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  • Meteorology and Climatology  (9)
  • Astrophysics  (3)
  • Female  (3)
  • 2000-2004  (15)
  • 1
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    Gene expression during the life cycle of Drosophila melanogaster (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-28
    Description: Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arbeitman, Michelle N -- Furlong, Eileen E M -- Imam, Farhad -- Johnson, Eric -- Null, Brian H -- Baker, Bruce S -- Krasnow, Mark A -- Scott, Matthew P -- Davis, Ronald W -- White, Kevin P -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2002 Sep 27;297(5590):2270-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12351791" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Cluster Analysis ; Drosophila Proteins/genetics/physiology ; Drosophila melanogaster/embryology/*genetics/*growth & development ; Embryo, Nonmammalian/physiology ; Female ; *Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; *Genes, Insect ; Germ Cells/physiology ; Larva/genetics ; Life Cycle Stages/*genetics ; Male ; Oligonucleotide Array Sequence Analysis ; Organ Specificity ; Pupa/genetics ; RNA, Messenger/genetics/metabolism ; Sex Characteristics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-12-23
    Description: Plasma Abeta42 (amyloid beta42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta42, we used plasma Abeta42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Abeta. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Abeta.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ertekin-Taner, N -- Graff-Radford, N -- Younkin, L H -- Eckman, C -- Baker, M -- Adamson, J -- Ronald, J -- Blangero, J -- Hutton, M -- Younkin, S G -- AG06656/AG/NIA NIH HHS/ -- MH59490/MH/NIMH NIH HHS/ -- P50 AG16574/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2303-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11125143" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/*blood/*genetics ; Amyloid beta-Peptides/*blood/genetics ; Chromosomes, Human, Pair 10/*genetics ; Female ; *Genetic Linkage ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Lod Score ; Male ; Middle Aged ; Pedigree ; Peptide Fragments/*blood/genetics ; Phenotype ; *Quantitative Trait, Heritable
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Matriarchs as repositories of social knowledge in African elephants (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-21
    Description: Despite widespread interest in the evolution of social intelligence, little is known about how wild animals acquire and store information about social companions or whether individuals possessing enhanced social knowledge derive biological fitness benefits. Using playback experiments on African elephants (Loxodonta africana), we demonstrated that the possession of enhanced discriminatory abilities by the oldest individual in a group can influence the social knowledge of the group as a whole. These superior abilities for social discrimination may result in higher per capita reproductive success for female groups led by older individuals. Our findings imply that the removal of older, more experienced individuals, which are often targets for hunters because of their large size, could have serious consequences for endangered populations of advanced social mammals such as elephants and whales.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McComb, K -- Moss, C -- Durant, S M -- Baker, L -- Sayialel, S -- New York, N.Y. -- Science. 2001 Apr 20;292(5516):491-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Psychology, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK. karenm@biols.susx.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11313492" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; *Behavior, Animal ; Biological Evolution ; Conservation of Natural Resources ; *Discrimination (Psychology) ; *Elephants/physiology ; Exploratory Behavior ; Female ; Kenya ; Reproduction ; Social Behavior ; *Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The Influence of Soil Moisture, Coastline Curvature, and Land-Breeze Circulations on Sea-Breeze Initiated Precipitation (2000)
    In:  CASI
    Details
    Publication Date: 2013-08-29
    Description: Idealized numerical simulations are performed with a coupled atmosphere/land-surface model to identify the roles of initial soil moisture, coastline curvature, and land breeze circulations on sea breeze initiated precipitation. Data collected on 27 July 1991 during the Convection and Precipitation Electrification Experiment (CAPE) in central Florida are used. The 3D Goddard Cumulus Ensemble (GCE) cloud resolving model is coupled with the Goddard Parameterization for Land-Atmosphere-Cloud Exchange (PLACE) land surface model, thus providing a tool to simulate more realistically land-surface/atmosphere interaction and convective initiation. Eight simulations are conducted with either straight or curved coast-lines, initially homogeneous soil moisture or initially variable soil moisture, and initially homogeneous horizontal winds or initially variable horizontal winds (land breezes). All model simulations capture the diurnal evolution and general distribution of sea-breeze initiated precipitation over central Florida. The distribution of initial soil moisture influences the timing, intensity and location of subsequent precipitation. Soil moisture acts as a moisture source for the atmosphere, increases the connectively available potential energy, and thus preferentially focuses heavy precipitation over existing wet soil. Strong soil moisture-induced mesoscale circulations are not evident in these simulations. Coastline curvature has a major impact on the timing and location of precipitation. Earlier low-level convergence occurs inland of convex coastlines, and subsequent precipitation occurs earlier in simulations with curved coastlines. The presence of initial land breezes alone has little impact on subsequent precipitation. however, simulations with both coastline curvature and initial land breezes produce significantly larger peak rain rates due to nonlinear interactions.
