Publication Date:
1997-02-07
Description:
Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6-hydroxydopamine (6-OHDA) injected into the striatum. Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Choi-Lundberg, D L -- Lin, Q -- Chang, Y N -- Chiang, Y L -- Hay, C M -- Mohajeri, H -- Davidson, B L -- Bohn, M C -- NS31957/NS/NINDS NIH HHS/ -- T32AG00107/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):838-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Anatomy, University of Rochester, Box 603, 601 Elmwood Avenue, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9012352" target="_blank"〉PubMed〈/a〉
Keywords:
Adenoviridae/genetics
;
Animals
;
Corpus Striatum/metabolism/pathology
;
Dopamine/*physiology
;
Gene Expression
;
*Genetic Therapy
;
Genetic Vectors
;
Glial Cell Line-Derived Neurotrophic Factor
;
Humans
;
Male
;
Molecular Sequence Data
;
*Nerve Degeneration
;
*Nerve Growth Factors
;
Nerve Tissue Proteins/*genetics
;
Neurons/pathology/physiology
;
*Neuroprotective Agents
;
Oxidopamine
;
PC12 Cells
;
Parkinson Disease/pathology/*therapy
;
Rats
;
Rats, Inbred F344
;
Substantia Nigra/metabolism/pathology
;
Transgenes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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