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  • Humans  (9)
  • American Association for the Advancement of Science (AAAS)  (9)
  • 2000-2004  (9)
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  • American Association for the Advancement of Science (AAAS)  (9)
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Year
  • 1
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    Livestock diseases and human health (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zinsstag, J -- Weiss, M G -- New York, N.Y. -- Science. 2001 Oct 19;294(5542):477.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11641468" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Diseases/prevention & control/transmission ; Animal Husbandry ; Animal Welfare ; Animals ; *Animals, Domestic ; Cattle ; Encephalopathy, Bovine Spongiform/prevention & control/transmission ; Foot-and-Mouth Disease/prevention & control/transmission ; *Health ; *Health Policy ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Why stem cells? (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-02-26
    Description: Stem cells are viewed from the perspectives of their function, evolution, development, and cause. Counterintuitively, most stem cells may arise late in development, to act principally in tissue renewal, thus ensuring an organism's long-term survival. Surprisingly, recent reports suggest that tissue-specific adult stem cells have the potential to contribute to replenishment of multiple adult tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van der Kooy, D -- Weiss, S -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1439-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada. derek.van.der.kooy@utoronto.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10688784" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Bone Marrow Cells/cytology/physiology ; Cell Differentiation ; Cell Division ; Cell Lineage ; Embryo, Mammalian/cytology ; Germ Cells/cytology/physiology ; Hematopoietic Stem Cells/cytology/physiology ; Humans ; Neurons/cytology ; Stem Cells/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Archaeology. What drives societal collapse? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, H -- Bradley, R S -- New York, N.Y. -- Science. 2001 Jan 26;291(5504):609-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Anthropology and Near Eastern Languages and Civilizations, Yale University, New Haven, CT 06520, USA. harvey.weiss@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11158667" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; *Archaeology ; *Climate ; *Disasters ; Forecasting ; Humans ; *Social Conditions ; Socioeconomic Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Food science. Why is a soggy potato chip unappetizing? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, G -- New York, N.Y. -- Science. 2001 Sep 7;293(5536):1753-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11546850" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cooking ; Elasticity ; Fats/metabolism ; *Food ; Food Analysis ; *Food Preferences/physiology/psychology ; Hot Temperature ; Humans ; Perception ; *Research ; *Sensation ; Smell ; Taste ; Viscosity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Neutrophil extracellular traps kill bacteria (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-06
    Description: Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria. NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinkmann, Volker -- Reichard, Ulrike -- Goosmann, Christian -- Fauler, Beatrix -- Uhlemann, Yvonne -- Weiss, David S -- Weinrauch, Yvette -- Zychlinsky, Arturo -- AI037720/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 5;303(5663):1532-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001782" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appendicitis/immunology ; Bacterial Proteins/metabolism ; Blood Bactericidal Activity ; Cytochalasin D/pharmacology ; Cytoplasmic Granules/metabolism ; DNA/analysis/metabolism ; Dysentery, Bacillary/immunology ; Endopeptidases/metabolism ; Histones/analysis/metabolism ; Humans ; *Immunity, Innate ; Leukocyte Elastase/analysis/metabolism ; Microscopy, Electron ; *Neutrophil Activation ; Neutrophils/chemistry/*immunology/physiology/ultrastructure ; Phagocytosis ; Rabbits ; Salmonella typhimurium/immunology/*physiology ; Shigella flexneri/immunology/*physiology ; Staphylococcus aureus/immunology/*physiology ; Virulence Factors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-08-23
