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  • Springer  (114)
  • 1
    Electronic Resource
    Electronic Resource
    Treatment of Cells with Detergent Activates Caspases and Induces Apoptotic Cell Death (2000)
    Springer
    The journal of membrane biology 175 (2000), S. 181-189 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Detergent — Triton X-100 — Nonidet P-40 — n-Octylglucoside — Sodium deoxycholate — Apoptosis — Caspase — Jurkat T lymphoblast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Due to their amphiphilic properties, detergents readily disrupt cellular membranes and cause rapid cytolysis. In this study we demonstrate that treatment of cells with sublytic concentrations of detergents such as Triton X-100, Nonidet P-40, n-octylglucoside and the bile salt sodium deoxycholate induce typical signs of apoptosis including DNA fragmentation and cleavage of poly(ADP-ribose) polymerase molecules. The detergent concentration required for apoptosis was below the critical micellar concentration. Induction of apoptosis was not restricted to human cells but similarly occurred in a variety of other vertebrate cell lines. Unstimulated peripheral blood mononuclear cells were susceptible to apoptosis induction by detergent suggesting that apoptosis in this circumstance is not mediated by CD95. Cell death was not due to influx of calcium from the medium. Apoptosis was blocked and cytolysis prevented by treatment with peptide inhibitors of caspases. These findings suggest a process of apoptosis that is initiated upon nonspecific alterations at the cell membrane level. Physiologic correlates of this process still have to be defined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00232001066
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  • 2
    Electronic Resource
    Electronic Resource
    Characterisation of the alpha-1-antitrypsin M3 gene, a normal variant (1990)
    Springer
    Human genetics 〈Berlin〉 85 (1990), S. 381-382 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary By sequence analysis of the complete proteincoding region of the human alpha-1-antitrypsin gene using polymerase chain reaction techniques, we have characterised one of the normal variants, M3. We have identified a single point mutation between M1 Va1213 and M3 at codon position 376 which is a GAA(Glu) to GAC(Asp) transversion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206766
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  • 3
    Electronic Resource
    Electronic Resource
    PGD Port Elizabeth: A new variant found in South Africa (1992)
    Springer
    Human genetics 〈Berlin〉 88 (1992), S. 709-709 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new 6-phosphogluconate dehydrogenase variant tentatively named PGD Port Elizabeth is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265307
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  • 4
    Electronic Resource
    Electronic Resource
    DNA polymorphisms associated with a new α1-antitrypsin PI Q0 variant (PI Q0riedenburg) (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 522-524 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new PI Q0 variant (PI Q0riedenburg) is described; it is caused by a complete deletion of the α1-antitrypsin (α1AT) gene. The deletion gives rise to four new restriction fragment length polymorphisms (RFLPs) detected with a genomic probe of the 5′ region of the gene. Analysis of the RFLPs indicates that the deletion starts immediately upstream of exon Ic. The deletion extends into the 3′ flanking region of the gene but does not include the α1AT-related gene (the PIL gene), which is located 12 kb downstream of the α1AT gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194647
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of fluvastatin therapy on lipids, antioxidants, oxidation of low density lipoproteins and trace metals (1997)
    Springer
    European journal of clinical pharmacology 53 (1997), S. 65-69 
    Details
    ISSN: 1432-1041
