ALBERT

Description: Searches for transient astrophysical sources often reveal unexpected classes of objects that are useful physical laboratories. In a recent survey for pulsars and fast transients, we have uncovered four millisecond-duration radio transients all more than 40 degrees from the Galactic plane. The bursts' properties indicate that they are of celestial rather than terrestrial origin. Host galaxy and intergalactic medium models suggest that they have cosmological redshifts of 0.5 to 1 and distances of up to 3 gigaparsecs. No temporally coincident x- or gamma-ray signature was identified in association with the bursts. Characterization of the source population and identification of host galaxies offers an opportunity to determine the baryonic content of the universe.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornton, D -- Stappers, B -- Bailes, M -- Barsdell, B -- Bates, S -- Bhat, N D R -- Burgay, M -- Burke-Spolaor, S -- Champion, D J -- Coster, P -- D'Amico, N -- Jameson, A -- Johnston, S -- Keith, M -- Kramer, M -- Levin, L -- Milia, S -- Ng, C -- Possenti, A -- van Straten, W -- New York, N.Y. -- Science. 2013 Jul 5;341(6141):53-6. doi: 10.1126/science.1236789.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, University of Manchester, Manchester, UK. thornton@jb.man.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23828936" target="_blank"〉PubMed〈/a〉

Description: Rapid cycling of reactive nitrogen in the marine boundary layer Nature 532, 7600 (2016). doi:10.1038/nature17195 Authors: Chunxiang Ye, Xianliang Zhou, Dennis Pu, Jochen Stutz, James Festa, Max Spolaor, Catalina Tsai, Christopher Cantrell, Roy L. Mauldin, Teresa Campos, Andrew Weinheimer, Rebecca S. Hornbrook, Eric C. Apel, Alex Guenther, Lisa Kaser, Bin Yuan, Thomas Karl, Julie Haggerty, Samuel Hall, Kirk Ullmann, James N. Smith, John Ortega & Christoph Knote Nitrogen oxides are essential for the formation of secondary atmospheric aerosols and of atmospheric oxidants such as ozone and the hydroxyl radical, which controls the self-cleansing capacity of the atmosphere. Nitric acid, a major oxidation product of nitrogen oxides, has traditionally been considered to be a permanent sink of nitrogen oxides. However, model studies predict higher ratios of nitric acid to nitrogen oxides in the troposphere than are observed. A ‘renoxification’ process that recycles nitric acid into nitrogen oxides has been proposed to reconcile observations with model studies, but the mechanisms responsible for this process remain uncertain. Here we present data from an aircraft measurement campaign over the North Atlantic Ocean and find evidence for rapid recycling of nitric acid to nitrous acid and nitrogen oxides in the clean marine boundary layer via particulate nitrate photolysis. Laboratory experiments further demonstrate the photolysis of particulate nitrate collected on filters at a rate more than two orders of magnitude greater than that of gaseous nitric acid, with nitrous acid as the main product. Box model calculations based on the Master Chemical Mechanism suggest that particulate nitrate photolysis mainly sustains the observed levels of nitrous acid and nitrogen oxides at midday under typical marine boundary layer conditions. Given that oceans account for more than 70 per cent of Earth’s surface, we propose that particulate nitrate photolysis could be a substantial tropospheric nitrogen oxide source. Recycling of nitrogen oxides in remote oceanic regions with minimal direct nitrogen oxide emissions could increase the formation of tropospheric oxidants and secondary atmospheric aerosols on a global scale.

Description: Millisecond pulsars are thought to be neutron stars that have been spun-up by accretion of matter from a binary companion. Although most are in binary systems, some 30% are solitary, and their origin is therefore mysterious. PSR J1719-1438, a 5.7-millisecond pulsar, was detected in a recent survey with the Parkes 64-meter radio telescope. We show that this pulsar is in a binary system with an orbital period of 2.2 hours. The mass of its companion is near that of Jupiter, but its minimum density of 23 grams per cubic centimeter suggests that it may be an ultralow-mass carbon white dwarf. This system may thus have once been an ultracompact low-mass x-ray binary, where the companion narrowly avoided complete destruction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailes, M -- Bates, S D -- Bhalerao, V -- Bhat, N D R -- Burgay, M -- Burke-Spolaor, S -- D'Amico, N -- Johnston, S -- Keith, M J -- Kramer, M -- Kulkarni, S R -- Levin, L -- Lyne, A G -- Milia, S -- Possenti, A -- Spitler, L -- Stappers, B -- van Straten, W -- New York, N.Y. -- Science. 2011 Sep 23;333(6050):1717-20. doi: 10.1126/science.1208890. Epub 2011 Aug 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Astrophysics and Supercomputing and ARC Centre for All-Sky Astrophysics (CAASTRO), Swinburne University of Technology, Post Office Box 218 Hawthorn, VIC 3122, Australia. mbailes@swin.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21868629" target="_blank"〉PubMed〈/a〉

