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  • 1
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    Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-30
    Description: Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437729/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437729/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Q -- Schwarz, J -- Bucana, C -- Olson, E N -- R01 HL053351/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1997 May 30;276(5317):1404-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9148, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9162005" target="_blank"〉PubMed〈/a〉
    Keywords: Acyltransferases/metabolism ; Animals ; Gene Expression Regulation, Developmental ; Gene Targeting ; Heart/*embryology ; Heart Ventricles/cytology/embryology ; In Situ Hybridization ; MEF2 Transcription Factors ; Mice ; Mice, Inbred C57BL ; *Morphogenesis/genetics/physiology ; Mutagenesis ; Myocardium/cytology ; Myogenic Regulatory Factors/genetics/*physiology ; Stem Cells
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Type VII collagen is required for Ras-driven human epidermal tumorigenesis (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-19
    Description: Type VII collagen defects cause recessive dystrophic epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers. To study the role of collagen VII in these cancers, we examined Ras-driven tumorigenesis in RDEB keratinocytes. Cells devoid of collagen VII did not form tumors in mice, whereas those retaining a specific collagen VII fragment (the amino-terminal noncollagenous domain NC1) were tumorigenic. Forced NC1 expression restored tumorigenicity to collagen VII-null epidermis in a non-cell-autonomous fashion. Fibronectin-like sequences within NC1 (FNC1) promoted tumor cell invasion in a laminin 5-dependent manner and were required for tumorigenesis. Tumor-stroma interactions mediated by collagen VII thus promote neoplasia, and retention of NC1 sequences in a subset of RDEB patients may contribute to their increased susceptibility to squamous cell carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ortiz-Urda, Susana -- Garcia, John -- Green, Cheryl L -- Chen, Lei -- Lin, Qun -- Veitch, Dallas P -- Sakai, Lynn Y -- Lee, Hyangkyu -- Marinkovich, M Peter -- Khavari, Paul A -- AR43799/AR/NIAMS NIH HHS/ -- AR44012/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1773-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774758" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Antibodies/immunology ; Apoptosis ; Carcinoma, Squamous Cell/etiology/*physiopathology ; Cell Adhesion Molecules/immunology/metabolism ; Cell Proliferation ; Cell Transformation, Neoplastic ; Child ; Collagen Type VII/chemistry/*genetics/immunology/*physiology ; Disease Susceptibility ; Epidermolysis Bullosa Dystrophica/complications/*genetics/metabolism/pathology ; Female ; *Genes, ras ; Humans ; I-kappa B Proteins/genetics/metabolism ; Keratinocytes/*metabolism/pathology ; Male ; Mice ; Mice, SCID ; Middle Aged ; Mutation ; Neoplasm Invasiveness ; Protein Structure, Tertiary ; Skin Neoplasms/etiology/pathology/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Amphibious flies and paedomorphism in the Jurassic period (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-02-22
    Description: The species of the Strashilidae (strashilids) have been the most perplexing of fossil insects from the Jurassic period of Russia and China. They have been widely considered to be ectoparasites of pterosaurs or feathered dinosaurs, based on the putative presence of piercing and sucking mouthparts and hind tibio-basitarsal pincers purportedly used to fix onto the host's hairs or feathers. Both the supposed host and parasite occur in the Daohugou beds from the Middle Jurassic epoch of China (approximately 165 million years ago). Here we analyse the morphology of strashilids from the Daohugou beds, and reach markedly different conclusions; namely that strashilids are highly specialized flies (Diptera) bearing large membranous wings, with substantial sexual dimorphism of the hind legs and abdominal extensions. The idea that they belong to an extinct order is unsupported, and the lineage can be placed within the true flies. In terms of major morphological and inferred behavioural features, strashilids resemble the recent (extant) and relict members of the aquatic fly family Nymphomyiidae. Their ontogeny are distinguished by the persistence in adult males of larval abdominal respiratory gills, representing a unique case of paedomorphism among endopterygote insects. Adult strashilids were probably aquatic or amphibious, shedding their wings after emergence and mating in the water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Diying -- Nel, Andre -- Cai, Chenyang -- Lin, Qibin -- Engel, Michael S -- England -- Nature. 2013 Mar 7;495(7439):94-7. doi: 10.1038/nature11898. Epub 2013 Feb 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China. dyhuang@nigpas.ac.cn〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23426262" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aquatic Organisms/physiology ; China ; Dinosaurs/parasitology ; Diptera/*anatomy & histology/growth & development/*physiology ; Female ; *Fossils ; *Freshwater Biology ; Gills ; Larva ; Male ; *Models, Biological ; Sexual Behavior, Animal ; Wings, Animal
