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  • 1
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    Cell biology. Bacterial spelunkers (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-19
    Description: Bacteria that are engulfed by phagocytic cells of the immune system are usually destroyed once inside the host cell but not always. Why is it that sometimes engulfed bacteria survive and thrive quite happily inside the host cell? As Mulvey and Hultgren explain in their Perspective, the answer may lie in small indentations in the host cell plasma membrane called caveolae that direct certain signal transduction pathways inside the host cell (Shin et al.). If bacteria adhere to regions of the host cell surface that is rich in caveolae, they are better able to survive once inside the cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mulvey, M A -- Hultgren, S J -- New York, N.Y. -- Science. 2000 Aug 4;289(5480):732-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110-1093, USA. mulvey@borcim.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10950716" target="_blank"〉PubMed〈/a〉
    Keywords: Adhesins, Bacterial/metabolism ; *Adhesins, Escherichia coli ; Animals ; Antigens, CD/metabolism ; Bacterial Adhesion ; Caveolin 1 ; *Caveolins ; Cell Membrane/chemistry/*metabolism/microbiology/ultrastructure ; *Endocytosis ; Escherichia coli/*metabolism/pathogenicity ; *Fimbriae Proteins ; Glycosylphosphatidylinositols/metabolism ; Macrophages/microbiology ; Mast Cells/metabolism/*microbiology/ultrastructure ; Membrane Proteins/analysis ; Mice ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-25
    Description: Virtually all uropathogenic strains of Escherichia coli, the primary cause of cystitis, assemble adhesive surface organelles called type 1 pili that contain the FimH adhesin. Sera from animals vaccinated with candidate FimH vaccines inhibited uropathogenic E. coli from binding to human bladder cells in vitro. Immunization with FimH reduced in vivo colonization of the bladder mucosa by more than 99 percent in a murine cystitis model, and immunoglobulin G to FimH was detected in urinary samples from protected mice. Furthermore, passive systemic administration of immune sera to FimH also resulted in reduced bladder colonization by uropathogenic E. coli. This approach may represent a means of preventing recurrent and acute infections of the urogenital mucosa.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Langermann, S -- Palaszynski, S -- Barnhart, M -- Auguste, G -- Pinkner, J S -- Burlein, J -- Barren, P -- Koenig, S -- Leath, S -- Jones, C H -- Hultgren, S J -- R01DK51406/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1997 Apr 25;276(5312):607-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MedImmune, Inc., Gaithersburg, MD 20878, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9110982" target="_blank"〉PubMed〈/a〉
    Keywords: Adhesins, Bacterial/*immunology/metabolism ; *Adhesins, Escherichia coli ; Animals ; Antibodies, Bacterial/analysis/immunology ; Bacterial Adhesion ; *Bacterial Vaccines/administration & dosage/immunology ; Child ; Cystitis/immunology/*prevention & control ; Epithelium/microbiology ; Escherichia coli/immunology/metabolism/pathogenicity ; Escherichia coli Infections/immunology/*prevention & control ; Female ; *Fimbriae Proteins ; Fimbriae, Bacterial/immunology ; Humans ; Immunity, Mucosal ; Mice ; Mice, Inbred C3H ; Neutrophils/immunology ; Rabbits ; Urinary Bladder/microbiology ; Vaccination ; *Vaccines, Synthetic/administration & dosage/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-11-20
    Description: Virtually all uropathogenic strains of Escherichia coli encode filamentous surface adhesive organelles called type 1 pili. High-resolution electron microscopy of infected mouse bladders revealed that type 1 pilus tips interacted directly with the lumenal surface of the bladder, which is embedded with hexagonal arrays of integral membrane glycoproteins known as uroplakins. Attached pili were shortened and facilitated intimate contact of the bacteria with the uroplakin-coated host cells. Bacterial attachment resulted in exfoliation of host bladder epithelial cells as part of an innate host defense system. Exfoliation occurred through a rapid apoptosis-like mechanism involving caspase activation and host DNA fragmentation. Bacteria resisted clearance in the face of host defenses within the bladder by invading into the epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mulvey, M A -- Lopez-Boado, Y S -- Wilson, C L -- Roth, R -- Parks, W C -- Heuser, J -- Hultgren, S J -- AI09787/AI/NIAID NIH HHS/ -- R01AI29549/AI/NIAID NIH HHS/ -- R01DK51406/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1998 Nov 20;282(5393):1494-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Microbiology and Microbial Pathogenesis, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9822381" target="_blank"〉PubMed〈/a〉
    Keywords: Adhesins, Bacterial/metabolism ; *Adhesins, Escherichia coli ; Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Apoptosis ; Bacterial Adhesion ; Caspase Inhibitors ; Caspases/metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Cystitis/*microbiology/pathology ; DNA Fragmentation ; Escherichia coli/genetics/*pathogenicity ; Escherichia coli Infections/*microbiology/pathology ; Female ; *Fimbriae Proteins ; Fimbriae, Bacterial/physiology/ultrastructure ; In Situ Nick-End Labeling ; Membrane Glycoproteins/analysis/metabolism ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Tetraspanins ; Urinary Bladder/chemistry/*microbiology/pathology ; Uroplakin Ib ; Urothelium/microbiology/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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