Description: The formation and growth processes of supermassive black holes (SMBHs) are not well constrained. SMBH population models, however, provide specific predictions for the properties of the gravitational-wave background (GWB) from binary SMBHs in merging galaxies throughout the universe. Using observations from the Parkes Pulsar Timing Array, we constrain the fractional GWB energy density (Omega(GW)) with 95% confidence to be Omega(GW)(H0/73 kilometers per second per megaparsec)(2) 〈 1.3 x 10(-9) (where H0 is the Hubble constant) at a frequency of 2.8 nanohertz, which is approximately a factor of 6 more stringent than previous limits. We compare our limit to models of the SMBH population and find inconsistencies at confidence levels between 46 and 91%. For example, the standard galaxy formation model implemented in the Millennium Simulation Project is inconsistent with our limit with 50% probability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shannon, R M -- Ravi, V -- Coles, W A -- Hobbs, G -- Keith, M J -- Manchester, R N -- Wyithe, J S B -- Bailes, M -- Bhat, N D R -- Burke-Spolaor, S -- Khoo, J -- Levin, Y -- Oslowski, S -- Sarkissian, J M -- van Straten, W -- Verbiest, J P W -- Wang, J-B -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):334-7. doi: 10.1126/science.1238012.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Commonwealth Scientific and Industrial Research Organisation (CSIRO) Astronomy and Space Science, Australia Telescope National Facility, Post Office Box 76, Epping, New South Wales 1710, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136962" target="_blank"〉PubMed〈/a〉

Description: Gravitational waves are expected to be radiated by supermassive black hole binaries formed during galaxy mergers. A stochastic superposition of gravitational waves from all such binary systems would modulate the arrival times of pulses from radio pulsars. Using observations of millisecond pulsars obtained with the Parkes radio telescope, we constrained the characteristic amplitude of this background, A(c,yr), to be 〈1.0 x 10(-15) with 95% confidence. This limit excludes predicted ranges for A(c,yr) from current models with 91 to 99.7% probability. We conclude that binary evolution is either stalled or dramatically accelerated by galactic-center environments and that higher-cadence and shorter-wavelength observations would be more sensitive to gravitational waves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shannon, R M -- Ravi, V -- Lentati, L T -- Lasky, P D -- Hobbs, G -- Kerr, M -- Manchester, R N -- Coles, W A -- Levin, Y -- Bailes, M -- Bhat, N D R -- Burke-Spolaor, S -- Dai, S -- Keith, M J -- Oslowski, S -- Reardon, D J -- van Straten, W -- Toomey, L -- Wang, J-B -- Wen, L -- Wyithe, J S B -- Zhu, X-J -- New York, N.Y. -- Science. 2015 Sep 25;349(6255):1522-5. doi: 10.1126/science.aab1910.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Commonwealth Science and Industrial Research Organization (CSIRO) Astronomy and Space Science, Australia Telescope National Facility, Post Office Box 76, Epping, New South Wales 1710, Australia. International Centre for Radio Astronomy Research, Curtin University, Bentley, Western Australia 6102, Australia. ; Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Post Office Box 218, Hawthorn, Victoria 3122, Australia. ; Astrophysics Group, Cavendish Laboratory, JJ Thomson Avenue, Cambridge CB3 0HE, UK. ; Monash Centre for Astrophysics, School of Physics and Astronomy, Monash University, Post Office Box 27, Victoria 3800, Australia. ; Commonwealth Science and Industrial Research Organization (CSIRO) Astronomy and Space Science, Australia Telescope National Facility, Post Office Box 76, Epping, New South Wales 1710, Australia. ; Department of Electrical and Computer Engineering, University of California-San Diego, La Jolla, CA 92093, USA. ; International Centre for Radio Astronomy Research, Curtin University, Bentley, Western Australia 6102, Australia. ; National Radio Astronomical Observatory, Array Operations Center, Post Office Box O, Socorro, NM 87801-0387, USA. ; Commonwealth Science and Industrial Research Organization (CSIRO) Astronomy and Space Science, Australia Telescope National Facility, Post Office Box 76, Epping, New South Wales 1710, Australia. Department of Astronomy, School of Physics, Peking University, Beijing 100871, China. ; Jodrell Bank Centre for Astrophysics, University of Manchester, Manchester M13 9PL, UK. ; Department of Physics, Universitat Bielefeld, Universitatsstrasse 25, D-33615 Bielefeld, Germany. Max-Planck-Institut fur Radioastronomie, Auf dem Hugel 69, 53121 Bonn, Germany. ; Xinjiang Astronomical Observatory, Chinese Academy of Sciences, 150 Science 1-Street, Urumqi, Xinjiang 830011, China. ; School of Physics, University of Western Australia, Crawley, Western Australia 6009, Australia. ; School of Physics, University of Melbourne, Parkville, Victoria 3010, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26404832" target="_blank"〉PubMed〈/a〉

