Publication Date:
2004-03-06
Description:
Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria. NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinkmann, Volker -- Reichard, Ulrike -- Goosmann, Christian -- Fauler, Beatrix -- Uhlemann, Yvonne -- Weiss, David S -- Weinrauch, Yvette -- Zychlinsky, Arturo -- AI037720/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 5;303(5663):1532-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001782" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Appendicitis/immunology
;
Bacterial Proteins/metabolism
;
Blood Bactericidal Activity
;
Cytochalasin D/pharmacology
;
Cytoplasmic Granules/metabolism
;
DNA/analysis/metabolism
;
Dysentery, Bacillary/immunology
;
Endopeptidases/metabolism
;
Histones/analysis/metabolism
;
Humans
;
*Immunity, Innate
;
Leukocyte Elastase/analysis/metabolism
;
Microscopy, Electron
;
*Neutrophil Activation
;
Neutrophils/chemistry/*immunology/physiology/ultrastructure
;
Phagocytosis
;
Rabbits
;
Salmonella typhimurium/immunology/*physiology
;
Shigella flexneri/immunology/*physiology
;
Staphylococcus aureus/immunology/*physiology
;
Virulence Factors/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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