ISSN:
1432-1041
Keywords:
Key words Fluvastatin
;
LDL oxidation; plasma trace metals
;
α-tocopherol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: Oxidation of low density lipoproteins (LDL) is thought to be an important step in the development of atherosclerosis. Trace metals are involved in oxidative processes. It was of interest to determine whether lipid-lowering therapy with fluvastatin, a potent HMGCoA reductase inhibitor, affected LDL oxidation and trace metal levels. Methods: Twenty hypercholesterolemic patients were treated with fluvastatin (40 mg twice daily) or placebo for 8 weeks in a double-blind, randomized study. LDL composition, antioxidants and oxidizability as well as plasma zinc, copper, selenium and manganese concentrations were investigated. Results: After fluvastatin treatment, total cholesterol was reduced by 24%, triglycerides fell by 26% and plasma Zn fell by 8%. Cu, Se and Mn changed insignificantly. LDL were separated by ultracentrifugation. LDL were reduced by 18%, LDL-C by 29% and LDL-TG by 19%. The concentrations of α-tocopherol and retinol in LDL changed insignificantly. LDL preparations were incubated with copper ions (204 μmol · l−1 LDL-C/3.2 μmol · l−1 Cu) and formation of conjugated dienes was monitored at 234 nm for 5 h. Treatment with fluvastatin caused a reduction of diene production by 16% and of diene production rate by 14%, effects being significantly different from placebo (P=0.02). The change of the lagtime did not reach significance; however, it was positively correlated with the change in LDL α-tocopherol. In the placebo group, no significant effects were observed. Conclusion: Fluvastatin therapy had lipid-lowering and antioxidative effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050338