    Keywords: Meteorology and Climatology
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  • 5
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    Autonomous Sciencecraft Experiment (ASE) Test Operations in 2003 (2003)
    In:  CASI
    Details
    Publication Date: 2017-10-02
    Description: NASA has identified the development of an autonomously operating spacecraft as a necessity for an expanded program of missions exploring the Solar System. The Autonomous Sciencecraft Experiment (ASE) has been selected for flight demonstration by NASA s New Millennium Program (NMP) as part of the Space Technology 6 (ST6) mission. ASE is scheduled to fly on the US Air Force Research Laboratory (AFRL) Techsat-21 constellation in 2006. Tech- Sat-21 consists of three satellites flying in a variable-geometry formation in Earth orbit. Each satellite is equipped with X-band Synthetic Aperture Radar, yielding high spatial resolution images (approx. 3 m) of the Earth s surface. The constellation will fly at an altitude of 550 km, in a 35.4 inclination circular orbit, yielding exact repeat-track observations every 13 days. Prior to full deployment, elements of the versatile ASE spacecraft command and control software, image formation software and science processing software will be utilized and tested on two very different platforms in 2003: AirSAR and EO-1 (described below). Advantages of Autonomous Operations: ASE will demonstrate advanced autonomous science data acquisition, processing, and product downlink prioritization, as well as autonomous spacecraft command and control, and fault detection. The advantages of spacecraft autonomy are to future missions include: (a) making the best use of reduced downlink; (b) the overcoming of communication delays through decisionmaking in situ, enabling fast reaction to dynamic events; (c) an increase of science content per byte of returned data; and (d) an avoidance of return of null (no-change/no feature) datasets: if there is no change detectable between two scenes of the same target, there is no need to return the second dataset.
    Keywords: Astrophysics
    Type: Lunar and Planetary Science XXXIV; LPI-Contrib-1156
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  • 6
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    High-Resolution Mesoscale Simulations of the 6-7 May 2000 Missouri Flash Flood: Impact of Model Initialization and Land Surface Treatment (2004)
    In:  CASI
    Details
    Publication Date: 2018-06-06
    Description: High-resolution mesoscale model simulations of the 6-7 May 2000 Missouri flash flood event were performed to test the impact of model initialization and land surface treatment on timing, intensity, and location of extreme precipitation. In this flash flood event, a mesoscale convective system (MCS) produced over 340 mm of rain in roughly 9 hours in some locations. Two different types of model initialization were employed: 1) NCEP global reanalysis with 2.5-degree grid spacing and 12-hour temporal resolution, and 2) Eta reanalysis with 40- km grid spacing and $hour temporal resolution. In addition, two different land surface treatments were considered. A simple land scheme. (SLAB) keeps soil moisture fixed at initial values throughout the simulation, while a more sophisticated land model (PLACE) allows for r interactive feedback. Simulations with high-resolution Eta model initialization show considerable improvement in the intensity of precipitation due to the presence in the initialization of a residual mesoscale convective vortex (hlCV) from a previous MCS. Simulations with the PLACE land model show improved location of heavy precipitation. Since soil moisture can vary over time in the PLACE model, surface energy fluxes exhibit strong spatial gradients. These surface energy flux gradients help produce a strong low-level jet (LLJ) in the correct location. The LLJ then interacts with the cold outflow boundary of the MCS to produce new convective cells. The simulation with both high-resolution model initialization and time-varying soil moisture test reproduces the intensity and location of observed rainfall.
    Keywords: Meteorology and Climatology
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  • 7
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    Soil Moisture and Mesoscale Convective Complex Development During the 1993 US Midwest Flood: Results from the MM5-PLACE Atmosphere/Land-Surface Model (2000)
    In:  Other Sources
    Details
    Publication Date: 2019-07-27
    Description: The 1993 US Midwest Flood produced record levels of flooding, in the Mississippi River Basin. This flooding resulted from repeated frontal passages and mesoscale convective complexes (MCCs) during the months of June and July. A better understanding of processes that influenced MCC development during the 1993 Flood may lead to improved forecasts of heavy precipitation and flooding. Here, we consider the impact of soil moisture on MCC development during a two-day period (June 23-24) of the 1993 US Midwest Flood. The purpose of this study is to assess the importance of soil moisture distribution on the timing, intensity, and location of heavy precipitation. In this study, the MM5-PLACE Atmosphere/Land-Surface Model is utilized. The atmospheric component consists of the Penn State/NCAR MM5 mesoscale model, and the land-surface component consists of the Goddard Parameterization for Land Atmosphere-Cloud Exchange (PLACE). Initial soil moisture is provided from two sources: 1) NCEP reanalysis, and 2) Antecedent Precipitation Index (API) using NOAA rain gauge measurements as a proxy for soil moisture. NCEP reanalysis provides coarse resolution initial soil moisture (2.5 degree), while API provides high resolution initial soil moisture (10-200 km depending on NOAA rain gauge spacing). Initial results indicate that the distribution of soil moisture has a significant impact on the timing and location of heavy precipitation during this two-day flood event. Precipitation in simulations with high resolution initial soil moisture agrees more closely with observed precipitation. These results suggest that high resolution soil moisture observations are necessary to accurately predict severe storm development, heavy precipitation, and subsequent flooding.