Description: Li et al. (Reports, 18 April 2014, p. 292) proposed a unity nitrous acid (HONO) yield for reaction between nitrogen dioxide and the hydroperoxyl-water complex and suggested a substantial overestimation in HONO photolysis contribution to hydroxyl radical budget. Based on airborne observations of all parameters in this chemical system, we have determined an upper-limit HONO yield of 0.03 for the reaction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ye, Chunxiang -- Zhou, Xianliang -- Pu, Dennis -- Stutz, Jochen -- Festa, James -- Spolaor, Max -- Cantrell, Christopher -- Mauldin, Roy L -- Weinheimer, Andrew -- Haggerty, Julie -- New York, N.Y. -- Science. 2015 Jun 19;348(6241):1326. doi: 10.1126/science.aaa1992.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wadsworth Center, New York State Department of Health, Albany, NY, USA. ; Wadsworth Center, New York State Department of Health, Albany, NY, USA. Department of Environmental Health Sciences, State University of New York, Albany, NY, USA. xianliang.zhou@health.ny.gov. ; Department of Environmental Health Sciences, State University of New York, Albany, NY, USA. ; University of California, Los Angeles, CA, USA. ; University of Colorado, Boulder, CO, USA. ; University of Colorado, Boulder, CO, USA. Department of Physics, University of Helsinki, Helsinki, Finland. ; National Center for Atmosphere Research, Earth System Laboratory, Boulder, CO, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26089507" target="_blank"〉PubMed〈/a〉

Description: Nitrogen oxides are essential for the formation of secondary atmospheric aerosols and of atmospheric oxidants such as ozone and the hydroxyl radical, which controls the self-cleansing capacity of the atmosphere. Nitric acid, a major oxidation product of nitrogen oxides, has traditionally been considered to be a permanent sink of nitrogen oxides. However, model studies predict higher ratios of nitric acid to nitrogen oxides in the troposphere than are observed. A 'renoxification' process that recycles nitric acid into nitrogen oxides has been proposed to reconcile observations with model studies, but the mechanisms responsible for this process remain uncertain. Here we present data from an aircraft measurement campaign over the North Atlantic Ocean and find evidence for rapid recycling of nitric acid to nitrous acid and nitrogen oxides in the clean marine boundary layer via particulate nitrate photolysis. Laboratory experiments further demonstrate the photolysis of particulate nitrate collected on filters at a rate more than two orders of magnitude greater than that of gaseous nitric acid, with nitrous acid as the main product. Box model calculations based on the Master Chemical Mechanism suggest that particulate nitrate photolysis mainly sustains the observed levels of nitrous acid and nitrogen oxides at midday under typical marine boundary layer conditions. Given that oceans account for more than 70 per cent of Earth's surface, we propose that particulate nitrate photolysis could be a substantial tropospheric nitrogen oxide source. Recycling of nitrogen oxides in remote oceanic regions with minimal direct nitrogen oxide emissions could increase the formation of tropospheric oxidants and secondary atmospheric aerosols on a global scale.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ye, Chunxiang -- Zhou, Xianliang -- Pu, Dennis -- Stutz, Jochen -- Festa, James -- Spolaor, Max -- Tsai, Catalina -- Cantrell, Christopher -- Mauldin, Roy L 3rd -- Campos, Teresa -- Weinheimer, Andrew -- Hornbrook, Rebecca S -- Apel, Eric C -- Guenther, Alex -- Kaser, Lisa -- Yuan, Bin -- Karl, Thomas -- Haggerty, Julie -- Hall, Samuel -- Ullmann, Kirk -- Smith, James N -- Ortega, John -- Knote, Christoph -- England -- Nature. 2016 Apr 28;532(7600):489-91. doi: 10.1038/nature17195. Epub 2016 Apr 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wadsworth Center, New York State Department of Health, Albany, New York, USA. ; Department of Environmental Health Sciences, State University of New York, Albany, New York, USA. ; Department of Atmospheric and Oceanic Sciences, University of California, Los Angeles (UCLA), California, USA. ; Department of Atmospheric and Oceanic Sciences, University of Colorado at Boulder, Boulder, Colorado, USA. ; Department of Physics, University of Helsinki, Helsinki, Finland. ; National Center for Atmospheric Research, Boulder, Colorado, USA. ; Pacific Northwest National Laboratory, Richland, Washington, USA. ; NOAA, Earth System Research Laboratory, Chemical Sciences Division, Boulder, Colorado, USA. ; Cooperative Institute for Research in Environmental Sciences, University of Colorado at Boulder, Boulder, Colorado, USA. ; Institute for Meteorology and Geophysics, University of Innsbruck, Innsbruck, Austria. ; University of Eastern Finland, Kuopio, Finland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27064904" target="_blank"〉PubMed〈/a〉