    Keywords: Key words Fluvastatin ; LDL oxidation; plasma trace metals ; α-tocopherol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Oxidation of low density lipoproteins (LDL) is thought to be an important step in the development of atherosclerosis. Trace metals are involved in oxidative processes. It was of interest to determine whether lipid-lowering therapy with fluvastatin, a potent HMGCoA reductase inhibitor, affected LDL oxidation and trace metal levels. Methods: Twenty hypercholesterolemic patients were treated with fluvastatin (40 mg twice daily) or placebo for 8 weeks in a double-blind, randomized study. LDL composition, antioxidants and oxidizability as well as plasma zinc, copper, selenium and manganese concentrations were investigated. Results: After fluvastatin treatment, total cholesterol was reduced by 24%, triglycerides fell by 26% and plasma Zn fell by 8%. Cu, Se and Mn changed insignificantly. LDL were separated by ultracentrifugation. LDL were reduced by 18%, LDL-C by 29% and LDL-TG by 19%. The concentrations of α-tocopherol and retinol in LDL changed insignificantly. LDL preparations were incubated with copper ions (204 μmol · l−1 LDL-C/3.2 μmol · l−1 Cu) and formation of conjugated dienes was monitored at 234 nm for 5 h. Treatment with fluvastatin caused a reduction of diene production by 16% and of diene production rate by 14%, effects being significantly different from placebo (P=0.02). The change of the lagtime did not reach significance; however, it was positively correlated with the change in LDL α-tocopherol. In the placebo group, no significant effects were observed. Conclusion: Fluvastatin therapy had lipid-lowering and antioxidative effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050338
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  • 6
    Electronic Resource
    Electronic Resource
    Co-dergocrine mesylate inhibits the increase in plasma catecholamines caused by nifedipine in essential hypertension (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 435-439 
    Details
    ISSN: 1432-1041
    Keywords: co-dergocrine mesylate ; hypertension ; aldosterone ; catecholamines ; nifedipine ; renin side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Co-dergocrine mesylate (Cod), which inhibits norepinephrine secretion by stimulating presynaptic dopamine receptors, and has no known metabolic side effect, has an additive antihypertensive effect to that of Nifedipine (Nif). Plasma norepinephrine, epinephrine, renin activity and aldosterone have been measured after acute administration of Nif and Cod alone and in combination to 18 patients with a diastolic blood pressure 〉 105 mm Hg in a cross-over, randomized, double-blind study. Every patient received 4 mg Cod then 20 mg Nif, placebo then 20 mg Nif and 4 mg Cod then placebo. The second treatment was always given 1 h after the first medication. Blood pressure was measured before and every 15 min during the study period. Blood for measurement of catecholamines, aldosterone and renin activity was collected before medication, 1 h after the first dose and 90 min after the second treatment. Blood pressure was significantly lower (P 〈 0.05) where Cod preceded Nif. Cod caused a significant decrease in plasma norepinephrine from 293 to 202 pg · ml−1 and in epinephrine from 67 to 55 pg · ml−1. The Nif-induced increase in norepinephrine from a pre-treatment value of 293 pg · ml−1 with preceding Cod to 331 pg · ml−1 was much less than the increase with placebo as premedication, from 284 to 440 pg · ml−1. Nif caused an increase in renin activity but no increase in aldosterone. Nif-related side effects, such as flushing and headache, occurred in 6 patients of whom 5 had no received Cod as premedication. Due to the stabilizing action of Cod on catecholamines and on the side effects of Nif, Cod may be preferable to other antihypertensives in augmenting the antihypertensive action of Nif.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280932
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  • 7
    Electronic Resource
    Electronic Resource
    Transferrin subtypes and variants in Germany; Further evidence for a Tf null allele (1984)
    Springer
    Human genetics 〈Berlin〉 66 (1984), S. 356-360 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Isoelectric focusing (IEF) with carrier ampholytes was used for the determination of transferrin C subtypes and transferrin B and D variants in a sample of 1125 unrelated individuals from Southern Germany. The observed TfC allele frequencies were Tf*C1=0.7872, Tf*C2=0.1365, and Tf*C3=0.0675. The rare C subtype C6 was observed twice. A new C subtype, called C10, was observed and identified by IEF with immobilized pH gradients. The rare C subtypes C4 and C8 were also studied by this method. TfB and TfD variants were found with a heterozygous frequency of 1.53%. One new TfD was found which is located between D1 and D2 and therefore named D1-2. Evidence for a Tf null allele was obtained in a child and the putative father; they were considered to be heterozygous for an allele Tf0. The theoretical exclusion rate for paternity examinations was calculated for the Tf system and found to be 17.95%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00287641