    Keywords: Meteorology and Climatology
    Type: 2001 American Meteorological Society meeting; 14-19 Jan. 2001`; Albuquerque, NM; United States
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  • 8
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    Simulation of the Onset of the Southeast Asian Monsoon during 1997 and 1998: The Impact of Surface Processes (2004)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: The onset of the southeast Asian monsoon during 1997 and 1998 was simulated with a coupled mesoscale atmospheric model (MM5) and a detailed land surface model. The rainfall results from the simulations were compared with observed satellite data from the TRMM (Tropical Rainfall Measuring Mission) TMI (TRMM Microwave Imager) and GPCP (Global Precipitation Climatology Project). The simulation with the land surface model captured basic signatures of the monsoon onset processes and associated rainfall statistics. The sensitivity tests indicated that land surface processes had a greater impact on the simulated rainfall results than that of a small sea surface temperature change during the onset period. In both the 1997 and 1998 cases, the simulations were significantly improved by including the land surface processes. The results indicated that land surface processes played an important role in modifying the low-level wind field over two major branches of the circulation; the southwest low-level flow over the Indo-China peninsula and the northern cold front intrusion from southern China. The surface sensible and latent heat exchange between the land and atmosphere modified the low-level temperature distribution and gradient, and therefore the low-level. The more realistic forcing of the sensible and latent heat from the detailed land surface model improved the monsoon rainfall and associated wind simulation. The model results will be compared to the simulation of the 6-7 May 2000 Missouri flash flood event. In addition, the impact of model initialization and land surface treatment on timing, intensity, and location of extreme precipitation will be examined.
    Keywords: Meteorology and Climatology
    Type: 7th Workshop on Regional Climate Simulation; Sep 27, 2004 - Sep 29, 2004; Jhong-Li; Taiwan, Province of China
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  • 9
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    Simulation of the Onset of the Southeast Asian Monsoon During 1997 and 1998: The Impact of Surface Processes (2004)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: The onset of the southeast Asian monsoon during 1997 and 1998 was simulated with a coupled mesoscale atmospheric model (MM5) and a detailed land surface model. The rainfall results from the simulations were compared with observed satellite data from the TRMM (Tropical Rainfall Measuring Mission) TMI (TRMM Microwave Imager) and GPCP (Global Precipitation Climatology Project). The simulation with the land surface model captured basic signatures of the monsoon onset processes and associated rainfall statistics. The sensitivity tests indicated that land surface processes had a greater impact on the simulated rainfall results than that of a small sea surface temperature change during the onset period. In both the 1997 and 1998 cases, the simulations were significantly improved by including the land surface processes. The results indicated that land surface processes played an important role in modifying the low-level wind field over two major branches of the circulation; the southwest low-level flow over the Indo-China peninsula and the northern cold front intrusion from southern China. The surface sensible and latent heat exchange between the land and atmosphere modified the low-level temperature distribution and gradient, and therefore the low-level. The more realistic forcing of the sensible and latent heat from the detailed land surface model improved the monsoon rainfall and associated wind simulation. The model results will be compared to the simulation of the 6-7 May 2000 Missouri flash flood event. In addition, the impact of model initialization and land surface treatment on timing, intensity, and location of extreme precipitation will be examined.
    Keywords: Meteorology and Climatology
    Type: 7th Workshop on Regional Climate Simulation; Oct 04, 2004 - Oct 06, 2004; Cjimg-Li; Taiwan, Province of China
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  • 10
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    Evolving a Puncture Black Hole with Fixed Mesh Refinement (2004)
    In:  CASI
    Details
    Publication Date: 2019-07-10
    Description: We present a detailed study of the effects of mesh refinement boundaries on the convergence and stability of simulations of black hole spacetimes. We find no technical problems. In our applications of this technique to the evolution of puncture initial data, we demonstrate that it is possible to simulaneously maintain second order convergence near the puncture and extend the outer boundary beyond 100M, thereby approaching the asymptotically flat region in which boundary condition problems are less difficult.
    Keywords: Astrophysics
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