Description: In recent years, millisecond-duration radio signals originating in distant galaxies appear to have been discovered in the so-called fast radio bursts. These signals are dispersed according to a precise physical law and this dispersion is a key observable quantity, which, in tandem with a redshift measurement, can be used for fundamental physical investigations. Every fast radio burst has a dispersion measurement, but none before now have had a redshift measurement, because of the difficulty in pinpointing their celestial coordinates. Here we report the discovery of a fast radio burst and the identification of a fading radio transient lasting ~6 days after the event, which we use to identify the host galaxy; we measure the galaxy's redshift to be z = 0.492 +/- 0.008. The dispersion measure and redshift, in combination, provide a direct measurement of the cosmic density of ionized baryons in the intergalactic medium of OmegaIGM = 4.9 +/- 1.3 per cent, in agreement with the expectation from the Wilkinson Microwave Anisotropy Probe, and including all of the so-called 'missing baryons'. The ~6-day radio transient is largely consistent with the radio afterglow of a short gamma-ray burst, and its existence and timescale do not support progenitor models such as giant pulses from pulsars, and supernovae. This contrasts with the interpretation of another recently discovered fast radio burst, suggesting that there are at least two classes of bursts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keane, E F -- Johnston, S -- Bhandari, S -- Barr, E -- Bhat, N D R -- Burgay, M -- Caleb, M -- Flynn, C -- Jameson, A -- Kramer, M -- Petroff, E -- Possenti, A -- van Straten, W -- Bailes, M -- Burke-Spolaor, S -- Eatough, R P -- Stappers, B W -- Totani, T -- Honma, M -- Furusawa, H -- Hattori, T -- Morokuma, T -- Niino, Y -- Sugai, H -- Terai, T -- Tominaga, N -- Yamasaki, S -- Yasuda, N -- Allen, R -- Cooke, J -- Jencson, J -- Kasliwal, M M -- Kaplan, D L -- Tingay, S J -- Williams, A -- Wayth, R -- Chandra, P -- Perrodin, D -- Berezina, M -- Mickaliger, M -- Bassa, C -- England -- Nature. 2016 Feb 25;530(7591):453-6. doi: 10.1038/nature17140.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Square Kilometre Array Organisation, Jodrell Bank Observatory, SK11 9DL, UK. ; Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Mail H29, PO Box 218, Victoria 3122, Australia. ; Australian Research Council Centre of Excellence for All-sky Astrophysics (CAASTRO), Australia. ; Commonwealth Science and Industrial Research Organisation (CSIRO), Astronomy and Space Science, Australia Telescope National Facility, PO Box 76, Epping, New South Wales 1710, Australia. ; International Centre for Radio Astronomy Research, Curtin University, Bentley, Western Australia 6102, Australia. ; Instituto Nazionale di Astrofisica (INAF)-Osservatorio Astronomico di Cagliari, Via della Scienza 5, I-09047 Selargius (CA), Italy. ; Research School of Astronomy and Astrophysics, Australian National University, Canberra, Australian Capital Territory 2611, Australia. ; Max-Planck-Institut fur Radioastronomie (MPIfR), Auf dem Hugel 69, D-53121 Bonn, Germany. ; Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL, UK. ; National Radio Astronomy Observatory, Socorro, New Mexico, USA. ; Department of Astronomy, the University of Tokyo, Hongo, Tokyo 113-0033, Japan. ; National Astronomical Observatory of Japan, 2 Chome-21-1 Osawa, Mitaka, Tokyo 181-8588, Japan. ; Department of Astronomical Science, SOKENDAI (Graduate University for the Advanced Study), Osawa, Mitaka 181-8588, Japan. ; Subaru Telescope, National Astronomical Observatory of Japan, 650 North A'ohoku Place, Hilo, Hawaii 96720, USA. ; Institute of Astronomy, Graduate School of Science, University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015, Japan. ; Kavli Institute for the Physics and Mathematics of the Universe (WPI), Institutes for Advanced Study, University of Tokyo, Kashiwa, Chiba 277-8583, Japan. ; Department of Physics, Faculty of Science and Engineering, Konan University, 8-9-1 Okamoto, Kobe, Hyogo 658-8501, Japan. ; Cahill Center for Astrophysics, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA. ; Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA. ; National Centre for Radio Astrophysics, Tata Institute of Fundamental Research, Pune University Campus, Ganeshkhind, Pune 411 007, India. ; ASTRON, the Netherlands Institute for Radio Astronomy, Postbus 2, NL-7990 AA Dwingeloo, The Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26911781" target="_blank"〉PubMed〈/a〉

