Publication Date:
2012-04-07
Description:
Marine stickleback fish have colonized and adapted to thousands of streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop a high-quality reference genome assembly for threespine sticklebacks. By sequencing the genomes of twenty additional individuals from a global set of marine and freshwater populations, we identify a genome-wide set of loci that are consistently associated with marine-freshwater divergence. Our results indicate that reuse of globally shared standing genetic variation, including chromosomal inversions, has an important role in repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during early stages of reproductive isolation. Both coding and regulatory changes occur in the set of loci underlying marine-freshwater evolution, but regulatory changes appear to predominate in this well known example of repeated adaptive evolution in nature.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322419/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322419/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Felicity C -- Grabherr, Manfred G -- Chan, Yingguang Frank -- Russell, Pamela -- Mauceli, Evan -- Johnson, Jeremy -- Swofford, Ross -- Pirun, Mono -- Zody, Michael C -- White, Simon -- Birney, Ewan -- Searle, Stephen -- Schmutz, Jeremy -- Grimwood, Jane -- Dickson, Mark C -- Myers, Richard M -- Miller, Craig T -- Summers, Brian R -- Knecht, Anne K -- Brady, Shannon D -- Zhang, Haili -- Pollen, Alex A -- Howes, Timothy -- Amemiya, Chris -- Broad Institute Genome Sequencing Platform & Whole Genome Assembly Team -- Baldwin, Jen -- Bloom, Toby -- Jaffe, David B -- Nicol, Robert -- Wilkinson, Jane -- Lander, Eric S -- Di Palma, Federica -- Lindblad-Toh, Kerstin -- Kingsley, David M -- 095908/Wellcome Trust/United Kingdom -- P50 HG002568/HG/NHGRI NIH HHS/ -- P50 HG002568-09/HG/NHGRI NIH HHS/ -- P50 HG002568-09S1/HG/NHGRI NIH HHS/ -- P50-HG002568/HG/NHGRI NIH HHS/ -- R01 HG003474/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Apr 4;484(7392):55-61. doi: 10.1038/nature10944.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22481358" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological/*genetics
;
Alaska
;
Animals
;
Aquatic Organisms/genetics
;
*Biological Evolution
;
Chromosome Inversion/genetics
;
Chromosomes/genetics
;
Conserved Sequence/genetics
;
Ecotype
;
Female
;
Fresh Water
;
Genetic Variation/genetics
;
Genome/*genetics
;
Genomics
;
Molecular Sequence Data
;
Seawater
;
Sequence Analysis, DNA
;
Smegmamorpha/*genetics
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
