ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-03-13
    Description: Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snippert, Hugo J -- Haegebarth, Andrea -- Kasper, Maria -- Jaks, Viljar -- van Es, Johan H -- Barker, Nick -- van de Wetering, Marc -- van den Born, Maaike -- Begthel, Harry -- Vries, Robert G -- Stange, Daniel E -- Toftgard, Rune -- Clevers, Hans -- New York, N.Y. -- Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20223988" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Lineage ; Epidermis/cytology ; Gene Expression Profiling ; Gene Knock-In Techniques ; Hair/cytology/embryology/growth & development ; Hair Follicle/*cytology/embryology/growth & development ; Mice ; Mice, Nude ; Receptors, G-Protein-Coupled/*genetics/*metabolism ; Sebaceous Glands/cytology ; Signal Transduction ; Skin/*cytology ; Stem Cell Transplantation ; Stem Cells/*cytology/metabolism ; Wound Healing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-03
    Description: The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains controversial. Studying mouse models, we provide direct, functional evidence for the presence of stem cell activity within primary intestinal adenomas, a precursor to intestinal cancer. By "lineage retracing" using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat-containing heterotrimeric guanine nucleotide-binding protein-coupled receptor 5) also marks a subpopulation of adenoma cells that fuel the growth of established intestinal adenomas. These Lgr5(+) cells, which represent about 5 to 10% of the cells in the adenomas, generate additional Lgr5(+) cells as well as all other adenoma cell types. The Lgr5(+) cells are intermingled with Paneth cells near the adenoma base, a pattern reminiscent of the architecture of the normal crypt niche.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schepers, Arnout G -- Snippert, Hugo J -- Stange, Daniel E -- van den Born, Maaike -- van Es, Johan H -- van de Wetering, Marc -- Clevers, Hans -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):730-5. doi: 10.1126/science.1224676. Epub 2012 Aug 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22855427" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma/genetics/metabolism/*pathology ; Animals ; Biomarkers/analysis ; Cell Lineage ; Cell Transformation, Neoplastic ; Gene Expression Profiling ; Gene Knock-In Techniques ; Genes, Reporter ; Intestinal Mucosa/metabolism/pathology ; Intestinal Neoplasms/genetics/*pathology ; Mice ; Multipotent Stem Cells/pathology/physiology ; Neoplastic Stem Cells/*pathology/*physiology ; Paneth Cells/pathology ; Receptors, G-Protein-Coupled/*analysis ; Stem Cell Niche ; Tamoxifen/pharmacology ; Tumor Stem Cell Assay
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...