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  • General, theoretical and mathematical biophysics (including logic of biosystems, quantum biology and relevant aspects of thermodynamics, information theory, cybernetics and bionics)  (2)
  • 61.46. + w  (1)
  • Bleomycin  (1)
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Keywords
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  • 1
    Electronic Resource
    Electronic Resource
    Silver nanoclusters formation in ion-exchanged waveguides by annealing in hydrogen atmosphere (1996)
    Springer
    Applied physics 63 (1996), S. 403-407 
    Details
    ISSN: 1432-0630
    Keywords: 42.70 ; 61.46. + w ; 68.55.Ln
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Light waveguides containing silver, introduced by ion-exchange process in soda-lime glass, has been annealed in hydrogen atmosphere at temperatures in the 120–250°C range. Annealings cause a near-surface precipitation of metallic silver to form nanometer-size clusters with good uniformity in size and spatial distribution. Hydrogen permeation and ion-exchange between hydrogen and sodium (which remains in the glass matrix after silver-for-sodium exchange) are steps of the annealing process. A further step is the diffusion of silver ions towards the surface, and its eventual precipitation, with an activation energy close to that measured for silver-sodium interdiffusion in glasses of comparable composition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01567335
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  • 2
    Electronic Resource
    Electronic Resource
    Secondary structure of T2 intraphage DNA: a spectrophotometric study (1983)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 2 (1983), S. 1480-1488 
    Details
    ISSN: 0392-6737
    Keywords: General, theoretical and mathematical biophysics (including logic of biosystems, quantum biology and relevant aspects of thermodynamics, information theory, cybernetics and bionics)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto In questo lavoro si mettono in evidenza significative differenze nelle proprietà spettrali del DNA di T2 intrafagico e libero in soluzione nell'intervallo (230÷320) nm. Queste differenze sono molto simili a quelle ottenute in una soluzione di DNA nativo abbassando ilpH a partire dal valore neutro. Su questa base si avanza l'ipotesi di una protonazione della citosina nel DNA intrafagico.
    Abstract: Резюме В этой работе рассматриваются различия в спектральных свойствах (в области (230÷320) нм) между внутрифаговыми и свободными T2 ДНК. Эти различия очень сходны с изменениями в поглощении, полученными для естественного раствора ДНК, когдаpH уменьшается по сравнению с нейтральной величиной. На основе этого подхода выдвигается гипотеза протонации цитозина во внутрифаговой ДНК.
    Notes: Summary Relevant differences in the spectral properties (in the (230÷320) nm range) between intraphage and free T2 DNA are reported in this work. These differences are very similar to the variation in absorption obtained for a native DNA solution when thepH is lowered starting from the neutral value. On this basis, cytosine protonation in intraphage DNA is hypothesized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02460226
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  • 3
    Electronic Resource
    Electronic Resource
    UV damage of T2-phage particles and conformation of DNAin situ (1983)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 2 (1983), S. 1489-1496 
    Details
    ISSN: 0392-6737
    Keywords: General, theoretical and mathematical biophysics (including logic of biosystems, quantum biology and relevant aspects of thermodynamics, information theory, cybernetics and bionics)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Si studia l'effetto dell'irraggiamento UV sul DNA del fago T2 in situ e libero in soluzione mediante un'analisi delle modificazioni dei profili di fusione e degli spettri d'assorbimento. L'analogo comportamento fotochimico osservato nei due sistemi sembra escludere significative differenze nella loro struttura secondaria.
    Abstract: Резюме Исследуется влияние ультрафиолетового облучения на ДНК фага T2 на месте и на свободные молекулы ДНК в растворе, посредством анализа изменений профилей плавления и изменений спектров поглощения. Аналогичное фотохимическое ооведение, полученное в этих двух системах, по-видимому, исключает значительные различия между их вторичными структурами.
    Notes: Summary The effect of UV irradiation onin situ and free T2 DNA is studied by analysing the melting profiles and absorption spectra modifications. The similar photochemical behaviour obtained in the two systems seems to exclude significant differences in their secondary structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02460227
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  • 4
    Electronic Resource
    Electronic Resource
    Modulation of bleomycin-induced mitotic recombination in yeast by the aminothiols cysteamine and WR-1065 (1995)
    Springer
    Molecular genetics and genomics 249 (1995), S. 366-374 
    Details
    ISSN: 1617-4623
    Keywords: Bleomycin ; Cysteamine ; WR-1065 ; Saccharomyces ; Antimutagens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The cancer chemotherapy drug bleomycin (BLM) is a potent inducer of genetic damage in a wide variety of assays. The radioprotectors cysteamine (CSM) and WR-1065 have been shown in previous studies to potentiate the induction of micronuclei and chromosome aberrations by BLM in Go human lymphocytes. By contrast, WR-1065 is reported to reduce the induction of hprt mutations by BLM in Chinese hamster cells. To elucidate the basis for these interactions, we examined the effects of CSM and WR-1065 on the induction of mitotic gene conversion by BLM in the yeast Saccharomyces cerevisiae. Treatment with BLM causes a dose-dependent increase in the frequency of mitotic gene conversion and gene mutations. Unlike its potentiation of BLM in G0 lymphocytes, WR-1065 protected against the recombinagenicity of BLM in yeast. CSM was also strongly antirecombinagenic under some conditions., but the nature of the interaction depended strongly on the treatment conditions. Under hypoxic conditions, cysteamine protected against BLM, but under oxygenrich conditions CSM potentiated the genetic activity og BLM. The protective effect of aminothiols against BLM may be ascribed to the depletion of oxygen required for the activation of BLM and the processing of BLM-induced damage. Aminothiols may potentiatc the effect of BLM by acting as an electron source for the activation of BLM and/or by causing conformational alterations that make DNA more accessible tc BLM. The results indicate that aminothiols have a strong modulating influence on the genotoxicity of BLM in yeast as they do in other genetic assays. Moreover, the modulation differs markedly depending on physiological conditions. Thus, yeast assays help to explain why aminothiols have been observed to potentiate BLM in some genetic systems and to protect against it in others.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00287098
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