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Pharmacodynamics and urine pharmacokinetics of three doses of piretanide (1983)

Meyer, B. H. ; Müller, F. O. ; Grigoleit, H.-G. ; [et al.]

Springer

European journal of clinical pharmacology 25 (1983), S. 783-785

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ISSN: 1432-1041

Keywords: piretanide ; urine K+ and Na+ clearance ; pharmacodynamic effects ; pharmacokinetic effects ; diuretic effects ; dose-response relationship ; trial design

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Three doses (3 mg, 6 mg and 12 mg) of piretanide, a new high ceiling diuretic, and placebo were given to 8 volunteers to investigate the relationship between the pharmacodynamic parameters, the dose and its urinary excretion. Intake of food and fluid were standardized from 48 h before until 24 h after drug administration. Urinary output, excretion of unchanged drug, and the excretion and clearance of Na+ and K+ were measured hourly for 7 h after treatment. A clear dose-response relationship was found for cumulative urinary output, cumulative excretion of Na+ and K+, clearance of Na+ and K+ and the urinary sodium/potassium ratio. A significant correlation was found between the net urine volume and the excretion of piretanide per time interval. The clearances of Na+ and K+ were significantly correlated with the excretion of piretanide. Clearance values correlated well with corresponding urine volumes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00542520

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Co2+ and Mn2+ ion locations in doped CsCdCl3 (1983)

Bensekrane, M. ; Goltzene, A. ; Meyer, B. ; [et al.]

Springer

Il nuovo cimento della Società Italiana di Fisica 2 (1983), S. 1964-1970

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ISSN: 0392-6737

Keywords: Electron paramagnetic resonance and relaxation

Source: Springer Online Journal Archives 1860-2000

Topics: Physics

Description / Table of Contents: Riassunto Gli ioni di sostituzione Co2+ e Mn2+ in due diverse posizioni nel Cd nel composto CsCdCl3 sono state studiati usando la risonanza paramagnetica elettronica. L'occupazione preferenziale, Co2+ nel sito CdII, Mn2+ nel sito CdI, è discussa in termini di argomenti di simmetria della chimica dei cristalli.

Abstract: Резюме Используя электронный парамагнитный резонанс, в соединении CsCdCl3 исследуются местоположения ионов замещения Co2+ и Mn2+ в двух различных положениях Cd. В терминах кристалло-химической симметрии обсуждается предпочтительное расположение Co2+ в положении CdII и Mn2+ в положении CdI.

Notes: Summary Substitutional Co2+ and Mn2+ ions at the two different Cd sites in the compound CsCdCl3 have been studied by using electron paramagnetic resonance. The preferential occupation, Co2+ in the CdII site, Mn2+ in the CdI site, is discussed in terms of crystallochemical symmetry arguments.