ISSN:
1432-0983
Keywords:
DNA repair
;
Pyrimidine dimers
;
Epistasis groups
;
Neurospora crassa
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary DNA repair mutants in eucaryotes are normally assigned to three epistasis groups. Each epistasis group represents a “pathway” for DNA repair. The pathways are commonly designated (1) nucleotide excision repair, (2) recombination repair and (3) mutagenic repair. An excision repair epistasis group has been established in Neurospora and the mutants assigned to this group should be limited in their ability to excise pyrimidine dimers and other bulky lesions from DNA. Using a pyrimidine dimer-specific assay, we have found that all Neurospora crassa mutants assigned to the excision repair epistasis group are capable of removing pyrimidine dimers from the DNA at a rate similar to the wild-type organism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00318382
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