    Description: Helicobacter pylori (Hp) vacuolating cytotoxin VacA induces cellular vacuolation in epithelial cells. We found that VacA could efficiently block proliferation of T cells by inducing a G1/S cell cycle arrest. It interfered with the T cell receptor/interleukin-2 (IL-2) signaling pathway at the level of the Ca2+-calmodulin-dependent phosphatase calcineurin. Nuclear translocation of nuclear factor of activated T cells (NFAT), a transcription factor acting as a global regulator of immune response genes, was abrogated, resulting in down-regulation of IL-2 transcription. VacA partially mimicked the activity of the immunosuppressive drug FK506 by possibly inducing a local immune suppression, explaining the extraordinary chronicity of Hp infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gebert, Bettina -- Fischer, Wolfgang -- Weiss, Evelyn -- Hoffmann, Reinhard -- Haas, Rainer -- New York, N.Y. -- Science. 2003 Aug 22;301(5636):1099-102.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max von Pettenkofer-Institut fur Hygiene und Medizinische Mikrobiologie, LMU Munchen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12934009" target="_blank"〉PubMed〈/a〉
    Keywords: Apoptosis ; Bacterial Proteins/pharmacology/*physiology ; Bacterial Toxins/pharmacology ; Calcineurin/metabolism ; Calcineurin Inhibitors ; Cyclins/metabolism ; Cytotoxins/pharmacology ; DNA-Binding Proteins/genetics/metabolism ; G1 Phase ; Gene Expression Regulation ; HeLa Cells ; Helicobacter pylori/genetics/*pathogenicity ; Humans ; Interleukin-2/genetics/metabolism ; Jurkat Cells ; *Lymphocyte Activation ; NFATC Transcription Factors ; *Nuclear Proteins ; Oligonucleotide Array Sequence Analysis ; S Phase ; Signal Transduction ; T-Lymphocytes/*immunology/*microbiology/physiology ; Tacrolimus/pharmacology ; Transcription Factors/genetics/metabolism ; Transcription, Genetic ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Cancer risks. Acrylamide in food: uncharted territory (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, Giselle -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098675" target="_blank"〉PubMed〈/a〉
    Keywords: Acrylamide/*adverse effects/*analysis/metabolism ; Advisory Committees ; Animals ; *Carcinogens/analysis ; *Cooking ; *Food ; Food Analysis ; Humans ; Neurons/metabolism ; Protein Binding ; Proteins/metabolism ; Temperature ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Public health. European Union plans for its own CDC (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-08-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, Giselle -- New York, N.Y. -- Science. 2003 Aug 1;301(5633):581.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12893917" target="_blank"〉PubMed〈/a〉
    Keywords: Communicable Disease Control ; *European Union ; Humans ; International Cooperation ; Population Surveillance ; *Public Health/economics/manpower ; *Public Health Administration/economics/manpower
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-10-18
    Description: We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as gamma chain (gamma(c)) deficiency] in 9 out of 10 patients by retrovirus-mediated gamma(c) gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncontrolled exponential clonal proliferation of mature T cells (with gammadelta+ or alphabeta+ T cell receptors) has occurred in the two youngest patients. Both patients' clones showed retrovirus vector integration in proximity to the LMO2 proto-oncogene promoter, leading to aberrant transcription and expression of LMO2. Thus, retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hacein-Bey-Abina, S -- Von Kalle, C -- Schmidt, M -- McCormack, M P -- Wulffraat, N -- Leboulch, P -- Lim, A -- Osborne, C S -- Pawliuk, R -- Morillon, E -- Sorensen, R -- Forster, A -- Fraser, P -- Cohen, J I -- de Saint Basile, G -- Alexander, I -- Wintergerst, U -- Frebourg, T -- Aurias, A -- Stoppa-Lyonnet, D -- Romana, S -- Radford-Weiss, I -- Gross, F -- Valensi, F -- Delabesse, E -- Macintyre, E -- Sigaux, F -- Soulier, J -- Leiva, L E -- Wissler, M -- Prinz, C -- Rabbitts, T H -- Le Deist, F -- Fischer, A -- Cavazzana-Calvo, M -- New York, N.Y. -- Science. 2003 Oct 17;302(5644):415-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM Unit 429, Cedex 15, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14564000" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Clinical Trials as Topic ; Clone Cells/physiology ; DNA-Binding Proteins/*genetics ; Gene Expression Regulation ; Gene Transfer Techniques ; Genetic Therapy/*adverse effects ; *Genetic Vectors ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/physiology ; Humans ; Infant ; LIM Domain Proteins ; Leukemia-Lymphoma, Adult T-Cell/*etiology ; Metalloproteins/*genetics ; Mutagenesis, Insertional ; Promoter Regions, Genetic ; Proto-Oncogene Proteins ; Proto-Oncogenes ; Receptors, Interleukin-2/genetics ; Retroviridae/*genetics/physiology ; Severe Combined Immunodeficiency/*therapy ; T-Lymphocytes/*physiology ; Transcription, Genetic ; Virus Integration ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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