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Pharmacokinetic aspects of the interaction between clobazam and cimetidine (1983)

Grigoleit, H. -G. ; Hajdú, P. ; Hundt, H. K. L. ; [et al.]

Springer

European journal of clinical pharmacology 25 (1983), S. 139-142

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ISSN: 1432-1041

Keywords: clobazam ; cimetidine ; N-desmethylclobazam ; kinetic interaction ; man

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The pharmacokinetic interaction between clobazam and cimetidine was studied in 9 healthy male volunteers in an open-labelled study. After a single oral dose of clobazam 30 mg, a wash-out period of 14 days was followed by daily doses of cimetidine 1 g for one week. Thereafter a single oral dose of clobazam 30 mg was again given. The plasma concentrations of clobazam and its main metabolite N-desmethyl-clobazam were measured by gas-chromatography. The area under the curve (AUC0−∞) of plasma clobazam level was significantly larger after pretreatment with cimetidine and the elimination half life of clobazam was significantly longer. There were no statistically significant differences in Cmax and tmax for plasma clobazam. The plasma levels of N-desmethyl-clobazam did not show any significant change after the intake of cimetidine.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00544031

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Co2+ and Mn2+ ion locations in doped CsCdCl3 (1983)

Bensekrane, M. ; Goltzene, A. ; Meyer, B. ; [et al.]

Springer

Il nuovo cimento della Società Italiana di Fisica 2 (1983), S. 1964-1970

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ISSN: 0392-6737

Keywords: Electron paramagnetic resonance and relaxation

Source: Springer Online Journal Archives 1860-2000

Topics: Physics

Description / Table of Contents: Riassunto Gli ioni di sostituzione Co2+ e Mn2+ in due diverse posizioni nel Cd nel composto CsCdCl3 sono state studiati usando la risonanza paramagnetica elettronica. L'occupazione preferenziale, Co2+ nel sito CdII, Mn2+ nel sito CdI, è discussa in termini di argomenti di simmetria della chimica dei cristalli.

Abstract: Резюме Используя электронный парамагнитный резонанс, в соединении CsCdCl3 исследуются местоположения ионов замещения Co2+ и Mn2+ в двух различных положениях Cd. В терминах кристалло-химической симметрии обсуждается предпочтительное расположение Co2+ в положении CdII и Mn2+ в положении CdI.

Notes: Summary Substitutional Co2+ and Mn2+ ions at the two different Cd sites in the compound CsCdCl3 have been studied by using electron paramagnetic resonance. The preferential occupation, Co2+ in the CdII site, Mn2+ in the CdI site, is discussed in terms of crystallochemical symmetry arguments.