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Dopaminergic neurons protected from degeneration by GDNF gene therapy (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-07
    Description: Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6-hydroxydopamine (6-OHDA) injected into the striatum. Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Choi-Lundberg, D L -- Lin, Q -- Chang, Y N -- Chiang, Y L -- Hay, C M -- Mohajeri, H -- Davidson, B L -- Bohn, M C -- NS31957/NS/NINDS NIH HHS/ -- T32AG00107/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):838-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Anatomy, University of Rochester, Box 603, 601 Elmwood Avenue, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9012352" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviridae/genetics ; Animals ; Corpus Striatum/metabolism/pathology ; Dopamine/*physiology ; Gene Expression ; *Genetic Therapy ; Genetic Vectors ; Glial Cell Line-Derived Neurotrophic Factor ; Humans ; Male ; Molecular Sequence Data ; *Nerve Degeneration ; *Nerve Growth Factors ; Nerve Tissue Proteins/*genetics ; Neurons/pathology/physiology ; *Neuroprotective Agents ; Oxidopamine ; PC12 Cells ; Parkinson Disease/pathology/*therapy ; Rats ; Rats, Inbred F344 ; Substantia Nigra/metabolism/pathology ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Quantitative Characterization of the Nanoscale Local Lattice Strain Induced by Sr Dopants in ${\mathrm{La}}_{1.92}{\mathrm{Sr}}_{0.08}{\mathrm{CuO}}_{4}$ (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-05-12
    Description: Author(s): J. Q. Lin, X. Liu, E. Blackburn, S. Wakimoto, H. Ding, Z. Islam, and S. K. Sinha The nanometer scale lattice deformation brought about by the dopants in the high temperature superconducting cuprate La 2 − x Sr x CuO 4 ( x = 0.08 ) was investigated by measuring the associated x -ray diffuse scattering around multiple Bragg peaks. A characteristic diffuse scattering pattern was observed, whic... [Phys. Rev. Lett. 120, 197001] Published Fri May 11, 2018
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Human adult germline stem cells in question (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-06-26
    Description: Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data and comparing the expression of pluripotency marker genes in haGSCs and hESCs, and in haGSCs and human fibroblast samples derived from different laboratories, including our own. We find that haGSCs and fibroblasts have a similar gene-expression profile, but that haGSCs and hESCs do not. The pluripotency of Conrad and colleagues' haGSCs is therefore called into question.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ko, Kinarm -- Arauzo-Bravo, Marcos J -- Tapia, Natalia -- Kim, Julee -- Lin, Qiong -- Bernemann, Christof -- Han, Dong Wook -- Gentile, Luca -- Reinhardt, Peter -- Greber, Boris -- Schneider, Rebekka K -- Kliesch, Sabine -- Zenke, Martin -- Scholer, Hans R -- England -- Nature. 2010 Jun 24;465(7301):E1; discussion E3. doi: 10.1038/nature09089.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Munster 48149, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20577160" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Biomarkers/analysis ; Biopsy ; Cells, Cultured ; Embryonic Stem Cells/cytology/metabolism ; Fibroblasts/cytology/metabolism ; Gene Expression Profiling ; Germ Cells/*cytology ; Humans ; Induced Pluripotent Stem Cells/*cytology/*metabolism ; Male ; Mice ; RNA, Messenger/analysis/genetics ; Reproducibility of Results ; Testis/cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Incoherent c-Axis Interplane Response of the Iron Chalcogenide FeTe_{0.55}Se_{0.45} Superconductor from Infrared Spectroscopy (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-05-24
    Description: Author(s): S. J. Moon, C. C. Homes, A. Akrap, Z. J. Xu, J. S. Wen, Z. W. Lin, Q. Li, G. D. Gu, and D. N. Basov We report on the interplane c -axis electronic response of FeTe 0.55 Se 0.45 investigated by infrared spectroscopy. We find that the normal-state c -axis electronic response of FeTe 0.55 Se 0.45 is incoherent and bears significant similarities to those of mildly underdoped cuprates. The c -axis optical condu... [Phys. Rev. Lett. 106, 217001] Published Mon May 23, 2011
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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