Description: A direct localization of a fast radio burst and its host Nature 541, 7635 (2017). doi:10.1038/nature20797 Authors: S. Chatterjee, C. J. Law, R. S. Wharton, S. Burke-Spolaor, J. W. T. Hessels, G. C. Bower, J. M. Cordes, S. P. Tendulkar, C. G. Bassa, P. Demorest, B. J. Butler, A. Seymour, P. Scholz, M. W. Abruzzo, S. Bogdanov, V. M. Kaspi, A. Keimpema, T. J. W. Lazio, B. Marcote, M. A. McLaughlin, Z. Paragi, S. M. Ransom, M. Rupen, L. G. Spitler & H. J. van Langevelde Fast radio bursts are astronomical radio flashes of unknown physical nature with durations of milliseconds. Their dispersive arrival times suggest an extragalactic origin and imply radio luminosities that are orders of magnitude larger than those of all known short-duration radio transients. So far all fast radio bursts have been detected with large single-dish telescopes with arcminute localizations, and attempts to identify their counterparts (source or host galaxy) have relied on the contemporaneous variability of field sources or the presence of peculiar field stars or galaxies. These attempts have not resulted in an unambiguous association with a host or multi-wavelength counterpart. Here we report the subarcsecond localization of the fast radio burst FRB 121102, the only known repeating burst source, using high-time-resolution radio interferometric observations that directly image the bursts. Our precise localization reveals that FRB 121102 originates within 100 milliarcseconds of a faint 180-microJansky persistent radio source with a continuum spectrum that is consistent with non-thermal emission, and a faint (twenty-fifth magnitude) optical counterpart. The flux density of the persistent radio source varies by around ten per cent on day timescales, and very long baseline radio interferometry yields an angular size of less than 1.7 milliarcseconds. Our observations are inconsistent with the fast radio burst having a Galactic origin or its source being located within a prominent star-forming galaxy. Instead, the source appears to be co-located with a low-luminosity active galactic nucleus or a previously unknown type of extragalactic source. Localization and identification of a host or counterpart has been essential to understanding the origins and physics of other kinds of transient events, including gamma-ray bursts and tidal disruption events. However, if other fast radio bursts have similarly faint radio and optical counterparts, our findings imply that direct subarcsecond localizations may be the only way to provide reliable associations.

Description: Motivation Acute myeloid leukemia (AML) is one of the most common hematological malignancies, characterized by high relapse and mortality rates. The inherent intra-tumor heterogeneity in AML is thought to play an important role in disease recurrence and resistance to chemotherapy. Although experimental protocols for cell proliferation studies are well established and widespread, they are not easily applicable to in vivo contexts, and the analysis of related time-series data is often complex to achieve. To overcome these limitations, model-driven approaches can be exploited to investigate different aspects of cell population dynamics. Results In this work, we present ProCell, a novel modeling and simulation framework to investigate cell proliferation dynamics that, differently from other approaches, takes into account the inherent stochasticity of cell division events. We apply ProCell to compare different models of cell proliferation in AML, notably leveraging experimental data derived from human xenografts in mice. ProCell is coupled with Fuzzy Self-Tuning Particle Swarm Optimization, a swarm-intelligence settings-free algorithm used to automatically infer the models parameterizations. Our results provide new insights on the intricate organization of AML cells with highly heterogeneous proliferative potential, highlighting the important role played by quiescent cells and proliferating cells characterized by different rates of division in the progression and evolution of the disease, thus hinting at the necessity to further characterize tumor cell subpopulations. Availability and implementation The source code of ProCell and the experimental data used in this work are available under the GPL 2.0 license on GITHUB at the following URL: https://github.com/aresio/ProCell. Supplementary information Supplementary data are available at Bioinformatics online.