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  • 8
    Electronic Resource
    Electronic Resource
    Two new Bf S subtypes revealed by isoelectric focusing and immunofixation (1984)
    Springer
    Human genetics 〈Berlin〉 68 (1984), S. 90-92 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The genetic types of the properdin factor B were analyzed by isoelectric focusing on polyacrylamide gels and subsequent immunofixation. Sera from 516 unrelated, healthy individuals from Southern Germany were examined. Two new subtypes of the Bf*S allele were observed. They were provisionally named Bf*Sb1 and Bf*Sb2 (b = basic), since the position of their bands is located slightly towards the cathode. Whereas Bf Sb2 has, thus far, been found only in a single individual, Bf Sb1 was found in five unrelated persons and in a mother and her child indicating a simple codominant mode of inheritance. The combined frequency of the Bf*Sb alleles was calculated to be 0.0067.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293880
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  • 9
    Electronic Resource
    Electronic Resource
    A “new” allele of esterase D in a retinoblastoma family (1988)
    Springer
    Human genetics 〈Berlin〉 78 (1988), S. 289-290 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We describe a new rare allele for esterase D (EsD) occurring in a Portuguese family with retinoblastoma in two generations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291680
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  • 10
    Electronic Resource
    Electronic Resource
    Untersuchungen über die Ausbreitung von Nonnenfaltern durch Markierung mit Seltenen Erden (1966)
    Springer
    Journal of pest science 39 (1966), S. 17-22 
    Details
    ISSN: 1612-4766
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary The present paper describes laboratory experiments in marking nun-caterpillars and nun-moths with the rare earths Europium and Dysprosium, as well as field studies on the spread of nun-moths marked with Europium. Nun-moths, sprayed with quantities of 1γ/individual in the caterpillar stage, proved distinctly marked, and so did pine spinners(Dendrolimus pini) treated the same way past year. Marking of moths succeeded in both laboratory and field by spraying with 10γ Europium, in the laboratory also with 10γ Dysprosium per individual. Spreading studies revealed marked moths overflying distances of 2 kilometres.
    Abstract: Résumé L'ouvrage présent traite d'essais en laboratoire sur le marquage de chenilles et de papillons de la Nonne(L. monacha) au moyen des terres rares Europium et Dysprosium, ainsi que de recherches au terrain sur l'expansion de papillons de cette espèce marqués d'Europium. Les images de la Nonne, ayant été aspérgées au stade larvaire d'une dose de 1γ par individu, se sont avérées distinctement marquées, de même que les Bombyx du Pin traités de la même manière l'année passée. — Le marquage de papillons a été effectué avec succès au laboratoire et au terrain au moyen de 10γ d'Europium — au laboratoire aussi de 10γ de Dysprosium — par individu, appliqués par aspersion. Les recherches sur l'expansion ont révélé un survol de papillons marqués à une distance de 2 km.
    Notes: Zusammenfassung In der vorliegenden Arbeit werden Laborversuche zur Markierung von Nonnenraupen und Nonnenfaltern mit den Seltenen Erden Europium und Dysprosium behandelt, sowie Freilanduntersuchungen zum Studium der Ausbreitung mit Europium gekennzeichneter Nonnenfalter. Imagines, die mit Mengen von 1γ/Exemplar im Raupenstadium besprüht worden waren, erwiesen sich, ebenso wie im Vorjahr in derselben Weise behandelte Kiefernspinner, als deutlich markiert. Zur Kennzeichnung der Falter gelangten im Labor und im Freiland 10γ Europium, im Labor auch 10γ Dysprosium/Exemplar mittels Besprühung erfolgreich zur Anwendung. Die Ausbreitungsuntersuchungen ergaben einen Überflug markierter Falter auf eine Entfernung von 2 km.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290088
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