun, Linus -- Kashi, Sandhya -- Kim, Alice -- Kim, Esther -- Kung, James -- Martinez, Sabrina P -- Muchhal, Umesh S -- Nguyen, Duc-Hanh T -- O'Brien, Christopher -- O'Keefe, Donald -- Singer, Karen -- Vafa, Omid -- Vielmetter, Jost -- Yoder, Sean C -- Dahiyat, Bassil I -- New York, N.Y. -- Science. 2003 Sep 26;301(5641):1895-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Xencor, 111 West Lemon Avenue, Monrovia, CA 91016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14512626" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Substitution ; Animals ; Antigens, CD/metabolism ; Apoptosis ; Arthritis, Experimental/drug therapy ; Biopolymers ; Caspases/metabolism ; Cell Line ; Cell Nucleus/metabolism ; Computer Simulation ; Disease Progression ; Enzyme-Linked Immunosorbent Assay ; Female ; Galactosamine/pharmacology ; HeLa Cells ; Humans ; Liver/drug effects ; NF-kappa B/metabolism ; Point Mutation ; *Protein Engineering ; Rats ; Receptors, Tumor Necrosis Factor/metabolism ; Receptors, Tumor Necrosis Factor, Type I ; Receptors, Tumor Necrosis Factor, Type II ; *Signal Transduction ; Transcription Factor RelA ; Transcription, Genetic ; Tumor Necrosis Factor-alpha/*antagonists & ; inhibitors/genetics/metabolism/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    IRootLab: a free and open-source MATLAB toolbox for vibrational biospectroscopy data analysis (2013)
    Oxford University Press
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    Publikationsdatum: 2013-04-13
    Beschreibung: : IRootLab is a free and open-source MATLAB toolbox for vibrational biospectroscopy (VBS) data analysis. It offers an object-oriented programming class library, graphical user interfaces (GUIs) and automatic MATLAB code generation. The class library contains a large number of methods, concepts and visualizations for VBS data analysis, some of which are introduced in the toolbox. The GUIs provide an interface to the class library, including a module to merge several spectral files into a dataset. Automatic code allows developers to quickly write VBS data analysis scripts and is a unique resource among tools for VBS. Documentation includes a manual, tutorials, Doxygen-generated reference and a demonstration showcase. IRootLab can handle some of the most popular file formats used in VBS. License: GNU-LGPL. Availability: Official website: http://irootlab.googlecode.com/ . Contact: juliotrevisan@gmail.com Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Digitale ISSN: 1460-2059
    Thema: Biologie , Informatik , Medizin
    Publiziert von Oxford University Press
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  • 5
    Digitale Medien
    Digitale Medien
    The isolation of non-collagen protein moiety from dentin collagen (1968)
    Springer
    Calcified tissue international 2 (1968), S. 16-16 
    Details
    ISSN: 1432-0827
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02065198
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  • 6
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    Behavioral Hypotheses of Internal Control (1970)
    Menasha, Wis. : Periodicals Archive Online (PAO)
    The Accounting Review. 45:2 (1970:Apr.) 235 
    Details
    ISSN: 0001-4826
    Thema: Wirtschaftswissenschaften
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5030-1970-045-02-000002
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  • 7
    Digitale Medien
    Digitale Medien
    Frozen Vegetable Quality as Influenced by High Temperature Short Time (HTST) Steam Blanching (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 51 (1986), S. 0 
    Details
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Quality differences in processed vegetables can be controlled with high pressure steam blanching (HTST). In addition, HTST blanching required significantly less energy to blanch vegetables than water blanching. HTST-blanched vegetables displayed quality parameters distinctly different than water-blanched vegetables. Differences in quality parameters were highly dependent upon the vegetable being blanched and the pressure and time of the HTST blanch. The quality of vegetables were similar between water and HTST blanching treatments, but by controlling the pressure and time of the HTST blanch, quality characteristics could be changed to meet individual requirements. High quality frozen vegetables can be produced with HTST steam blanching but quality is dependent upon the particular vegetable and pressure and time of the HTST steam blanch.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.1986.tb13131.x
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  • 8
    Digitale Medien
    Digitale Medien
    Insulin-mediated inhibition of the induction of tyrosine aminotransferase by dexamethasone
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 298 (1992), S. 522-526 
    Details
    ISSN: 0003-9861
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0003-9861(92)90444-2
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  • 9
    Digitale Medien
    Digitale Medien
    Insulin-responsive tyrosine aminotransferase transcription requires multiple promoter regions
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 187 (1992), S. 778-782 
    Details
    ISSN: 0006-291X
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0006-291X(92)91263-P
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  • 10
    Digitale Medien
    Digitale Medien
    Ruthenium(II) complexes of a 2,2'-biphosphinine
    Amsterdam : Elsevier
    Inorganica Chimica Acta 198-200 (1992), S. 437-441 
    Details
    ISSN: 0020-1693
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0020-1693(00)92387-9
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